CDC2 is down-regulated by ionizing radiation in a p53-dependent manner

Cell Growth and Differentiation

Volumn 8, Issue 11, 1997, Pages 1161-1169

  Azzam, Edouard I ^a   De Toledo, Sonia M ^b   Pykett, Mark J ^a   Nagasawa, Hatsumi ^a   Little, John B ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b Atomic Energy of Canada   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; DNA; PROTEIN P21;

ARTICLE; DNA DAMAGE; DOSE RESPONSE; ENZYME REGULATION; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CDC2 PROTEIN KINASE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOWN-REGULATION; ENZYME INHIBITORS; FIBROBLASTS; HUMANS; MICE; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030859716     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Little, J. B. Failla Memorial Lecture. Changing views of cellular radiosensitivity. Radiat. Res., 140: 299-311, 1994.
2. 2 block induced by ionizing radiation. Cancer Res., 57: 5113-5117, 1991.
3. 1 arrest. Cell, 76: 1013-1023, 1994.
4. de Toledo, S. M., Azzam, E. I., Gasmann, M. K., and Mitchel, R. E. J. Use of semiquantitative reverse transcription-polymerase chain reaction to study gene expression in normal human skin fibroblasts following low dose-rate irradiation. Int. J. Radiat. Biol., 67: 135-143, 1995.
5. Kastan, M. B., Onyekwere, O., Sidransky, D., Vogelstein, B., and Craig, R. W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51: 6304-6311, 1991.
6. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wylie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849-852, 1993.
7. Maxwell, S. A., and Jack, A. R. Posttranslational regulation of p53 tumor suppressor protein function. Crit. Rev. Oncog., 39: 23-57, 1994.
8. Su, L-N., and Little, J. B. Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and p53 binding domains. Int. J. Radiat. Biol., 62: 461-468, 1992.
9. Li, C., Nagasawa, H., Tsang, N-M., and Little, J. B. Radiation-induced irreversible G(0)/G(1) block is abolished in human diploid fibroblasts transfected with the human papilloma virus E6 gene: implications of the p53-Cip1/waf1 pathway. Int. J. Oncol., 6: 233-236, 1995.
10. 1 checkpoint control. Cell, 82: 675-684, 1995.
11. Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., and Hannon, G. J. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature (Lond.), 377: 552-557, 1995.
12. 1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc. Natl. Acad. Sci. USA, 91: 5320-5324, 1994.
13. 1-S-regulatory genes. Mol. Cell. Biol., 15: 4215-4224, 1995.
14. 1 cyclin-dependent kinases. Genes Dev., 9: 1149-1163, 1995.
15. Nurse, P. Ordering S phase and M phase in the cell cycle. Cell, 79: 547-550, 1994.
16. Forsburg, S. L., and Nurse, P. Cell cycle regulation in the yeast Saccharomyces cerevisiae and Schizosaccharomyces pombe. Annu. Rev. Cell Biol., 7: 227-256, 1991.
17. Draetta, G., and Beach, D. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell, 54: 17-26, 1988.
18. 1 to S transition in human T lymphocytes. Science (Washington DC), 250: 805-808, 1990.
19. Pagano, M., Pepperkok, R., Lukas, J., Baldin, V., Ansorge, W., Bartek, J., and Draetta, G. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J. Cell Biol., 121: 101-111, 1993.
20. Loyer, P., Glaise, D., Cariou, S., Baffet, G., Meijer, L., and GuguenGuillouzo, C. Expression and activation of cdks (1 and 2) and cyclins in the cell cycle progression during liver regeneration. J. Biol. Chem., 269: 2492-2500, 1994.
21. 2 arrest in Chinese hamster ovary cells. Cancer Res., 50: 3761-3766, 1990.
22. cdc2. Cancer Res., 54: 1412-1414, 1994.
23. 2-phase arrest in HeLa cells. Radiat. Res., 743: 286-292, 1995.
24. 2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res., 55: 1763-1773, 1995.
25. Barth, H., Hoffmann, I., and Kinzel, V. Radiation with 1 Gy prevents the activation of the mitotic inducers mitosis-promoting factor (MPF) and cdc25-C in HeLa cells. Cancer Res., 56: 2268-2272, 1996.
26. Beamish, H., Williams, R., Chen, P., and Lavin, M. F. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia postirradiation. J. Biol. Chem., 271: 20486-20493, 1996.
27. cdc2 kinases in irradiated human B-cell precursors. J. Biol. Chem., 277: 6389-6397, 1996.
28. cdc2Cancer Res., 56: 3617-3621, 1996.
29. 1-S transitions of the cell cycle: identification of major phosphorylation sites. EMBO J., 70: 305-316, 1991.
30. cdc2 protein kinase at the start of S phase in the human cell cycle. Mol. Biol. Cell., 3: 389-401, 1992.
31. cdc2 synthesis by transforming growth factor β in cycling epithelial cells. Cell Growth Differ., 5: 109-116, 1994.
32. Hall, E. J. Radiosensitivity and cell age in mitotic cycle. In: E. J. Hall (ed.), Radiobiology for the Radiologist, pp. 113-128. Philadelphia: Harper & Row, 1978.
33. Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., and Howley, P. M. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell, 63: 1129-1136, 1990.
34. Crook, T., Tidy, J. A., and Vousden, K. H. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and transactivation. Cell, 67: 547-556, 1991.
35. Tsang, N-M., Nagasawa, H., Li, C., and Little, J. B. Abrogation of p53 function by transfection of HPV 16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. Oncogene, 10: 2403-2408, 1995.
36. Linke, S. P., Clarkin, K. C., and Wahl, G. M. p53 mediates permanent arrest over multiple cell cycles in response to γ-irradiation. Cancer Res., 57: 1171-1179, 1997.
37. Lees, E. Cyclin-dependent kinase regulation. Curr. Opin. Cell Biol., 7: 773-780, 1995.
38. Nevins, J. R. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (Washington DC), 258: 424-429, 1992.
39. Dimri, G. P., Nakanishi, M., Desprez, P-Y., Smith, J. R., and Campisi, J. Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein. Mol. Cell. Biol., 16: 2987-2997, 1996.
40. Dalton, S. Cell cycle regulation of the human CDC2 gene. EMBO J., 11: 1797-1804, 1992.
41. Furukawa, Y., Terui, Y., Sakoe, K., Ohta, M, and Saito, M. The role of cellular transcription factor E2F in the regulation of CDC2 mRNA expression and cell cycle control of human hematopoietic cells, J. Biol. Chem., 269: 26249-26258, 1994.
42. 1-S boundary-specific enhancer of the rat cdc2 promoter. Mol. Cell. Biol., 15: 2882-2892, 1995.
43. Tomassi, S., and Pfeifer, G. In vivo structure of the human cdc2 promoter: release of a p130-E2F-4 complex from sequences immediately upstream of the transcription initiation site coincides with induction of cdc2 expression. Mol. Cell. Biol., 75: 6901-6913, 1995.
44. Zwicker, J., Lucibello, F. C., Wolfraim, L. A., Gross, C., Truss, M., Engeland, K., and Müller, R. Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J., 14: 4514-4522, 1995.
45. 1 cell state. Mol. Cell. Biol., 16: 6965-6976, 1996.
46. Shiyanov, P., Bagchi, S., Adami, G., Kokontis, J., Hay, N., Arroyo, M., Morozov, A., and Raychaudhuri, P. p21 disrupts the interaction between cdk2 and the E2F-p130 complex. Mol. Cell. Biol., 16: 737-744, 1996.
47. Little, J. B., and Nagasawa, H. Effect of confluent holding on potentially lethal damage repair, cell cycle progression, and chromosomal aberrations in human normal and ataxia telangiectasia fibroblasts. Radiat. Res., 101: 81-93, 1985.
48. 2-M by p53. Oncogene, 10: 109-115, 1995.
49. Waldman, T., Lengauer, C., Kinzler, K. W., and Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (Lond.), 381: 713-716, 1996.
50. Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell, 81: 323-330, 1995.
51. Taya, Y., Yasuda, H., Kamijo, M., Nakaya, K., Nakamura, Y., Ohba, Y., and Nishimura, S. In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase. Biochem. Biophys. Res. Commun., 764: 580-586, 1989.
52. Datta, R., Mass, R., Gunji, H., Weichselbaum, R., and Kufe, D. Downregulation of cell cycle control genes by ionizing radiation. Cell Growth Differ., 3: 637-644, 1992.
53. Kung, A. L., Sherwood, S. W., and Schimke, R. T. Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc. Natl. Acad. Sci. USA, 87: 9553-9557, 1990.
54. Pardee, A. B. Multiple molecular levels of cell cycle regulation. J. Cell. Biochem., 54: 375-378, 1994.
55. Nagasawa, H., Latt, S. A., Lalande, M. E., and Little, J. B. Effects of X-irradiation on cell cycle progression, induction of chromosomal aberrations and cell killing in ataxia telangiectasia (AT) fibroblasts. Mutat. Res., 148: 71-82, 1985.
56. nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989.
57. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Anal. Biochem., 162: 156-159, 1987.