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Volumn 24, Issue 4, 1997, Pages 697-709

Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM MUTANT; CELL INVASION; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

EID: 0031007756     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1997.3741745.x     Document Type: Article
Times cited : (152)

References (49)
  • 1
    • 0026496235 scopus 로고
    • MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins
    • Allaoui, A., Sansonetti, P.J., and Parsot, C. (1992) MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins. J Bacteriol 174: 7661-7669.
    • (1992) J Bacteriol , vol.174 , pp. 7661-7669
    • Allaoui, A.1    Sansonetti, P.J.2    Parsot, C.3
  • 3
    • 0029416946 scopus 로고
    • hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes
    • Bajaj, V., Hwang, C., and Lee, C.A. (1995) hilA is a novel ompR/toxR family member that activates the expression of Salmonella typhimurium invasion genes. Mol Microbiol 18: 715-727.
    • (1995) Mol Microbiol , vol.18 , pp. 715-727
    • Bajaj, V.1    Hwang, C.2    Lee, C.A.3
  • 4
    • 0030031402 scopus 로고    scopus 로고
    • The Ipf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches
    • Baumler, A.J., Tsolis, R.M., and Heffron, F. (1996) The Ipf fimbrial operon mediates adhesion of Salmonella typhimurium to murine Peyer's patches. Proc Natl Acad Sci USA 93: 279-283.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 279-283
    • Baumler, A.J.1    Tsolis, R.M.2    Heffron, F.3
  • 5
    • 0027323056 scopus 로고
    • A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells
    • Behlau, I., and Miller, S.I. (1993) A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells. J Bacteriol 175: 4475-4484.
    • (1993) J Bacteriol , vol.175 , pp. 4475-4484
    • Behlau, I.1    Miller, S.I.2
  • 6
    • 0029818081 scopus 로고    scopus 로고
    • Salmonella spp. are cytotoxic for cultured macrophages
    • Chen, L.M., Kaniga, K., and Galán, J.E. (1996) Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol 21: 1101-1115.
    • (1996) Mol Microbiol , vol.21 , pp. 1101-1115
    • Chen, L.M.1    Kaniga, K.2    Galán, J.E.3
  • 7
    • 0028086368 scopus 로고
    • Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells
    • Clark, M.A., Jepson, M.A., Simmons, N.L., and Hirst, B.H. (1994) Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells. Res Microbiol 145: 543-552.
    • (1994) Res Microbiol , vol.145 , pp. 543-552
    • Clark, M.A.1    Jepson, M.A.2    Simmons, N.L.3    Hirst, B.H.4
  • 8
    • 0029816502 scopus 로고    scopus 로고
    • Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells
    • Clark, M.A., Reed, K.A., Lodge, J., Stephen, J., Hirst, B.H., and Jepson, M.A. (1996) Invasion of murine intestinal M cells by Salmonella typhimurium inv mutants severely deficient for invasion of cultured cells. Infect Immun 64: 4363-4368.
    • (1996) Infect Immun , vol.64 , pp. 4363-4368
    • Clark, M.A.1    Reed, K.A.2    Lodge, J.3    Stephen, J.4    Hirst, B.H.5    Jepson, M.A.6
  • 9
    • 0028957850 scopus 로고
    • Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus
    • Collazo, C.M., Zierler, M.K., and Galán, J.E. (1995) Functional analysis of the Salmonella typhimurium invasion genes invl and invJ and identification of a target of the protein secretion apparatus encoded in the inv locus. Mol Microbiol 15: 25-38.
    • (1995) Mol Microbiol , vol.15 , pp. 25-38
    • Collazo, C.M.1    Zierler, M.K.2    Galán, J.E.3
  • 10
    • 0021760092 scopus 로고
    • A comprehensive set of sequence analysis programs for the VAX
    • Devereux, J., Haeberli, P., and Smithies, O. (1984) A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res 12: 387-395.
    • (1984) Nucleic Acids Res , vol.12 , pp. 387-395
    • Devereux, J.1    Haeberli, P.2    Smithies, O.3
  • 11
    • 0025309187 scopus 로고
    • Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium
    • Ernst, R.K., Dombroski, D.M., and Merrick, J.M. (1990) Anaerobiosis, type 1 fimbriae, and growth phase are factors that affect invasion of HEp-2 cells by Salmonella typhimurium. Infect Immun 58: 2014-2016.
    • (1990) Infect Immun , vol.58 , pp. 2014-2016
    • Ernst, R.K.1    Dombroski, D.M.2    Merrick, J.M.3
  • 12
    • 0025852616 scopus 로고
    • Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells
    • Finlay, B.B., Ruschkowski, S., and Dedhar, S. (1991) Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells. J Cell Sci 99: 283-296.
    • (1991) J Cell Sci , vol.99 , pp. 283-296
    • Finlay, B.B.1    Ruschkowski, S.2    Dedhar, S.3
  • 13
    • 0026499462 scopus 로고
    • Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low-oxygen conditions
    • Francis, C.L., Starnbach, M.N., and Falkow, S. (1992) Morphological and cytoskeletal changes in epithelial cells occur immediately upon interaction with Salmonella typhimurium grown under low-oxygen conditions. Mol Microbiol 6: 3077-3087.
    • (1992) Mol Microbiol , vol.6 , pp. 3077-3087
    • Francis, C.L.1    Starnbach, M.N.2    Falkow, S.3
  • 14
    • 0027218124 scopus 로고
    • Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria
    • Francis, C.L., Ryan, T.A., Jones, B.D., Smith, S.J., and Falkow, S. (1993) Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature 364: 639-642.
    • (1993) Nature , vol.364 , pp. 639-642
    • Francis, C.L.1    Ryan, T.A.2    Jones, B.D.3    Smith, S.J.4    Falkow, S.5
  • 15
    • 0029879556 scopus 로고    scopus 로고
    • Molecular genetic bases of Salmonella entry into host cells
    • Galán, J.E. (1996) Molecular genetic bases of Salmonella entry into host cells. Mol Microbiol 20: 263-271.
    • (1996) Mol Microbiol , vol.20 , pp. 263-271
    • Galán, J.E.1
  • 16
    • 0024323292 scopus 로고
    • Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells
    • Galán, J.E., and Curtiss, III, R. (1989) Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells. Proc Natl Acad Sci USA 86: 6383-6387.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 6383-6387
    • Galán, J.E.1    Curtiss III, R.2
  • 17
    • 0025374683 scopus 로고
    • Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling
    • Galén, J.E., and Curtiss, III, R. (1990) Expression of Salmonella typhimurium genes required for invasion is regulated by changes in DNA supercoiling. Infect Immun 58: 1879-1885.
    • (1990) Infect Immun , vol.58 , pp. 1879-1885
    • Galén, J.E.1    Curtiss III, R.2
  • 18
    • 0026778387 scopus 로고
    • Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells
    • Ginocchio, C., Pace, J., and Galán, J.E. (1992) Identification and molecular characterization of a Salmonella typhimurium gene involved in triggering the internalization of salmonellae into cultured epithelial cells. Proc Natl Acad Sci USA 89: 5976-5980.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5976-5980
    • Ginocchio, C.1    Pace, J.2    Galán, J.E.3
  • 19
    • 0027246618 scopus 로고
    • Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri
    • Groisman, E.A., and Ochman, H. (1993) Cognate gene clusters govern invasion of host epithelial cells by Salmonella typhimurium and Shigella flexneri. EMBO J 12: 3779-3787.
    • (1993) EMBO J , vol.12 , pp. 3779-3787
    • Groisman, E.A.1    Ochman, H.2
  • 20
    • 0029051014 scopus 로고
    • Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells
    • Hermant, D., Menard, R., Arricau, N., Parsot, C., and Popoff, M.Y. (1995) Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells. Mol Microbiol 17: 781-789.
    • (1995) Mol Microbiol , vol.17 , pp. 781-789
    • Hermant, D.1    Menard, R.2    Arricau, N.3    Parsot, C.4    Popoff, M.Y.5
  • 21
    • 0029560515 scopus 로고
    • Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins
    • Hueck, C.J., Hantman, M.J., Bajaj, V., Johnston, C., Lee, C.A., and Miller, S.I. (1995) Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol Microbiol 18: 479-490.
    • (1995) Mol Microbiol , vol.18 , pp. 479-490
    • Hueck, C.J.1    Hantman, M.J.2    Bajaj, V.3    Johnston, C.4    Lee, C.A.5    Miller, S.I.6
  • 22
    • 0027981613 scopus 로고
    • Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization
    • Jones, B.D., and Falkow, S. (1994) Identification and characterization of a Salmonella typhimurium oxygen-regulated gene required for bacterial internalization. Infect Immun 62: 3745-3752.
    • (1994) Infect Immun , vol.62 , pp. 3745-3752
    • Jones, B.D.1    Falkow, S.2
  • 23
    • 0029965794 scopus 로고    scopus 로고
    • Typhoid fever: Host immune response and Salmonella virulence determinants
    • Jones, B.D., and Falkow, S. (1996) Typhoid fever: host immune response and Salmonella virulence determinants. Annu Rev Immunol 14: 533-561.
    • (1996) Annu Rev Immunol , vol.14 , pp. 533-561
    • Jones, B.D.1    Falkow, S.2
  • 24
    • 0028214086 scopus 로고
    • Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches
    • Jones, B.D., Ghori, N., and Falkow, S. (1994) Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med 180: 15-23.
    • (1994) J Exp Med , vol.180 , pp. 15-23
    • Jones, B.D.1    Ghori, N.2    Falkow, S.3
  • 25
    • 0027982037 scopus 로고
    • The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PuID family of proteins
    • Kaniga, K., Bossio, J.C., and Galán, J.E. (1994) The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PuID family of proteins. Mol Microbiol 13: 555-568.
    • (1994) Mol Microbiol , vol.13 , pp. 555-568
    • Kaniga, K.1    Bossio, J.C.2    Galán, J.E.3
  • 26
    • 0028886418 scopus 로고
    • Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins
    • Kaniga, K., Trollinger, D., and Galán, J.E. (1995a) Identification of two targets of the type III protein secretion system encoded by the inv and spa loci of Salmonella typhimurium that have homology to the Shigella IpaD and IpaA proteins. J Bacteriol 177: 7078-7085.
    • (1995) J Bacteriol , vol.177 , pp. 7078-7085
    • Kaniga, K.1    Trollinger, D.2    Galán, J.E.3
  • 27
    • 0029059332 scopus 로고
    • Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells
    • Kaniga, K., Tucker, S., Trollinger, D., and Galán, J.E. (1995b) Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. J Bacteriol 177: 3965-3971.
    • (1995) J Bacteriol , vol.177 , pp. 3965-3971
    • Kaniga, K.1    Tucker, S.2    Trollinger, D.3    Galán, J.E.4
  • 28
    • 0017740196 scopus 로고
    • Endocytosis of Salmonella typhimurium 395 MS and MR10 by HeLa cells
    • Kihlström, E., and Nilsson, L. (1977) Endocytosis of Salmonella typhimurium 395 MS and MR10 by HeLa cells. Acta Path Microbiol Scand 85: 322-328.
    • (1977) Acta Path Microbiol Scand , vol.85 , pp. 322-328
    • Kihlström, E.1    Nilsson, L.2
  • 29
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 30
    • 0025334009 scopus 로고
    • The ability of Salmonella to enter mammalian cells is affected by bacterial growth state
    • Lee, C.A., and Falkow, S. (1990) The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc Natl Acad Sci USA 87: 4304-4308.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4304-4308
    • Lee, C.A.1    Falkow, S.2
  • 31
    • 0026546878 scopus 로고
    • Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants
    • Lee, C.A., Jones, B.D., and Falkow, S. (1992) Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci USA 89: 1847-1851.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1847-1851
    • Lee, C.A.1    Jones, B.D.2    Falkow, S.3
  • 32
    • 0029123044 scopus 로고
    • Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica
    • Li, J., Ochman, H., Groisman, E.A., Boyd, E.F., Solomon, F., Nelson, K., and Selander, R.K. (1995) Relationship between evolutionary rate and cellular location among the Inv/Spa invasion proteins of Salmonella enterica. Proc Natl Acad Sci USA 92: 7252-7256.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7252-7256
    • Li, J.1    Ochman, H.2    Groisman, E.A.3    Boyd, E.F.4    Solomon, F.5    Nelson, K.6    Selander, R.K.7
  • 33
    • 0028920524 scopus 로고
    • A 40kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome
    • Mills, D.M., Bajaj, V., and Lee, C.A. (1995) A 40kb chromosomal fragment encoding Salmonella typhimurium invasion genes is absent from the corresponding region of the Escherichia coli K-12 chromosome. Mol Microbiol 15: 749-759.
    • (1995) Mol Microbiol , vol.15 , pp. 749-759
    • Mills, D.M.1    Bajaj, V.2    Lee, C.A.3
  • 34
    • 0028821259 scopus 로고
    • Nucleotide sequence of iagA and iagB genes involved in invasion of HeLa cells by Salmonella enterica ssp. enterica ser
    • Miras, I., Hermant, D., Arricau, N., and Popoff, M.Y. (1995) Nucleotide sequence of iagA and iagB genes involved in invasion of HeLa cells by Salmonella enterica ssp. enterica ser. Typhi. Res Microbiol 146: 17-20.
    • (1995) Typhi. Res Microbiol , vol.146 , pp. 17-20
    • Miras, I.1    Hermant, D.2    Arricau, N.3    Popoff, M.Y.4
  • 35
    • 0029793103 scopus 로고    scopus 로고
    • Salmonella typhimurium invasion induces apoptosis in infected macrophages
    • Monack, D.M., Raupach, B., Hromockyj, A.E., and Falkow, S. (1996) Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc Natl Acad Sci USA 93: 9833-9838.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9833-9838
    • Monack, D.M.1    Raupach, B.2    Hromockyj, A.E.3    Falkow, S.4
  • 36
    • 84873762502 scopus 로고
    • Culture characteristics of four permanent lines of human cancer cells
    • Moore, A.E., Sabachewsky, L., and Toolan, H.W. (1955) Culture characteristics of four permanent lines of human cancer cells. Cancer Res 15: 598.
    • (1955) Cancer Res , vol.15 , pp. 598
    • Moore, A.E.1    Sabachewsky, L.2    Toolan, H.W.3
  • 37
    • 0014757386 scopus 로고
    • A general method applicable to the search for similarities in the amino acid sequence of two proteins
    • Needleman, S.B., and Wunsch, C.D. (1970) A general method applicable to the search for similarities in the amino acid sequence of two proteins. J Mol Biol 48: 443-453.
    • (1970) J Mol Biol , vol.48 , pp. 443-453
    • Needleman, S.B.1    Wunsch, C.D.2
  • 38
    • 0029095837 scopus 로고
    • PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: Evidence for a role in protein secretion
    • Pegues, D.A., Hantman, M.J., Behlau, I., and Miller, S.I. (1995) PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion. Mol Microbiol 17: 169-181.
    • (1995) Mol Microbiol , vol.17 , pp. 169-181
    • Pegues, D.A.1    Hantman, M.J.2    Behlau, I.3    Miller, S.I.4
  • 39
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percentage endpoints
    • Reed, L.J., and Muench, H. (1938) A simple method of estimating fifty percentage endpoints. Am J Hygiene 27: 493-497.
    • (1938) Am J Hygiene , vol.27 , pp. 493-497
    • Reed, L.J.1    Muench, H.2
  • 41
    • 0027120750 scopus 로고
    • Salmonella typhimurium induces an inositol phosphate flux in infected epithelial cells
    • Ruschkowski, S., Rosenshine, I., and Finlay, B.B. (1992) Salmonella typhimurium induces an inositol phosphate flux in infected epithelial cells. FEMS Microbiol Lett 74: 121-126.
    • (1992) FEMS Microbiol Lett , vol.74 , pp. 121-126
    • Ruschkowski, S.1    Rosenshine, I.2    Finlay, B.B.3
  • 42
    • 0025965137 scopus 로고
    • Anaerobic growth of Salmonella typhimurium results in increased uptake by Henle 407 epithelial and mouse peritoneal cells in vitro and repression of a major outer membrane protein
    • Schiemann, D.A., and Shope, S.R. (1991) Anaerobic growth of Salmonella typhimurium results in increased uptake by Henle 407 epithelial and mouse peritoneal cells in vitro and repression of a major outer membrane protein. Infect Immun 59: 437-440.
    • (1991) Infect Immun , vol.59 , pp. 437-440
    • Schiemann, D.A.1    Shope, S.R.2
  • 43
    • 0029913901 scopus 로고    scopus 로고
    • Identification of a virulence locus encoding a second type III secretion sytem in Salmonella typhimurium
    • Shea, J.E., Hensel, M., Gleeson, C., and Holden, D.W. (1996) Identification of a virulence locus encoding a second type III secretion sytem in Salmonella typhimurium. Proc Natl Acad Sci USA 93: 2593-2597.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2593-2597
    • Shea, J.E.1    Hensel, M.2    Gleeson, C.3    Holden, D.W.4
  • 44
    • 0022869287 scopus 로고
    • The construction of a cloning vector designed for gene replacement in Bordetella pertussis
    • Stibitz, S., Black, W., and Falkow, S. (1986) The construction of a cloning vector designed for gene replacement in Bordetella pertussis. Gene 50: 133-140.
    • (1986) Gene , vol.50 , pp. 133-140
    • Stibitz, S.1    Black, W.2    Falkow, S.3
  • 46
    • 0014037522 scopus 로고
    • Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium
    • Takeuchi, A. (1967) Electron microscope studies of experimental Salmonella infection. I. Penetration into the intestinal epithelium by Salmonella typhimurium. Am J Pathol 50: 109-136.
    • (1967) Am J Pathol , vol.50 , pp. 109-136
    • Takeuchi, A.1
  • 47
    • 0028951802 scopus 로고
    • The hrp gene locus of Pseudomonas solanacearum, which controls the production of a type III secretion system, encodes eight proteins related to components of the bacterial flagellar biogenesis complex
    • Van Gijsegem, F., Gough, C., Zischek, C., Niqueux, E., Arlat, M., Genin, S., Barberis, P., German, S., Castello, P., and Boucher, C. (1995) The hrp gene locus of Pseudomonas solanacearum, which controls the production of a type III secretion system, encodes eight proteins related to components of the bacterial flagellar biogenesis complex. Mol Microbiol 15: 1095-1114.
    • (1995) Mol Microbiol , vol.15 , pp. 1095-1114
    • Van Gijsegem, F.1    Gough, C.2    Zischek, C.3    Niqueux, E.4    Arlat, M.5    Genin, S.6    Barberis, P.7    German, S.8    Castello, P.9    Boucher, C.10
  • 48
    • 0018015813 scopus 로고
    • Experimental Salmonella typhimurium infection in calves
    • Wray, C., and Sojka, W.J. (1978) Experimental Salmonella typhimurium infection in calves. Res Vet Sci 25:139-143.
    • (1978) Res Vet Sci , vol.25 , pp. 139-143
    • Wray, C.1    Sojka, W.J.2
  • 49
    • 0029090966 scopus 로고
    • Contact with cultured epithelial cells stimulates secretion of Salmonella typhimurium invasion protein InvJ
    • Zierler, M.K., and Galán, J.E. (1995) Contact with cultured epithelial cells stimulates secretion of Salmonella typhimurium invasion protein InvJ. Infect Immun 63: 4024-4028.
    • (1995) Infect Immun , vol.63 , pp. 4024-4028
    • Zierler, M.K.1    Galán, J.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.