A review of brain aromatase cytochrome P450

Brain Research Reviews

Volumn 22, Issue 1, 1996, Pages 1-26

  Lephart, Edwin D ^a  

^a BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

Aromatase; Development; Differentiation; Human; Neuroendocrine function; Rodent; Sexual behavior

Indexed keywords

AROMATASE; CYTOCHROME P450;

ANDROGEN METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN DEVELOPMENT; FEMALE; FETUS; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; REVIEW; RODENT; SEXUAL BEHAVIOR;

EID: 0030174660     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-0173(96)00002-1     Document Type: Review

References (335)

1. [1] Abdelgadir, S.E., Resko, J.A., Ojeda, S.R., Lephart, E.D., McPhaul, M.J. and Roselli, C.E., Androgens regulate aromatase cytochrome P450 messenger RNA in rat brain, Endocrinology, 135 (1994) 395-401.
2. [2] Abe-Dohmae, S., Tanaka, R. and Harada, N., Cell type-and region-specific expression of aromatase mRNA in cultured brain cells, Mol. Brain Res., 24 (1994) 153-158.
3. [3] Aleem, F.A., Valdivia, E. and Colás, A.E., The aromatizing activity of placental mitochondrial and microsomal fractions, Gynecol. Invest., 1 (1970) 277-287.
4. [4] Allen, L.S., Hines, H., Shryne, J.E. and Gorski, R.A., Two sexually dimorphic cell groups in the human brain, J. Neurol. Sci., 9 (1989) 497-506.
5. [5] Allen, L.S. and Gorski, R.A., Sex differences in the bed nucleus of the stria terminalis of the human brain, J. Comp. Neurol., 302 (1990) 697-706.
6. [6] Altman, J. and Bayer, S.A., Development of the diencephalon in the rat, J. Comp. Neurol., 182 (1978) 945-972.
7. [7] Anderson, C.H., Time of neuron origin in the anterior hypothalamus of the rat, Brain Res., 154 (1978) 119-122.
8. [8] Anderson, D.K., Rhees, R.W. and Fleming, D.E., Effects of prenatal stress on differentiation of the sexually dimorphic nucleus of the preoptic area (SDN-POA) of the rat brain, Brain Res., 332 (1985) 113-118.
9. [9] Anderson, D.K., Fleming, D.E., Rhees, R.W. and Kinghorn, E., Relationship between sexual activity, plasma testosterone, and the volume of the sexually dimorphic nucleus of the preoptic area in prenatally stressed and non-stressed rats, Brain Res., 370 (1986) 1-10.
10. [10] Arendash, G.W. and Gorski, R.A., Effects of discrete lesions on the sexually dimorphic nucleus of the preoptic area or other medial preoptic regions on the sexual behavior of male rats, Brain Res. Bull., 10 (1983) 147-154.
11. [11] Arnold, A.P. and Gorski, R.A., Gonadal steroid induction of structural sex differences in the central nervous system. A. Rev. Neurosci., 7 (1984) 413-442.
12. [12] Bach, F., Flugge, G. and Wuttke, W., GABAergic influence on the development of the sexually dimorphic nucleus of male and female rats, Brain Res., 573 (1992) 341-344.
13. 1-Fetoprotein, Vol. 1. CRC Press, Boca Raton, FL, 1987, pp. 36-50.
14. [14] Ball, P., Haupt, M. and Knuppen, R., Comparative studies on the metabolism of oestradiol in the brain, the pituitary and the liver of the rat, Acta Endocrinol., 87 (1978) 1-11.
15. [15] Ball, P. and Knuppen, R., Formation of 2-and 4-hydroxyestrogens by brain, pituitary, and liver of the human fetus, J. Clin. Endocrinol. Metab., 47 (1978) 732-737.
16. [16] Ball, P. and Knuppen, R., Catechol estrogens (2-and 4-hydroxyestrogens). Chemistry, biogenesis, metabolism, occurrence and physiological significance, Acta Endocrinol. (Copenh.), 93 (1980) Suppl 232, 1-127.
17. [17] Ball, P. and Knuppen, R., Formation, metabolism, and physiologic importance of catecholestrogens, Am. J. Obstet. Gynecol., 163 (1990) 2163-2170.
18. [18] Balthazart, J., Foidart, A., Surlemont, C. Vockel, A. and Harada, N., Distribution of aromatase in the brain of the Japanese quail, ring dove, and zebra finch: An immunocytochemical study, J. Comp. Neurol., 301 (1990) 276-288.
19. [19] Balthazart, J., Foidart, A., Surlemont, C. and Harada, N., Neuroanatomical specificity in the co-localization of aromatase and estrogen receptors, J. Neurobiol., 22 (1991) 143-157.
20. [20] Balthazart, J., Foidart, A., Surlemont, C. and Harada, N., Distribution of aromatase-immunoreactive cells in the mouse forebrain, Cell Tissue Res., 263 (1991) 71-79.
21. [21] Balthazart, J., Surlemont, C. and Harada, N., Aromatase as a cellular marker of testosterone action in the preoptic area, Physiol. Behav., 51 (1992) 395-409.
22. [22] Balthazart, J. and Foidart, A., Brain aromatase and the control of male sexual behavior, J. Steroid Biochem. Mol. Biol., 44 (1993) 521-540.
23. [23] Balthazart, J., Stoop, R., Foidart, A., Granneman, J.C. and Lambert, J.G., Distribution and regulation of estrogen-2-hydroxylase in the quail brain, Brain Res. Bull., 35 (1994) 339-345.
24. [24] Barraclough, C.A. and Gorksi, R.A., Studies on mating behaviour in the androgen-sterilized female rat in relation to the hypothalamic regulation of sexual behaviour. J. Endocrinol., 25 (1962) 175-182.
25. [25] Baum, M.J., Tobet, S.A., Starr, M.S. and Bradshaw, W.G., Implantation of dihydrotestosterone propionate into the lateral septum or medial amygdala facilitates copulation in castrated male rats given estradiol systemically. Horm. Behav., 16 (1982) 208-223.
26. [26] Baum, M.J., Brand, T., Ooms, M., Vreeburg, J.T.M. and Slob, A.K., Immediate postnatal rise in whole androgen content in male rats: correlation with increased testicular content and reduced body clearance of testosterone, Biol. Reprod., 38 (1988) 980-986.
27. [27] Bayer, S.A. and Altman, J., Development of the preoptic area: time and site of origin, migratory routes, and setting patterns of its neurons, J. Comp. Neurol., 265 (1987) 65-95.
28. 2 dopamine receptor binding, Brain Res., 637 (1994) 163-172.
29. [29] Beach, F.A., Copulatory behavior in prepuberally castrated male rats and its modification by estrogen administration, Endocrinology, 31 (1942) 679-683.
30. [30] Becker, J.B. and Beer, M.E., The influence of estrogen on nigostriatal dopamine activity: behavioural and neurochemical evidence for both pre-and postsynaptic components, Behav. Brain. Res., 19 (1986) 27-33.
31. [31] Becker, J.B. and Cha, J.H., Estrous cycle-dependent variation in amphetamine-induced behaviors and striatal dopamine release assessed with microdialysis, Behav. Brain Res., 35 (1989) 117-125.
32. [32] Becker, J.B., Direct effect of 17β-estradiol on striatum: sex differences in dopamine release, Synapse, 5 (1990) 157-164.
33. [33] Becker, J.B., Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis, Neurosci. Lett., 118 (1990) 169-171.
34. [34] Beyer, C., Morali, G., Naftolin, F., Larsson, K. and Pérez-Palacios, G., Effects of some antiestrogens and aromatase inhibitors on androgen induced sexual behavior in castrated male rats, Horm. Behav., 7 (1976) 353-363.
35. [35] Beyer, C., Wozniak, A. and Hutchison, J.B., Sex-specific aromatization of testosterone in mouse hypothalamic neurons, Neuroendocrinology, 58 (1993) 673-681.
36. [36] Beyer, C., Green, S.J., Barker, P.J., Huskisson, N.S. and Hutchison, J.B., Aromatase-immunoreactivity is localized in neurones in the developing mouse hypothalamus and cortex, Brain Res., 638 (1994) 203-210.
37. [37] Beyer, C., Green, S.J. and Hutchison, J.B., Androgens influence sexual differentiation of embryonic mouse hypothalamic aromatase neurons in vitro, Endocrinology, 135 (1994) 1220-1226.
38. [38] Beyer, C., Tramonte, R., Hutchison, R.E., Sharp, P.J., Barker, P.J., Huskisson, N.S. and Hutchison, J.B., Aromatase-immunoreactive neurons in the adult female chicken brain detected using a specific antibody, Brain Res. Bull., 33 (1994) 583-588.
39. [39] Bonsall, R.W., Clancy, A.N. and Michael, R.P., Effects of the nonsteriodal aromatase inhibitor, Fadrozole, on sexual behavior in male rats, Horm. Behav., 26 (1992) 240-254.
40. [40] Booth, J.E., Effects of the aromatization inhibitor androst-4-ene-3, 6, 17-trione on sexual differentation induced by testosterone in the neonatally castrated rat, J. Endocrinol., 79 (1978) 69-76.
41. [41] Breedlove, S.M., Sexual differentiation of the brain and behavior, In J.B. Becker, S.M. Breedlove, D. Crews, (Eds.), Behavioral Endocrinology, MIT Press, Cambridge, MA, 1992, pp. 39-70.
42. [42] Brown, T. J., MacLusky, N.J., Shanabrough, M. and Naftolin, F., Comparison of age-and sex-related changes in cell nuclear estrogen-binding capacity and progestin receptor induction in the rat brain, Endocrinology, 126 (1990) 2965-2972.
43. [43] Brown, T.J. and MacLusky, N.J., Androgen treatment decreases estrogen receptor binding in the ventromedial nucleus of the rat brain: a quantitative in vitro autoradiographic analysis, Mol. Cell. Neurosci., 5 (1994) 549-555.
44. [44] Brown-Grant, K., Munck, A., Naftolin, F. and Sherwood, M.R., The effects of the adminstration of testosterone propionate alone or with phenobarbitone and of testestosterone metabolites to neonatal female rats, Horm. Behav., 2 (1971) 173-182.
45. [45] Bulun, S.E., Rosenthal, I.M., Brodie, A.M., Inkster, S.E., Zeller, W.P., DiGeorge, A.M., Frasier, S.D., Kilgore, M.W. and Simpson, E.R., Use of tissue-specific promoters in the regulation of aromatase cytochrome P450 gene expression in human testicular and ovarian sex cord tumors, as well as in normal fetal and adult gonads, J. Clin. Endocrinol. Metab., 77 (1993) 1616-1621.
46. [46] Bulun, S.E., Aromatase deficiency in women and men: would you have predicted the phenotypes?, J. Clin. Endocrinol. Metab., (1996) in press.
47. [47] Callard, G.V., Petro, Z. and Ryan, K.J., Phyolgenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system, Endocrinology, 103 (1978) 2283-2290.
48. [48] Callard, G.V., Hoffman, R.A., Petro, Z. and Ryan, R.J., In vitro aromatization and other androgen transformations in the brain of the hamster (Mesocricetus auratus), Biol. Reprod., 21 (1979) 33-38.
49. [49] Callard, G.V., Mak, P. and Solomon, D.J., Effects of short days on aromatization and accumulation of nuclear estrogen receptors in the hamster brain, Biol. Reprod., 35 (1986) 282-291.
50. [50] Callard, G.V., Petro, Z. and Ryan, K.J., Conversion of androgen to estrogen and other steroids in vertebrate brain, Am. Zool., 18 (1987) 511-523.
51. [51] Canick, J.A., Vaccaro, D.E., Ryan, K.J. and Leeman, S.E., The aromatization of androgens by primary monolayer cultures of fetal rat hypothalamus, Endocrinology, 100 (1977) 250-253.
52. [52] Canick, J.A., Vaccaro, D.E., Livingston, E.M., Leeman, S.E., Ryan, K.J. and Fox, T.O., Localization of aromatase and 5α-reductase to neuronal and non-neuronal cells in the fetal rat hypothalamus, Brain Res., 372 (1986) 277-282.
53. [53] Canick, J.A., Tobet, S.A., Baum, M.J., Vaccaro, D.E., Ryan, K.J., Leeman, S.E. and Fox, T.O., Studies on the role of catecholamines in the regulation of the developmental pattern of hypothalamic aromatase, Steroids. 50 (1987) 509-521.
54. [54] Carrer, H.F., Whitmoyer, D.I. and Sawyer, C.H., Effects of hippocampal and amygdaloid stimulation on the firing of preoptic neurons in the proestrus female rat, Brain Res., 142 (1978) 363-367.
55. [55] Caspi, E., Wicha, J., Arunachalam, T., Spiteller, G. and Nelson, P., Aspects of estrogen biosynthesis: concerning the pathway via 2β-hydroxy-10β-formyl-androst-4-ene-3.17-dione. In P.A. Frey (Ed.), Mechanism of Enzymatic Reactions: Stereochemistry, Elsevier. New York, NY, 1986, pp. 281-292.
56. [56] Castner, S.A., Xiao, L. and Becker, J.B., Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies. Brain Res., 610 (1993) 127-134.
57. [57] Celotti, F., Melcangi, C. and Martini, L., The 5α-reductase in the brain: molecular aspects and relation to brain function, Frontiers Neuroendocrinol., 13 (1992) 163-215.
58. [58] Chambers, K.C., Thornton, J.E. and Roselli, C.E., Age-related deficits in brain androgen binding and metabolism, testosterone, and sexual behavior of male rats, Neurobiol. Aging. 12 (1991) 123-130.
59. [59] Choate, J.V. and Resko, J.A., Prenatal inhibition of aromatase activity affects luteinizing hormone feedback mechanisms and reproductive behaviors of adult guinea pigs, Biol. Reprod., 51 (1994) 1273-1278.
60. [60] Christensen, L.W. and Clemens, L.G., Blockade of testosterone-induced mounting behavior in the male rat with intracranial application of the aromatase inhibitor, androst-1,4,6-triene-3.17-dione, Endocrinology, 97 (1975) 1545-1551.
61. [61] Clark, A.S., MacLusky, N.J. and Goldman-Rakic, P.S., Androgen binding and metabolism in the cerebral cortex of the developing rhesus monkey, Endocrinology, 123 (1988) 932-940.
62. [62] Clemens, G.C. and Gladue, B.A., Feminine sexual behavior in rats enhanced by prenatal inhibition of androgen aromatization. Horm. Behav., 11 (1978) 190-201.
63. [63] Clopton, J.K. and Gordon, J.H., The possible role of 2-hydroxyestradiol in the development of estrogen-induced striatal dopamine receptor hypersensitivity. Brain Res., 333 (1985) 1-10.
64. [64] Cole, P.A. and Robinson, C.H., A peroxide model reaction for placental aromatase, J. Am. Chem. Soc., 110 (1988) 1284-1285.
65. [65] Compaan, J.C. and Wozniak, A., De Ruiter, A.J., Koolhaas, J.M. and Hutchison, J.B., Brain aromatase activity and plasma testosterone levels are elevated in aggressive male mice during early ontogeny, Dev. Brain Res., 82 (1994) 185-192.
66. [66] Coniglio, L.P., Paup, D.C. and Clemens, L.G., Hormonal factors controlling the development of sexual behavior in the male golden hamster. Physiol. Behav., 10 (1973) 1087-1094.
67. [67] Connolly, P.B., Roselli, C.E. and Resko, J.A., Aromatase activity in adult guinea pigs is androgen-dependent, Biol. Reprod., 43 (1990) 698-703.
68. [68] Connolly, P.B., Roselli, C.E. and Resko, J.A., Aromatase activity in developing guinea pig brain: ontogeny and effects of exogenous androgens, Biol. Reprod., 50 (1994) 436-441.
69. [69] Conte, F.A., Grumbach, M.M., Ito, Y., Fisher, C. and Simpson, E.R., A syndrome of female pseudohermaphrodism, hypergonadotropic hypogonadism, and multicystic ovaries associated with missense mutations in the gene encoding aromatase (P450arom). J. Clin. Endocrinol. Metab., 78 (1994) 1287-1292.
70. [70] Corbier, P., Kerdelhue, B., Picon, R. and Roffi, J., Changes in testicular weight and serum gonadotropin and testosterone levels before, during and after birth in the perinatal rat, Endocrinology, 103 (1978) 1985-1991.
71. [71] Corbin, J.C., Graham-Lorence, S., McPhaul, M.J., Mason, J.I., Mendelson, C.R. and Simpson, E.R., Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in non-steroidogenic cells, Proc. Natl. Acad. Sci. USA, 85 (1988) 8948-8953.
72. [72] Cottingham, S.L. and Pfaff, D., Interconnectedness of steroid hormone-binding neurons: existence and implications. In D. Ganten and D. Pfaff (Eds.), Current Topics in Neuroendocrinology, Vol. 7, Springer-Verlag, Berlin/Heidelberg, 1986, pp. 223-249.
73. [73] Davidson, J.M., Activation of male rat's sexual behavior by intracerebral implantation of androgen, Endocrinology, 79 (1966) 783-794.
74. [74] Davidson, J.M., Effects of estrogen on the sexual behavior of male rats. Endocrinology, 84 (1969) 1365-1372.
75. [75] Davis, P.G. and Barfield, R.J., Activation of masculine sexual behavior by intracranial estradiol benzoate implants in male rats, Neurendocrinology, 28 (1979) 217-227.
76. [76] De Voss, J.J. and Ortiz de Montellano, P.R., Computer-assisted, structure-based prediction of substrates for cytochrome P450cam. J. Am. Chem. Soc., 117 (1995) 4185-4186.
77. [77] Dellovade, T.L., Rissman, E.F., Thompson, N., Harada, N. and Ottinger, M.A., Co-localization of aromatase enzyme and estrogen receptor immunoreactivity in the preoptic area during reproductive aging. Brain Res., 674 (1995) 181-187.
78. [78] Denef, C., 5α-Dihydrotestosterone formation and its functional significance in rat anterior pituitary, subpopulations of gonadotrophs and cell cultures, J. Steroid Biochem., 19 (1983) 235-239.
79. [79] Dhawan, A., Parmar, D., Das, M. and Seth, P.K., Cytochrome P-450 dependent monooxygenases in neuronal and glial cells: inductibility and specificity, Biochem. Biophys. Res. Commun., 170 (1990) 441-447.
80. [80] Dodson, R.E. and Gorski, R.A., Testosterone propionate administration prevents the loss of neurons within the central part of the medial preoptic nucleus, J. Neurobiol., 24 (1993) 80-88.
81. [81] Dohler, K.D., Hancke, J.L., Srivastava, S.S., Hofmann, C., Shryne, J.E. and Gorski, R.A., Participation of estrogens in female sexual differentiation of the brain: neuroanatomical, neuroendocrine and behavioral evidence, Prog. Brain Res., 61 (1984) 99-117.
82. [82] Dorrington, J.H., James, J., Bendell, J. and Lobb, D.K., Aromatase activity in granulosa cells: regulation by growth factors, Steroids, 50 (1987) 411-422.
83. [83] Erskine, M.S., Tobet, S.A. and Baum, M.J., Effect of birth on plasma testosterone, brain aromatase activity, and hypothalamic estradiol in male and female ferrets. Endocrinology, 122 (1988) 524-530.
84. [84] Feder, H.H. and Whalen, R.E., Feminine behavor in neonatally castrated and estrogen-treated male rats. Science, 147 (1965) 306-307.
85. [85] Ferretti, C., Ghi, P., Blengio, M., Gaietta, G., Barrera, G. andMaltese crosss signMaltese cross sign Genazzani, E., Are the catcholestrogens involved in estrogen-induced striatal dopamine receptor supersensitivity?, Eur. J. Pharmacol., 166 (1989) 149-156.
86. [86] Fischer, L., Catz, D. and Kelley, D., An androgen receptor mRNA isoform associated with hormone-induced cell proliferation, Proc. Natl. Acad. Sci. USA, 90 (1993) 8254-8258.
87. [87] Fishman, J. and Norton, B., Catechol estrogen formation in the central nervous system of the rat, Endocrinology, 96 (1975) 1054-1059.
88. [88] Fishman, J., Naftolin, F., Davies, I.J., Ryan, K.J. and Petro, Z., Catechol estrogen formation by the human fetal brain and pituitary, J. Clin. Endocrinol. Metab., 42 (1976) 177-180.
89. [89] Fishman, J., Biochemical mechanism of aromatization, Cancer Res. (Suppl.), 42 (1982) 3277s-3280s.
90. [90] Fishman, J., Aromatic hydroxylation of estrogens, Ann. Rev. Physiol., 45 (1983) 61-72.
91. [91] Fitz, I.B., Griswold, M.D., Louis, B.G. and Dorrington, J.H., Similarity of responses of cultured Sertoli cells to cholera toxin and FSH, Mol. Cell. Endocrinol., 5 (1976) 289-294.
92. [92] Fitzpatrick, S.L. and Richards, J.S., Cis-acting elements of the rat aromatase promoter required for cyclic adenosine 3′, 5′-monophosphate induction in ovarian granulosa cells and constitutive expression in R2C Leydig cells, Mol. Endocrinol., 7 (1993) 341-354.
93. [93] Floody, O.R. and Petropoulos, A.C., Aromatase inhibition depresses ultrasound production and copulation in male hamsters, Horm. Behav., 21 (1987) 100-104.
94. [94] Flores, F., Naftolin, F. and Ryan, K.J., Aromatization of androstendione and testosterone by rhesus monkey hypothalamus and limbic systems, Neuroendocrinology, 11 (1973) 177-182.
95. [95] Foidart, A., Harada, N. and Balthazart, J., Aromatase-immunoreactive cells are present in mouse brain areas that are known to express high levels of aromatase activity, Cell Tissue Res., 280 (1995) 561-574.
96. [96] Forman, M.M. and Porter, J.C., Effects of catechol estrogens and catecholamines on hypothalamic and corpus striatal tyrosine hydroxylase activity, J. Neurochem., 34 (1980) 1175-1183.
97. 1-Fetoprorein, CRC Press, Boca Raton, FL, 1987, Vol. 1, pp. 181-187.
98. [98] Franks, S., Neuroendocrine effects of catechol estrogens. In G.R. Merriam and M.B. Lipsett (Eds.), Catechol Estrogens, Raven Press, New York, 1983, pp. 265-272.
99. [99] García-Segura, L.M., Olmos, G., Tranque, P. and Naftolin, F., Rapid effects of gonadal steroids upon hypothalamic neuronal membrane ultrastructure, J. Steroid Biochem., 27 (1987) 615-623.
100. [100] García-Segura, L.M., Olmos, G., Robbins, R.J., Hernández, P., Meyer, J.H. and Naftolin, F., Estradiol induces rapid remodelling of plasma membranes in developing rat cerebrocortical neurons in culture, Brain Res., 498 (1989) 339-343.
101. [101] Genot, A., Loras, B., Monbon, M. and Bertrand, J., In vitro metabolism of testosterone in the rat brain during sexual maturation. III Studies of the formation of main androstane-diols and androstene-diols, J. Steroid Biochem., 6 (1975) 1247-1256.
102. [102] George, F.W., Tobleman, W.T., Milewich, L. and Wilson, J.D., Aromatase activity in the developing rabbit brain, Endocrinology. 102 (1978) 86-91.
103. [103] George, F.W. and Ojeda, S.R., Changes in aromatase activity in the rat brain during embryonic, neonatal, and infantile development. Endocrinology. 111 (1982) 522-529.
104. [104] Gerall, A.A., Dunlap, J.L. and Wagner, R.A., Effects of dihydrotestosterone and gonadotrophins on the development of female behavior, Physiol. Behav., 17 (1976) 121-126.
105. [105] Goldstein, L.A. and Sengelaub, D.R., Differential effects of dihydrotestosterone and estrogen on the development of motoneuron morphology in a sexually dimorphic rat spinal nucleus, J. Neurobiol., 25 (1994) 878-892.
106. [106] González, M.I. and Leret, M.L., Role of monoamines in the male differentiation of the brain induced by androgen aromatization. Pharm. Biochem. Behav., 41 (1992) 733-737.
107. [107] Gorski, R.A., Structural sex differences in the brain: Their origin and significance. In J.A. Lakoski, J. Regino Perez-Polo and D.K. Rassin (Eds.), Neural Control of Reproductive Function. Alan R. Liss, New York, 1989, pp. 33-44.
108. [108] Goto, J. and Fishman, J., Participation of a nonenzymatic transformation in the biosynthesis of estrogens from androgens, Science. 195 (1977) 80-81.
109. [109] Gray, S.A., Mannan M.A. and O'Shaughnessy, P.J., Development of cytochrome P450 aromatase mRNA levels and enzymatic activity in ovaries of normal and hypogonadal (hpg) mice, J. Mol. Endocrinol., 14 (1995) 295-301.
110. [110] Habert, R. and Picon, R., Control of testicular steroidogensis in foetal rat: effect of decapitation on testosterone and plasma luteinizing hormone-like activity, Acta Endocrinol., 99 (1982) 466-473.
111. [111] Hahn, E.F. and Fishman, J., Stereochemistry of 1,2-hydrogen loss during aromatization in the brain, J. Steroid Biochem., 22 (1985) 597-600.
112. [112] Hahn, E.F., Miyairi, S. and Fishman, J., 19-Hydroxylation of androgens in the rat brain, Proc. Natl. Acad. Sci. USA, 82 (1985) 2728-2730.
113. [113] Harada, N., A unique aromatase (P450arom) mRNA formed by alternative use of tissue specific exons I in human fibroblasts, Biochem. Biophys. Res. Commun., 189 (1992) 1001-1007.
114. [114] Harada, N. and Yamada, K., Ontogeny of aromatase messenger ribonucleic acid in mouse brain: Fluorometrical quantitation by polymerase chain reaction, Endocrinology, 131 (1992) 2306-2312.
115. [115] Harada, N., Yamada, K., Foidart, A. and Balthazart, J., Regulation of aromatase cytochrome P-450 (estrogen synthetase) transcripts in the quail brain by testosterone, Mol. Brain Res., 15 (1992) 19-26.
116. [116] Harada, N., Abe-Dohmae, S., Loeffen, R., Foidart, A. and Balthazart, J., Synergism between androgens and estrogens in the induction of aromatase and its messenger RNA in the brain, Brain Res., 622 (1993) 243-256.
117. [117] Harada, N., Utsumi, T. and Takagi, Y., Tissue-specific expression of the human aromatase cytochrome P-450 gene by alternative use of multiple exon 1 and promoters, and switching of tissue-specific exons 1 in carcinogenesis, Proc. Natl. Acad. Sci. USA, 90 (1993) 11312-11316.
118. [118] Harris, G.W., Sex hormones, brain development and brain function, Endocrinology, 75 (1964) 627-648.
119. [119] Hatton, G.I., Sex steroid influences on cell-cell interactions in the magnocellular hypothalamoneurohypophyseal system. In P.E. Micevych and R.P. Hammer Jr. (Eds.), Neurobiological Effects of Sex Steroid Hormones, University of Cambridge Press, New York, NY, 1995, pp. 412-431.
120. [120] Heimer, L. and Larsson, K., Impairment of mating behavior in male rats following lesions the preoptic-anterior hypothalamic continuum. Brain Res., 3 (1967) 248-263.
121. [121] Henshelwood, M.M., Corbin, C.J., Tsang, P.C.W. and Simpson, E.R., Isolation and characterization of a complementary deoxyribonucleic acid insert encoding bovine aromatase cytochrome P450, Endocrinology, 133 (1993) 1971-1977.
122. [122] Hersey, R.M., Williams, K.I.H. and Weisz, J., Catechol estrogen formation by brain tissue: Characterization of a direct product isolation assay for estrogen-2-and 4-hydroxlase activity and its application to studies of 2-and 4-hydroxyestradiol formation by rabbit hypothalamus, Endocrinology, 109 (1981) 1912-1920.
123. [123] Hickey, G.J., Krasnow, J.S., Beattie, W.G. and Richards, J.S., Hormonal regulation, tissue distribution, and content of aromatase cytochrome P450 messenger ribonucleic acid and enzyme in the rat ovarian follicles and corpora lutea: relationship to estradiol biosynthesis, Mol. Endocrinol., 4 (1990) 3-12.
124. [124] Honda, S., Harada, N. and Takagi, Y., Novel exon I of the aromatase gene specific for aromatase transcripts in human brain. Biochem. Biophys. Res. Comm., 198 (1994) 1153-1160.
125. [125] Hruska, R.E. and Silbergeld, E.K., Estrogen treatment enhances dopamine receptor sensitivity in the rat striatum, Eur. J. Pharmacol., 61 (1980) 397-400.
126. [126] Hruska, R.E., Ludiner, L.M. and Pitman, K.T., De Ryck, M. and Silbergeld, E.K., Effects of estrogen on striatal dopamine receptor function in male and female rats, Pharmacol. Biochem. Behav., 16 (1982) 285-291.
127. [127] Hruska, R.E., Elevation of striatal dopamine receptors by estrogen: dose and time studies, J. Neurochem., 47 (1986) 1908-1915.
128. [128] Hsu, C.H., Blockage of lordosis by androst-1,4,6-triene-3,17-dione (ATD) and tamoxifen in female hamsters primed with testosterone propionate, Horm. Behav., 24 (1990) 14-19.
129. [129] Hutchison, J.B. and Steimer, T.H., Androgen metabolism in the brain: behavioral correlates, Prog. Brain Res., 61 (1984) 23-51.
130. [130] Hutchison, J.B., Andragen action in a changing behavioral environment: The role of brain aromatase. In J. Balthazart and R. Giles (Eds.), Hormones, Brain and Behavior, Basel, Karger, 1990, pp. 27-44.
131. [131] Hutchison, J.B., Beyer, C., Green, S. and Wozniak, A., Brain formation of oestrogen in the mouse: Sex dimorphism in aromatase development. J. Steroid Biochem. Mol. Biol., 49 (1994) 407-415.
132. [132] Hutchison, J.B., Beyer, C., Hutchison, R.E. and Wozniak, A., Sexual dimorphism in the developmental regulation of brain aromatase, J. Steroid Biochem. Mol. Biol., 53 (1995) 307-313.
133. [133] Hutchison, R.E., Hutchison, J.B., Steimer, T., Steel, E., Powers, J.B., Walker, A.P., Herbert, J. and Hastings, M.H., Brain aromatization of testosterone in the male Syrian hamster: effects of androgen and photoperiod. Neuroendocrinology, 53 (1991) 194-203.
134. [134] Hutton, L.A. and Simerly, R.B., Development of sexually dimorphic projection from the principal nucleus of the bed nuclei of the stria terminalis to the anteroventral peri ventricular nucleus, Ann. Mtg. Soc. Neurosci., Abstract 24.20, 1995, p. 9.
135. [135] Jackson, J.A. and Albrecht, E.D., The development of placental androstenedione and testosterone production and their utilization by the ovary for aromatization to estrogen during rat pregnancy, Biol. Reprod., 33 (1985) 451-457.
136. [136] Jacobson C.D., Davis, F.C. and Gorski, R.A., Formation of the sexually dimorphic nucleus of the preoptic area: neuronal growth, migration and change in cell number, Dev. Brain Res., 21 (1985) 7-18.
137. [137] Jakab, R.L., Horvath., T.L., Leranth, C., Harada, N. and Naftolin, F., Aromatase immunoreactivity in the rat brain: Gonadectomy-sensitive hypothalamic neurons and an unresponsive 'limbic ring' of the lateral septum-bed nucleus-amygdala complex. J. Steroid Biochem. Mol. Biol., 44 (1993) 481-498.
138. [138] Jakab, R.L., Harada, N. and Naftolin, F., Aromatase - (estrogen synthetase)-immunoreactive neurons in the rat septal area. A light and electron microscopic study. Brain Res., 664 (1994) 85-93.
139. [139] Jenkins, C., Micheal, D., Mahendroo, M. and Simpson, E.R., Exon-specific northern analysis and rapid amplification of cDNA ends (RACE) reveal that the proximal promoter II (PII) is responsible for aromatase cytochrome P450 (CY19) expression in human ovary, Mol. Cell Endocrinol., 91 (1993) R1-R6.
140. [140] Johnston, P. and Davidson, J.M., Intracerebral androgens and sexual behavior in the male rat. Horm. Behav., 3 (1972) 345-357.
141. [141] Jones, E.E. and Naftolin, F., Estrogen effects on the tuberoinfundibular dopaminergic system in the female rat brain, Brain Res., 510 (1990) 84-91.
142. [142] Kaylor Jr., W.M., Song, C.H., Copeland, S.J., Zuspan, F.P. and Kim, M.H., The effect of estrogen on monoamino systems in the fetal rat brain, J. Reprod. Med., 29 (1984) 489-492.
143. [143] Kelce, W.R. and Ganjam, V.K., Rudeen P.K., Effects of fetal alcohol exposure on brain 5α-reductase/aromatase activity, J. Steroid Biochem., 35 (1990) 103-106.
144. [144] Kelly, M.J., Electrical effects of steroids in neurons. In K.W. McKerns and V. Pantic (Eds.). Hormonally Active Brain Peptides, Plenum Press, New York, 1980, pp. 253-277.
145. [145] Kilgore, M.W., Means, G.D., Mendelson, C.R. and Simpson, E.R., Alternative promotion of aromatase P-450 expression in the human placenta, Mol. Cell Endocrinol., 83 (1992) R9-R16.
146. [146] Kostarcezyk, E.M., The amygdala and male reproductive functions: I. Anatomical and endocrine bases, Neurosci. Biobehav. Rev., 10 (1986) 67-77.
147. [147] Krey, L.C., MacLusky, N.J., Pfeiffer, D.G., Parsons, B., Merriam, G.R. and Naftolin, F., Role of catechol estrogens in estrogen-induced lordosis behavior in the female rat. In G.R. Merriam and M.B. Lipsett (Eds.), Catechol Estrogens. Raven Press, New York. 1983, pp. 249-264.
148. [148] Kuhemann, S., Brown, T.J., Hochberg, R.B. and MacLusky, N.J., Sex differences of estrogen receptors in the rat brain, Horm. Behav., 28 (1994) 483-491.
149. [149] Lauber, M.E. and Lichtensteiger, W., Pre-and postnatal ontogeny of aromatase cytochrome P450 messenger ribonucleic acid expression in the male rat brain studied by in situ hybridization, Endocrinology, 135 (1994) 1661-1668.
150. [150] Lephart, E.D., Andersson, S. and Simpson, E.R., Expression of neural 5α-reductase messenger ribonucleic acid: comparison to 5α-reductase activity during prenatal development in the rat, Endocrinology, 127 (1990) 1121-1128.
151. [151] Lephart, E.D., Peterson, K.G., Noble, J.F., George, F.W. and McPhaul, M.J., The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line, Mol. Cell Endocrinol., 70 (1990) 31-40.
152. [152] Lephart, E.D. and Ojeda, S.R., Hypothalamic aromatase activity in male and female rats during juvenile peripubertal development, Neuroendocrinology, 51 (1990) 385-393.
153. [153] Lephart, E.D. and Simpson, E.R., Techniques for the assay of aromatase cytochrome P450, Methods Enzymol., 206 (1991) 477-483.
154. [154] Lephart, E.D., Simpson, E.R. and McPhaul, M.J. Ovarian aromatase cytochrome P-450 mRNA levels correlate with enzyme activity and serum estradiol levels in anestrous, pregnant and lactating rats, Mol. Cell Endocrinol., 85 (1992) 205-214.
155. [155] Lephart, E.D., Simpson, E.R., McPhaul, M.J., Kilgore, M.W., Wilson, J.D. and Ojeda, S.R., Brain aromatase cytochrome P-450 messenger RNA levels and enzyme activity during prenatal and perinatal development in the rat, Mol. Brain Res., 16 (1992) 187-192.
156. [156] Lephart, E.D., Simpson, E.R. and Ojeda, S.R., Effects of cyclic AMP and androgens on in vitro brain aromatase enzyme activity during prenatal development in the rat. J. Neuroendocrinol., 4 (1992) 29-36.
157. [157] Lephart, E.D., A review of brain 5α-reductase: Cellular, enzymatic, and molecular perspectives and implications for biological function, Mol. Cell Neurosci., 4 (1993) 473-484.
158. [158] Lephart, E.D., Pituitary and brain 5α-reductase messenger RNA levels in control, castrated, and dihydrotestosterone-treated rats, Mol. Cell Neurosci., 4 (1993) 526-531.
159. [159] Lephart, E.D. and Husman, D., Aromatase and 5α-reductase activity in the rat brain following prenatal, perinatal or pre-and postnatal finasteride, flutamide or dihydrotestosterone treatment, Prog. Neuro-Psychopharmacol. Biol. Psychiat., 17 (1993) 991-1003.
160. [160] Lephart, E.D., Herbst, M.A. and McPhaul, M.J., Characterization of aromatase cytochrome P-450 mRNA in rat perinatal brain, ovary, and a Leydig tumor cell line: evidence for the existence of brain specific aromatase transcripts, Endocrine, 3 (1995) 25-31.
161. [161] Lephart, E.D. and Rhees, R.W., Frontal cortical brain aromatase enzyme activity in male and female rats during perinatal development, Ann. Mtg. Soc. Neurosci., Abstract 423.15, 1995, p. 215.
162. [162] Levine, S. and Mullins Jr., R., Estrogen administered neonatally affects adult sexual behavior in male and female rats. Science, 144 (1964) 185-187.
163. [163] Lloyd, T. and Weisz, J., Direct inhibition of tyrosine hydroxylase activity by catechol estrogens, J. Biol. Chem., 253 (1978) 4841-4843.
164. [164] Lorenzo, A., Diaz, H., Carrer, H. and Caceres, A., Amygdala neurons in vitro: Neurite growth and effects of estradiol, J. Neurosci. Res., 33 (1992) 418-435.
165. [165] Lustig, R.H., Hua, P., Wilson, M.C. and Federoff, H.J., Ontogeny, sex dimorphism, and neonatal sex hormone determination of synapse-associated messenger RNAs in rat brain, Mol. Brain Res., 20 (1993) 101-110.
166. [166] Luttge, W.G., Effects of anti-estrogens on testosterone stimulated male sexual behavior and peripheral target tissues in the castrated male rat, Physiol. Behav., 14 (1975) 839-846.
167. [167] Lynch, J.P., Lala, D.S., Peluso, J.J., Luo, W., Parker, K.L. and White, B.A., Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissue, Mol. Endocrinol., 7 (1993) 776-786.
168. [168] MacDonald, G.J. and Matt, D.W., Adrenal and placental steroid secretion during pregnancy in the rat, Endocrinology, 114 (1984) 2068-2073.
169. [169] MacLusky, N.J. and Naftolin, F., Sexual differentiation of the central nervous system, Science, 211 (1981) 1294-1302.
170. [170] MacLusky, N.J., Naftolin, F., Krey, L.C. and Franks, S., The catechol estrogens, J. Steroid Biochem., 15 (1981) 111-124.
171. [171] MacLusky, N.J., Philip, A., Hurlburt, C. and Naftolin, F., Estrogen formation in the developing rat brain: sex differences in aromatase activity during early post-natal life, Psychoneuroendocrinology, 10 (1985) 355-361.
172. [172] MacLusky, N.J., Krey, L.C., Parsons, B., Merriam, G.R., Loriaux, D.L., Pfeiffer, D.G. and Naftolin, F., Are catechol estrogens obliatory mediators of oestrogen action in the central nervous system? II Potencies of natural and snythetic oestrogens for induction of gonadotrophin release and female sexual behavior in the rat. J. Endocrinol., 110 (1986) 499-505.
173. [173] MacLusky, N.J., Naftolin, F. and Goldman-Rakic, P.S., Estrogen formation and binding in the cerebral cortex of the developing rhesus monkey, Proc. Natl. Acad. Sci., USA, 83 (1986) 513-516.
174. [174] MacLusky, N.J., Clark, A.S. and Naftolin, F., Goldman-Rakic, P.S., Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of the hippocampus and neocortex, Steroids, 50 (1987) 459-474.
175. [175] MacLusky, N.J., Clark, C.R., Shanabrough, M. and Naftolin, F., Metabolism and binding of androgens in the spinal cord of the rat, Brain Res., 422 (1987) 83-91.
176. [176] MacLusky, N.J., Walters, M.J., Clark, S. and Toran-Allerand, C.D., Aromatase in the cerebral cortex, hippocampus, and midbrain: ontogeny and developmental implications, Mol. Cell Neurosci., 5 (1994) 691-698.
177. [177] Mahendroo, M.S., Means, G.D., Mendelson, C.R. and Simpson, E.R., Tissue-specific expression of human P450AROM: The promoter responsible for expression in adipose is different from that utilized in placenta. J. Biol. Chem., 266 (1991) 11276-11281.
178. [178] Mahendroo, M.S., Mendelson, C.R. and Simpson, E.R., Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue, J. Biol. Chem., 268 (1993) 19463-19470.
179. [179] Malven, P.V., Neural control of adenohypophysis. In P.V. Malven (Ed.), Mammalian Neuroendocrinology, CRC Press, Boca Raton, FL, 1993, pp. 50-52.
180. [180] Martini, L., The 5α-reduction of testosterone in the neuroendocrine structures. Biochemical and physiological implications. Endocrine Rev., 3 (1982) 1-25.
181. [181] Massa, R., Justo, S. and Martini, L., Conversion of testosterone into 5α-reduced metabolites in the anterior pituitary and in the brain of maturing rats, J. Steroid Biochem., 6: (1975) 567-571.
182. [182] Matsumine, H., Herbst, M.A., Ou, S.H.I., Wilson, J.D. and McPhaul, M.J., Aromatase mRNA in the extragonadal tissues of chicken with the henny-feathering trait is derived from a distinctive promoter structure that contains a segment of a retroviral long terminal repeat, J. Biol. Chem., 266 (1991) 19900-19907.
183. [183] Matsumoto, A. and Arai, Y., Sexual dimorphism in 'wiring pattern' in the hypothalamic arcuate nucleus and its modification by neonatal hormone environment. Brain Res., 190 (1980) 238-242.
184. [184] Mayer, I., Borg, B., Berglund, I. and Lambert, J.G.D., Effects of castration and androgen treatment on aromatase activity in the brain of mature male atlantic salmon (Salmo salar L.) Parr, Gen. Comp. Endocrinol., 82 (1991) 86-92.
185. [185] McDonald, P.G., Beyer, C., Newton, F., Brien, B., Baker, R., Tan, H.S., Sampson, C., Kitching, P., Greenhill, R. and Pritchard, D., Failure of 5α-dihydrotestosterone to initiate sexual behavior in the castrated male rat. Nature, 227 (1970) 964-965.
186. [186] McDonald, P.G. and Doughty, C., Comparison of the effect of neonatal administration of testosterone and dihydrotestosterone in the female rat, J. Reprod. Fert., 30 (1972) 55-62.
187. [187] McDonald, P.G. and Doughty, C., Inhibition of androgen-sterilization in the female rat by administration of an antioestrogen, J. Endocrinol., 55 (1972) 455-456.
188. [188] McEwen, B.S., Binding and metabolism of sex steroids by the hypothalamic-pituitary unit: physiological implications, Annu. Rev. Physiol., 42 (1980) 97-110.
189. [189] McGivern, R.F., Roselli, C.E. and Handa, R.J., Perinatal aromatase activity in male and female rats: Effect of prenatal alcohol exposure. Alcohol. Clin. Exp. Res., 12 (1988) 769-772.
190. [190] McLachlan, R., Tempel, B., Miller, M., Bicknell, J., Bremmer, W. and Dorsa, D., Androgen receptor gene expression in the rat central nervous system: evidence for two mRNA transcripts, Mol. Cell. Neurosci., 2 (1991) 117-122.
191. [191] McNatty, K.P., Baird, D.T., Bolton, A., Chambers, P., Corker, C.S. and MacLean, H., Concentration of oestrogens an androgens in human ovarian venous plasma and follicular fluid throughout the menstrual cycle, J. Endocrinol., 71 (1976) 77-85.
192. [192] McPhaul, M.J., Noble, J.F., Simpson, E.R., Mendelson, C.R. and Wilson, J.D., The expression of a functional cDNA encoding the chicken cytochrome P-450 arom (Aromatase) that catalyzes the formation of estrogen from androgen, J. Biol. Chem., 263 (1988) 16358-16363.
193. [193] McPhaul, M.J., Herbst, M.A., Matsumme, H., Young, M. and Lephart, E.D., Diverse mechansims of control of aromatase gene expression, J. Steroid Biochem. Mol. Biol., 44 (1993) 341-346.
194. [194] Means, G.D., Kilgore, M.W., Mahendroo, M.S., Mendelson, C.R. and Simpson, E.R., Tissue-specific promoters regulate aromatase cytochrome P450 gene expression in human ovary and fetal tissues, Mol. Endocrinol., 5 (1991) 2005-2013.
195. [195] Meisel, R.L., O'Hanlon, J.K. and Sachs, B.D., Differential maintenance of penile responses and copulatory behavior by gonadal hormones in castrated male rats, Horm. Behav., 18 (1984) 56-64.
196. [196] Melcangi, R.C., Celotti, F., Ballabio, M., Castano, P., Massarelli, R., Poletti and A., Martini, L., 5α-Reductase acitivity in isolated and cultured neuronal and gial cells of the rat, Brain Res., 516 (1990) 229-236.
197. [197] Michael, R.P., Bonsall, R.W. and Rees, H.D., The nuclear accumulation of 3H-testosterone and 3H-estradiol in the brain of the female primate: Evidence for the aromatization hypothesis, Endocrinology, 118 (1986) 1935-1944.
198. [198] Michael, R.P., Zumpe, D. and Bonsall, R.W., Comparison of the effects of testosterone and dihydrotestosterone on the behavior or male cynomolgus monkeys (Macaca fascicularis), Physiol. Behav., 36 (1986) 349-355.
199. [199] Micheal, R.P., Bonsall, R.W. and Rees, H.D., Sites at which testosterone may act as an estrogen in the brain of the male primate, Neuroendocrinology, 46 (1987) 511-521.
200. [200] Michnovicz, J.J., Hahn, E.F. and Fishman, J., 19-Hydroxylation and aromatization of androgens in the developing rat brain. Endocrinology, 121 (1987) 1209-1214.
201. [201] Miyairi, S., Sugita, O., Sassa, S. and Fishman, J., Aromatization and 19-hydroxylation of androgens by rat brain cytochrome P-450, Biochem. Biophys. Res. Commun., 150 (1988) 311-315.
202. [202] Morali, G., Larsson, K. and Beyer, C., Inhibition of testosterone-induced sexual behavior in the castrated male rat by aromatase blockers, Horm. Behav., 9 (1977) 203-213.
203. [203] Morishima, A., Grumbach, M.M., Simpson, E.R., Fisher, C. and Kenan, Q., Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens, J. Clin. Endocrinol. Metab., 80 (1995) 3689-3698.
204. [204] Morrell, J.I., Wagner, C.K., Malik, K.F. and Lisciotto, C.A., Estrogen receptor mRNA: neuroanatomical distribution and regulation in three behaviorally relevant physiological models. In P.E. Micevych and R.P. Hammer Jr., (Eds.), Neurobiological Effects of Sex Steroid Hormones, University of Cambridge Press, New York, NY, 1995, pp. 57-84.
205. [205] Motelica-Heino, I., Castanier, M., Corbier, P., Edwards, D.A. and Roffi, J., Testosterone levels in plasma and testes of neonatal mice. J. Steroid Biochem., 31 (1988) 283-286.
206. [206] Mozell, R.L., Yeh, J., McKelvie, P.A. and Villa-Komaroff, L., Expression of aromatase mRNA in developing human brain: a pilot study. Ann. Mtg. Endocrinol. Soc., Washington, DC, Abstract 1337, 1991, p. 365.
207. [207] Naftolin, F., Ryan, K.J. and Petro, Z., Aromatization of androstenedione by the diencephalon, J. Clin. Endocrinol. Metab., 33 (1971) 368-370.
208. [208] Naftolin, F, Ryan, K.J. and Petro, Z., Aromatization of androstenedione by limbic system tissue from human foetuses, J. Endocrinol., 51 (1971) 795-796.
209. [209] Naftolin, F., Ryan, K.J., Davies, I.J., Reddy, V.V., Flores, F., Petro, Z., Kuhn, M., White, R.J., Takaoka, Y. and Wolin, L., The formation of estrogens by central neuroendocrine tissues, Rec. Prog. Horm. Res., 31 (1975) 295-314.
210. [210] Naftolin, F., Ryan, K.J. and Petro, Z., Aromatization of androstenedione by the anterior hypothalamus of adult male and female rats. Endocrinology, 90 (1977) 295-298.
211. [211] Naftolin, F. and MacLusky, N.J., Aromatization hypothesis revisited. In M. Serio (Ed.), Differentiation: Basic and Clinical Aspects, Raven Press, New York, 1984, pp. 79-91.
212. [212] Naftolin, F., MacLusky, N.J., Leranth, C.Z., Sakamoto, H.S. and García-Segura, L.M., The cellular effects of estrogens on neuroendocrine tissues. J. Steroid Biochem., 30 (1988) 195-207.
213. [213] Naftolin, F., García-Segura, L.M., Keefe, D., Leranth, C., MacLusky, N.J. and Brawer, J.R., Estrogen effects on the synaptology and neural membranes of the rat hypothalamic arcuate nucleus, Biol. Reprod., 42 (1990) 21-28.
214. [214] Naftolin, F., Leranth, C., Pérez, J. and García-Segura, L.M., Estrogen induces synaptic plasticity in adult primate neurons, Neuroendocrinology, 57 (1993) 935-939.
215. [215] Naftolin, F., Brain aromatization of androgens. J. Reprod. Med., 39 (1994) 257-261.
216. [216] Nawssany, S., Habert, R. and Picon, R., Effects of androgen injections and decapitation on the pituitary gonadal axis and on genital tract of fetal rats at the end of gestation, J. Endocrinol., 88 (1981) 359-366.
217. [217] Nebert, D.W., Nelson, D.R., Adesnik, M., Coon, MJ., Estrabrook, R.W., Gonzales, F.J., Guengerich, F.P., Gunsalus, I.C., Johnson, E.F., Kemper, B. and Levin, W., Philip I.R., Sato, R. and Waterman, M.R., The P450 superfamily: update listing of all genes and recommended nomenclature of the chromosomal loci, DNA. 8 (1989) 1-13.
218. [218] Negri-Cesi, P., Celotti, F. and Martini, L., Androgen metabolism in the male hamster-2. Aromatization of androstenedione in the hypothalamus and in the cerebral cortex: kinetic parameters and effect of exposure to different photoperiods, J. Steroid Biochem., 32 (1989) 65-70.
219. [219] Negri Cesi, P., Melcangi, R.C., Celotti, F. and Martini, L., Distribution of aromatase activity in cultured neurons and glia cells. J. Steroid Biochem. Mol. Biol., 44 (1993) 637-639.
220. [220] Nichizuka, M. and Aria, Y., Organizational action of sexual differentiation of the brain, Brain Res., 213 (1981) 422-426.
221. [221] Ohe, E., Effect of aromatase inhibitor on sexual differentiation of SDN-POA in rats, Acta Obstet. Gynaecol. Jpn., 46 (1994) 227-234.
222. [222] Osawa, Y., Higashiyama, T., Fronckowiak, M. and Yoshida, N., Yarborough C., Aromatase, J. Steroid Biochem., 27 (1987) 781-789.
223. [223] Osawa, Y., Yoshida, N., Fronckowiak, M. and Kitawaki, J., Immunoaffinity purification of aromatase cytochrome P-450 from human placental microsomes, metabolic switching from aromatization to 1β and 2β-monohydroxlation, and recognition of aromatase isozymes, Steroids, 50 (1987) 11-28.
224. [224] Paden, C.M. and Roselli, C.E., Modulation of aromatase activity by testosterone in transplants of fetal rat hypothalamus-preoptic area, Dev. Brain Res., 33 (1987) 127-133.
225. [225] Parsons, B., Rainbow, T.C. and McEwen, B.S., Organizational effects of testosterone via aromatization on feminine reproductive behavior and neural progestin receptors in rat brain, Endocrinology, 115 (1984) 1412-1417.
226. [226] Parducz, A. and Pérez, J. and García-Segura L.M., Estradiol induces plasticity of GABAergic synapses in the hypothalamus, Neuroscience, 53 (1993) 395-401.
227. [227] Pasmanik, M. and Callard, G.V., Changes in brain aromatase and 5α-reductase activities correlate significantly with seasonal reproductive cycles in goldfish (Carassius auratus), Endocrinology, 122 (1988) 1349-1356.
228. [228] Paul, S.M., Hoffman, A.R. and Axelrod, J., Catechol estrogens: synthesis and metabolism in brain and other endocrine tissues. In L. Martini and W.F. Ganong (Eds.), Frontiers in Neuroendocrinology, Vol. 6, Raven Press, New York, 1980, pp. 203-217.
229. [229] Paup, D.C., Coniglio, L.P. and Clemens, L.G., Masculinization of the female golden hamster by neonatal treatment with androgen or estrogen, Horm. Behav., 3 (1972) 123-131.
230. [230] Pérez, J., Luquin, S., Naftolin, F. and García-Segura, L.M., The role of estradiol and progesterone in phased synaptic remodelling of the rat arcuate nucleus, Brain Res., 608 (1993) 38-44.
231. [231] Peterson, B.S., Leckman, J.F., Scahill, L., Naftolin, F., Keefe, D., Charest, N.J. and Cohen, D.J., Steroid hormone and CNS sexual dimorphisms modulate symptom expression in Tourette's syndrome, Psychoneuroendocrinology, 17 (1992) 553-563.
232. [232] Pfaff, D.W., Steroid sex hormone binding by cells in the vertebrate brain. In D.W. Pfaff (Ed.), Estrogens and Brain Function, Springer-Verlag, New York, 1980, pp. 77-105.
233. [233] Pfaff, D.W. and Schwartz-Giblin, S., Cellular mechanisms of female repoductive behaviors. In E. Knobil and J. Neill (Eds.), The Physiology of Reproduction. Raven Press, New York, 1988, pp. 1487-1568.
234. [234] Pfeiffer, C.A., Effect of ovarian transplants upon the development and maintenance of the seminal vesicle and prostrate gland of the albino rat, Anat. Rec., 65 (1936) 213-232.
235. [235] Pfeiffer, C.A., Vaginal and uterine grafts in the rat as indicators of the production of oestrin., Am. J. Physiol., 117 (1936) 672-677.
236. [236] Pfeiffer, D.G., MacLusky, N.J., Barnea, E., Naftolin, F., Krey, L.C., Loriaux, D.L. and Merriam, G.R., Are catechol oestrogens obligatory mediators of oestrogen action on the central nervous system? I. Characterization of pharmacological probes with different receptor binding affinities and catechol oestrogen formation rates, J. Endocrinol., 110 (1986) 489-497.
237. [237] Phoenix, C.H., Goy, R.W., Gerrall, A.A. and Young, W.C., Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig, Endocrinology, 65 (1959) 369-382.
238. [238] Price, T., Aitken, J. and Simspon, E.R., Relative expression of aromatase cytochrome P450 in human fetal tissues as determined by competitive polymerase chain reaction (PCR) amplification, J. Clin. Endocrinol. Metab., 74 (1992) 879-883.
239. [239] Rainbow, T.C., Parsons, B., MacLusky, N.J. and McEwen, B.S., Estradiol receptor levels in rat hypothalamic and limbic nuclei, J. Neurosci., 2 (1982) 1439-1445.
240. [240] Raisman, G. and Field, P.S., Sexual dimorphism in the neuropile of the preoptic area of the rat and its dependence on neonatal androgen, Brain Res., 54 (1973) 1-29.
241. [241] Reddy, V.V.R., Naftolin, F. and Ryan, K.J., Aromatization in the central nervous system in rabbits: effects of castration and hormone treatment, Endocrinology, 92 (1973) 589-594.
242. [242] Reddy, V.V.R., Naftolin, F. and Ryan, K.J., Conversion of androstenedione to estrone by neural tissues from fetal and neonatal rats, Endocrinology, 94 (1974) 117-121.
243. [243] Resko, J.A., Connolly, P.B., Roselli, C.E. and Abdelgadir, S.E., Selective activation of androgen receptors in the subcortical brain of male Cynomologus Macaques by physiological hormone levels and its relationship to androgen-dependent aromatase activity. J. Clin. Endocrinol. Metab., 76 (1993) 1588-1593.
244. [244] Rhees, R.W., Shryne, J.E. and Gorski, R.A., Onset of the hormone-sensitive perinatal period for sexual differentiation of the sexually dimorphic nucleus of the preoptic area in female rats. J. Neurobiol., 21 (1990) 781-786.
245. [245] Rhees, R.W., Shryne, J.E. and Gorski, R.A., Termination of the hormone-sensitive period for differentiation of the sexually dimorphic nucleus of the preoptic area in male and female rats, Dev. Brain Res., 52 (1990) 17-23.
246. [246] Rhoda, J., Corbier, P. and Roffi, J., Gonadal steroid concentration in serum and hypothalamus of the rat at birth: aromatization of testosterone of 17β-estradiol, Endocrinology, 114 (1984) 1754-1760.
247. [247] Roselli, C.E., Ellinwood, W.E. and Resko, J.A., Regulation of brain aromatase activity in rats. Endocrinology, 114 (1984) 192-200.
248. [248] Roselli, C.E., Horton, L.E. and Resko, J.A., Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system. Endocrinology. 117 (1985) 2471-2477.
249. [249] Roselli, C.E., Horton, L.E. and Resko, J.A., Time-course and steroid specificity of aromatase induction in rat hypothalamus-preoptic area, Biol. Reprod., 37 (1987) 628-633.
250. [250] Roselli, C.E. and Resko, J.A., The distribution and regulation of aromatase activity in the central nervous system, Steroids, 50 (1987) 495-508.
251. [251] Roselli, C.E., Stadelman, H., Horton, L.E. and Resko, J.A., Regulation of androgen metabolism and luteinizing hormone-releasing hormone content in discrete hypothalalmic and limbic areas of male rhesus macaques, Endocrinology, 120 (1987) 97-106.
252. [252] Roselli, C.E., Sex differences in androgen receptors and aromatase activity in microdissected regions of the rat brain, Endocrinology, 128 (1991) 1310-1316.
253. [253] Roselli, C.E. and Resko, J.A., Aromatase activity in the rat brain: Hormonal regulation and sex differences. J. Steroid Biochem. Mol. Biol., 44 (1993) 499-508.
254. [254] Roselli, C.E., Subcellular localization and kenetic properties of aromatase activity in rat brain, J. Steroid Biochem. Mol. Biol., 52 (1995) 469-477.
255. [255] Rosenfeld, J.M., Daley, J.D., Ohon, S. and YoungLai, E.V., Central aromatization of testosterone in testicular feminized mice. Experientia, 33 (1977) 1392-1393.
256. [256] Rosso, P., Maternal-fetal exchange during protein malnutrition in the rat: Placental transfer of α-amino isobutyric acid. J. Nutr., 107 (1977) 2002-2005.
257. [257] Rosso P., Maternal-fetal exchange during protein malnutrition in the rat: Placental transfer of glucose and a nonmetabolizable glucose analog. J. Nutr., 107 (1977) 2006-2010.
258. [258] Roy, MM., Effects of prenatal testosterone and ATD on reproductive behavior in guinea pigs, Physiol. Behav., 51 (1991) 105-109.
259. [259] Ryan, K.J., Naftolin, F., Reddy, V., Flores, F. and Petro, Z., Estrogen formation in the brain. Am. J. Obstet. Gynec., 114 (1972) 454-459.
260. [260] Sachs, B.D. and Meisel, R.L., The physiology of male sexual behavoir. In E. Knobil and J. Neill (Eds.). The Physiology of Reproduction, Raven Press, New York, 1988, pp. 1403-1409.
261. [261] Sanghera, M.K., Simpson, E.R., McPhaul, M.J., Kozlowski, G., Conley, A.J. and Lephart, E.D., Immunocytochemical distribution of aromatase cytochrome P450 in the rat brain using peptide-generated polyclonal antibodies, Endocrinology, 129 (1991) 2834-2844.
262. [262] Schaeffer, J.M. and Hsueh, A.J.W., 2-Hydroxyestradiol interaction with dopamine receptor binding in rat anterior pituitary, J. Biol. Chem., 254 (1979) 5606-5608.
263. 3H]testosterone in fore-brain of male, female and androgen receptor-deficient Tfm mice: an autoradiographic study, Brain Res., 397 (1986) 290-296.
264. [264] Schlinger, B.A. and Callard, G.V., Localization of aromatase in synaptosomal and microsomal subfractions of quail (Coturnix coturnix japonica) brain, Neuroendocrinology, 49 (1989) 434-441.
265. [265] Schlinger, B.A. and Callard, G.V., Brain-steroid interactions and the control of aggressiveness in birds. In E.E. Muller and R.M. MacLeod (Eds.), Neuroendocrine Perspectives, Springer-Verlag, 1991, pp. 1-43.
266. [266] Schlinger, B.A., Amur-Umarjee, S., Shen, P., Campagnoni, A.T. and Arnold, A.P., Neuronal and non-neuronal aromatase in primary cultures of developing zebra finch telenecephalon, J. Neurosci., 14 (1994) 7541-7552.
267. [267] Schweikert, H.U., Milewich, L. and Wilson, J.D., Aromatization of androstenedione by cultured human fibroblasts, J. Clin. Endocrinol. Metab., 43 (1976) 785-795.
268. [268] Seidl, M. and Pirke, K-M., Testosterone metabolism in the medial basal hypothalamus of the starved male rat, J. Steroid Biochem., 26 (1987) 407-411.
269. [269] Sekihara, H., Torii, R., Osawa, Y. and Takaku, S., Angiostensin II induces the release of 19-hydroxyandrostenedione in man, J. Clin. Endocrinol. Metab., 61 (1985) 291-296.
270. [270] Selmanoff, M.K., Brodkin, L.D., Weiner, R.I. and Siiteri, P.K., Aromatization and 5α-reduction of androgens in discrete hypothalamic and limbic regions of the male and female rat, Endocrinology. 101 (1977) 841-847.
271. [271] Shen, P., Campagnoni, C.W., Kampf, K., Schlinger, B.A., Arnold, A.P. and Campagnoni, A.T., Isolation and characterization of a zebra finch aromatase cDNA: in situ hybridization reveals high aromatase expression in brain, Mol. Brain Res., 24 (1994) 227-237.
272. 2). J. Comp. Neurol., 290 (1989) 502-515.
273. 2 in rat olfaction: An immunohistochemical study of the olfactory bulb, J. Comp. Neurol., 294 (1990) 340-344.
274. [274] Shinoda, K., Mori, M., Ohtsuki, T. and Osawa, Y., An aromatase-associated cytoplasmic inclusion, the 'stigmoid body' in the rat brain: I. Distribution in the forebrain, J. Comp. Neurol., 322 (1992) 360-376.
275. [275] Shinoda, K., Nagano, M. and Osawa. Y., An aromatase-associated cytoplasmic inclusion, the 'stigmoid body', in the rat brain: II. Ultrastructure (with a review of its history and nomenclature), J. Comp. Neurol., 329 (1993) 1-19.
276. [276] Shinoda, K., Nagano, M. and Osawa, Y., Neuronal aromatase expression in preoptic, strial and amygdaloid regions during late prenatal and early postnatal development in the rat. J. Comp. Neurol., 343 (1994) 113-129.
277. [277] Shinoda, K., Brain aromatization and its associated structures, Endocrine J. (Japan), 41 (1994) 115-138.
278. [278] Sholl, S.A., Goy, R.W. and Kim, K.L., 5α-Reductase, aromatase, and androgen receptor levels in the monkey brain during fetal development. Endocrinology, 124 (1989) 627-634.
279. [279] Shozu, M., Akasofu, K., Harada, T. and Kubota, Y., A new case of female pseudohermaphroditism: Placental aromatase deficiency, J. Clin. Endocrinol. Metab., 72 (1991) 560-566.
280. [280] Skipper, J.K., Young, L.J., Bergeron, J.M., Tetzlaff, M.T., Osborn, C.T. and Crews, D., Identification of an isoform of the estogen-receptor messenger RNA lacking exon 4 and present in the brain, Proc. Natl. Acad. Sci. USA. 90 (1993) 7172-7175.
281. [281] Simerly, R.B., Chang, C., Muramatsu, M. and Swanson, L.W., Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: an in situ hybridization study. J. Comp. Neurol., 294 (1990) 76-95.
282. [282] Simerly, R.B. and Young, BJ., Regulation of estrogen receptor messenger ribonucleic acid in rat hypothalamus by sex steroid hormones. Mol. Endocrinol., 5 (1991) 424-432.
283. [283] Simpson, E.R., Merrill, J.C., Hollub, A.J., Graham-Lorence, S. and Mendelson, C.R., Regulation of estrogen biosynthesis by human adipose cells. Endocrine Rev., 10 (1989) 136-148.
284. [284] Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Corbin, C.J. and Mendelson, C.R., Tissue-specific promoters regulate aromatase cytochrome P450 expression, J. Steroid Biochem. Mol. Biol., 44 (1993) 321-330.
285. [285] Simpson, E.R., Mahendroo, M.S., Means, G.D., Kilgore, M.W., Hinshelwood, M.M., Graham-Lorence, S., Amarneh, B., Ito, Y., Fisher, C.R., Michael, M.D., Mendelson, C. R. and Buhm, S.E., Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis, Endocrine Rev., 15 (1994) 342-355.
286. [286] Smith, E.P., Boyd, J., Frank, G.R., Takahashi, H., Cohen, R.M., Specker, B., Williams, T.C., Lubahn, D.B. and Korach, K.S., Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man, New Engl. J. Med., 331 (1994) 1056-1061.
287. [287] Spicer, L.J. and Hammond, J.M., Regulation of ovarian function by catecholestrogens: current concepts, J. Steroid Biochem., 33 (1989) 489-501.
288. [288] Steel, E. and Hutchison, J.B., The aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), blocks testosterone-induced olfactory behavior in the hamster, Physiol. Behav., 39 (1987) 141-145.
289. [289] Steimer, T.H. and Hutchison, J.B., Is androgen-dependent aromatase activity sexually differentiated in the rat and dove preoptic area?. J. Neurobiol., 21 (1990) 787-795.
290. [290] Steinkampf, M., Mendelson, C.R. and Simpson, E.R., Effects of epidermal growth factor and insulin-like growth factor-I on the levels of mRNA encoding aromatase cytochrome P-450 in human ovarian granulosa cells. Mol. Cell Endocrinol., 59 (1988) 93-99.
291. [291] Stewart, J. and Rajabi, H., Estradiol derived from testosterone in prenatal life affects the development of catecholamine systems in the frontal cortex in the male rat, Brain Res., 646 (1994) 157-160.
292. [292] Stone, C.P., Copulatory activity in adult male rats following castration and injections of testosterone propionate. Endocrinology. 24 (1939) 165-174.
293. [293] Sugita, O., Miyairi, S., Sassa, S. and Kappas, A., Partial purification of cytochrome P450 from rat brain and demonstration of estradiol hydroxylation. Biochem. Biophy. Res. Commun., 147 (1987) 1245-1250.
294. [294] Summerfield, A.E., Diaz., P.J., Dolenga, M.P., Smith, H.E., Strader, C.D. and Toney, J.H., Tissue-specific pharmacology of testosterone and 5α-dihydrotestosterone analogue: Characterization of a novel canine liver androgen-binding protein. Mol. Pharm., 47 (1995) 1080-1088.
295. [295] Swaab, D.F. and Fliers, E., A sexually dimorphic nucleus in the human brain. Science, 228 (1985) 1112-1114.
296. [296] Takahashi, Y., Yamanaka, H., Akiyama, I. and Sakuma, Y., Brain aromatase activity and behavioral consequences in the male rat treated in utero with 4-hydroxy-androstenedione. Endocrinology Japan, 36 (1989) 29-36.
297. [297] Tanaka, M., Telecky, T.M., Fukada, S., Adachi, S., Chen, S. and Nagahama, Y., Cloning and sequence analysis of the cDNA encoding P-450 aromatase (P450arom) from a rainbow trout (Oncorhynchus mykiss) ovary: relationship between the amount of P450arom mRNA and the production of oestradiol-17β in the ovary, J. Mol. Endocrinol., 8 (1992) 53-61.
298. [298] Taylor, S.R., Widows, M.R. and Sengelaub, D.R., Estrogenic influence and possible site of action in development of motoneuron morphology in a sexually dimorphic rat spinal nucleus, Ann. Mtg. Soc. Neurosci. Abstract 24.17, 1995, p. 9.
299. [299] Tershima, M., Toda, K., Kawamoto, T., Kuribayashi, I., Ogawa, Y., Maeda, T. and Shizuta, Y., Isolation of a full-length cDNA encoding mouse aromatase P-450. Arch. Biochem. Biophys., 285 (1991) 231-237.
300. [300] Timmers R.J.M. and Lambert, J.G.D., Measurement of aromatase activity in the brain of the African catfish, CLARIS GARIEPINUS - a comparison of two assays methods, Comp. Biochem. Physiol., 88B (1987) 453-456.
301. [301] Thompson Jr., E.A. and Siiteri, P.K., The involvement of human placental microsomal cytochrome P-450 in aromatization, J. Biol. Chem., 249 (1974) 5373-5378.
302. [302] Thompson Jr., E.A. and Siiteri, P.K., Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione, J. Biol. Chem., 249 (1974) 5364-5372.
303. [303] Tobet, S.A., Baum, M.J., Tang, H.B., Shim, J.H. and Canick, J.A., Aromatase activity in the perinatal rat forebrain: effects of age, sex and intrauterine position, Dev. Brain Res., 23 (1985) 171-178.
304. [304] Tobet, S.A., Shim, J.H., Osiecki, S.T., Baum, M.J. and Canick, J.A., Androgen aromatization and 5α-reduction in ferret brain during perinatal development: effects of sex and testosterone manipulation, Endocrinology, 116 (1985) 1869-1877.
305. [305] Toda, K, Simpson, E.R., Mendelson, C.R., Shizuta, Y. and Kilgore, M.W., Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues, Mol. Endocrinol., 8 (1994) 210-217.
306. [306] Toran-Allerand, C.D., Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro: implications for sexual differentiation, Brain Res., 106 (1976) 407-412.
307. [307] Toran-Allerand, C.D., Hashimoto, K., Greenough, W.T. and Saltarelli, M., Sex steroids and the development of the newborn mouse hypothalamus and preoptic area in vitro: III. Effects of estrogen on dendritic differentiation, Dev. Brain Res., 7 (1983) 97-101.
308. [308] Toran-Allerand, C.D., On the genesis of sexual differentiation of the central nervous system: Morphologenetic consequences of steroidal exposure and possible role of α-fetoprotein, Progr. Brain Res., 61 (1984) 63-98.
309. [309] Toran-Allerand, C.D., Interactions of estrogen with growth factors in the developing central nervous system. In R.B. Hochberg and F. Naftolin (Eds.), The New Biology of Steroid Hormones, Raven Press, New York, 1991, pp. 311-323.
310. [310] Toran-Allerand, C.D., Developmental interactions of estogens with neurotrophins and their receptors. In P.E. Micevych and R.P. Hammer Jr. (Eds.), Neurobiological Effects of Sex Steroid Hormones, University of Cambridge Press, New York, 1995, pp. 391-411.
311. [311] Toyooka, K.T., Connolly, P.B. and Resko, J.A., Effects of exogenous steroids on androgen receptors in fetal guinea pigs brain, Biol. Reprod., 44 (1991) 1051-1062.
312. [312] Trant J.M., Isolation and characterization of the cDNA encoding the channel catfish (Ictalurus punctatus) form of cytochrome P450arom. Gen. Comp. Endocrinol., 95 (1994) 155-168.
313. [313] Tsuruo, Y., Ishimura, K., Fujita, H. and Osawa, Y., Immunocytochemical localization of aromatase-containing neurons in the rat brain during pre-and postnatal development. Cell Tissue Res., 278 (1994) 29-39.
314. [314] Ulibarri, C. and Micevych, P.E., Role of perinatal estrogens in sexual differentiation of the inhibition of lordosis by exogenous cholecystokinin, Physiol. Behav., 54 (1993) 95-100.
315. [315] Valladares, L.E. and Payne, A.H., Induction of testicular aromatization by luteinizing hormone in mature rats, Endocrinology, 105 (1979) 431-436.
316. [316] Vito, C.C. and Fox, T.O., Androgen and estrogen receptors in embryonic and neonatal rat brain, Dev. Brain Res., 2 (1982) 97-110.
317. [317] Von Ziegler, N.I., Schlumpf, M. and Lichtensteiger, W., Prenatal nicotine exposure selectively affects perinatal forebrain aromatase activity and fetal adrenal function in male rats. Dev. Brain Res., 62 (1991) 23-31.
318. [318] Wagner, C.K. and Morrell, J.L., The distribution of aromatase mRNA in the brain of adult male and female rats using in situ hybribization, Ann. Mtg. Soc. Neurosci., Abstract 709.7, 1994, p. 342.
319. [319] Warren, D.W., Haltmeyer, G.C. and Eik-Nes, K.B., Testosterone in the fetal rat testis, Biol. Reprod., 8 (1973) 560-565.
320. [320] Weaver, C.E. and Baum, M.J., Differential regulation of brain aromatase by androgen in adult and fetal ferrets, Endocrinology, 128 (1991) 1247-1254.
321. [321] Weidenfeld, J., Siegel, R.A. and Yanai, J., Effect of phenobarbital on in vitro aromatization of testosterone to estradiol by adult male mice brain, J. Steroid Biochem., 18 (1983) 201-203.
322. [322] Weisz, J. and Gibbs, C., Conversion of testosterone and androstenedione to estrogens in vitro by the brain of female rats, Endocrinology. 94 (1974) 616-620.
323. [323] Weisz, J. and Gibbs, C., Metabolites of testosterone in the brain of the newborn female rat after an injection of tritiated testosterone. Neuroendocrinology, 14 (1974) 72-86.
324. [324] Weisz, J. and Ward, I.L., Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring, Endocrinology, 106 (1980) 306-316.
325. [325] Weisz, J., Brown, B.L. and Ward, I.L., Maternal stress decreases steroid aromatase activity in brains of male and female rat fetuses, Neuroendocrinology, 35 (1982) 374-379.
326. [326] Whalen, R.E. and Nadler, R.D., Suppression of the development of female mating behavior by estrogen administered in infancy. Science, 141 (1963) 273-275.
327. [327] Whalen, R.E. and Luttge, W.G., Perinatal administration of dihydrotestosterone to female rats and the development of reproductive function, Endocrinology, 89 (1971) 1320-1322.
328. [328] Wilson, C.M. and McPhaul, M.J., A and B forms of the androgen receptor are present in human genital skin fibroblasts, Proc. Natl. Acad. Sci. USA, 91 (1994) 1234-1238.
329. [329] Winick, M. and Noble, A., Quantitative changes in ribonucleic acids and protein during normal gestation of rat placenta, Nature, 212 (1966) 34-35.
330. [330] Wong, M. and Moss, R.L., Modulation of single-unit activity in the rat medial amygdala by neurotransmitters, estrogen priming, and synaptic inputs from the hypothalamus and midbrain, Synapse, 10 (1992) 94-102.
331. [331] Wozniak, A., Hutchison, R.E. and Hutchison, J.B., Localization of aromatase activity in androgen target areas of the mouse brain, Neurosci. Lett., 146 (1992) 191-194.
332. [332] Yamada, K., Harada, N., Tamaru, M. and Takagi, Y., Effects of changes in gonadal hormones on the amount of aromatase messenger RNA in mouse brain diencephalon, Biochem. Biophys. Res. Commun., 195 (1993) 462-468.
333. [333] Yamada, N.M., Hirata, S. and Kato, J., Distribution and postnatal changes of aromatase mRNA in the female rat brain, J. Steroid Biochem. Mol. Biol., 48 (1994) 529-533.
334. [334] Yuan, H., Bowlby, D.A., Brown, T.J., Hochberg, R.B. and MacLusky, N.J., Distribution of occupied and unoccupied estrogen receptors in the rat brain: Effects of physiological gonadal steroid exposure, Endocrinology, 136 (1995) 96-105.
335. [335] Zumpe, D., Bonsall, R.W. and Michael, R.P., Effects of the nonsteriodal aromatase inhibitor, Fadrozole, on the sexual behavior of male cynomolgus monkeys (Macaca fascicularis), Horm. Behav., 27 (1993) 200-215.