All TRAFs are not created equal: Common and distinct molecular mechanisms of TRAF-mediated signal transduction

Journal of Cell Science

Volumn 115, Issue 4, 2002, Pages 679-688

  Chung, Jee Y ^a   Park, Young Chul ^a   Ye, Hong ^a   Wu, Hao ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

AP 1; IL 1R TLR; NF B; TNF; TRAF

Indexed keywords

INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG;

ADAPTATION; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; PROTEIN VARIANT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; HUMANS; MODELS, MOLECULAR; PHYLOGENY; PROTEIN CONFORMATION; PROTEINS; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 1; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF RECEPTOR-ASSOCIATED FACTOR 3; TNF RECEPTOR-ASSOCIATED FACTOR 4; TNF RECEPTOR-ASSOCIATED FACTOR 5; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

MAMMALIA;

EID: 0037084504     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (122)

1. Tumor necrosis factor receptor-associated factors (TRAFs) - A family of adapter proteins that regulates life and death
2. Translocation of TRAF proteins regulates apoptotic threshold of cells
3. NF-kappa B: Ten years after
4. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
5. Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
6. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
7. Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1)
8. IRAK: A kinase associated with the interleukin-1 receptor
9. TRAF6 is a signal transducer for interleukin-1
10. TRAF1 is a TNF inducible regulator of NF-kappaB activation
11. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
12. Involvement of CRAF1, a relative of TRAF, in CD40 signaling
13. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
14. Membrane localization of TRAF 3 enables JNK activation
15. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif
16. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
17. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
18. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
19. CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival
20. Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2
21. Tumor necrosis factor receptor-associated factor 1 is overexpressed in Reed-Sternberg cells of Hodgkin's disease and Epstein-Barr virus-transformed lymphoid cells
22. Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
23. Dominant negative mutants of TRAF3 reveal an important role for the coiled coil domains in cell death signaling by the lymphotoxin-beta receptor
24. Discrete signaling regions in the lymphotoxin-beta receptor for tumor necrosis factor receptor-associated factor binding, subcellular localization, and activation of cell death and NF-kappaB pathways
25. TRAF-3 interacts with p62 nucleoporin, a component of the nuclear pore central plug that binds classical NLS-containing import complexes
26. Complete structural characterisation of the mammalian and Drosophila TRAF genes: Implications for TRAF evolution and the role of RING finger splice variants
27. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
28. Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)
29. Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling
30. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
31. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
32. The TNF receptor 1-associated protein TRADD signals cell death and NF-kB activation
33. Toll receptors in innate immunity
34. Tumor necrosis factor receptor-associated factor (TRAF) family: Adapter proteins that mediate cytokine signaling
35. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
36. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
37. The regulation of AP-1 activity by mitogen-activated protein kinases
38. The death-domain kinase RIP mediates the TNF-induced NF-kB signal
39. TRAF-4 expression in epithelial progenitor cells. Analysis in normal adult, fetal, and tumor tissues
40. The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component
41. Assembly and regulation of the CD40 receptor complex in human B cells
42. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
43. TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival
44. Stimulus-dependent synergism of the antiapoptotic tumor necrosis factor receptor-associated factor 2 (TRAF2) and nuclear factor kappaB pathways
45. Physical and functional interaction of filamin (actin-binding protein- 280) and tumor necrosis factor receptor-associated factor 2
46. MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network
47. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κb activation prevents cell death
48. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase
49. The TNF and TNF receptor superfamilies: Integrating mammalian biology
50. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling
51. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
52. Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development
53. Crystallographic analysis of CD40 recognition and signaling by human TRAF2
54. Innate immune recognition: Mechanisms and pathways
55. Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)
56. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
57. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
58. Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice
59. TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor
60. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation
61. Impaired TNF-induced NF-kB activation and high sensitivity to TNF-induced cell death in TRAF2- and TRAF5-double deficient mice
62. Molecular basis for CD40 signaling mediated by TRAF3
63. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
64. ASK1 is essential for JNK/SAPK activation by TRAF2
65. Inhibited neutrophil apoptosis: Proteasome dependent NF-kappaB translocation is required for TRAF-1 synthesis
66. Structural basis for self-association and receptor recognition of human TRAF2
67. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction
68. Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization
69. Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development
70. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: Regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
71. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma
72. Identification and characterization of an IkappaB kinase
73. Tumor necrosis factor alpha-induced activation of c-jun N-terminal kinase is mediated by TRAF2
74. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
75. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
76. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40
77. The human tumor necrosis factor (TNF) receptor-associated factor 1 gene (TRAF1) is upregulated by cytokines of the TNF ligand family and modulates TNF-induced activation of NF-kappaB and c-Jun N-terminal kinase
78. AP-1 in cell proliferation and survival
79. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
80. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related
81. TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction
82. TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs
83. TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase
84. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
85. The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
86. Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
87. A regulatory role for TRAF1 in antigen-induced apoptosis of T cells
88. NF-kB activation: The IkB kinase revealed?
89. RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
90. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
91. Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway
92. Both amino- and carboxyl-terminal domains of TRAF3 negatively regulate NF-kappaB activation induced by OX40 signaling
93. Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
94. TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF- kappaB activation
95. CD40 signaling in human dendritic cells is initiated within membrane rafts
96. Tumor necrosis factor receptor and Fas signaling mechanisms
97. Identification of a TRAF (TNF receptor-associated factor) gene in Caenorhabditis elegans
98. The TNF-receptor-associated factor family: Scaffold molecules for cytokine receptors, kinases and their regulators
99. TAK1 is a ubiquitin-dependent kinase of MKK and IKK
100. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
101. Micrococci and peptidoglycan activate TLR2->MyD88->IRAK->TRAF->NIK->IKK->NF-kappaB signal transduction pathway that induces transcription of interleukin-8
102. MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
103. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
104. The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor
105. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src
106. TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
107. Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses
108. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
109. Il-1 induced chemokine production through the association of syk with tnf receptor-associated factor-6 in nasal fibroblast lines
110. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
111. The essential role of MEKK3 in TNF-induced NF-kappaB activation
112. The structural basis for the recognition of diverse receptor sequences by TRAF2
113. Thermodynamic characterization of the interaction between TRAF2 and receptor peptides by isothermal titration calorimetry
114. TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction
115. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
116. Gene targeting in the analysis of mammalian apoptosis and TNF receptor superfamily signaling
117. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
118. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
119. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
120. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity
121. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
122. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation