Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis

Microscopy Research and Technique

Volumn 59, Issue 1, 2002, Pages 58-67

  Nakamoto, Masaru ^a   Bergemann, Andrew D ^b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Breast; Cancer; Ephrin; Oncogene; Signaling

Indexed keywords

AMINO ACIDS; CELLS; CYTOLOGY; DISEASES; ENZYMES; MOLECULES; PATHOLOGY; TUMORS;

BREAST; CANCER; CARCINOGENESES; EPHRINS; ONCOGENE; ONCOGENIC TRANSFORMATION; ONCOGENICS; PROPERTY; RECEPTOR-TYROSINE KINASE; SIGNALING;

LIGANDS;

EPHRIN; PROTEIN TYROSINE KINASE;

ANGIOGENESIS; ARTICLE; BREAST CANCER; CARCINOGENESIS; DEPHOSPHORYLATION; ENZYME ANALYSIS; HUMAN; MALIGNANT TRANSFORMATION; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0036785161     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jemt.10177     Document Type: Article

References (126)

1. Adams RH, Wilkinson GA, Weiss C, Diella F, Gale NW, Deutsch U, Risau W, Klein R. 1999. Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. Genes Dev 13:295-306.
2. Adams RH, Diella F, Hennig S, Helmbacher F, Deutsch U, Klein R. 2001. The cytoplasmic domain of the ligand ephrin-B2 is required for vascular morphogenesis but not cranial neural crest migration. Cell 104:57-69.
3. Andres AC, Behini O, Schubaur B, Dolder B, LeMeur M, Gerlinger P. 1991. H-ras induced transformation of mammary epithelium is favoured by increased oncogene expression or by inhibition of mammary regression. Oncogene 6:771-779.
4. Andres AC, Reid HH, Zurcher G, Blaschke RJ, Albrecht D, Ziemiecki A. 1994. Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis. Oncogene 9:1461-1467.
5. Bartley TD, Hunt RW, Welcher AA, Boyle WJ, Parker VP, Lindberg RA, Lu HS, Colombero AM, Elliott RL, Guthrie BA, Holst PL, Skrine JD, Toso RJ, Zhang M, Fernandez E, Trail G, Varnum B, Yarden Y, Hunter T, Fox GM. 1994. B61 is a ligand for the ECK receptor protein-tyrosine kinase. Nature 368:558-560.
6. Becker N, Seitanidou T, Murphy P, Mattei M-G, Topilko P, Nieto MA, Wilkinson DG, Charnay P, Gilardi-Hebenstreit P. 1994. Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev 47:3-17.
7. Beckmann MP, Cerretti DP, Baum P, Vanden Bos T, James L, Farrah T, Kozlosky C, Hollingsworth T, Shilling H, Marakovsky E, Fletcher FA, Lhotak V, Pawson T, Lyman SD. 1994. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors. EMBO J 13:3757-3762.
8. Bennett BD, Wang Z, Kuang W-J, Wang A, Groopman JE, Goeddel DV, Scadden DT. 1994. Cloning and characterization of Htk, a novel transmembrane tyrosine kinase of the Eph subfamily. J Biol Chem 269:14211-14218.
9. Berclaz G, Andres AC, Albrecht D, Dreher E, Ziemiecki A, Gusterson BA, Crompton MR. 1996. Expression of the receptor tyrosine kinase myk-1/htk in normal and malignant mammary epithelium. Biochem Biophys Res Commun 226:869-875.
10. Bergemann AD, Cheng H-J, Brambilla R, Klein R, Flanagan JG. 1995. ELF-2, a new member of the Eph ligand family, is segmentally expressed in mouse embryos in the region of the hindbrain and newly forming somites. Mol Cell Biol 15:4921-4929.
11. Birgbauer E, Cowan CA, Sretavan DW, Henkemeyer M. 2000. Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina. Development 127:1231-1241.
12. Bohme B, Holtrich U, Wolf G, Luzius H, Grzeschik KH, Strebhardt K, Rubsamen-Waigmann H. 1993. PCR mediated detection of a new human receptor-tyrosine-kinase, HEK 2. Oncogene 8:2857-2862.
13. Bovenkamp DE, Greer PA. 2001. Degenerate PCR-based cloning method for eph receptors and analysis of their expression in the developing murine central nervous system and vasculature. DNA Cell Biol 20:203-213.
14. Boyd AW, Ward LD, Wicks IP, Simpson RJ, Salvaris E, Wilks A, Welch K, Loudovaris M, Rockman S, Busmanis I. 1992. Isolation and characterization of a novel receptor-type protein tyrosine kinase (hek) from a human pre-B cell line. J Biol Chem 267:3262-3267.
15. Brambilla R, Schnapp A, Casagranda F, Labrador JP, Bergemann AD, Flanagan JG, Pasquale EB, Klein R. 1995. Membrane-bound LERK2 ligand can signal through three different Eph-related receptor tyrosine kinases. EMBO J 14:3116-3126.
16. Bruce V, Olivieri G, Eickelberg O, Miescher GC. 1999. Functional activation of EphA5 receptor does not promote cell proliferation in the aberrant EphA5 expressing human glioblastoma U-118 MG cell line. Brain Res 821:169-176.
17. Bruckner K, Pasquale EB, Klein R. 1997. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 275:1640-1643.
18. Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R. 1999. Ephrin B ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22:511-524.
19. Buchert M, Schneider S, Meskenaite V, Adams MT, Canaani E, Baechi T, Moelling K, Hovens CM. 1999. The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J Cell Biol 144:361-371.
20. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, SoltoffS. 1991. Oncogenes and signal transduction. Cell 64:281-302.
21. Chaib H, Cockrell EK, Rubin MA, Macoska JA. 2001. Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis. Neoplasia 3:43-52.
22. Chen WS, Kung HJ, Yang WK, Lin WC. 1999. Comparative tyrosinekinase profiles in colorectal cancer: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Int J Cancer 83:579-584.
23. Cheng H-J, Nakamoto M, Bergemann AD, Flanagan JG. 1995. Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map. Cell 82:371-381.
24. Chiari R, Hames G, Stroobant V, Texier C, Maillere B, Boon T, Coulie PG. 2000. Identification of a tumor-specific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA classII molecules. Cancer Res 60:4855-4863.
25. Clark GJ, Kinch MS, Gilmer TM, Burridge K, Der CJ. 1996. Overexpression of the Ras-related TC21/R-Ras2 protein may contribute to the development of human breast cancers. Oncogene 12:169-176.
26. Davis S, Gale NW, Aldrich TH, Maisonpierre PC, Lhotak V, Pawson T, Goldfarb M, Yancopoulos GD. 1994. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266:816-819.
27. Davy A, Robbins SM. 2000. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner. EMBO J 19:5396-5405.
28. Davy A, Gale NW, Murray EW, Klinghoffer RA, Soriano P, Feuerstein C, Robbins SM. 1999. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev 13:3125-3135.
29. Dodelet VC, Pasquale EB. 2000. Eph receptors and ephrin ligands: embryogenesis to tumorigenesis. Oncogene 19:5614-5619.
30. Dodelet VC, Pazzagli C, Zisch AH, Hauser CA, Pasquale EB. 1999. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-ras and Rap1A. J Biol Chem 274:31941-31946.
31. Dottori M, Down M, Huttmann A, Fitzpatrick DR, Boyd AW. 1999. Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells. Blood 94:2477-2486.
32. Drescher U, Kremoser C, Handwerker C, Loschinger J, Noda M, Bonhoeffer F. 1995. In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases. Cell 82:359-370.
33. Easty DJ, Bennett DC. 2000. Protein tyrosine kinases in malignant melanomas. Melanoma Res 10:401-411.
34. Easty DJ, Herlyn M, Bennett DC. 1995a. Abnormal protein tyrosine kinase gene expression during melanoma progression and metastasis. Int J Cancer 60:129-136.
35. Easty DJ, Guthrie BA, Maung K, Farr CJ, Lindberg RA, Toso RJ, Herlyn M, Bennett DC. 1995b. Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression. Cancer Res 55:2528-2532.
36. Easty DJ, Mitchell PJ, Patel K, Florenes VA, Spritz RA, Bennett DC. 1997. Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma. Int J Cancer 71:1061-1065.
37. Easty DJ, Hill SP, Hsu MY, Fallowfield ME, Florenes VA, Herlyn M, Bennett DC. 1999. Up-regulation of ephrin-A1 during melanoma progression. Int J Cancer 84:494-501.
38. Ellis C, Kasmi F, Ganju P, Walls E, Panayotou G, Reith AD. 1996. A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. Oncogene 12:1727-1736.
39. Eph Nomenclature Committee 1997. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90;403-404.
40. Even-Ram SC, Maoz M, Pokroy E, Reich R, Katz BZ, Gutwein P, Altevogt P, Bar-Shavit R. 2001. Tumor cell invasion is promoted by activation of protease activated receptor-1 in co-operation with the alpha vbeta 5 integrin. J Biol Chem 276:10952-10962.
41. Flanagan JG, Vanderhaeghen P. 1998. The ephrins and Eph receptors in neural development. Annu Rev Neurosci 21:309-345.
42. Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. 1996. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134:793-799.
43. Gale NW, Holland SJ, Valenzuela DM, Flenniken A, Pan L, Ryan TE, Henkemeyer M, Strebhardt K, Hirai H, Wilkinson DG, Pawson T, Davis S, Yancopoulos GD. 1996. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17:9-19.
44. Gale NW, Baluk P, Pan L, Kwan M, Holash J, DeChiara TM, McDonald DM, Yancopoulos GD. 2001. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth muscles. Dev Biol 230:151-160.
45. George SE, Simokat K, Hardin J, Chisholm AD. 1998. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell 92:633-643.
46. Gerety SS, Wang HU, Chen ZF, Anderson DJ. 1999. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell 4:403-414.
47. Giunciuglio D, Culty M, Fassina G, Masiello L, Melchiori A, Paglialunga A, Arand G, Ciardiello F, Basolo F, Thompson EW, Albini A. 1995. Invasive phenotype of MCF10A cells over-expressing c-Haras and c-erb-B2 oncogenes. Int J Cancer 63:815-822.
48. Gu C, Park S. 2001. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol Cell Biol 21:4579-4597.
49. Helbling PM, Saulnier DM, Brandli AW. 2000. The receptor tyrosine kinase EphB4 and ephrin-B ligands restrict angiogenic growth of embryonic veins in Xenopus laevis. Development 127:269-278.
50. Henkemeyer M, Orioli D, Henderson JT, Saxton TM, Roder J, Pawson T, Klein R. 1996. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell 86:35-46.
51. Hess AR, Seftor EA, Gardner LM, Carles-Kinch K, Schneider GB, Seftor RE, Kinch MS, Hendrix MJ. 2001. Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2). Cancer Res 61:3250-3255.
52. Himanen JP, Henkemeyer M, Nikolov DB. 1998. Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2. Nature 396:486-491.
53. Hirai H, Maru Y, Hagiwara K, Nishida J, Takaku F. 1987. A novel putative tyrosine kinase receptor encoded by the eph gene. Science 238:1717-1720.
54. Hock B, Bohme B, Karn T, Feller S, Rubsamen-Waigman H, Strebhardt K. 1998. Tyrosine-614 the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions. Oncogene 17:255-260.
55. Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T. 1996. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 383:722-725.
56. Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T. 1997. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J 16:3877-3888.
57. Holmberg J, Clarke DL, Frisen J. 2000. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature 408:203-206.
58. Huai J, Drescher U. 2001. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein. J Biol Chem 276:6689-6694.
59. Ikegaki N, Tang XX, Liu XG, Biegel JA, Allen C, Yoshioka A, Sulman EP, Brodeur GM, Pleasure DE. 1995. Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase of the EPH family. Hum Mol Genet 4:2033-2045.
60. Ilangumaran S, He HT, Hoessli DC. 2000. Microdomains in lymphocyte signalling: beyond GPI-anchored proteins. Immunol Today 21:2-7.
61. Iwase T, Tanaka M, Suzuki M, Naito Y, Sugimura H, Kino I. 1993. Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. Biochem Biophys Res Commun 194:698-705.
62. Kalo MS, Pasquale EB. 1999. Multiple in vivo tyrosine phosphorylation sites in EphB receptors. Biochemistry 38:14396-14408.
63. Kinch MS, Clark GJ, Der CJ, Burridge K. 1995. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J Cell Biol 130:461-471.
64. Kiyokawa E, Takai S, Tanaka M, Iwase T, Suzuki M, Xiang YY, Naito Y, Yamada K, Sugimura H, Kino I. 1994. Overexpression of ERK, an EPH family receptor tyrosine kinase, in various human tumors. Cancer Res 54:3645-3650.
65. Knoll B, Zarbalis K, Wurst W, Drescher U. 2001. A role for the EphA family in the topographic targeting ofvomeronasal axons. Development 128:895-906.
66. Kozlosky CJ, Marakovsky E, McGrew JT, Vanden Bos T, Teepe M, Lyman SD, Srinivasan S, Fletcher FA, Gayle RB III, Cerretti DP, Beckmann MP. 1995. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins. Oncogene 10:299-306.
67. Krull CE, Lansford R, Gale NW, Collazo A, Marcelle C, Yancopoulos GD, Fraser SE, Bronner-Fraser M. 1997. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. Curr Biol 7:571-580.
68. Kumar R, Mandal M, Vadlamudi R. 2000. New insights into anti-HER-2 receptor monoclonal antibody research. Semin Oncol 27:84-91.
69. Lackmann M, Oates AC, Dottori M, Smith FM, Do C, Power M, Kravets L, Boyd AW. 1998. Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. J Biol Chem 273:20228-20237.
70. Lamorte LPark M. 2001. The receptor tyrosine kinases: role in cancer progression. Surg Oncol Clin N Am 10:271-288.
71. Lindberg RA, Hunter T. 1990. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol Cell Biol 10:6316-6324.
72. Lu Q, Sun EE, Klein RS, Flanagan JG. 2001. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell 105:69-79.
73. Maru Y, Hirai H, Yoshida MC, Takaku F. 1988. Evolution, expression, and chromosomal location of a novel receptor tyrosine kinase gene, eph. Mol Cell Biol 8:3770-3776.
74. Maru Y, Hirai H, Takaku F. 1990. Overexpression confers an oncogenic potential upon the eph gene. Oncogene 5:445-447.
75. McBride JL, Ruiz JC. 1998. Ephrin-A1 is expressed at sites of vascular development in mouse. Mech Dev 77:201-204.
76. Mellitzer G, Xu Q, Wilkinson DG. 1999. Eph receptors and ephrins restrict cell intermingling and communication. Nature 400:77-81.
77. Menzel P, Valencia F, Godement P, Dodelet VC, Pasquale EB. 2001. Ephrin-A6, a new ligand for EphA receptors in the developing nervous system. Dev Biol 230:74-88.
78. Miao H, Burnett E, Kinch M, Simon E, Wang B. 2000. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat Cell Biol 2:62-69.
79. Miao H, Wei BR, Peehl DM, Li Q, Alexandrou T, Schelling JR, Rhim JS, Sedor JR, Burnett E, Wang B. 2001. Activation of the EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway. Nat Cell Biol 3:527-530.
80. Miescher GC, Taylor V, Olivieri G, Mindermann T, Schrock E, Steck AJ. 1997. Extensive splice variation and localization of the EHK-1 receptor tyrosine kinase in adult brain and glial tumors. Brain Res Mol Brain Res 46:17-24.
81. Munthe E, Rian E, Holien T, Rasmussen AM, Levy FO, Aasheim HC. 2000. Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett 466:169-174.
82. Nakamoto M, Cheng H-J, Friedman GC, McLaughlin T, Hansen MJ, Yoon CH, O'Leary DD, Flanagan JG. 1996. Topographic specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell 86:755-766.
83. Nieto MA, Gilardi-Hebenstreit P, Charnay P, Wilkinson DG. 1992. A receptor protein tyrosine kinase implicated in the segmental patterning of the hindbrain and mesoderm. Development 116:1137-1150.
84. Nikolova Z, Djonov V, Zuercher G, Andres AC, Ziemiecki A. 1998. Cell-type specific and estrogen dependent expression of the receptor tyrosine kinase Eph B4 and its ligand ephrin-B2 during mammary gland morphogenesis. J Cell Sci 111:2741-2751.
85. Oba SM, Wang YJ, Song JP, Li ZY, Kobayashi K, Tsugane S, Hamada GS, Tanaka M, Sugimura H. 2001. Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer. Cancer Lett 164:97-104.
86. Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB. 2000. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 19:6043-6052.
87. Pandey A, Lazar DF, Saltiel AR, Dixit VM. 1994. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J Biol Chem 269:30154-30157.
88. Pandey A, Duan H, Dixit VM. 1995. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J Biol Chem 270:19201-19204.
89. Robinson D, He F, Pretlow T, Kung HJ. 1996. A tyrosine kinase profile of prostate carcinoma. Proc Natl Acad Sci USA 93:5958-5962.
90. Rosenberg IM, Goke M, Kanai M, Reinecker HC, Podolsky DK 1997. Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier function. Am J Physiol 273:G824-G832.
91. Ruoslahti E. 1994. Cell adhesion and tumor metastasis. Princess Takamatsu Symp 24:99-105.
92. Saarma M. 2000. GDNF - a stranger in the TGF-beta superfamily. Eur J Biochem 267:6968-6971.
93. Sakano S, Serizawa R, Inada T, Iwama A, Itoh A, Kato C, Shimuzu Y, Shinkai F, Shimizu R, Kondo S, Ohno M, Suda T. 1996. Characterization of a ligand for receptor-tyrosine kinase HTK expressed in immature hematopoietic cells. Oncogene 13:813-822.
94. Schoenenberger CA, Andres AC, Groner B, van der Valk MA, LeMeur M, Gerlinger P. 1988. Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBOJ 7:169-175.
95. Segatto O, King CR, Pierce JH, Di Fiore PP, Aaronson SA. 1988. Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene. Mol Cell Biol 8:5570-5574.
96. Shamah SM, Lin MZ, Goldberg JL, Estrach S, Sahin M, Hu L, Bazalakova M, Neve RL, Corfas G, Debant A, Greenberg ME. 2001. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105:233-244.
97. Shen Y, Schaller MD. 1999. Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation., Mol Biol Cell 10:2507-2518.
98. Shimoyama M, Matsuoka H, Tamekane A, Ito M, Iwata N, Inoue R, Chihara K, Furuya A, Hanai N, Matsui T. 2000. T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells. Growth Factors 18:63-78.
99. Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahura T, Stavrakis G, Isner J, Folkman J, Gimbrone MA Jr, Anderson DJ. 2001. Expression of ephrin-B2 identifies a stable genetic difference between arterial and venous smooth muscle as well as endothelial cells, and marks subsets of microvessels as sites of adult neovascularization. Dev Biol 230:139-150.
100. Simons K, Ikonen E. 1997. Functional rafts in cell membranes. Nature 387:569-572.
101. Smalla M, Schmieder P, Kelly M, Ter Laak A, Krause G, Ball L, Wahl M, Bork P, Oschinat H. 1999. Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sites. Protein Sci 8:1954-1961.
102. Sommers CL, Byers SW, Thompson EW, Torri JA, Gelmann EP. 1994. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat 31:325-335.
103. Stein E, Cerretti DP, Daniel TO. 1996. Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells. J Biol Chem 271:23588-23593.
104. Stein E, Huynh-Do U, Lane AA, Cerretti DP, Daniel TO. 1998a. Nck recruitment to EPH receptor, EPHB1/ELK, couples ligand activation to c-Jun kinase. J Biol Chem 273:1303-1308.
105. Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO. 1998b. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev 12:667-678.
106. Steube KG, Meyer C, Habig S, Uphoff CC, Drexler HG. 1999. Expression of receptor tyrosine kinase HTK (hepatoma transmembrane kinase) and HTK ligand by leukemia-lymphoma cell lines. Leuk Lymphoma 33:371-376.
107. Takai N, Miyazaki T, Fujisawa K, Nasu K, Miyakawa I. 2001. Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer. Oncol Rep 8:567-573.
108. Tang XX, Pleasure DE, Brodeur GM, Ikegaki N. 1998. A variant transcript encoding an isoform of the human protein tyrosine kinase EPHB2 is generated by alternative splicing and alternative use of polyadenylation signals. Oncogene 17:521-526.
109. Tang XX, Brodeur GM, Campling BG, Ikegaki N. 1999. Coexpression of transcripts encoding EPHB receptor protein tyrosine kinases and their ephrin-B ligands in human small cell lung carcinoma. Clin Cancer Res 5:455-460.
110. Tang XX, Zhao H, Robinson ME, Cnaan A, London W, Cohn SL, Cheung NK, Brodeur GM, Evans AE, Ikegaki N. 2000a. Prognostic significance of EPHB6, EFNB2, and EFNB3 expressions in neuroblastoma. Med Pediatr Oncol 35:656-658.
111. Tang XX, Zhao H, Robinson ME, Cohen B, Cnaan A, London W, Cohn SL, Cheung NK, Brodeur GM, Evans AE, Ikegaki N. 2000b. Implications of EPHB6, EFNB2, and EFNB3 expression in human neuroblastoma. Proc Natl Acad Sci USA 97:10936-10941.
112. Tessier-Lavigne M. 1995. Eph receptor tyrosine kinases, axon repulsion, and the development of topographic maps. Cell 82:345-348.
113. Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD. 1998. PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron 21:1453-1463.
114. Tuzi NL, Gullick WJ. 1994. eph, the largest known family of putative growth factor receptors. Br J Cancer 69:417-421.
115. Vogt T, Stolz W, Welsh J, Jung B, Kerbel RS, Kobayashi H, Landthaler M, McClelland M. 1998. Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. Clin Cancer Res 4:791-797.
116. Walker-Daniels J, Coffman K, Azimi M, Rhim JS, Bostwick DG, Snyder P, Kerns BJ, Waters DJ, Kinch MS. 1999. Overexpression of the EphA2 tyrosine kinase in prostate cancer. Prostate 41:275-280.
117. Wang HU, Anderson DJ. 1997. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18:383-396.
118. Wang HU, Chen Z-F, Anderson DJ. 1998. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93:741-753.
119. Weaver VM, Howlett AR, Langton-Webster B, Peterson OW, Bissell MJ. 1995. The development of a functionally relevant cell culture model of progressive human breast cancer. Semin Cancer Biol 6:175-184.
120. Wicks IP, Wilkinson D, Salvaris E, Boyd AW. 1992. Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cells. Proc Natl Acad Sci USA 89:1611-1615.
121. Winslow JW, Moran P, Valverde J, Shih A, Yuan JQ, Wong SC, Tsai SP, Goddard A, Henzel WJ, Hefti F, Beck KD, Caras IW. 1995. Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation. Neuron 14:973-981.
122. Xu LH, Yang X, Bradham CA, Brenner DA, Balswin AS Jr, Craven RJ, Cance WG. 2000. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways. J Biol Chem 275:30597-30604.
123. Xu Q, Alldus G, Holder N, Wilkinson DG. 1995. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development 121:4005-4016.
124. Zantek ND, Azimi M, Fedoro-Chaiken M, Wang B, Brackenbury R, Kinch MS. 1999. E-cadherin regulates the function of the EphA2 receptor tyrosine kinase. Cell Growth Differ 10:629-638.
125. Zelinski DP, Zantek ND, Stewart JC, Irizarry AR, Kinch MS. 2001. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res 61:2301-2306.
126. Zisch AH, Kalo MS, Chong LD, Pasquale EB. 1998. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene 16:2657-2670.