Diminished glutathione levels cause spontaneous and mitochondria- mediated cell death in neurons from trisomy 16 mice: A model of Down's syndrome

Journal of Neurochemistry

Volumn 74, Issue 3, 2000, Pages 1205-1214

  Schuchmann, S ^a   Heinemann, U ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Cyclosporin A; Down's syndrome; Glutathione; Mitochondria; Tocopherol

Indexed keywords

ANTIOXIDANT; CYCLOSPORIN A; CYSTEINE; CYSTINE; GLUTAMIC ACID; GLUTATHIONE; TOCOPHEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DOWN SYNDROME; MICROFLUOROMETRY; MITOCHONDRION; MOUSE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 0033952295     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.741205.x     Document Type: Article

References (59)

1. Anderson M. E. (1985) Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113, 548-555.
2. Avraham K. B., Schickler M., Sapoznikov D., Yarom R., and Groner Y. (1988) Down's syndrome: abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase. Cell 54, 823-829.
3. Bains J. S. and Shaw C. A. (1997) Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res. Rev. 25, 335-358.
4. Bambrick L. L., Yarowsky P. J., and Krueger B. K. (1995) Glutamate as a hippocampal neuron survival factor: an inherited detect in the trisomy 16 mouse. Proc. Natl. Acad. Sci. USA 92, 9692-9696.
5. Bannai S, .and Tateishi N. (1986) Role of membrane transport in metabolism and function of glutathione in mammals. J. Membr. Biol. 89, 1-8.
6. Behl C., Davis J. B., Lesley R., and Schubert D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77, 817-827.
7. Bernardi P. (1996) The permeability transition pore. Control points of cyclosporin A-sensitive mitochondrial channel involved in cell death. Biochim. Biophys. Acta 1275, 5-9.
8. Brookes P. S., Land J. M., Clark J. B., and Heales S. J. R. (1998) Peroxynitrite and brain mitochondria: evidence for increased proton leak. J. Neurochem. 70, 2195-2202.
9. Busciglio J. and Yankner B. A. (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378, 776-779.
10. Choi D. W. (1995) Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18, 58-60.
11. Clarke D. D. (1991) Fluoroacetate and fluorocitrate: mechanism of action. Neurochem. Res. 16, 1055-1058.
12. Colton C. A., Yao J., Gilbert D., and Oster-Granite M. L. (1990) Enhanced production of superoxide anion by microglia from trisomy 16 mice. Brain Res. 519, 236-242.
13. Cooper A. J. L. and Kristal B. S. (1997) Multiple roles of glutathione in the central nervous system. Biol. Chem. Hoppe Seyler 378, 793-802.
14. Coyle J. T. and Puttfarcken P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
15. Dringen R. and Hamprecht B. (1996) Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures. J. Neurochem. 67, 1375-1382.
16. Dringen R., Pfeiffer B., and Hamprecht B. (1999) Synthesis of the antioxidant glutathione in neurons, supply by astrocytes of Cys-Gly as precursor for neuronal glutathione. J. Neurosci. 19, 562-569.
17. Dubinsky J. M., Kristal B. S., and Elizondo-Fournier M. (1995) On the probabilistic nature of excitotoxic neuronal death in hippocampal neurons. Neuropharmacology 34, 701-711.
18. Duchen M. R. (1999) Contribution of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. J. Physiol. (Lond.) 516, 1-17.
19. Dugan L. L., Sensi S. L., Canzoniero L. M. T., Handran S. D., Rothman S. M., Lin T.-S., Goldberg M. P., and Choi D. W. (1995) Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. J. Neurosci. 15, 6377-6388.
20. Epstein C. J. (1986) The Neurobiology of Down Syndrome. Raven Press, New York.
21. Fernández-Checa J. C. and Kaplowitz N. (1990) The use of monochlorobimane to determine hepatic GSH levels and synthesis. Anal. Biochem. 190, 212-219.
22. Galdzicki Z., Coan E., and Rapoport S. I. (1993) Cultured hippocampal neurons from trisomy 16 mouse, a model for Down syndrome, have abnormal action potential due to reduced inward sodium current. Brain Res. 604, 69-78.
23. Groner Y., Elroy-Stein O., Avraham K. B., Schickler M., Knobler H., Minc-Golomb D., Bar-Peled O., Yarom R., and Rotshenker S. (1994) Cell damage by excess CuZnSOD and Down's syndrome. Biomed. Pharmacother. 48, 231-240.
24. Gunter T. E., Gunter K. K., Sheu S.-S., and Gavin C. E. (1994) Mitochondrial calcium transport: physiological and pathological relevance. Am. J. Physiol. 267, C313-C339.
25. Hulbert P. B. and Yakubu S. I. (1983) Monobromobimane: a substrate for the fluorimetric assay of glutathione transferase. J. Pharm. Pharmacol. 35, 384-386.
26. Jain A., Martensson J., Stole E., Auld P. A. M., and Meister A. (1991) Glutathione deficiency leads to mitochondrial damage in brain. Proc. Natl. Acad. Sci. USA 88, 1913-1917.
27. Kato S., Ishita S., Sugawara K., and Mawatari K. (1993) Cysteine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity. Neuroscience 57, 473-482.
28. 2+ is dependent on mitochondrial-generated reactive oxygen species. FEBS Lett. 378, 150-152.
29. Kranich O., Hamprecht B., and Dringen R. (1996) Different preferences in the utilization of amino acids for glutathione synthesis in cultured neurons and astroglial cells derived from rat brain. Neurosci. Lett. 219, 211-214.
30. Lane N. J., Balbo A., and Rapoport S. I. (1996) A fine structural study of hippocampus and dorsal root ganglion in mouse trisomy 16, a model of Down's syndrome. Cell Biol. Int. 20, 673-680.
31. Makar T. K., Nedergaard M., Preuss A., Gelbard A. S., Perumal A. S., and Cooper A. J. L. (1994) Vitamin E, ascorbate, glutathione, glutathione desulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J. Neurochem. 62, 45-53.
32. Mattson M. P., Cheng B., Davis D., Bryant K., Lieberburg I., and Rydel R. E. (1992) β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12, 376-389.
33. Mattson M. P., Zhang Y., and Bose S. (1993) Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose. Exp. Neurol. 121, 1-13.
34. Mattson M. P., Barger S. W., Begley J. G., and Mark R. J. (1995) Calcium, free radicals, and excitotoxic neuronal cell death in primary cell culture. Methods Cell Biol. 46, 187-216.
35. Meister A. (1988) Glutathione metabolism and its selective modification. J. Biol. Chem. 263, 17205-17208.
36. Meister A. and Anderson M. E. (1983) Glutathione. Annu. Rev. Biochem. 52, 711-760.
37. Murphy T. H., Miyamoto M., Sastre A., Schnaar R. L., and Coyle J. T. (1989) Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron 2, 1547-1558.
38. Neuschwander-Tetri B. A. and Roll F. J. (1989) Glutathione measurement by high-performance liquid chromatography separation and fluorometric detection of the glutathione-orthophthalaldehyde adduct. Anal. Biochem. 179, 236-241.
39. Nicolli A., Basso E., Petronilli V., Wenger R. M., and Bernardi P. (1996) Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, a cyclosporin A-sensitive channel. J. Biol. Chem. 271, 2185-2192.
40. 2 in rat hepatocytes studied by multiparameter digitized video microscopy, in Optical Microscopy for Biology (Herman B. and Jacobson K., eds), pp. 323-335. Wiley-Liss, New York.
41. Nieminen A.-L., Petrie T. G., Lemasters J. J., and Selman W. R. (1996) Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition. Neuroscience 75, 993-997.
42. Peacock J. H., Rush D. F., and Mathers L. H. (1979) Morphology of dissociated hippocampal cultures from fetal mice. Brain Res. 169, 231-346.
43. Reed D. J. and Savage M. K. (1995) Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status. Biochim. Biophys. Acta 1271, 43-50.
44. Reynolds I. J. and Hastings T. G. (1995) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. J. Neurosci. 15, 3318-3327.
45. Richards S. J., Waters J. J., Beyreuther K., Masters C. L., Wischik C. M., Sparkman D. R., White C. L., Abraham C. R., and Dunnett S. B. (1991) Transplants of mouse trisomy 16 hippocampus provide a model of Alzheimer's disease neuropathology. EMBO J. 10, 297-303.
46. 2+ homeostasis, cell death, proliferation, and differentiation. Chem. Biol. Interact. 77, 1-23.
47. Richter C., Gogvadze V., Laffranchi R., Schlapbach R., Schweizer M., Suter M., Walter P., and Yaffee M. (1995) Oxidants in mitochondria: from physiology to diseases. Biochim. Biophys. Acta 1271, 67-74.
48. Sagara J., Miura K., and Bannai S. (1993) Maintenance of neuronal glutathione by glial cells. J. Neurochem. 61, 1672-1676.
49. Savage M. K. and Reed D. J. (1994) Release of mitochondrial glutathione and calcium by a cyclosporin A-sensitive mechanism occurs without large amplitude swelling. Arch. Biochem. Biophys. 315, 142-152.
50. Scanlon J. M. and Reynolds I. J. (1998) Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons. J. Neurochem. 71, 2392-2400.
51. Schinder A. F., Olson E. C., Spitzer N. C., and Montal M. (1996) Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16, 6125-6133.
52. 2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome. J. Neurosci. 18, 7216-7231.
53. Sinet P. M. (1982) Metabolism of oxygen derivatives in Down's syndrome. Ann. NY Acad. Sci. 396, 83-94.
54. Stabel-Burow J., Kleu A., Schuchmann S., and Heinemann U. (1997) Glutathione levels and nerve cell loss in hippocampal cultures from trisomy 16 mouse - a model of Down syndrome. Brain Res. 765, 313-318.
55. 2+ in the oxidative stress-induced dissipation of the mitochondrial membrane potential. J. Biol. Chem. 269, 14546-14552.
56. White R. J. and Reynolds I. J. (1996) Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. J. Neurosci. 16, 5688-5697.
57. Yim M. B., Chock P. B., and Stadtman E. R. (1993) Enzyme function of copper, zinc superoxide dismutase as a free radical generator. J. Biol. Chem. 268, 4099-4105.
58. Zamzami N., Marchetti P., Castedo M., Decudin D., Macho A., Hirsch T., Susin S. A., Petit P. X., Mignotte B., and Kroemer G. (1995) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp. Med. 182, 367-377.
59. Zamzami N., Susin S. A., Marchetti P., Hirsch T., Gómez-Monterrey I., Castedo M., and Kroemer G. (1996) Mitochondrial control of nuclear apoptosis. J. Exp. Med. 183, 1533-1544.