Glial expression of estrogen and androgen receptors after rat brain injury

Journal of Comparative Neurology

Volumn 450, Issue 3, 2002, Pages 256-271

  García Ovejero, Daniel ^a   Veiga, Sergio ^a   García Segura, Luis Miguel ^a   Doncarlos, Lydia L ^b  

^a INSTITUTO CAJAL   (Spain)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Astrocytes; Gonadal steroids; Kainic acid; Microglia; Neuroprotection; Stab wound

Indexed keywords

ANDROGEN RECEPTOR; CELL MARKER; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; LECTIN; LECTIN 1; PROTEIN OX 6; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ARTICLE; ASTROCYTE; BRAIN INJURY; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE MARKER; DISEASE MODEL; GLIA CELL; GRIFFONIA SIMPLICIFOLIA; HIPPOCAMPUS; HORMONE RECEPTOR INTERACTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; WOUND;

ANIMALS; ASTROCYTES; BRAIN; BRAIN INJURIES; DISEASE MODELS, ANIMAL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; LECTINS; MALE; MICROGLIA; NERVE DEGENERATION; NERVE REGENERATION; NEUROGLIA; PLANT LECTINS; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; VIMENTIN;

EID: 0037179117     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10325     Document Type: Article

References (177)

1. Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds
2. Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis
3. Gonadal steroid induction of structural sex differences in the central nervous system
4. Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus
5. Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling
6. Localization of estrogen receptor beta-immunoreactivity in astrocytes of the adult rat brain
7. Astroglia play a key role in the neuroprotective actions of estrogen
8. Quantitative estimation of estrogen and androgen receptor-cells in the forebrain of neonatally estrogen-deprived male rats
9. Alterations in temporal/spatial distribution of GFAP- and vimentin-positive astrocytes after spinal cord contusion with the New York University spinal cord injury device
10. Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner
11. Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids
12. Rapid effects of estrogen or progesterone on the amphetamine-induced increase in striatal dopamine are enhanced by estrogen priming: A microdialysis study
13. Neuroprotective activities of estrogen: An update
14. Sex-steroid actions on neurotransmission
15. Cytoplasmic estrogen receptors in rat brain: Immunocytochemical evidence using three antibodies with distinct epitopes
16. Estrogen receptors in dendrites and axon terminals in the guinea pig hypothalamus
17. Reactive astrocytes express estrogen receptors in the injured primate brain
18. Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female rat
19. Ovary-dependent degeneration in the hypothalamic arcuate nucleus
20. In vitro labeling of gonadal steroid hormone receptors in brain tissue sections
21. Anti-inflammatory effects of estrogen on microglial activation
22. Estrogen astrocyteluteinizing hormone-releasing hormone signaling: A role for transforming growth factor beta
23. Co-expression of glial fibrillary acidic protein and vimentin in reactive astrocytes following brain injury in rats
24. Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain
25. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism
26. Sexual dimorphism and sex steroid modulation of glial fibrillary acidic protein messenger RNA and immunoreactivity levels in the rat hypothalamus
27. Neurosteroids: Biosynthesis and function of these novel neuromodulators
28. Sexual differentiation of the vertebrate brain: Principles and mechanisms
29. Androgen and estrogen receptors are present in primary cultures of human synovial macrophages
30. Cellular forms and functions of brain microglia
31. Gonadal steroids regulate the expression of glial fibrillary acidic protein in the adult male rat hippocampus
32. The effect of age and testosterone on the expression of glial fibrillary acidic protein in the rat cerebellum
33. Neurosteroids modulate the reaction of astroglia to high extracellular potassium levels
34. DHEAS inhibits TNF production in monocytes, astrocytes and microglial cells
35. Kainate glutamate receptors (GluR5-7) in the rat arcuate nucleus: Relationship to tanycytes, astrocytes, neurons and gonadal steroid receptors
36. Neuroprotective effects of estrogen upon the nigrostriatal dopaminergic system
37. Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1-40) and lipopolysaccharides
38. Cells containing immunoreactive estrogen receptor-alpha in the human basal forebrain
39. Distribution of estrogen receptor-immunoreactive cells in the forebrain of the female guinea pig
40. Cellular phenotype of androgen receptor expressing cells in the brain
41. Androgen receptor immunoreactive axons in the rat cerebral cortex
42. Female sex steroids: Effects upon microglial cell activation
43. Neuroprotective effects of estradiol in middle-aged female rats
44. Molecular profile of reactive astrocytesimplications for their role in neurologic disease
45. Intermediate filament protein partnership in astrocytes
46. Cholinergic sprouting in the hippocampus: A proposed role for IL-1
47. The glial scar and central nervous system repair
48. Immunoreactivity for intracellular androgen receptors in identified subpopulations of neurons, astrocytes and oligodendrocytes in primate prefrontal cortex
49. Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus
50. Cellular and molecular mechanisms of glial scarring and progressive cavitation: In vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma
51. Ovariectomy of adult rats leads to increased expression of astrocytic basic fibroblast growth factor in the ventral tegmental area and in dopaminergic projection regions of the entorhinal and prefrontal cortex
52. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury
53. Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive astroglia in the male rat brain after a penetrating brain injury
54. The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids
55. Astrocytic shape and glial fibrillary acidic protein immunoreactivity are modified by estradiol in primary rat hypothalamic cultures
56. Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms
57. Gonadal hormone regulation of glial fibrillary acidic protein immunoreactivity and glial ultrastructure in the rat neuroendocrine hypothalamus
58. Estradiol promotion of changes in the morphology of astroglia growing in culture depends on the expression of polysialic acid of neural membranes
59. Aromatase expression by astrocytes after brain injury: Implications for local estrogen formation in brain repair
60. Insulin-like growth factor-I receptors and estrogen receptors interact in the promotion of neuronal survival and neuroprotection
61. Neuroprotection by estradiol
62. Chemokine expression in rat stab wound brain injury
63. Reactive cell proliferation and microglia following injury to the rat brain
64. The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat
65. Neuroprotective effects of estrogens: Potential mechanisms of action
66. Estrogen receptor immunoreactivity in Schwann-like brain macroglia
67. Schwann-like macroglia in adult rat brain
68. Glial fibrillary acidic protein (GFAP)-immunoreactivity is reduced by castration in the interpeduncular nucleus of male rats
69. Gonadal steroid hormone receptors and sex differences in the hypothalamo-pituitaryadrenal axis
70. Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats
71. Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1 beta is required for the production of ciliary neurotrophic factor
72. Selective potentiation of NMDA-induced neuronal injury following induction of astrocytic iNOS
73. Histochemical and electrophysiological evidence for estrogen receptors on cultured astrocytes: Colocalization with cholinergic receptors
74. Changes of growth inhibitory factor after stab wounds in rat brain
75. Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds - An immunocytochemical study using confocal laser scan microscope
76. Co-expression of GFAP and vimentin in astrocytes proliferating in response to injury in the mouse cerebral hemisphere. A combined autoradiographic and double immunocytochemical study
77. Morphological and immunophenotypic microglial changes in the denervated fascia dentata of adult rats: Correlation with blood-brain barrier damage and astroglial reactions
78. Gonadal steroids as promoting factors in axonal regeneration
79. Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: Effects of axotomy and testosterone
80. Androgenic regulation of the central glia response following nerve damage
81. Microglial and astroglial reactions to ischemic and kainic acid-induced lesions of the adult rat hippocampus
82. Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells
83. Rapid effects of estrogen to modulate G protein-coupled receptors via activation of protein kinase A and protein kinase C pathways
84. Microglial secreted cathepsin B induces neuronal apoptosis
85. Temporal profile of expression and cellular localization of inducible nitric oxide synthase, interleukin-1beta and interleukin converting enzyme after cryogenic lesion of the rat parietal cortex
86. Glial fibrillary acidic protein mRNA increases at proestrus in the arcuate nucleus of mice
87. Microglia: A sensor for pathological events in the CNS
88. Testosterone regulation of the regenerative properties of injured rat sciatic motor neurons
89. Modulation of G protein coupled receptors by an estrogen receptor that activates protein kinase A
90. Estrogen rapidly attenuates a GABA(B) response in hypothalamic neurons
91. Estrogen receptor-immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: Electron microscopy
92. Peripheral nerve stimulated macrophages simulate a peripheral nerve-like regenerative response in rat transected optic nerve
93. A review of brain aromatase cytochrome P450
94. A time course for the focal elevation of synthesis of basic fibroblast growth factor and one of its high-affinity receptors (flg) following a localized cortical brain injury
95. Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat
96. Androgen receptor in mouse brain: Sex differences and similarities in autoregulation
97. Natural fluctuation and gonadal hormone regulation of astrocyte immunoreactivity in dentate gyrus
98. Transforming growth factor-alpha gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation
99. Sexual differentiation of the central nervous system
100. Lipopolysaccharide stimulated rat brain macrophages release NGF in vitro
101. Localization of androgen receptor expression in human bone marrow
102. Glial changes following an excitotoxic lesion in the CNS: Microglia/macrophages
103. Dramatic phenotypic improvement during pregnancy in a genetic leukodystrophy: Estrogen appears to be a critical factor
104. Ontogeny of region-specific sex differences in androgen receptor messenger ribonucleic acid expression in the rat forebrain
105. Androgen receptor expression is greater in macrophages from male than from female donors. A sex difference with implications for atherogenesis
106. Dehydroepiandrosterone modulation of lipopolysaccharide-stimulated monocyte cytotoxicity
107. Glial cells and neuroendocrine function
108. Activation of microglial cells by beta-amyloid protein and interferon-gamma
109. Estradiol reduces calcium currents in rat neostriatal neurons via a membrane receptor
110. Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites
111. Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
112. Microglial and astrocytic cell responses in the rat hippocampus after an intracerebroventricular kainic acid injection
113. Androgen receptor immunoreactivity in the forebrain of the eastern fence lizard (Sceloporus undulatus)
114. Steroid-induced developmental plasticity in hypothalamic astrocytes: Implications for synaptic patterning
115. The concept of microglia in relation to central nervous system disease and regeneration
116. Estrogen and microglia: A regulatory system that affects the brain
117. Expression ofimmunomolecules on microglial cells following neonatal sciatic nerve axotomy
118. Estrogen: Mechanisms for a rapid action in CA1 hippocampal neurons
119. The cellular effects of estrogens on neuroendocrine tissues
120. Trophic effects of androgen receptor expression and the survival of laryngeal motor neurons after axotomy
121. Androgen mitigates axotomy-induced decreases in calbindin expression in motor neurons
122. Rapid upregulation of aromatase mRNA and protein following neural injury in the zebra finch (Taeniopygia guttata)
123. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies
124. Activated macrophage/microglial cells can promote the regeneration of sensory axons into the injured spinal cord
125. Androgen receptor localization in different cell types of the adult rat prostate
126. Immunocytochemical detection of androgen receptor in human temporal cortex characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues
127. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth
128. Membrane receptors for estrogen, progesterone, and testosterone in the rat brain: Fantasy or reality
129. Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: Studies of ERα and ERβ expressed in Chinese hamster ovary cells
130. Alterations in fibroblast growth factor receptor expression following brain injury
131. Reactive astrocytes: Cellular and molecular cues to biological function
132. Contribution of peripheral macrophages and microglia to the cellular reaction after mechanical or neurotoxin-induced lesions of the rat brain
133. Gender differences in acute CNS trauma and stroke: Neuroprotective effects of estrogen and progesterone
134. Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard
135. Cytokines in neurodegeneration and repair
136. Expression of vascular endothelial growth factor by reactive astrocytes and associated neoangiogenesis
137. Estrogen receptor is expressed in different types of glial cells in culture
138. Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages
139. Cascading glia reactions: A common pathomechanism and its differentiated control by cyclic nucleotide signaling
140. Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans
141. Distribution of estrogen receptor beta immunoreactivity in the rat central nervous system
142. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system
143. Ultrastructural characteristics of estrogen receptor-containing neurons of the ventrolateral nucleurs of the guinea-pig hypothalamus
144. Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study
145. The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons
146. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: Convergence of estrogen and neurotrophin signaling pathways
147. Estrogen-induced activation of the mitogen-activated protein kinase cascade in the cerebral cortex of estrogen receptor-alpha knock-out mice
148. Sex steroid effects on extrahypothalamic CNS. I. Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum
149. Sex steroids modulate motor-correlated increases in cerebellar discharge
150. Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro
151. Bidirectional transcription regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro
152. An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4)
153. Lectin binding by resting and reactive microglia
154. Reactive microgliosis
155. Immunohistochemical studies on the proliferation of reactive astrocytes and the expression of cytoskeletal proteins following brain injury in rats
156. Gonadal steroid regulation of hamster facial nerve regeneration: Effects of dihydrotestosterone and estradiol
157. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. Influence of pre- and post-traumatic treatment with Ro5 4864, a peripheral-type (p site) benzodiazepine ligand
158. Gonadal steroids: Effects on excitability of hippocampal pyramidal cells
159. Downregulation of in vitro neurotoxicity of brain macrophages by prostaglandin E2 and a betaadrenergic agonist
160. Novel sites and mechanisms of oestrogen action in the brain
161. Novel mechanisms of estrogen action in the brain: New players in an old story
162. Estradiol promotes cell shape changes and glial fibrillary acidic protein redistribution in hypothalamic astrocytes in vitro: A neuronal-mediated effect
163. Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis
164. Estrogen prevents the lipopolysaccharide-induced inflammatory response to microglia
165. Evidence for estrogen receptor in cell nuclei and axon terminals within the lateral habenula of the rat: Regulation during pregnancy
166. Spatial and temporal changes in the insulin-like growth factor (IGF) axis indicate autocrine/paracrine actions of IGF-I within wounds of the rat brain
167. Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia
168. Distribution and hormone regulation of estrogen receptor-immunoreactive cells in the hippocampus of male and female rats
169. Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury
170. Cytokine production in the central nervous system
171. DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium
172. Administration of testosterone attenuates neuronal loss following axotomy in the brain-stem motor nuclei of female rats
173. Distribution of occupied and unoccupied estrogen receptors in the rat brain: Effects of physiological gonadal steroid exposure
174. 17-Beta-estradiol induces an inhibitor of active caspases
175. TGF-alpha differentially regulates GFAP, vimentin, and nestin gene expression in U-373 MG glioblastoma cells: Correlation with cell shape and motility
176. Spatiotemporal patterns of microglial proliferation in rat brain injured at the postmitotic stage of postnatal development