E-cadherin regulates the function of the EphA2 receptor tyrosine kinase

Cell Growth and Differentiation

Volumn 10, Issue 9, 1999, Pages 629-638

  Zantek, Nicole Dodge ^a   Azimi, Minoudokht ^a   Fedor Chaiken, Mary ^b   Wang, Bingcheng ^c   Brackenbury, Robert ^d   Kinch, Michael S ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

TYROSINE KINASE RECEPTOR; UVOMORULIN;

ARTICLE; BREAST CANCER; CELL ADHESION; CELL GROWTH; CELL INTERACTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

BREAST NEOPLASMS; CADHERINS; CELL ADHESION; CELL DIVISION; EPHRIN-A2; EPITHELIAL CELLS; HUMANS; PHOSPHORYLATION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0032834125     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. van der Geer, P., Hunter, A. J., and Lindberg, R. A. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu. Rev. Cell Biol., 10: 251-337, 1994.
2. Cance, W. G., and Liu, E. T. Protein kinases in human breast cancer. Breast Cancer Res. Treat., 35: 105-114, 1995.
3. Kopreski, M. S., Witters, L., Brennan, W. A. J., Buckwalter, E. A., Chinchilli, V. M., Demers, L. M., and Lipton, A. Protein tyrosine kinase activity in breast cancer and its relation to prognostic indicators. Anticancer Res, 16: 3037-3041, 1996.
4. Lower, E. E., Franco, R. S., Miller, M. A., and Martelo, O. J. Enzymatic and immunohistochemical evaluation of tyrosine phosphorylation in breast cancer specimens. Breast Cancer Res. Treat., 26: 217-224, 1993.
5. Lindberg, R. A., and Hunter, T. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases. Mol. Cell. Biol., 10: 6316-6324, 1990.
6. Gale, N. W., and Yancopoulos, G. D. Ephrins and their receptors: a repulsive topic? CeH Tissue Res., 290: 227-241, 1997.
7. Pasquale, E. B. The Eph family of receptors. Curr. Opin. Cell Biol., 9: 608-615, 1997.
8. Zisch, A. H., and Pasquale, E. B. The Eph family: a multitude of receptors that mediate cell recognition signals. Cell Tissue Res., 290: 217-226, 1997.
9. Rosenberg, I. M., Goke, M., Kanai, M., Reinecker, H. C., and Podolsky, D. K. Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier function. Am. J. Physiol., 273: G824-G832, 1997.
10. Pandey, A., Shao, H., Marks, R. M., Polverini, P. J., and Dixit, V. M. Role of B61, the ligand for the Eck receptor tyrosine kinase, in TNF-α-induced angiogenesis. Science (Washington DC), 268: 567-569, 1995.
11. Magal, E., Holash, J. A., Toso, R. J., Chang, D., Lindberg, R. A., and Pasquale, E. B. B61, a ligand for the Eck receptor protein-tyrosine kinase, exhibits neurotrophic activity in cultures of rat spinal cord neurons. J. Neurosci. Res., 43: 735-744, 1996.
12. Easty, D. J., Guthrie, B. A., Maung, K., Farr, C. J., Lindberg, R. A., Toso, R. J., Herlyn, M., and Bennett, D. C. Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression. Cancer Res., 55: 2528-2532, 1995.
13. Andres, A. C., Zuercher, G., Djonov, V., Flueck, M., and Ziemiecki, A. Protein tyrosine kinase expression during the estrous cycle and carcinogenesis of the mammary gland. Int. J. Cancer, 63: 288-296, 1995.
14. Maher, P. A., Pasquale, E. B., Wang, J. Y., and Singer, S. J. Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc. Natl. Acad. Sci. USA, 82: 6576-6580, 1985.
15. Kinch, M. S., Kilpatrick, K., and Zhong, C. Identification of tyrosine phosphorylated adhesion proteins in human cancer cells. Hybridoma, 17: 227-235, 1998.
16. Geiger, B., and Ayalon, O. Cadherins. Annu. Rev. Cell Biol., 8: 307-332, 1992.
17. Fagotto, F., and Gumbiner, B. M. Cell contact-dependent signaling. Dev. Biol., 180: 445-454, 1996.
18. Behrens, J., and Birchmeier, W. Cell-cell adhesion in invasion and metastasis of carcinomas. Cancer Treat. Res., 71: 251-266, 1994.
19. Hamaguchi, M., Matsuyoshi, N., Ohnishi, Y., Gotoh, B., Takeichi, M., and Nagai, Y. p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system. EMBO J., 12: 307-314, 1993.
20. Matsuyoshi, N., Hamaguchi, M., Taniguchi, S., Nagafuchi, A., Tsukita, S., and Takeichi, M. Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts. J. Cell Biol., 118: 703-714, 1992.
21. Kinch, M. S., Clark, G. J., Der, C. J., and Burridge, K. Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia. J. Cell Biol., 130: 461-471, 1995.
22. Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van, R. F., Mareel, M. M., and Birchmeier, W. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/ β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J. Cell Biol., 120: 757-766, 1993.
23. Volberg, T., Zick, Y., Dror, R., Sabanay, I., Gilon, C., Levitzki, A., and Geiger, B. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J., 11: 1733-1742, 1992.
24. Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Lochner, D., and Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol., 113: 173-185, 1991.
25. Marrs, J. A., Andersson-Fisone, C., Jeong, M. C., Cohen-Gould, L., Zurzolo, C., Nabi, I. R., Rodriguez-Boulan, E., and Nelson, W. J. Plasticity in epithelial cell phenotype: modulation by expression of different cadherin cell adhesion molecules. J. Cell Biol., 129: 507-519, 1995.
26. Kandikonda, S., Oda, D., Niederman, R., and Sorkin, B. C. Cadherin-mediated adhesion is required for normal growth regulation of human gingival epithelial cells. Cell Adhes. Commun., 4: 13-24, 1996.
27. Chen, H., Paradies, N. E., Fedor-Chaiken, M., and Brackenbury, R. E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms. J. Cell Sci., 110: 345-356, 1997.
28. Kinch, M. S., Petch, L., Zhong, C., and Burridge, K. E-cadherin engagement stimulates tyrosine phosphorylation. Cell Adhes. Commun., 4: 425-437, 1997.
29. Paine, T. M., Soule, H. D., Pauley, R. J., and Dawson, P. J. Characterization of epithelial phenotypes in mortal and immortal human breast cells. Int. J. Cancer, 50: 463-473, 1992.
30. Pauley, R. J., Soule, H. D., Tait, L., Miller, F. R., Wolman, S. R., Dawson, P. J., and Heppner, G. H. The MCF10 family of spontaneously immortalized human breast epithelial cell lines: models of neoplastic progression. Eur. J. Cancer Prev., 2 (Suppl. 3): 67-76, 1993.
31. Price, J. E. Metastasis from human breast cancer cell lines. Breast Cancer Res. Treat., 39: 93-102, 1996.
32. Zhang, R. D., Fidler, I. J., and Price, J. E. Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metastasis, 11: 204-215, 1991.
33. Foulkes, J. G., Chow, M., Gorka, C., Frackelton, A. R. J., and Baltimore, D. Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus. J. Biol. Chem., 260: 8070-8077, 1985.
34. Hutchcroft, J. E., Harrison, M. L., and Geahlen, R. L. B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J. Biol. Chem., 266: 14846-14849, 1991.
35. Pandey, A., Lazar, D. F., Saltiel, A. R., and Dixit, V. M. Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity. J. Biol. Chem., 269: 30154-30157, 1994.
36. Gale, N. W., Holland, S. J., Valenzuela, D. M., Flenniken, A., Pan, L., Ryan, T. E., Henkemeyer, M., Strebhardt, K., Hirai, H., Wilkinson, D. G., Pawson, T., Davis, S., and Yancopoulos, G. D. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron, 17: 9-19, 1996.
37. Vestweber, D., and Kemler, R. Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues. Exp. Cell Res., 152: 169-178, 1984.
38. Ozawa, M., Hoschutzky, H., Herrenknecht, K., and Kemler, R. A possible new adhesive site in the cell-adhesion molecule uvomorulin. Mech. Dev., 33: 49-56, 1990.
39. Burridge, K., and Chrzanowska-Wodnicka, M. Focal adhesions, contractility, and signaling. Annu. Rev. Cell Dev. Biol., 12: 463-518, 1996.
40. Parsons, J. T. Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-bindirg proteins. Curr. Opin. Cell Biol., 8: 146-152, 1996.
41. Press, M. F., Jones, L. A., Godolphin, W., Edwards, C. L., and Slamon, D. J. HER-2/neu oncogene amplification and expression in breast and ovarian cancers. Prog. Clin. Biol. Res., 354A: 209-221, 1990.
42. Murphy, L. C., Murphy, L. J., Dubik, D., Bell, G. I., and Shiu, R. P. Epidermal growth factor gene expression in human breast cancer cells: regulation of expression by progestins. Cancer Res., 48: 4555-4560, 1988.
43. Holland, S. J., Gale, N. W., Gish, G. D., Roth, R. A., Songyang, Z., Cantley, L. C., Henkemeyer, M., Yancopoulos, G. D., and Pawson, T. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/ Nuk to specific SH2 domain proteins in neuronal cells. EMBO J., 16: 3877-3888, 1997.
44. George, S. E., Simokat, K., Hardin, J., and Chisholm, A. D. The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. Cell, 92: 633-643, 1998.
45. Henkemeyer, M., Orioli, D., Henderson, J. T., Saxton, T. M., Roder, J., Pawson, T., and Klein, R. Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell, 86: 35-46, 1996.
46. Bae, S. N., Arand, G., Azzam, H., Pavasant, P., Torri, J., Frandsen, T. L., and Thompson, E. W. Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res. Treat., 24: 241-255, 1993.
47. Vestweber, D., and Kemler, R. Some structural and functional aspects of the cell adhesion molecule uvomorulin. Cell Differ., 15: 269-273, 1984.
48. Burridge, K., Fath, K., Kelly, T., Nuckolls, G., and Turner, C. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol., 4: 487-525, 1988.
49. Kinch, M. S., and Burridge, K. Altered adhesions in ras-transformed breast epithelial cells. Biochem. Soc. Trans., 23: 446-450, 1995.
50. Vestweber, D., and Kemler, R. Identification of a putative cell adhesion domain of uvomorulin. EMBO J., 4: 3393-3398, 1985.
51. Stein, E., Huynh-Do, U., Lane, A. A., Cerretti, D. P., and Daniel, T. O. Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J. Biol. Chem., 273: 1303-1308, 1998.
52. Stein, E., Lane, A. A., Cerretti, D. P., Schoecklmann, H. O., Schroff, A. D., Van, E., RL, and Daniel, T. O. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev., 12: 667-678, 1998.
53. Zisch, A. H., Kalo, M. S., Chong, L. D., and Pasquale, E. B. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene, 16: 2657-2670, 1998.
54. Owens, L. V., Xu, L., Craven, R. J., Dent, G. A., Weiner, T. M., Kornberg, L., Liu, E. T., and Cance, W. G. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res., 55; 2752-2755, 1995.
55. Maru, Y., Hirai, H., and Takaku, F. Overexpression confers an oncogenic potential upon the eph gene. Oncogene, 5: 445-447, 1990.
56. Pandey, A., Duan, H., and Dixit, V. M. Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase. J. Biol. Chem., 270: 19201-19204, 1995.
57. Roche, S., Alonso, G., Kazlauskas, A., Dixit, V. M., Courtneidge, S. A., and Pandey, A. Src-like adaptor protein (SLAP) is a negative regulator of mitogenesis. Curr. Biol., 8: 975-978, 1998.
58. Takeichi, M. Cadherins in cancer: implications for invasion and metastasis. Curr. Opin. Cell Biol., 5: 806-811, 1993.
59. Nose, A., Nagafuchi, A., and Takeichi, M. Expressed recombinant cadherins mediate cell sorting in model systems. Cell, 54: 993-1001, 1988.
60. Southern, P. J., and Berg, P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet., 1: 327-341, 1982.