Testosterone receptor blockade after hemorrhage in male: Restoration of the depressed immune functions and improved survival following subsequent sepsis

Archives of Surgery

Volumn 132, Issue 11, 1997, Pages 1207-1214

  Angele, Martin K ^a   Wichmann, Matthias W ^a,b   Ayala, Alfred ^a   Cioffi, William G ^a   Chaudry, Irshad H ^a  

^a BROWN UNIVERSITY   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; CORTICOSTERONE; CYTOKINE; DRUG VEHICLE; FLUTAMIDE; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; RECEPTOR BLOCKING AGENT; RINGER LACTATE SOLUTION; TESTOSTERONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; HEMORRHAGIC SHOCK; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION; SURVIVAL RATE;

EID: 0030699110     PISSN: 00040010     EISSN: None     Source Type: Journal    
DOI: 10.1001/archsurg.1997.01430350057010     Document Type: Conference Paper

References (36)

1. McGowan JE, Barnes MW, Finland N. Bacteremia at Boston City Hospital: occurrence and mortality during 12 selected years (1935-1972) with special reference to hospital-acquired cases. J Infect Dis. 1975;132:316-335.
2. Bone RC. Toward an epidemiology and natural history ot SIRS (systemic inflammatory response syndrome). JAMA. 1992;268:3452-3455.
3. Kemp CJ. Drinkwater NR. Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer Res. 1989;49:5044-5047.
4. Schuurs AHWM, Verheul HAM. Effects of gender and sex steroids on the immune response. J Steroid Biochem. 1990;35:157-172.
5. Viselli SM, Stanziale S, Shults K, Kovacs WJ, Olsen NJ. Castration alters peripheral immune function in normal male mice. Immunology. 1995;84:337-342.
6. Roubinian JR, Talal N, Greenspan JS, Goodman JR Siiteri PK. Delayed androgen treatment prolongs survival in murine lupus. J Clin Invest. 1979;63:902-911.
7. 1 mice treated with the testosterone-blocking drug flutamide. J Lab Clin Med. 1994;124:401-407.
8. Luster MI, Pfeifer RW, Tucker AN. Influence of sex hormones on immunoregulation with specific reference to natural and environmental estrogens. In: Thomas JA, Korach KS, McLachlan JA, eds. Endocrine Toxicology. New York, NY: Raven Press; 1985:67-83.
9. Olsen NJ, Kovacs WJ. Gonadalsteroidsandimmunity. EndocrRev.1996;17:369-384.
10. Olsen NJ, Kovacs WJ. Case report: testosterone treatment of systemic lupus erythematosus in a patient with Klinefelter's syndrome. Am J Med Sci. 1995;310.158-160.
11. Weinstein Y, Ran S, Segal S. Sex-associated differences in the regulation of immune responses controlled by the MHC of the mouse. J Immunol. 1984;132:656-661.
12. 1 mice: its relevance to autoimmunity. J Immunol. 1981;126:998-1002.
13. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. Mechanisms of immunosuppression in males following trauma-hemorrhage: critical role of testosterone. Arch Surg. 1996;131:1186-1192.
14. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in murine cecal ligation and puncture model. Surgery. 1983; 94:331-335.
15. Zellweger R, Ayala A, DeMaso CM, Chaudry IH. Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock. 1995;4:149-153.
16. Stephan RN, Kupper TS, Geha AS, Baue AS, Chaudry IH. Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg. 1987;122:62-68.
17. Ihle JN, Keller J, Greenberger JS, Henderson L, Yetter RA, Morse HC. Phenotypic characteristics of cell lines requiring IL-3 for growth. J Immunol. 1982; 129:1377-1383.
18. Meldrum DR, Ayala A, Perrin MM, Ertel W, Chaudry IH. Diltiazem restores IL-2, IL-3, IL-6 and IFN-gamma synthesis and decreases susceptibility to sepsis following hemorrhage. J Surg Res. 1991;51:158-164.
19. Mizel SB. Production and quantitation of lymphocyte-activating factor (interleukin 1). In: Herscowitz HB, Holden HT, Bellanti JA, Ghaffar A, eds. Manual of Macrophage Methodology. New York, NY: Marcel Dekker Inc; 1981:407-441.
20. Ertel W, Morrison MH, Ayala A, Chaudry IH. Chloroquine attenuates hemorrhagic shock induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. Blood. 1991;78:1781-1788.
21. Hültner L, Szöts H, Welle M, Van Snick J, Moeller J, Dörmer P. Mouse bone marrow-derived interleukin 3-dependent mast cells and autonomous sublines produce interleukin 6. Immunology. 1989;67:408-413.
22. Calzolari A. Recherches experimentales sur un rapport probable entre la function du thymus et celle des testicules. Arch Ital Biol. 1898;30:71-77.
23. Wichmann MW, Angele MK, Ayala A, Cioffi WG, Chaudry IH. Flutamide: a novel agent for restoring the depressed cell: mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock. In press.
24. Avala A, Ertel W, Chaudry IH. Trauma-induced suppression of antigen presentation and expression of major histocompatibility class II antigen complex in leukocytes. Shock. 1996;5:79-90.
25. Chaudry IH, Ayala A, Ertel W, Stephan RN. Hemorrhage and resuscitation: immunological aspects. Am J Physiol. 1990;259(pt 2):R663-R678.
26. Ayala A, Lehman DL, Herdon CD, Chaudry IH. Mechanism of enhanced susceptibility to sepsis following hemorrhage: interleukin (lL)-10 suppression of T-cell response is mediated by eicosanoid induced IL-4 release. Arch Surg. 1994;129:1172-1178.
27. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. Enhanced immune responses in females as opposed to decreased responses in males following hemorrhagic shock. Cytokine. 1996;8:853-863.
28. Sharma AC, Motew SJ, Hales KH. Progression of sepsis severely depresses serum concentration of testosterone in rats. Shock. 1996;5(suppl 2):38.
29. Benten WPM, Wunderlich F, Mossmann H. Testosterone-induced suppression of self-healing Plasmodium chabaudi malaria: an effect not mediated by androgen receptors? Endocrinology. 1992;135:407-413.
30. Araneo BA, Shelby J, Li G, Ku W, Daynes RA. Dehydroepiandrosterone antagonizes the suppressive effects of dexamethasone on lymphocyte proliferation. Arch Surg. 1993;128:318-325.
31. Canonaco M, Ando S, Valenti A. The in-vitro transformation of [3H]dehydroepiandrosterone into its principal metabolites in the adrenal cortex of adult castrated male rats and following steroid treatment. J Endocrinol. 1997;152:419-424.
32. Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez EA, Bach JF, Dardenne M. Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol. 1991;40:619-637.
33. Viselli SM, Olsen NJ, Shults K, Steizer G, Kovacs WJ. Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes. Mol Cell Endocrinol. 1995;109:19-26.
34. Sheridan PJ. Can a single androgen receptor fill the bill? Mol Cell Endocrinol. 1991;76:C39-C45.
35. Takeda H, Chodak G, Mutchnik S, Nakamoto T, Chang C. Immunohistochemical localization of androgen receptors with mono-and polyclonal antibodies to androgen receptors. Endocrinology. 1990;126:17-25.
36. Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH. Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit Care Med. 1997;25:106-110.