Towards an understanding of somatic hypermutation

Current Opinion in Immunology

Volumn 13, Issue 2, 2001, Pages 208-218

  Jacobs, H ^a   Bross, L ^a  

^a BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; B LYMPHOCYTE; DNA STRAND BREAKAGE; GENE DELETION; GERMINAL CENTER; MOUSE; NONHUMAN; POINT MUTATION; REVIEW; SOMATIC MUTATION; TRANSCRIPTION REGULATION;

EID: 0035313995     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00206-5     Document Type: Review

References (61)

1. Specificity in V(D)J recombination: New lessons from biochemistry and genetics
2. Variations in affinities of antibodies during the immune response
3. Variability in the lambda light chain sequences of mouse antibody
4. The molecular basis of somatic hypermutation of immunoglobulin genes
5. Molecular insights into the immunopathogenesis of follicular lymphoma
6. Composition and function of T-cell receptor and B-cell receptor complexes on precursor lymphocytes
7. Germinal centers
8. Clonal selection and learning in the antibody system
9. Somatic hypermutation
10. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin
11. Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development
12. Maturation of the immune response in germinal centers
13. DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
14. Frequent occurrence of deletions and duplications during somatic hypermutation: Implications for oncogene translocations and heavy chain disease
15. Somatic hypermutation of human immunoglobulin heavy chain genes: Targeting of RGYW motifs on both DNA strands
16. Both DNA strands of antibody genes are hypermutation targets
17. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis
18. The targeting of somatic hypermutation
19. Poliota, a remarkably error-prone human DNA polymerase
20. DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells
21. A plethora of lesion-replicating DNA polymerases
22. Sloppier copier DNA polymerases involved in genome repair
23. Cis-acting sequences that affect somatic hypermutation of Ig genes
24. Somatic hypermutation: Another piece in the hypermutation puzzle
25. Somatic hypermutation in the heavy chain locus correlates with transcription
26. Tuning somatic hypermutation by transcription
27. Elements regulating somatic hypermutation of an immunoglobulin kappa gene: Critical role for the intron enhancer/matrix attachment region
28. Mutations of the chloramphenicol acetyl transferase transgene driven by the immunoglobulin promoter and intron enhancer
29. Targeting of non-Ig sequences in place of the V segment by somatic hypermutation
30. Hypermutation targets a green fluorescent protein-encoding transgene in the presence of immunoglobulin enhancers
31. DNA repair domains within a human gene: Selective repair of sequences near the transcription initiation site
32. Somatic hypermutation of immunoglobulin genes is linked to transcription
33. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
34. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
35. Cellular origin of human B-cell lymphomas
36. The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells
37. Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice
38. Mismatch repair and immunoglobulin gene hypermutation: Did we learn something?
39. Different mismatch repair deficiencies all have the same effects on somatic hypermutation: Intact primary mechanism accompanied by secondary modifications
40. The role of DNA repair in somatic hypermutation of immunoglobulin genes
41. V(D)J hypermutation and DNA mismatch repair: Vexed by fixation
42. Intraclonal generation of antibody mutants in germinal centres
43. Probing immunoglobulin gene hypermutation with microsatellites suggests a nonreplicative short patch DNA synthesis process
44. Isolated human germinal center centroblasts have an intact mismatch repair system
45. Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process
46. Severe attenuation of the B cell immune response in Msh2-deficient mice
47. Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair protein
48. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting
49. TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line
50. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: Clustering, polarity, and specific hot spots
51. Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites
52. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
53. Molecular cloning of Apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA
54. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family
55. Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene
56. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
57. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
58. A novel cytidine deaminase affects antibody diversity
59. Cell-cycle-regulated DNA double strand breaks in somatic hypermutation of immunoglobulin genes
60. Strand breaks in immunoglobulin gene hypermutation