Complexity of the mechanisms of initiation and maintenance of DNA damage-induced G2-phase arrest and subsequent G1-phase arrest: TP53-dependent and TP53-independent roles

Radiation Research

Volumn 159, Issue 1, 2003, Pages 72-85

  DeSimone, John N ^a   Bengtsson, Ulla ^a   Wang, Xiao Qi ^a   Lao, Xiao Yan ^a   Redpath, J Leslie ^a   Stanbridge, Eric J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN E; CYCLINE; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN KINASE; PROTEIN P21; TRANSCRIPTION FACTOR E2F; TYROSINE;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA PROTEIN COMPLEX; ENZYME ACTIVITY; GAMMA IRRADIATION; GENE; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKIN FIBROBLAST; TP53 GENE; TRANSCRIPTION REGULATION;

EID: 0037225464     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2003)159[0072:COTMOI]2.0.CO;2     Document Type: Article

References (76)

1. 1 arrest after gamma-irradiation. Proc. Natl. Acad. Sci. USA 96, 1002-1007 (1999).
2. Y. Gu, C. W. Turck and D. O. Morgan, Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710 (1993).
3. 1 cyclin-dependent kinases. Cell 75, 805-816 (1993).
4. Y. Xiong, G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi and D. Beach, p21 is a universal inhibitor of cyclin kinases. Nature 366, 701-704 (1993).
5. M. E. Ewen, H. K. Sluss, C. J. Sherr, H. Matsushime, J. Kato and D. M. Livingston, Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487-497 (1993).
6. J. Kato, H. Matsushime, S. W. Hiebert, M. E. Ewen and C. J. Sherr, Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev. 7, 331-342 (1993).
7. 1 cyclins. Cell 73, 1059-1065 (1993).
8. 1 phase progression: cycling on cue. Cell 79, 551-555 (1994).
9. R. A. Weinberg, The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
10. S. A. Ezhevsky, H. Nagahara, A. M. Vocero-Akbani, D. R. Gius, M. C. Wei and S. E Dowdy, Hypo-phosphorylation of the retino-blastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb. Proc. Natl. Acad. Sci. USA 94, 10699-10704 (1997).
11. 1 arrest. Cell 76, 1013-1023 (1994).
12. 2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res. 55, 1763-1773 (1995).
13. S. M. de Toledo, E. I. Azzam, P. Keng, S. Laffrenier and J. B. Little, Regulation by ionizing radiation of CDC2, cyclin A, cyclin B, thymidine kinase, topoisomerase IIα, and RAD51 expression in normal human diploid fibroblasts is dependent on p53/p21Wafl. Cell Growth Differ. 9, 887-896 (1998).
14. E. I. Azzam, S. M. de Toledo, M. J. Pykett, H. Nagasawa and J. B. Little, CDC2 is down-regulated by ionizing radiation in a p53-dependent manner. Cell Growth Differ. 8, 1161-1169 (1997).
15. 2/M arrest in human cells. Mol. Cell. Biol. 20, 2358-2366 (2000).
16. S. Matsuoka, M. Huang and S. J. Elledge, Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897 (1998).
17. A. J. Muslin, J. W. Tanner, P. M. Allen and A. S. Shaw, Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 84, 889-897 (1996).
18. 2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of cdc25C on serine-216. Science 277, 1501-1505 (1997).
19. C. Y. Peng, P. R. Graves, S. Ogg, R. S. Thoma, M. J. Byrnes, 3rd, Z. Wu, M. T. Stephenson and H. Piwnica-Worms, C-TAK1 protein kinase phosphorylates human cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ. 9, 197-208 (1998).
20. Y. Sanchez, C. Wong, R. S. Thoma, R. Richman, Z. Wu, H. Piwnica-Worms and S. J. Elledge. Conservation of the Chk1 checkpoint pathway in mammals: Linkage of DNA damage to Cdk regulation through Cdc25. Science 277, 1497-1501 (1997).
21. 2 DNA damage checkpoint. J. Biol. Chem. 275, 30638-30643 (2000).
22. H. Leffers, E. Madsen, H. H. Rasmussen, B. Honore, A. H. Andersen, E. Walbum, J. Vandekerckhove and J. E. Celis, Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. J. Mol. Biol. 231, 982-998 (1993).
23. G. L. Prasad, E. M. Valverius, E. McDuffie and H. L. Cooper, Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells. Cell Growth Differ. 3, 507-513 (1992).
24. 2/M progression. Mol. Cell. 1, 3-11 (1997).
25. S. N. Dalal, C. M. Schweitzer, J. Gan and J. A. DeCaprio, Cytoplasmic localization of human CDC25C during interphase requires an intact 14-3-3 binding site. Mol. Cell. Biol. 19, 4465-4479 (1999).
26. J. N. DeSimone, H. Dolezalova, J. L. Redpath and E. J. Stanbridge, Prolonged cell cycle arrest in irradiated human diploid skin fibroblasts: The role of nutrient deprivation. Radiat. Res. 153, 131-143 (2000).
27. 2 arrest after DNA damage. Science 282, 1497-1501 (1998).
28. S. Banin, L. Moyal, S. Shieh, Y. Taya, C. W. Anderson, L. Chessa, N. I. Smorodinsky, C. Prives, Y. Reiss and Y. Ziv, Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281 1674-1677 (1998).
29. 1 cell cycle checkpoint pathway and ataxia-telangiectasia. Cancer Res. 54, 5054-5058 (1994).
30. M. Fiscella, S. J. Ullrich, N. Zambrano, M. T Shields, D. Lin, S. P. Lees-Miller, C. W. Anderson, W. E. Mercer and E. Appella. Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression. Oncogene 8, 1519-1528 (1993).
31. S. Y. Shieh, M. Ikeda, Y. Taya and C. Prives, DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334 (1997).
32. E Liu, J. J. Stanton, Z. Wu and H. Piwnica-Worms, The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Mol. Cell. Biol. 17, 571-583 (1997).
33. C. H. McGowan and P. Russell, Human Weel kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyrl5. EMBO J. 12, 75-85 (1993).
34. L. L. Parker and H. Piwnica-Worms, Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science 257, 1955-1957 (1992).
35. J. B. Millar, J. Blevitt, L. Gerace, K. Sadhu, C. Featherstone and P. Russell, p55CDC25 is a nuclear protein required for the initiation of mitosis in human cells. Proc. Natl. Acad. Sci. USA 88, 10500-10504 (1991).
36. A. Kumagai and W. G. Dunphy, The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 64, 903-914 (1991).
37. A. Nagata, M. Igarashi, S. Jinno, K. Suto and H. Okayama, An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. New Biol. 3, 959-968 (1991).
38. 1/S-regulatory genes. Mol. Cell Biol. 15, 4215-4224 (1995).
39. J. DeGregori, G. Leone, A. Miron, L. Jakoi and J. R. Nevins, Distinct roles for E2F proteins in cell growth control and apoptosis. Proc. Natl. Acad. Sci. USA 94, 7245-7250 (1997).
40. R. K. Hurford, Jr., D. Cobrinik, M. H. Lee and N. Dyson, pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev. 11, 1447-1463 (1997).
41. J. Wells, K. E. Boyd, C. J. Fry, S. M. Bartley and P. J. Farnham, Target gene specificity of E2F and pocket protein family members in living cells. Mol. Cell Biol. 20, 5797-5807 (2000).
42. M. Pagano, A. M. Theodoras, S. W. Tam and G. F. Draetta, Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8, 1627-1639 (1994).
43. R. Li, G. J. Hannon, D. Beach and B. Stillman, Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage. Curr. Biol. 6, 189-199 (1996).
44. 1 Cell 98, 859-869 (1999).
45. A. S. Lundberg and R. A. Weinberg, Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell Biol. 18, 753-761 (1998).
46. M. Kitagawa, H. Higashi, H. K. Jung, I. Suzuki-Takahashi, M. Ikeda, K. Tamai, J. Kato, K. Segawa, E. Yoshida, S. Nishimura and Y. Taya, The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 15, 7060-7069 (1996).
47. E Girard, U. Strausfeld, A. Fernandez and N. J. Lamb, Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179 (1991).
48. M. Pagano, R. Pepperkok, E Verde, W. Ansorge and G. Draetta, Cyclin A is required at two points in the human cell cycle. EMBO J. 11, 961-971 (1992).
49. 2 phases of the cell cycle and associates with cyclin A. Proc. Natl. Acad. Sci. USA 89, 2824-2828 (1992).
50. D. H. Walker and J. L. Maller, Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature 354, 314-317 (1991).
51. 2 checkpoint function precedes human cell immortalization. Cancer Res. 55, 7-11 (1995).
52. 2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol. Chem. 268, 8298-8308 (1993).
53. 2-phase arrest in HeLa cells. Radiat. Res. 143, 286-292 (1995).
54. R. Y. Poon. M. S. Chau, K. Yamashita and T. Hunter. The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 57, 5168-5178 (1997).
55. S. D. Leach, C. D. Scatena, C. J. Keefer, H. A. Goodman, S. Y. Song, L. Yang and J. A. Pietenpol, Negative regulation of Weel expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis. Cancer Res. 58, 3231-3236 (1998).
56. 2 arrest in human cells. J. Cell Biol. 134, 963-970 (1996).
57. N. Rhind, B. Furnari and P. Russell, Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast. Genes Dev. 11, 504-511 (1997).
58. T A. Chan, H. Hermeking, C. Lengauer. K. W. Kinzler and B. Vogelstein, 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401, 616-620 (1999).
59. R. Datta, R. Hass, H. Gunji, R. Weichselbaum and D. Kufe, Down-regulation of cell cycle control genes by ionizing radiation. Cell Growth Differ. 3, 637-644 (1992).
60. 1 checkpoint in human diploid fibroblasts. Cancer Res. 60, 2623-2631 (2000).
61. R. J. Muschel, H. B. Zhang and W. G. McKenna, Differential effect of ionizing radiation on the expression of cyclin A and cyclin B in HeLa cells. Cancer Res. 53, 1128-1135 (1993).
62. 2 arrest following DNA damage. Cell Growth Differ. 6, 1053-1061 (1995).
63. 2 checkpoint is retinoblastoma protein dependent. Mol. Cell Biol. 20, 4210-4223 (2000).
64. 2 checkpoint is maintained by redundant pathways. Mol. Cell Biol. 19, 5872-5881 (1999).
65. 2 block induced by DNA damage: A caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation and H1 kinase activity. Cancer Res. 58, 2639-2645 (1998).
66. 2 cell cycle arrest in human keratinocytes by inhibitory phosphorylation of the cdc2 cell cycle kinase. Oncogene 11, 2151-2156 (1995).
67. P. Jin, S. Hardy and D. O. Morgan, Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. J. Cell Biol. 141, 875-885 (1998).
68. S. Kharbanda, A. Saleem, R. Datta, Z. M. Yuan, R. Weichselbaum and D. Kufe, Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2. Cancer Res. 54, 1412-1414 (1994).
69. P. M. O'Connor, D. K. Ferris, G. A. White, J Pines, T Hunter, D. L. Longo and K. W. Kohn, Relationships between cdc2 kinase, DNA cross-linking and cell cycle perturbations induced by nitrogen mustard. Cell Growth Differ. 3, 43-52 (1992).
70. W. S. el-Deiry, T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler and B. Vogelstein, WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825 (1993).
71. M. K. Shivji, S. J. Grey, U. P. Strausfeld, R. D. Wood and J. J. Blow, Cip1 inhibits DNA replication but not PCNA-dependent nucleotide excision-repair. Curr. Biol. 4, 1062-1068 (1994).
72. R. Li, S. Waga, G. J. Hannon, D. Beach and B. Stillman, Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371, 534-537 (1994).
73. 2 cell cycle arrest in p53-deficient cells. Oncogene 16, 311-320 (1998).
74. R. Bravo and H. Macdonald-Bravo, Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites. J. Cell Biol. 105, 1549-1554 (1987).
75. F. Wenz, E. I. Azzam and J. B. Little, The response of proliferating cell nuclear antigen to ionizing radiation in human lymphoblastoid cell lines is dependent on p53. Radiat. Res. 149, 32-40 (1998).
76. A. S. Balajee and C. R. Geard, Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acids Res. 29, 1341-1351 (2001).