Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages

Journal of Endocrinology

Volumn 164, Issue 2, 2000, Pages 161-169

  Schmidt, M ^b   Kreutz, M ^c   Loffler G ^c   Scholmerich J ^c   Straub R H ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTENEDIONE; AROMATASE; CARBON 14; ESTRADIOL; ESTRIOL; ESTRONE; LIPOPOLYSACCHARIDE; MESSENGER RNA; PRASTERONE; TESTOSTERONE;

ADRENAL GLAND; ARTICLE; CELL CULTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOMODULATION; ISOTOPE LABELING; MACROPHAGE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TARGET CELL; THIN LAYER CHROMATOGRAPHY;

EID: 0002845980     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1640161     Document Type: Article

References (50)

1. Alexandersen P, Haarbo J & Christiansen C 1996 The relationship of natural androgens to coronary heart disease in males: a review. Atherosclerosis 125 1-13.
2. Carr DJ 1998 Increased levels of IFN-gamma in the trigeminal ganglion correlate with protection against HSV-1-induced encephalitis following subcutaneous administration with androstenediol. Journal of Neuroimmunology 89 160-167.
3. Correale J, Arias M & Gilmore W 1998 Steroid hormone regulation of cytokine secretion by proteolipid protein-specific CD4+ T cell clones isolated from multiple sclerosis patients and normal control subjects. Journal of Immunology 161 3365-3374.
4. Danenberg HD, Alpert G, Lustig S & Ben-Nathan D 1992 Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production. Antimicrobial Agents and Chemotherapy 36 2275-2279.
5. Daynes RA, Araneo BA, Ershler WB, Maloney C, Li GZ & Ryu SY 1993 Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative. Journal of Immunology 150 5219-5230.
6. Deighton CM, Watson MJ & Walker DJ 1992 Sex hormones in postmenopausal HLA-identical rheumatoid arthritis discordant sibling pairs. Journal of Rheumatology 19 1663-1667.
7. Deshpande R, Khalili H, Pergolizzi RG, Michael SD & Chang MD 1997 Estradiol down-regulates LPS-induced cytokine production and NFκB activation in murine macrophages. American Journal of Reproductive Immunology 38 46-54.
8. Di Santo E, Foddi MC, Ricciardi-Castagnoli P, Mennini T & Ghezzi P 1996 DHEAS inhibits TNF production in monocytes, astrocytes and microglial cells. Neuroimmunomodulation 3 285-288.
9. Gordon GB, Bush DE & Weisman HF 1988 Reduction of atherosclerosis by administration of dehydroepiandrosterone. A study in the hypercholesterolemic New Zealand white rabbit with aortic intimal injury. Journal of Clinical Investigation 82 712-720.
10. Hennebold JD & Daynes RA 1994 Regulation of macrophage dehydroepiandrosterone sulfate metabolism by inflammatory cytokines. Endocrinology 135 67-75.
11. Hernandez-Pando R, De La Luz S, Orozco H, Arriaga K, Pavon L, Al-Nakhli SA & Rook GA 1998 The effects of androstenediol and dehydroepiandrosterone on the course and cytokine profile of tuberculosis in BALB/c mice. Immunology 95 234-241.
12. Jakob F, Homann D & Adamski J 1995 Expression and regulation of aromatase and 17 beta-hydroxysteroid dehydrogenase type 4 in human THP 1 leukemia cells. Journal of Steroid Biochemistry and Molecular Biology 55 555-563.
13. Kassem M, Harris SA, Spelsberg TC & Riggs BL 1996 Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogen receptors. Journal of Bone and Mineral Research 11 193-199.
14. Kimura M, Tanaka S, Yamada Y, Kiuchi Y, Yamakawa T & Sekihara H 1998 Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity: independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 139 3249-3253.
15. Kreutz M & Andreesen R 1990 Induction of human monocyte to macrophage maturation in vitro by 1,25-dihydroxyvitamin D3. Blood 76 2457-2461.
16. Lahita RG, Bradlow HL, Ginzler E, Pang S & New M 1987 Low plasma androgens in women with systemic lupus erythematosus. Arthritis and Rheumatism 30 241-248.
17. Leighton B, Tagliaferro AR & Newsholme EA 1987 The effect of dehydroepiandrosterone acetate on liver peroxisomal enzyme activities of male and female rats. Journal of Nutrition 117 1287-1290.
18. Loria RM, Inge TH, Cook SS, Szakal AK & Regelson W 1988 Protection against acute lethal viral infections with the native steroid dehydroepiandrosterone (DHEA). Journal of Medical Virology 26 301-314.
19. Lucas JA, Ahmed SA, Casey ML & MacDonald PC 1985 Prevention of autoantibody formation and prolonged survival in New Zealand black/New Zealand white F1 mice fed dehydroisoandrosterone. Journal of Clinical Investigation 75 2091-2093.
20. McLachlan JA, Serkin CD & Bakouche O 1996 Dehydroepiandrosterone modulation of lipopolysaccharide-stimulated monocyte cytotoxicity. Journal of Immunology 156 328-335.
21. Mattox VR, Litwiller RD & Carpenter PC 1979 Comparison of the resolving properties of a group of chromatography systems for a collection of compounds. Journal of Chromatography 175 243-260.
22. Meikle AW, Dorchuck RW, Araneo BA, Stringham JD, Evans TG, Spruance SL & Daynes RA 1992 The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells. Journal of Steroid Biochemistry and Molecular Biology 42 293-304.
23. Milewich L, Kaimal V &Toews GB 1983 Androstenedione metabolism in human alveolar macrophages. Journal of Clinical Endocrinology and Metabolism 56 920-924.
24. Padgett DA & Loria RM 1998 Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol. Journal of Neuroimmunology 84 61-68.
25. Padgett DA, Loria RM & Sheridan JF 1997 Endocrine regulation of the immune response to influenza virus infection with a metabolite of DHEA-androstenediol. Journal of Neuroimmunology 78 203-211.
26. Pottratz ST. Bellido T, Mocharla H, Crabb D & Manolagas SC 1994 17 Beta-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. Journal of Clinical Investigation 93 944-950.
27. Okabe T, Haji M, Takayanagi R, Adachi M, Imasaki K, Kurimoto F, Watanabe T & Nawata H 1995 Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes. Journal of Clinical Endocrinology and Metabolism 80 2993-2996.
28. Ralston SH, Russell RG & Gowen M 1990 Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women. Journal of Bone and Mineral Research 5 983-988.
29. Rasmussen KR, Healey MC, Cheng L & Yang S 1995 Effects of dehydroepiandrosterone in immunosuppressed adult mice infected with Cryptosporidium parvum. Journal of Parasitology 81 429-433.
30. Ray A, Prefontaine KE & Ray P 1994 Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. Journal of Biological Chemistry 269 12940-12946.
31. Sakuma M, Yamada J & Suga T 1993 Induction of peroxisomal beta-oxidation by structural analogues of dehydroepiandrosterone in cultured rat hepatocytes: structure-activity relationships. Biochimica et Biophysica Acta 1169 66-72.
32. Sambrook PN, Eisman JA, Champion GD & Pocock NA 1988 Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis and Rheumatism 31 973-978.
33. Sambrook J, Fritsch EF & Maniatis T 1989 Molecular Cloning, edn 2. Cold Spring Harbor: Cold Spring Harbor Laboratory Press.
34. Schmidt M & Löffler G 1994 The human breast cancer cell line MDA-MB231 produces an aromatase stimulating activity. European Journal of Cell Biology 63 96-101.
35. Schmidt M & Löffler G 1997 RU486 is a potent inhibitor of aromatase induction in human breast adipose tissue stromal cells. Journal of Steroid Biochemistry and Molecular Biology 60 197-204.
36. Schmidt M, Renner C & Löffler G 1998 Progesterone inhibits glucocorticoid-dependent aromatase induction in human adipose fibroblasts. Journal of Endocrinology 158 401-407.
37. Shanker G, Sorci-Thomas M & Adams MR 1994 Estrogen modulates the expression of tumor necrosis factor alpha mRNA in phorbol ester-stimulated human monocytic THP-1 cells. Lymphokine and Cytokine Research 13 377-382.
38. Spencer NF, Poynter ME, Im SY & Daynes RA 1997 Constitutive activation of NF-kappa B in an animal model of aging. International Immunology 9 1581-1588.
39. Straub RH, Zeuner M, Antoniou E, Scholmerich J & Lang B 1996 Dehydroepiandrosterone sulfate is positively correlated with soluble interleukin 2 receptor and soluble intercellular adhesion molecule in systemic lupus erythematosus. Journal of Rheumatology 23 856-861.
40. Straub RH, Zeuner M, Lock G, Scholmerich J & Lang B 1997 High prolactin and low dehydroepiandrosterone sulphate serum levels in patients with severe systemic sclerosis. British Journal of Rheumatology 36 426-432.
41. Straub RH, Konecna L, Hrach S, Rothe G, Kreutz M, Scholmerich J, Falk W & Lang B 1998a Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Journal of Clinical Endocrinology and Metabolism 83 2012-2017.
42. Straub RH, Vogl D, Gross V, Lang B, Scholmerich J & Andus T 1998b Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease. American Journal of Gastroenterology 93 2197-2202.
43. Sukovich DA, Kauser K, Shirley FD, DelVecchio V, Halks-Miller M & Rubanyi GM 1998 Expression of interleukin-6 in atherosclerotic lesions of male ApoE-knockout mice: inhibition by 17beta-estradiol. Arteriosclerosis Thrombosis and Vascular Biology 18 1498-1505.
44. de la Torre B, Fransson J & Scheynius A 1995 Blood dehydroepiandrosterone sulphate (DHEAS) levels in pemphigoid/ pemphigus and psoriasis. Clinical and Experimental Rheumatology 13 345-348.
45. Touchstone JC 1986 Steroids. Boca Raton: CRC Press.
46. van Vollenhoven RF, Engleman EG & McGuire JL 1994 An open study of dehydroepiandrosterone in systemic lupus erythematosus. Arthritis and Rheumatism 37 1305-1310.
47. van Vollenhoven RF, Morabito LM, Engleman EG & McGuire JL 1998 Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. Journal of Rheumatology 25 285-289.
48. Yamada J, Sugiyama H, Sakuma M & Suga T 1994 Specific binding of dehydroepiandrosterone sulfate to rat liver cytosol: a possible association with peroxisomal enzyme induction. Biochimica et Biophysica Acta 1224 139-146.
49. Yanase T, Fukahori M, Taniguchi S, Nishi Y, Sakai Y, Takayanagi R, Haji M & Nawata H 1996 Serum dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEA-S) in Alzheimer's disease and in cerebrovascular dementia. Endocrine Journal 43 119-123.
50. Zuckerman SH, Ahmari SE, Bryan-Poole N, Evans GF, Short L & Glasebrook AL 1996 Estriol: a potent regulator of TNF and IL-6 expression in a murine model of endotoxemia. Inflammation 20 581-597.