Telomere length deregulation and enhanced sensitivity to genotoxic stress in Arabidopsis mutants deficient in Ku70

EMBO Journal

Volumn 21, Issue 11, 2002, Pages 2819-2826

  Riha, Karel ^a   Watson, J Matthew ^a   Parkey, Jeffrey ^a   Shippen, Dorothy E ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Double strand break repair; Genome stability; Methyl methanosulfonate; Non homologous end joining; Telomerase

Indexed keywords

MESYLIC ACID METHYL ESTER; TELOMERASE;

3' UNTRANSLATED REGION; ARABIDOPSIS; ARTICLE; DIMERIZATION; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DNA SYNTHESIS; GAMMA IRRADIATION; GENE EXPRESSION; GENOME; GENOTOXICITY; GERMINATION; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PLANT DEVELOPMENT; PRIORITY JOURNAL; SEEDLING; TELOMERE;

ALLELES; AMINO ACID SEQUENCE; ANTIGENS, NUCLEAR; ARABIDOPSIS; DIMERIZATION; DNA HELICASES; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENETIC COMPLEMENTATION TEST; METHYL METHANESULFONATE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENS; MUTATION; NUCLEAR PROTEINS; RNA, COMPLEMENTARY; SACCHAROMYCES CEREVISIAE PROTEINS; TELOMERE;

ANIMALIA; ARABIDOPSIS; INSERTION SEQUENCES; MAMMALIA;

EID: 0037013922     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.11.2819     Document Type: Article

References (68)

1. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. Elegans
2. SAP - A putative DNA-binding motif involved in chromosomal organization
3. A large scale analysis of cDNA in Arabidopsis thaliana: Generation of 12, 028 non-redundant expressed sequence tags from normalized and size-selected cDNA libraries
4. DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
5. Protection of telomeres by the Ku protein in fission yeast
6. In planta Agrobacterium mediated gene transfer by infiltration of adult Arabidopsis thaliana plants
7. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
8. Molecular genetics of DNA repair in higher plants
9. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity
10. Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues
11. A central region of Ku80 mediates interaction with Ku70 in vivo
12. Genomic sequencing
13. P1-Bh, an anthocyanin regulatory gene of maize that leads to variegated pigmentation
14. Mammalian telomeres and telomerase
15. DNA end-joining: From yeast to man
16. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
17. A short C-terminal domain of Yku70p is essential for telomere maintenance
18. Homologous and non-homologous recombination differentially affect DNA damage repair in mice
19. Ku, a DNA repair protein with multiple cellular functions?
20. Subtelomeric repeat amplification is associated with growth at elevated temperature in yku70 mutants of Saccharomyces cerevisiae
21. Disruption of the telomerase catalytic subunit gene from Arabidopsis inactivates telomerase and leads to a slow loss of telomeric DNA
22. RAD50 function is essential for telomere maintenance in Arabidopsis
23. Disruption of the Arabidopsis RAD50 gene leads to plant sterility and MMS sensitivity
24. Specificity of mutations induced by methyl methanesalfonate in mismatch repair-deficient human cancer cell lines
25. Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment
26. Yeast Ku as a regulator of chromosomal DNA end structure
27. Molecular characterisation of two paralogous SPOII homologues in Arabidopsis thaliana
28. DNA effects in repair-deficient V79 Chinese hamster cells studied with the comet assay
29. DNA repair: Rad52-the means to an end
30. Ku acts in a unique way at the mammalian telomere to prevent end joining
31. Species-specific double-strand break repair and genome evolution in plants
32. Chromosomal localization of the mouse and rat DNA double-strand break repair genes Ku p70 and Ku p80/XRCC5 and their mRNA expression in various mouse tissues
33. The Drosophila melanogaster DmRAD54 gene plays a crucial role in double-strand break repair after P-element excision and acts synergistically with Ku70 in the repair of X-ray damage
34. T-DNA as an insertional mutagen in Arabidopsis
35. Mutation of yeast Ku genes disrupts the suhnuclear organization of telomeres
36. Involvement of the Saccharomyces ceravisiae HDF1 gene in DNA double-strand break repair and recombination
37. Novel functional requirements for non- homologous DNA end joining in Schizosaccharomyces pombe
38. Replication and recombination intersect
39. Callus culture and regeneration
40. Prospects for the precise engineering of plant genomes by homologous recombination
41. An SMC-like protein is required for efficient homologous recombination in Arabidopsis
42. Replication fork arrest and DNA recombination
43. The telomerase reverse transcriptase: Components and regulation
44. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
45. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
46. Defining the minimal domain of Ku80 for interaction with Ku70
47. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku
48. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
49. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit
50. Living with genome instability: Plant responses to telomere dysfunction
51. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
52. Loss of a yeast telomere: Arrest recovery and chromosome loss
53. Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break
54. Control of human telomere length by TRF1 and TRF2
55. Interaction of human Ku70 with TRF2
56. Homologous recombination and non homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
57. Homologous recombinational repair of DNA ensures mammalian chromosome stability
58. Mitogen-activated protein kinase phosphatase is required for genotoxic stress relief in Arabidopsis
59. TRF2 protects human telomeres from end-to-end fusions
60. Deletion of Ku86 causes early onset of senescence in mice
61. DNA repair in higher plants
62. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
63. Arabidopsis DNA ligase IV is induced by γ-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4
64. 1 arrest in plant seeds induced by a p53-related pathway?
65. A mini binary vector series for plant transformation
66. Specific association of a small protein with the telomeric DNA-protein complex during the onset of leaf senescence in Arabidopsis thaliana
67. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres