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Volumn 162, Issue , 1998, Pages 97-105

Somatic hypermutation in mouse λ chains

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CHLORAMPHENICOL ACETYLTRANSFERASE; CIS ACTING ELEMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; LEUCINE; MONOCLONAL ANTIBODY; TRYPTOPHAN;

EID: 0031953638     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1998.tb01433.x     Document Type: Review
Times cited : (16)

References (47)
  • 1
    • 0014943022 scopus 로고
    • Variability in the lambda light chain sequences of mouse antibody
    • Weigert MG, Cesari IM, Yonkovich SJ, Cohn M. Variability in the lambda light chain sequences of mouse antibody. Nature 1970;228:1045-1047.
    • (1970) Nature , vol.228 , pp. 1045-1047
    • Weigert, M.G.1    Cesari, I.M.2    Yonkovich, S.J.3    Cohn, M.4
  • 2
    • 0015764068 scopus 로고
    • Amino acid sequence of the light chain of a mouse myeloma (MOPC-315)
    • Dugan ES, Bradshaw RA, Simms ES, Eisen HN. Amino acid sequence of the light chain of a mouse myeloma (MOPC-315). Biochemistry 1973;12:5400-5416.
    • (1973) Biochemistry , vol.12 , pp. 5400-5416
    • Dugan, E.S.1    Bradshaw, R.A.2    Simms, E.S.3    Eisen, H.N.4
  • 3
    • 0019464685 scopus 로고
    • Identification of a third type of λ light chain in mouse immunoglobulins
    • Azuma T, Steiner LA, Eisen HN. Identification of a third type of λ light chain in mouse immunoglobulins. Proc Natl Acad Sci USA 1981;78:565-573.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 565-573
    • Azuma, T.1    Steiner, L.A.2    Eisen, H.N.3
  • 4
    • 0020051420 scopus 로고
    • Structural alterations in J regions of mouse immunoglobulin λ genes are associated with differential gene expression
    • Miller J, Selsing E, Storb U. Structural alterations in J regions of mouse immunoglobulin λ genes are associated with differential gene expression. Nature 1982;295:428-430.
    • (1982) Nature , vol.295 , pp. 428-430
    • Miller, J.1    Selsing, E.2    Storb, U.3
  • 5
    • 0020024393 scopus 로고
    • DNA sequences of the joining regions of mouse λ light chain immunoglobulin genes
    • Bronberg B, Tonegawa S. DNA sequences of the joining regions of mouse λ light chain immunoglobulin genes. Proc Natl Acad Sci USA 1982;79:530-533.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 530-533
    • Bronberg, B.1    Tonegawa, S.2
  • 6
    • 0019970877 scopus 로고
    • Unusual association of V, J, and C regions in a mouse immunoglobulin lamda chain
    • Elliot BC Jr, Steiner LA, Eisen HN. Unusual association of V, J, and C regions in a mouse immunoglobulin lamda chain. Nature 1982;299:559-561.
    • (1982) Nature , vol.299 , pp. 559-561
    • Elliot Jr., B.C.1    Steiner, L.A.2    Eisen, H.N.3
  • 8
    • 0022290916 scopus 로고
    • Lambda chains and genes in inbred mice
    • Eisen HN, Reily EB. Lambda chains and genes in inbred mice. Annu Rev Immunol 1985;3:337-365.
    • (1985) Annu Rev Immunol , vol.3 , pp. 337-365
    • Eisen, H.N.1    Reily, E.B.2
  • 9
    • 0021744414 scopus 로고
    • Variability at the V-J boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity
    • Azuma T, Igras V, Reilly EB, Eisen HN. Variability at the V-J boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity. Proc Natl Acad Sci USA 1984;81:6139-6143.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 6139-6143
    • Azuma, T.1    Igras, V.2    Reilly, E.B.3    Eisen, H.N.4
  • 10
    • 0018764065 scopus 로고
    • The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies
    • Imanishi-Karri T, Rajnavolgi E, Takemori T, Jack RS, Rajewsky K. The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies. Eur J Immunol 1979;9:324-331.
    • (1979) Eur J Immunol , vol.9 , pp. 324-331
    • Imanishi-Karri, T.1    Rajnavolgi, E.2    Takemori, T.3    Jack, R.S.4    Rajewsky, K.5
  • 12
    • 0028889516 scopus 로고
    • Role of conserved amino acid residues in the complementarity determining regions on hapten-antibody interaction of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies
    • Taketani M, Naito A, Motoyama N, Azuma T. Role of conserved amino acid residues in the complementarity determining regions on hapten-antibody interaction of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies. Mol Immunol 1995;32:983-990.
    • (1995) Mol Immunol , vol.32 , pp. 983-990
    • Taketani, M.1    Naito, A.2    Motoyama, N.3    Azuma, T.4
  • 13
    • 0025774040 scopus 로고
    • Somatic mutation in constant regions of mouse λ1 light chains
    • Motoyama N, Okada H, Azuma T. Somatic mutation in constant regions of mouse λ1 light chains. Proc Natl Acad Sci USA 1991;88:7933-7937.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7933-7937
    • Motoyama, N.1    Okada, H.2    Azuma, T.3
  • 14
    • 0028063853 scopus 로고
    • Comparison of somatic mutation frequency among immunoglobulin genes
    • Motoyama N, Miwa T, Suzuki Y, Okada H, Azuma T. Comparison of somatic mutation frequency among immunoglobulin genes. J Exp Med 1994;179:395-403.
    • (1994) J Exp Med , vol.179 , pp. 395-403
    • Motoyama, N.1    Miwa, T.2    Suzuki, Y.3    Okada, H.4    Azuma, T.5
  • 15
    • 0025093522 scopus 로고
    • Murine lambda gene rearrangements: The stochastic model prevails over the ordered model
    • Nadel B, Cazenave P-A, Sanchez P. Murine lambda gene rearrangements: the stochastic model prevails over the ordered model. EMBO J 1990;9:435-440.
    • (1990) EMBO J , vol.9 , pp. 435-440
    • Nadel, B.1    Cazenave, P.-A.2    Sanchez, P.3
  • 16
    • 0028125606 scopus 로고
    • Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes
    • Rogerson BJ. Mapping the upstream boundary of somatic mutations in rearranged immunoglobulin transgenes and endogenous genes. Mol Immunol 1994;31:83-98.
    • (1994) Mol Immunol , vol.31 , pp. 83-98
    • Rogerson, B.J.1
  • 17
    • 0025630537 scopus 로고
    • Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ∼1 kb from V(D)J gene
    • Lebecque SG, Gearhart PJ. Boundaries of somatic mutation in rearranged immunoglobulin genes: 5′ boundary is near the promoter, and 3′ boundary is ∼1 kb from V(D)J gene. J Exp Med 1990;172:1717-1727.
    • (1990) J Exp Med , vol.172 , pp. 1717-1727
    • Lebecque, S.G.1    Gearhart, P.J.2
  • 18
    • 0027194781 scopus 로고
    • Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable region
    • Rothenflush HS, Taylor L, Bothwell ALM, Both GW, Steele EJ. Somatic hypermutation in 5′ flanking regions of heavy chain antibody variable region. Eur J Immunol 1993;23:2152-2159.
    • (1993) Eur J Immunol , vol.23 , pp. 2152-2159
    • Rothenflush, H.S.1    Taylor, L.2    Bothwell, A.L.M.3    Both, G.W.4    Steele, E.J.5
  • 19
    • 0030588542 scopus 로고    scopus 로고
    • Somatic hypermutation of a λ2 transgene under the control of the λ enhancer ot the heavy chain intron enhancer
    • Klotz EL, Storb U. Somatic hypermutation of a λ2 transgene under the control of the λ enhancer ot the heavy chain intron enhancer. J Immunol 1996;157:4458-4463.
    • (1996) J Immunol , vol.157 , pp. 4458-4463
    • Klotz, E.L.1    Storb, U.2
  • 20
    • 0025362667 scopus 로고
    • A novel enhancer in immunoglobulin λ locus is duplicated and functionally independent of NFκB
    • Hagman J, Rudin CM, Haasch D, Chaplon D, Storb U. A novel enhancer in immunoglobulin λ locus is duplicated and functionally independent of NFκB. Genes Dev 1990;4:978-992.
    • (1990) Genes Dev , vol.4 , pp. 978-992
    • Hagman, J.1    Rudin, C.M.2    Haasch, D.3    Chaplon, D.4    Storb, U.5
  • 21
    • 0021730596 scopus 로고
    • Unrearranged immunoglobulin λ variable region is transcribed in κ-producing myelomas
    • Picard D, Schaffner W. Unrearranged immunoglobulin λ variable region is transcribed in κ-producing myelomas. EMBO J 1984;3:3031-3035.
    • (1984) EMBO J , vol.3 , pp. 3031-3035
    • Picard, D.1    Schaffner, W.2
  • 22
    • 0023321780 scopus 로고
    • Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of λ light chains
    • Weiss S, Wu GE. Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of λ light chains. EMBO J 1987;6:927-932.
    • (1987) EMBO J , vol.6 , pp. 927-932
    • Weiss, S.1    Wu, G.E.2
  • 23
    • 0027510316 scopus 로고
    • Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer
    • Azuma T, Motoyama N, Fields LE, Loh DY. Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer. Int Immunol 1993;5:121-130.
    • (1993) Int Immunol , vol.5 , pp. 121-130
    • Azuma, T.1    Motoyama, N.2    Fields, L.E.3    Loh, D.Y.4
  • 24
    • 0027410278 scopus 로고
    • Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: Implications for the location of cis-acting elements required for somatic mutation
    • Giusti AM, Manser T. Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutation. J Exp Med 1993;177:797-809.
    • (1993) J Exp Med , vol.177 , pp. 797-809
    • Giusti, A.M.1    Manser, T.2
  • 25
    • 0031041632 scopus 로고    scopus 로고
    • The transcriptional promoter regulates hypermutation of the antibody heavy chain locus
    • Tumas-Brundage K, Manser T. The transcriptional promoter regulates hypermutation of the antibody heavy chain locus. J Exp Med 1997;185:239-250.
    • (1997) J Exp Med , vol.185 , pp. 239-250
    • Tumas-Brundage, K.1    Manser, T.2
  • 26
    • 0027468552 scopus 로고
    • Somatic hypermutation of an immunoglobulin μ heavy chain transgene
    • Sohn J, Gerstein RM, Hsieh C-L, Lemer M, Selsing E. Somatic hypermutation of an immunoglobulin μ heavy chain transgene. J Exp Med 1993;177:493-504.
    • (1993) J Exp Med , vol.177 , pp. 493-504
    • Sohn, J.1    Gerstein, R.M.2    Hsieh, C.-L.3    Lemer, M.4    Selsing, E.5
  • 27
    • 0025000908 scopus 로고
    • Isotype swiching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
    • Gerstein RM, et al. Isotype swiching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes. Cell 1990;63:537-548.
    • (1990) Cell , vol.63 , pp. 537-548
    • Gerstein, R.M.1
  • 28
    • 0028270307 scopus 로고
    • Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for intron enhancer/matrix attachment region
    • Betz AG, Milstein C, Gonzalez-Fernandez A, Pannell R, Larson T, Neuberger MS. Elements regulating somatic hypermutation of an immunoglobulin κ gene: critical role for intron enhancer/matrix attachment region. Cell 1994;77:239-248.
    • (1994) Cell , vol.77 , pp. 239-248
    • Betz, A.G.1    Milstein, C.2    Gonzalez-Fernandez, A.3    Pannell, R.4    Larson, T.5    Neuberger, M.S.6
  • 29
    • 0029938674 scopus 로고    scopus 로고
    • Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes
    • Johnston JM, et al. Analysis of hypermutation in immunoglobulin heavy chain passenger transgenes. Eur J Immunol 1996;26:1058-1062.
    • (1996) Eur J Immunol , vol.26 , pp. 1058-1062
    • Johnston, J.M.1
  • 31
    • 0027491651 scopus 로고
    • Tracing B cell development in human germinal centres by molecular analysis of single cell picked from histological sections
    • Kuppers R, Zhao M, Hansman M-L, Rajewsky K. Tracing B cell development in human germinal centres by molecular analysis of single cell picked from histological sections. EMBO J 1993;12:4955-4967.
    • (1993) EMBO J , vol.12 , pp. 4955-4967
    • Kuppers, R.1    Zhao, M.2    Hansman, M.-L.3    Rajewsky, K.4
  • 32
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek C, Berger A, Apel M. Maturation of the immune response in germinal centers. Cell 1991;67:1121-1129.
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 33
    • 0026060620 scopus 로고
    • Intradonal generation of antibody mutants in germinal centres
    • 3. Jacob J, Kelsoe G, Rajewsky K, Weiss U. Intradonal generation of antibody mutants in germinal centres. Nature 1991;354:389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 35
    • 15144351999 scopus 로고    scopus 로고
    • + germinal center (GC) B cells which occupy GC at a high frequency during the primary anti-hapten response in mice
    • + germinal center (GC) B cells which occupy GC at a high frequency during the primary anti-hapten response in mice. Eur J Immunol 1997;27:268-279.
    • (1997) Eur J Immunol , vol.27 , pp. 268-279
    • Kimoto, H.1
  • 36
    • 0018179467 scopus 로고
    • Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response
    • Reth M, Hammerling GL, Rajewsky K. Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur J Immunol 1978;8:393-400.
    • (1978) Eur J Immunol , vol.8 , pp. 393-400
    • Reth, M.1    Hammerling, G.L.2    Rajewsky, K.3
  • 37
    • 0022802257 scopus 로고
    • Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP
    • Cumano A, Rajewsky K. Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J 1986;10:2459-2486.
    • (1986) EMBO J , vol.10 , pp. 2459-2486
    • Cumano, A.1    Rajewsky, K.2
  • 38
    • 0023510298 scopus 로고
    • Evolutionary and somatic selection of the antibody repertoire in the mouse
    • Rajewsky K, Forster I, Cumano A. Evolutionary and somatic selection of the antibody repertoire in the mouse. Science 1987;238:1088-1094.
    • (1987) Science , vol.238 , pp. 1088-1094
    • Rajewsky, K.1    Forster, I.2    Cumano, A.3
  • 39
    • 0024044570 scopus 로고
    • Antibody engineering for the analysis of affinity maturation of anti-hapten response
    • Allen D, Simon T, Sablitzky F, Rajewsky K, Cumano A. Antibody engineering for the analysis of affinity maturation of anti-hapten response. EMBO J 1988;7:1995-2001.
    • (1988) EMBO J , vol.7 , pp. 1995-2001
    • Allen, D.1    Simon, T.2    Sablitzky, F.3    Rajewsky, K.4    Cumano, A.5
  • 40
    • 0025601012 scopus 로고
    • The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
    • Weiss U, Rajewsky K. The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response. J Exp Med 1990;172:1681-1689.
    • (1990) J Exp Med , vol.172 , pp. 1681-1689
    • Weiss, U.1    Rajewsky, K.2
  • 41
    • 0028835227 scopus 로고
    • Three-dimensional structures of Fab fragment and its (4-hydroxy-3-nitrophenyl)acetate complex of murine N1G9 antibody from primary immune response
    • Mizutani R, Miura K, Nakayama T, Shimada I, Arata Y, Satow Y. Three-dimensional structures of Fab fragment and its (4-hydroxy-3-nitrophenyl)acetate complex of murine N1G9 antibody from primary immune response. J Mol Biol 1995;254:208-222.
    • (1995) J Mol Biol , vol.254 , pp. 208-222
    • Mizutani, R.1    Miura, K.2    Nakayama, T.3    Shimada, I.4    Arata, Y.5    Satow, Y.6
  • 42
    • 0028357638 scopus 로고
    • Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2
    • Chen C, Martin TM, Stevens S, Rittenberg MB. Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2. J Exp Med 1994;180:577-586.
    • (1994) J Exp Med , vol.180 , pp. 577-586
    • Chen, C.1    Martin, T.M.2    Stevens, S.3    Rittenberg, M.B.4
  • 43
    • 0029047689 scopus 로고
    • Enhancement and destruction of antibody function by somatic mutation: Unequal occurrence is controlled by V gene combinatorial associations
    • Chen C, Roberts VA, Stevens S, Brown M, Stenzel-Poore MP, Rittenberg MB. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J 1995;14:2784-2794.
    • (1995) EMBO J , vol.14 , pp. 2784-2794
    • Chen, C.1    Roberts, V.A.2    Stevens, S.3    Brown, M.4    Stenzel-Poore, M.P.5    Rittenberg, M.B.6
  • 45
    • 0017031328 scopus 로고
    • The mechanism of reassembly of immunoglobulin G
    • Tokyo
    • Azuma T, Hamaguchi K. The mechanism of reassembly of immunoglobulin G. J Biochem (Tokyo) 1976;80:1023-1038.
    • (1976) J Biochem , vol.80 , pp. 1023-1038
    • Azuma, T.1    Hamaguchi, K.2
  • 46
    • 0029067875 scopus 로고
    • Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
    • Yelamos J, et al. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation. Nature 1995;376:225-229.
    • (1995) Nature , vol.376 , pp. 225-229
    • Yelamos, J.1
  • 47
    • 0030063726 scopus 로고    scopus 로고
    • Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
    • Peters A, Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation. Immunity 1996;4:57-65.
    • (1996) Immunity , vol.4 , pp. 57-65
    • Peters, A.1    Storb, U.2


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