The response of proliferating cell nuclear antigen to ionizing radiation in human lymphoblastoid cell lines is dependent on p53

Radiation Research

Volumn 149, Issue 1, 1998, Pages 32-40

  Wenz, Frederik ^a   Azzam, Edouard I ^a   Little, John B ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DETERGENT; DNA DIRECTED DNA POLYMERASE GAMMA; PROTEIN P21; PROTEIN P53;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DNA REPLICATION; EXCISION REPAIR; HUMAN; HUMAN CELL; IONIZING RADIATION; LYMPHOBLASTOID CELL LINE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; TUMOR SUPPRESSOR GENE;

CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DIMERIZATION; DNA DAMAGE; FIBROBLASTS; HUMANS; PROLIFERATING CELL NUCLEAR ANTIGEN; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031983319     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579679     Document Type: Article

References (47)

1. K. Miyachi, M. J. Fritzler and E. M. Tan, Autoantibody to a nuclear antigen in proliferating cells. J. Immunol. 121, 2228-2234 (1978).
2. M. B. Mathews, R. M. Bernstein, B. R. Franza and J. I. Garrels, Identity of the proliferating cell nuclear antigen and cyclin. Nature 309, 374-376 (1984).
3. C-K. Tan, C. Castillo, A. G. So and K. M. Downey, An auxiliary protein for DNA polymerase δ from fetal calf thymus. J. Biol. Chem. 261, 12310-12316 (1986).
4. S. H. Lee, Z. Q. Pan, A. D. Kwong, P. M. J. Burgers and J. Hurwitz, Synthesis of DNA by DNA polymerase ε in vitro. J. Biol. Chem. 266, 22707-22717 (1991).
5. G. Prelich, C-K. Tan, M. Kostura, M. B. Mathews, A. G. So, K. M. Downey and B. Stillman, Functional identity of proliferating cell nuclear antigen and a DNA polymerase & auxiliary protein. Nature 326, 517-520 (1987).
6. D. Jakulski, J. K. deRiel, W. E. Mercer, B. Calabretta and R. Baserga, Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science 240, 1544-1546 (1988).
7. M. K. K. Shivji, M. K. Kenny and R. D. Wood, Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69, 367-374 (1992).
8. R. Bravo and H. MacDonald-Bravo, Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: Association with DNA replication sites. J. Cell. Biol. 105, 1549-1554 (1987).
9. G. Landberg and G. Roos, Antibodies to proliferating cell nuclear antigen as S-phase probes in flow cytometric cell cycle analysis. Cancer Res, 51, 4570-4574 (1991).
10. Y. Xiong, H. Zhang and D. Beach, D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71, 504-514 (1992).
11. H. Zhang, Y. Xiong and D. Beach, Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell 4, 897-906 (1993).
12. L. Toschi and R. Bravo, Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis. J. Cell Biol. 107, 1623-1628 (1988).
13. H. MacDonald-Bravo and R. Bravo, Induction of the nuclear protein cyclin in serum-stimulated quiescent 3T3 cells is independent of DNA synthesis. Exp. Cell. Res. 156, 455-461 (1985).
14. R. Bravo, Synthesis of the nuclear protein cyclin (PCNA) and its relationship with DNA replication. Exp. Cell Res. 163, 287-293 (1986).
15. E. Prosperi, L. A. Stivala, E. Sala, A. I. Scovassi and L. Bianchi, Proliferating cell nuclear antigen complex formation induced by ultraviolet irradiation in human quiescent fibroblasts as detected by immunostaining and flow cytometry. Exp. Cell Res. 205, 320-325 (1993).
16. E. Prosperi, A. I. Scovassi, L. A. Stivala and L. Bianchi, Proliferating cell nuclear antigen bound to DNA synthesis sites: Phosphorylation and association with cyclin D1 and cyclin A. Exp. Cell Res. 215, 357-362 (1994).
17. T. S. R. Krishna, X-P. Kong, S. Gary, P. M. Burger and J. Kuriyan, Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell 79, 1233-1243 (1994).
18. P. Zhang, S-J. Zhang, Z. Zhang, J. F. Woessner and M. Y. W. T. Lee, Expression and physicochemical characterization of human proliferating cell nuclear antigen. Biochemistry 34, 10703-10712 (1995).
19. V. N. Podust, L. M. Podust, F. Goubin, B. Ducommun and U. Huebscher, Mechanism of inhibition of proliferating cell nuclear antigen-dependent DNA synthesis by the cyclin-dependent kinase inhibitor p21. Biochemistry 34, 8869-8875 (1995).
20. A. F. Nichols and A. Sancar, Purification of PCNA as a nucleotide excision repair protein. Nucleic Acids Res. 20, 2441-2446 (1992).
21. M. L. Smith, I-T. Chen, Q. Zhan, I. Bae, C-Y. Chen, T. M. Gilmer, M. B. Kastan, P. M. O'Connor and A. J. Fornace, Interaction of p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266, 1376-1380 (1994).
22. P. A. Hall, J. M. Kearsey, P. J. Coates, D. G. Norman, E. Warbrick and L. S. Cox, Characterisation of the interaction between PCNA and Gadd45. Oncogens 10, 2427-2433 (1995).
23. Cip1. Oncogene 11, 1675-1683 (1995).
24. WAF1/Cip1 with PCNA. Oncogene 11, 1931-1937 (1995).
25. Y. Li, C. W. Jenkins, M. A. Nichols and Y. Xiong, Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9, 2261-2268 (1994).
26. R. Li, S. Waga, G. J. Hannon, D. Beach and B. Stillman, Differential effects by p21 CDK inhibition on PCNA-dependent DNA replication and repair. Nature 371, 534-537 (1994).
27. S. Waga and B. Stillman, Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature 369, 207-212 (1994).
28. S. Waga, G. J. Hannon, D. Beach and B. Stillman, The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369, 574-578 (1994).
29. H. Flores-Rozas, Z. Kelman, F. B. Dean, Z. Q. Pan, J. W. Harper, S. J. Elledge, M. O'Donnell and J. Hurwitz, Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proc. Natl. Acad. Sci. USA 91, 8655-8659 (1994).
30. Z. Q. Pan, J. T. Reardon, L. Li, H. Flores-Rozas, R. Legerski, A. Sancar and J. Hurwitz, Inhibition of nucleotide excision repair by the cyclin-dependent kinase inhibitor p21. J. Biol. Chem. 270, 22008-22016 (1995).
31. V. N. Podust, L. M. Podust, F. Mueller and U. Huebscher, DNA polymerase δ holoenzyme: Action on single-stranded DNA and on double-stranded DNA in the presence of replicative DNA helicases. Biochemistry 34, 5003-5010 (1995).
32. WAF1.CIP1 -/- human cancer cells. Cancer Res. 56, 2250-2255 (1996).
33. M. Scheffner, B. A. Werness, J. M. Huibregtse, A. J. Levine and P. M. Howley, The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes degradation of p53. Cell 63, 1129-1136 (1990).
34. P. A. Havre, J. Yuan, L. Hedrick, K. R. Cho and P. M. Glazer, p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Res. 55, 4420-4424 (1995).
35. Y. Yu, C-Y. Li and J. B. Little, Abrogation of p53 function by HP16 E6 gene delays apopotosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblastoid cells. Oncogene 14, 1661-1667 (1997).
36. S. A. Amundson, F. Xia, K. Wolfson and H. L. Liber, Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutat. Res. 286, 233-241 (1993).
37. 1, arrest in two closely related human lymphoblastoid cell lines that differ in p53 status. J. Biol. Chem. 270, 11033-11036 (1995).
38. F. Lohr, F. Wenz, S. Hass and M. Flentje, Comparison of proliferating cell nuclear antigen (PCNA) staining and BrdUrd-labelhng index under different proliferative conditions in vitro by flow cytometry. Cell Prolif. 28, 93-104 (1995).
39. J. Sambrook, E. F. Fritsch and T. Maniatis, Molecular Cloning: A Laboratory Manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.
40. E. Maruyama, Biochemical characterization of mouse brain necdin. Biochem. J. 314, 895-901 (1996).
41. N-M. Tsang, H. Nagasawa, C-Y. Li and J. B. Little Abrogation of p53 function by transfection of HPV16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. Oncogene 10, 2403-2408 (1995).
42. waf1/cip1 protein associates with the detergent-insoluble form of PCNA concomitantly with disassembly of PCNA at nucleotide excision repair sites. Oncogene 13, 1591-1598 (1996).
43. M. Miura, M. Domon, T. Sasaki, S. Kondo and Y. Takasaki, Two types of proliferating cell nuclear antigen (PCNA) complex formation in quiescent normal and xeroderma pigmentosum group A fibroblasts following ultraviolet light (UV) irradiation. Exp. Cell Res. 201, 541-544 (1992).
44. L. A. Stivala, E. Prosperi, R. Rossi and L. Bianchi, Involvement of proliferating cell nuclear antigen in DNA repair after damage induced by genotoxic agents in human fibroblasts. Carcinogenesis 14, 2569-2573 (1993).
45. M. Pagano, A. M. Theodoras, S. W. Tam and G. F. Draetta, Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 8, 1627-1639 (1994).
46. S. Powell and T. J. McMillan, DNA damage and repair following treatment with ionizing radiation. Radiother. Oncol. 19, 95-108 (1990).
47. A. Umar, A. B. Buermeyer, J. A. Simon, D. C. Thomas, A. B. Clark, R. M. Liskay and T. A. Kunkel, Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis. Cell 87, 65-73 (1996).