Eph receptors and ephrins restrict cell intermingling and communication

Nature

Volumn 400, Issue 6739, 1999, Pages 77-81

  Mellitzer, Georg ^a   Xu, Qlling ^a   Wilkinson, David G ^a  

^a NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; EPHRIN; ISOPROTEIN; LIGAND; PROTEIN EPH; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL INTERACTION; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EXPERIMENTAL MODEL; GAP JUNCTION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ZEBRA FISH;

ANIMALS; BINDING SITES; CELL COMMUNICATION; EPHRIN-B1; EPHRIN-B2; FETAL PROTEINS; GAP JUNCTIONS; MEMBRANE PROTEINS; PHOSPHORYLATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHA4; RECEPTOR, EPHB2; RHOMBENCEPHALON; SIGNAL TRANSDUCTION; ZEBRAFISH;

ANIMALIA; DANIO RERIO; VERTEBRATA;

EID: 0033168047     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/21907     Document Type: Article

References (28)

1. Davis, S. et al. Ligands for EPH-related receptors that require membrane attachment or clustering for activity. Science 266, 816-819 (1994).
2. Flanagan, J. G. & Vanderhaeghen, P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurobiol. 21, 309-345 (1998).
3. O'Leary, D. D. M. & Wilkinson, D. G. Eph receptors and ephrins in neural development. Curr. Opin. Neurobiol. 9, 65-73 (1999).
4. Holland, S. J. et al. Bidirectional signalling through the Eph-family receptor Nuk and its transmembrane ligands. Nature 383, 722-725 (1996).
5. Bruckner, K., Pasquale, E. B. & Klein, R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science 275, 1640-1643 (1997).
6. Henkemeyer, M. et al. Nuk controls pathfinding of commisural axons in the mammalian central nervous system. Cell 86, 35-46 (1996).
7. Gale, N. W. et al. Eph receptors and ligands comprise two major specificity subclasses, and are reciprocally compartmentalised during embryogenesis. Neuron 17, 9-19 (1996).
8. Xu, Q., Alldus, G., Holder, N. & Wilkinson, D. G. Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrain. Development 121, 4005-4016 (1995).
9. Xu, Q., Mellitzer, G., Robinson, V. & Wilkinson, D. G. In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrins. Nature 399, 267-271 (1999).
10. Fraser, S., Keynes, R. & Lumsden, A. Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions. Nature 344, 431-435 (1990).
11. Eph Nomenclature Committee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell 90, 403-404 (1997).
12. Stein, E. et al. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev. 12, 667-678 (1998).
13. Torres, R. et al. PDZ domains bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron 21, 1453-1463 (1998).
14. Wang, H. U. & Anderson, D. J. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18, 383-396 (1997).
15. Krull, C. E. et al. Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration. Curr. Biol. 7, 571-580 (1997).
16. Martinez, S., Geijo, E., Sanchez-Vives, M. V., Puelles, L. & Gallego, R. Reduced junctional permeability at interrhombomeric boundaries. Development 116, 1069-1076 (1992).
17. Bagnall, K. M., Sanders, E. J. & Berdan, R. C. Communication compartments in the axial mesoderm of the chick embryo. Anat. Embryol, 186, 195-204 (1992).
18. Kumar, N. H. & Gilula, N. B. The gap junction communication channel. Cell 84, 381-388 (1996).
19. Bruzzone, R., White, T. W. & Paul, D. L. Connections with connexins: the molecular basis of direct intercellular signaling. Eur. J. Biochem. 238, 1-27 (1996).
20. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251, 1451-1455 (1991).
21. Gumbiner, B. M. Cell adhesion: the molecular basis of tissue architecture and morphogenesis. Cell 84, 345-357 (1996).
22. Wizenmann, A. & Lumsden, A. Segregation of rhombomeres by differential chemoaffinity. Mol. Cell. Neurosci. 9, 448-459 (1997).
23. Zisch, A. H. et al. Tyrosine phosphorylation of L1 family adhesion molecules: implication of the Eph kinase Cek5. J. Neurosci. Res. 47, 655-665 (1997).
24. Bruckner, K. & Klein, R. Signaling by Eph receptors and their ephrin ligands. Curr. Opin. Neurobiol. 8, 375-382 (1998).
25. Lo, C. W. The role of gap junction membrane channels in development. J. Bioenerg. Biomemb. 28, 379-385 (1996).
26. Simon, A. M. & Goodenough, D. A. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 8, 477-483 (1998).
27. Martinez, S., Marin, F., Nieto, M. A. & Puelles, L. Induction of ectopic engrailed expression and fate change in avian rhombomeres: intersegmental boundaries as barriers. Mech. Dev. 51, 289-303 (1995).
28. Warner, A. E. & Lawrence, P. A. Permeability of gap junctions at the segmental border in insect epidermis. Cell 28, 243-252 (1982).