Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes

Mutagenesis

Volumn 16, Issue 5, 2001, Pages 419-422

  Pincheira, Juana ^a   Bravo, Mireya ^a   Navarrete, Matilde H ^b,c   Marcelain, Katherine ^a   Lopez Sáez, Jorge F ^c   De La Torre, Consuelo ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CAFFEINE; DNA; ENZYME INHIBITOR; METHYLXANTHINE; PHOSPHOTRANSFERASE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CELL CYCLE G2 PHASE; CELL TYPE; CHILD; CHROMOSOME ABERRATION; CHROMOSOME DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPAIR; EUKARYOTIC CELL; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MODEL; MUTATION; PRIORITY JOURNAL; REGULATORY MECHANISM; X IRRADIATION; CELL CULTURE; CELL DIVISION; CHROMOSOME DISORDER; DNA DAMAGE; DRUG EFFECT; ENZYMOLOGY; GENETICS; LYMPHOCYTE; PATHOLOGY; PRESCHOOL CHILD;

ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; DNA DAMAGE; DNA-BINDING PROTEINS; FEMALE; G2 PHASE; HUMANS; LYMPHOCYTES; MALE; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 0034741595     PISSN: 02678357     EISSN: None     Source Type: Journal    
DOI: 10.1093/mutage/16.5.419     Document Type: Article

References (22)

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2. Caffeine inhibits the checkpoint kinase ATM
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5. Comments on the paper: The ATM gene and the radiobiology of ataxia-telangiectasia
6. ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
7. Splitting the ATM: Distinct repair and checkpoint defects in ataxia-telangiectasia
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11. Radiosensitivity in ataxia telangiectasia. A new explanation
12. Ionizing radiation activates the ATM kinase throughout the cell cycle
13. When checkpoints fail
14. 2 en linfocitos cultivados in vitro
15. 2 repair in Down syndrome: Effect of caffeine, adenosine and niacinamide in control and X-ray irradiated lymphocytes
16. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine
17. Cell cycle control, checkpoint mechanisms, and genotoxic stress
18. A rapid banding technique for human chromosomes
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20. Régulation du cycle cellulaire des cellules exposées aux radiations ionisantes
21. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
22. Caffeine abolishes the mammalian G2/M damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity