Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: Effects of axotomy and testosterone

Neurochemical Research

Volumn 22, Issue 11, 1997, Pages 1359-1366

  Jones, Kathryn J ^a,c   Kinderman, Nancy B ^a   Oblinger, Monica M ^b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b The Chicago Medical College   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Androgens; Astrocytes; Axonal injury; GFAP; Gonadal steroids; Peripheral nervo regeneration; Reactive gliesis

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; TESTOSTERONE PROPIONATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; CASTRATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FACIAL NERVE NUCLEUS; GLIOSIS; HAMSTER; IN SITU HYBRIDIZATION; INTERMEDIATE FILAMENT; MALE; MOTONEURON NUCLEUS; NERVE FIBER REGENERATION; NERVE FIBER TRANSECTION; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; AUTORADIOGRAPHY; AXOTOMY; CRICETINAE; FACIAL NERVE; FACIAL NERVE INJURIES; GLIAL FIBRILLARY ACIDIC PROTEIN; IN SITU HYBRIDIZATION; MALE; MESOCRICETUS; MOTOR NEURONS; RNA, MESSENGER; TESTOSTERONE;

ANIMALIA; CRICETINAE;

EID: 0030773788     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1022019106417     Document Type: Article

References (43)

1. Eng, L. F. 1988. Astrocytic response to injury, in Reier, P. J., Bunge, R. P., and Seil, F. J. (eds). Current Issues in Neural Regeneration Research. Alan R. Liss, New York.
2. Oblinger, M. M., Kost, S. A., and Singh, L. D. 1993. Regulation of type III intermediate filament protein genes in astrocytes during development and after injury. Pages 291-302 in Fedoroff, S., and Burkholder, G., (eds) Biology and Pathology of Astrocyte-Neuron Interactions. Plenum, New York.
3. Singh, L. D., and Oblinger, M. M. 1993. Reactive astrocytes in neonate brain upregulate intermediate filament gene expression in response to axonal injury. Int. J. Develop. Neurosci. 11:149-156.
4. Cammermeyer, J. 1955. Astrogial changes during retrograde atrophy of nucleus facialis in mice. J Comp. Neurol. 102:133-150.
5. Aldskogius, H. 1982. Glial cell responses in the adult rabbit dorsal motor vagal nucleus during axon reaction. J Neuropathol. Appl. Neurobiol. 8:341-349.
6. Graeber, M. V., and Kreutzberg, G. W. 1986. Astrocytes increase in glial acidic protein during retrograde changes of facial motor neurons. J. Neurol. 15:363-373.
7. LaVelle, A., and LaVelle, F. W. 1984. Neuronal reaction to injury during development. Pages 3-16. in Almki, C. R., and Finger, S. (eds). Developmental Neurobiology. Academic Press, New York.
8. Sar, M., and Stumpf, W. E. 1977. Androgen concentration in motor neurons of cranial nerves and spinal cord. Science 197:379-382.
9. Kujawa, K. A., Kinderman, N. B., and Jones, K. J. 1989. Testosterone-induced acceleration of recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters. Exp. Neurol. 105:80-85.
10. Kujawa, K. A., Emeric, E., and Jones, K. J. 1991. Testosterone differentially regulates the regenerative properties of injured hamster facial motoneurons. J. Neurosci. 11:3898-3906.
11. Kinderman, N. B., and Jones, K. J. 1993. Testosterone enhancement of the nerve cell body response to injury: Evidence using in situ hybridization and ribosomal DNA probes. J. Neurosci. 13: 1523-1532.
12. Jones, K. J., and Oblinger, M. M. 1994. Androgenic regulation of tubulin gene expression in axotomized hamster facial motoneurons. J. Neurosci. 14:3620-3627.
13. Garcia-Estrada, J., Del Rio, J. A., Luquin, S., Soriano, E., and Garcia-Segura, L. M. 1993. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Research. 628:271-278.
14. Jacob, S. K., Durica, T. E., and Jones, K. J. 1992. Testosterone effects on synaptic bouton changes after facial nerve injury in the hamster. Neurosci. Abs. 18:630.
15. Blinzinger, K., and Kreutzberg, G. 1968. Displacement of synaptic terminals from regeneration motoneurons by microglial cells. Zeitschrift für Zellforschung. 85:145-157.
16. Krey, L. C., and McGinnis, M. Y. 1990. Time courses of the appearance/disappearance of nuclear androgen + receptor complexes in the brain and adenohypophysis following testosterone administration/withdrawal to castrated male rats: Relationships with gonadotropin secretion. J. Steroid Biochem. 35:403-408.
17. Hawkins, R. A., and Mans, A. M. 1989. Determination of cerebral glucose use in rats using [14C] glucose. In: Neuromethods 11, Carbohydrates and Metabolism, pp. 195-230, Clifton, NJ, Humana.
18. Lewis, S. A., Balcarek, J. M., Krek, V., Sheanski, M., and Cowan, N. J. 1984. Sequence of cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments. PNAS USA 81:2743-2746.
19. Kost-Milcucki, S. A., and Oblinger, M. M. 1991. Changes in glial fibrillary acidic protein mRNA expression after corticospinal axotomy in the adult hamster. J Neurosci. Research 28:182-191.
20. 33P nucleotides for in situ hybridization. Du Pont Biotech Update 7:172-173.
21. Sokal, R. R., and Rohlf, F. J. 1981. F. J. Biometry: 2nd ed., San Francisco, Freeman.
22. Reier, P. J., Eng, L. F., and Jakeman, L. 1989. Reactive astrocytes and axonal outgrowth in the injured CNS: Is gliosis really an impediment to regeneration? in F. J. Seil (ed.), Neural regeneration and transplantation, Alan R. Liss, NY.
23. Tetzlaff, W., Graeber, M. B., Bisby, M. A., and Kreutzberg, G. W. 1988. Increased glial fibrillary acidic protein synthesis in astrocytes during retrograde reaction of the rat facial nucleus. Glia 1:90-95.
24. Jones, K. J., Harrington, C. A., Chikaraishi, D. M., and Pfaff, D. W. 1991. Estradiol regulation of ribosomal RNA processing in rat ventromedial hypothalamic neurons: Early detection by quantitative in situ hybridization. J. Neurosci. 10:1513-1521.
25. Kujawa, K. A., and Jones, K. J. 1995. Trophic actions of gonadal steroids on neuronal functioning normally and following injury. In: Advances in Neural Science (Malhotra, S., ed), Vol. 2, pp. 131-152. JAI Press Inc.
26. Kujawa, K. A., Tanzer, L., and Jones, K. J. 1995. Inhibition of the accelerative effects of testosterone on hamster facial nerve regeneration by the antiandrogen, flutamide. Exp. Neurol. in press.
27. Garcia-Segura, L. M., Suarez, I., Segovia, S., Tranque, P. A., Calés, J. M., Aguilera, P., Olmos, G., and Guillamón, A. 1988. The distribution of glial fibrillary acidic protein in the adult rat brain is influenced by the neonatal levels of sex steroids. Brain Research. 456:357-363.
28. Garcia-Segura, L. M., Torres-Aleman, I., and Naftolin, F. 1989. Astrocytic shape and glial fibrillary acidic protein immunoreactivity are modified by estradiol in primary rat hypothalamic cultures. Develop. Brain Res. 47:298-302.
29. Torres-Aleman, I., Rejas, M. T., Pons, S., and Garcia-Segura, L. M. 1992. Estradiol promotes cell shape changes and glial fibrillary acidic protein redistribution in hypothalamic astrocytes in vitro: A neuronal-mediated effect. Glia 6:180-187.
30. McQueen, J. K., Wright, A. K., Arbuthnott, G. W., and Fink, G. 1990. Glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes are increased in the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice. Neurosci. Letters. 118:77-81.
31. Nichols, N. R., Osterburg, H. H., Masters, J. N., Millar, S. L., and Finch, C. E. 1990. Messenger RNA for glial fibrillary acidic protein is decreased in rat brain following acute and chronic corticosterone treatment. Molec. Brain Research. 1:1-7.
32. O'Callaghan, J. P., Brinton, R. E., and McEwen, B. S. 1991. Glucocorticoids regulate the synthesis of glial fibrillary acidic protein intact and adrenalectomized rats but do not affect its expression following brain injury. Neurochem. 57:860-869.
33. Melcangi, R. C., Riva, M. A., Fumagalli, F., Magnaghi, V., Racagni, G., and Martini, L. 1996. Effect of progesterone, testosterone and their 5α-reduced metabolites on GFAP gene expression in type 1 astrocytes. Brain Research. 711:10-15.
34. Drengler, S. M., Handa, R. J., and Jones, K. J. 1996a. Sex differences in androgen receptor mRNA levels and regulation in hamster facial motoneurons. Molec. Brain Res. 35:131-138.
35. Drengler, S. M., Handa, R. J., and Jones, K. J. 1996b. Regulation of androgen receptor mRNA expression in hamster facial motoneurons: differential effects of nonaromatizable and aromatizable androgens. Molec. Brain Res. 35: in press.
36. Jung-Testas, I., Renoir, M., Bugnard, H., Greene, G. L., and Baulieu, E. E. 1992. Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells. J. Steroid. Biochem. Molec. Biol. 41:621-631.
37. Langub, M. C. Jr., and Watson, R. E. Jr. 1992. Estrogen receptor immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: electron microscopy. Endocrinology. 130:364-372.
38. Santagati, S., Melcangi, R. C., Celotti, F., Maritini, L., and Maggi, A. 1994. Estrogen receptor is expressed in different types of glial cells in culture. J. Neurochem. 63:2058-2064.
39. Martini, L., and Melcangi, R. C. 1991. Androgen metabolism in the brain. J. Steroid Biochem. Molec. Biol. 39:819-828.
40. Tanzer, L., and Jones, K. J. 1996. Gonadal steroid regulation of hamster facial nerve regeneration: effects of dihydrotestosterone and estradiol. Exp. Neurol., submitted.
41. Svensson, M., Törnqvist, E., Aldskogius, H., and Cova, J. L. 1991. Synaptic detachment from hypoglossal neurons after different types of nerve injury in the cat. J. Hirnforsch. 32:547-552.
42. Svensson, M., and Aldskogius, H. 1993. Synaptic density of axotomized hypoglossal motoneurons following pharmacological blockade of the microglial cell proliferation. Exp. Neurol. 120: 123-131.
43. Chen, D. H., Chambers, W. W., and Liu, C. N. 1977. Synaptic displacement in intracentral neurons of Clarke's nucleus following axotomy in the cat. Exp. Neurol. 57:1026-1041.