Evidence for peroxisome proliferator-activated receptor (PPAR)α-independent peroxisome proliferation: Effects of PPARγ/δ-specific agonists in PPARα-null mice

Molecular Pharmacology

Volumn 58, Issue 3, 2000, Pages 470-476

  DeLuca, John G ^a   Doebber, Thomas W ^a   Kelly, Linda J ^a   Kemp, Ramon K ^a   Molon Noblot, Sylvain ^a   Sahoo, Soumya P ^a   Ventre, John ^a   Wu, Margaret S ^a   Peters, Jeffrey M ^b   Gonzalez, Frank J ^b   Moller, David E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLORO 4 [3 (7 PROPYL 3 TRIFLUOROMETHYLBENZISOXAZOL 6 YLOXY)PROPYLTHIO]PHENYLACETIC ACID; 5 [4 [2[METHYL (2 PYRIDYL)AMINO]ETHOXY]BENZYL]THIAZOLIDINE 2,4 DIONE]; PEROXISOME PROLIFERATOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; STEROID RECEPTOR; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; FEMALE; LIVER CELL; MALE; MOUSE; NONHUMAN; PEROXISOME; PRIORITY JOURNAL;

EID: 0033867274     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.3.470     Document Type: Article

References (22)

1. Biogenesis of peroxisomes: Immunocytochemical investigation of peroxisomal membrane proteins in proliferating rat liver peroxisomes and in catalase-negative membrane loops
2. Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-gamma: Binding and activation correlate with antidiabetic actions in db/db mice
3. Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPAR delta ligands produce distinct biological effects
4. Estradiol induces proliferation of peroxisome-like microbodies and the production of 3-hydroxy fatty acid diesters, the female pheromones, in the uropygial glands of male and female mallards
5. Differential activation of adipogenesis by multiple PPAR isoforms
6. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
7. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
8. Rosiglitazone (BRL49653), a PPAR gamma-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
9. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2
10. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor
11. Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator-activated receptor alpha
12. Mechanisms of regulation of liver fatty acid-binding protein
13. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
14. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
15. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
16. Estrogen-induced production of a peroxisome proliferator-activated receptor (PPAR) ligand in a PPAR gamma-expressing tissue
17. Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
18. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
19. Peroxisome proliferator-activated receptors, orphans with ligands and functions
20. The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation
21. Fluorometric assay for rat liver peroxisomal fatty acyl-coenzyme A oxidase activity