Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different apoE genotypes

Experimental Neurology

Volumn 149, Issue 1, 1998, Pages 175-182

  Rebeck, G William ^a   Alonzo, Norma C ^a   Berezovska, Oksana ^a   Harr, Steven D ^a   Knowles, Roger B ^a   Growdon, John H ^a   Hyman, Bradley T ^a   Mendez, Armando J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Apolipoprotein E; Cerebrospinal fluid; Lipoprotein; Neurodegeneration

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; DIMER; PHOSPHOLIPID; PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CEREBROSPINAL FLUID EXAMINATION; CHOLESTEROL TRANSPORT; CLINICAL ARTICLE; GENOTYPE; HUMAN; HUMAN CELL; LIPID ANALYSIS; NERVE DEGENERATION; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 0031914130     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1997.6710     Document Type: Article

References (55)

1. Assmann G. Lipid Metabolism and Atherosclerosis. 1982;Schattauer, Stuttgart.
2. Bellosta S., Nathan B. P., Orth M., Dong L.-M., Mahley R. W., Pitas R. E. Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J. Biol. Chem. 270:1995;27063-27071.
3. Bilheimer D. W., Eisenberg S., Levy R. I. The metabolism of very low density lipoprotein proteins. Biochim. Biophys. Acta. 260:1972;212-221.
4. Blessed G., Tomlinson B. E., Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Brit. J. Psych. 114:1968;797-811.
5. Borghini I., Barja F., Pometta D., James R. W. Characterization of subpopulations of lipoprotein particles isolated from human cerebrospinal fluid. Biochim. Biophys. Acta. 1255:1995;192-200.
6. Boyles J. K., Pitas R. E., Wilson E., Mahley R. W., Taylor J. M. Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J. Clin. Invest. 76:1985;1501-1513.
7. Davignon J., Gregg R. E., Sing C. F. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 8:1988;1-21.
8. Fagan A. M., Bu G., Sun Y., Daugherty A., Holtzman D. M. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein. J. Biol. Chem. 271:1996;30121-30125.
9. Folch J., Lees M., Sloane Stanley G. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:1957;497-509.
10. Goldstein J. L., Basu S. K., Brown M. S. Receptor-mediated endocytosis of low-density lipoprotein in cultured cells. Methods Enzymol. 98:1983;241-260.
11. Gomez-Isla T., West H. L., Rebeck G. W., Harr S. D., Growdon J. H., Locasio J. J., Perls T. T., Lipsitz L. A., Hyman B. T. Clinical and pathological correlates of apolipoprotein E e4 in Alzheimer disease. Ann. Neurol. 39:1996;62-70.
12. Gregg R. E., Zech L. A., Schaefer E. J., Stark D., Wilson D., Brewer H. B. Jr. Abnormal in vivo metabolism of apolipoprotein E4 in humans. J. Clin. Invest. 78:1986;815-821.
13. Han S.-H., Einstein G., Weisgraber K. H., Strittmatter W. J., Saunders A. M., Pericak-Vance M., Roses A. D., Schmechel D. E. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: A light and electron microscopic study. J. Neuropathol. Exp. Neurol. 53:1994;535-544.
14. Han S.-H., Hulette C., Saunders A. M., Einstein G., Pericak-Vance M., Strittmatter W. J., Roses A. D., Schmechel A. E. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Exp. Neurol. 128:1994;13-26.
15. Handelmann G. E., Boyles J. K., Weisgraber K. H., Mahley R. W., Pitas R. E. Effects of apolipoprotein E, β-very low density lipoproteins, and cholesterol on the extensions of neurites by rabbit dorsal root ganglion neurons in vitro. J. Lipid Res. 33:1992;1677-1688.
16. Harr S. D., Uint L., Hollister R., Hyman B. T., Mendez A. J. Brain expression of apolipoproteins E, J, and AI, in Alzheimer's disease. J. Neurochem. 66:1996;2429-2435.
17. Havel R. J., Eder H. A., Brogdon J. H. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34:1955;1345-1352.
18. Hixson J. E., Vernier D. T. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with Hhal. J. Lipid Res. 31:1990;545-548.
19. Holtzman D. M., Pitas R. E., Kilbridge J., Nathan B., Mahley R. W., Bu G., Schwartz A. L. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc. Natl. Acad. Sci. USA. 92:1995;9480-9484.
20. Huang Y., von Eckardstein A., Wu S., Maeda N., Assman G. A plasma lipoprotein containing only apolipoprotein E and with γ mobility on electrophoresis releases cholesterol from cells. Proc. Natl. Acad. Sci. USA. 91:1994;1834-1838.
21. Hyman B. T., Gomez-Isla T., Briggs M., Chung H., Nichols S., Kohout F., Wallace R. Apolipoprotein E and cognitive change in an elderly population. Ann. Neurol. 40:1996;55-66.
22. Jensen T. G., Roses A. D., Jorgensen A. L. Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor. Neurosci. Lett. 180:1994;193-196.
23. Khachaturian Z. S. Diagnosis of Alzheimer's disease. Arch. Neurol. 42:1985;1097-1105.
24. Koudinov A. R., Koudinova N. V., Kumar A., Beavis R. C., Ghiso J. Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: Association with high density lipoproteins. Biochem. Biophys. Res. Commun. 223:1996;592-597.
25. Lovestone S., Anderton B. H., Hartley C., Jensen T. G., Jorgensen A. L. The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific. NeuroReport. 7:1996;1005-1008.
26. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
27. Mahley R. W. Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science. 240:1988;622-630.
28. Masliah E., Mallory M., Ge N., Alford M., Veinbergs I., Roses A. D. Neurodegeneration in the central nervous system of apoE-deficient mice. Exp. Neurol. 136:1995;107-122.
29. McFarlane A. S. Efficient trace-labelling of proteins with iodine. Nature. 182:1958;53.
30. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E. M. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA group under the auspices of Dept. of HHS Task Force on Alzheimer's Disease. Neurology. 34:1984;939-944.
31. Mendez A. J. Monensin and Brefeldin A inhibit high density lipoprotein-mediated cholesterol efflux from cholesterol enriched cells. Implications for intracellular cholesterol transport. J. Biol. Chem. 270:1995;5891-5900.
32. Mendez A. J., Oram J. F., Bierman E. L. Protein kinase C as a mediator of high density lipoprotein receptor-dependent efflux of intracellular cholesterol. J. Biol. Chem. 266:1991;10104-10111.
33. Metzger R. E., LaDu M. J., Pan J. B., Getz G. S., Frail D. E., Falduto M. T. Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: Implications for Alzheimer's disease. J. Neuropathol. Exp. Neurol. 55:1996;372-380.
34. Namba Y., Tomonaga M., Kawasaki H., Otomo E., Ikeda K. Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease. Brain Res. 541:1991;163-166.
35. Nathan B. P., Chang K.-C., Bellosta S., Brisch E., Ge N., Mahley R. W., Pitas R. E. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J. Biol. Chem. 370:1995;19791-19799.
36. Pitas R. E., Boyles J. K., Lee S. H., Foss D., Mahley R. W. Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins. Biochim. Biophys. Acta. 917:1987;148-161.
37. Pitas R. E., Boyles J. K., Lee S. H., Hui D., Weisgraber K. H. Lipoproteins and their receptors in the central nervous system. J. Biol. Chem. 262:1987;14352-14360.
38. Poirier J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci. 17:1994;525-530.
39. Poirier J., Hess M., May P. C., E F. C. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol. Brain Res. 11:1991;97-106.
40. Rebeck G. W., Perls T. T., West H. L., Sodhi P., Lipsitz L. A., Hyman B. T. Reduced apolipoprotein E4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology. 44:1994;1513-1516.
41. Rebeck G. W., Reiter J. S., Strickland D. K., Hyman B. T. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron. 11:1993;575-580.
42. Roheim P. S., Carey M., Forte T., Vega G. L. Apolipoproteins in human cerebrospinal fluid. Proc. Natl. Acad. Sci. USA. 76:1979;4646-4649.
43. Schmechel D. E., Saunders A. M., Strittmatter W. J., Crain B., Hulette C., Joo S. H., Pericak-Vance M. A., Goldgaber D., Roses A. D. Increased amyloid β-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimers disease. Proc. Natl. Acad. Sci. USA. 90:1993;9649-9653.
44. Segal M. B. Extracellular and cerebrospinal fluids. J. Inher. Metab. Dis. 16:1993;617-638.
45. Strittmatter W. J., Roses A. D. Apolipoprotein E and Alzheimer disease. Proc. Natl. Acad. Sci. USA. 92:1995;4725-4727.
46. Strittmatter W. J., Saunders A. M., Goedert M., Weisgraber K. H., Dong L.-M., Jakes R., Huang D. Y., Pericak-Vance M., Schmechel D., Roses A. D. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease. Proc. Natl. Acad. Sci. USA. 91:1994;11183-11186.
47. Tozuka M., Hidaka H., Miyachi M., Furihata K., Katsuyama T., Kanai M. Identification and characterization of apolipoprotein (AII-E2-AII) complex in human plasma lipoprotein. Biochim. Biophys. Acta. 1165:1992;61-67.
48. Uint L., Mendez A. J. Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus. J. Lipid Res. 37:1996;2510-2524.
49. Weisgraber K. H. Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. J. Lipid Res. 31:1990;1503-1511.
50. Weisgraber K. H., Mahley R. W. Apoprotein (E-AII) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction. J. Biol. Chem. 253:1978;6281-6288.
51. Weisgraber K. H., Mahley R. W. Subfractionation of human high density lipoproteins by heparin-Sepharose affinity chromatography. J. Lipid Res. 21:1980;316-325.
52. Weisgraber K. H., Shinto L. H. Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity. J. Biol. Chem. 266:1991;12029-12034.
53. Wernette-Hammond M. E., Lauer S. J., Corsini A., Walker D., Taylor J. M., Rall S. C. Jr. Glycosylation of human apolipoprotein E. J. Biol. Chem. 264:1989;9094-9101.
54. Wisniewski T., Frangione B. Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci. Lett. 135:1992;235-238.
55. Zannis V. I., Breslow J. L. Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. Biochemistry. 20:1981;1033-1041.