Kinetochore dynein: Its dynamics and role in the transport of the Rough deal checkpoint protein

Nature Cell Biology

Volumn 3, Issue 11, 2001, Pages 1001-1007

  Wojcik, Edward ^a,b   Basto, Renata ^c   Serr, Madeline ^b   Scaírou, Frädäric ^c   Karess, Roger ^c   Hays, Thomas ^b  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DYNACTIN; DYNAMITIN; DYNEIN ADENOSINE TRIPHOSPHATASE; GREEN FLUORESCENT PROTEIN; MUTANT PROTEIN; REGULATOR PROTEIN; ROUGH DEAL CHECKPOINT PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CELL POLARITY; CELL TRANSPORT; CENTROMERE; CONTROLLED STUDY; DROSOPHILA; DYNAMICS; EMBRYO; METAPHASE; MICROTUBULE; NEUROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; CELL CYCLE PROTEINS; CYTOPLASM; DROSOPHILA; DROSOPHILA PROTEINS; DYNEIN ATPASE; INSECT PROTEINS; KINETOCHORES; METAPHASE; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; NEURONS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 0035736325     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1101-1001     Document Type: Article

References (38)

1. Formation of spindle poles by Dynein/Dynactin-dependent transport of NuMA
2. Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila
3. Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization
4. Dynein is required for spindle assembly in cytoplasmic extracts of Spisula solidissima oocytes
5. Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts
6. A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly
7. Cytoplasmic dynein plays a role in mammalian mitotic spindle formation
8. Mammalian spindle orientation and position respond to changes in cell shape in a dynein-dependent fashion
9. Dynein-dependent movements of the mitotic spindle in Saccharomyces cerevisiae do not require filamentous actin
10. Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae
11. Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo
12. The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila
13. Disruption of mitotic spindle orientation in a yeast dynein mutant
14. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex
15. Localization of cytoplasmic dynein to mitotic spindles and kinetochores
16. Cytoplasmic dynein is localized to kinetochores during mitosis
17. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos
18. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants
19. ZW10 helps recruit dynactin and dynein to the kinetochore
20. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores
21. Rough deal and Zw10 are required for the metaphase checkpoint in Drosophila
22. Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension
23. Chromosome movement: Dynein-out at the kinetochore
24. Waiting for anaphase: Mad2 and the spindle assembly checkpoint
25. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis
26. Cytoplasmic dynein and dynactin in cell division and intracellular transport
27. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore
28. The rough deal protein is a new kinetochore component required for accurate chromosome segregation in Drosophila
29. Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation
30. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
31. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
32. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
33. The spindle checkpoint: Two transitions, two pathways
34. Cytoplasmic dynein function is essential in Drosophila melanogaster
35. The product of the Drosophila gene, Glued, is the functional homologue of the p150Glued component of the vertebrate dynactin complex
36. Regulation of cytoplasmic dynein function in vivo by the Drosophila Glued complex
37. Identification and characterization of mitotic mutations in Drosophila