Encoded combinatorial chemistry: Synthesis and screening of a library of highly functionalized pyrrolidines

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 7, 1997, Pages 2805-2810

  Maclean, Derek ^a   Schullek, John R ^a   Murphy, Martin M ^a   Ni, Zhi Jie ^a   Gordon, Eric M ^a   Gallop, Mark A ^a  

^a AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

combinatorial chemistry; encoded libraries; solid phase synthesis

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; POLYMER; PYRROLIDINE DERIVATIVE;

ARTICLE; DRUG ISOLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA ANALYSIS;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; DRUG DESIGN; PYRROLIDINES;

EID: 0030915475     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.7.2805     Document Type: Article

References (30)

1. Gallop, M. A., Barrett, R. W., Dower, W. J., Fodor, S. P. A. & Gordon, E. M. (1994) J. Med. Chem. 37, 1233-1251.
2. Gordon, E. M., Barrett, R. W., Dower, W. J., Fodor, S. P. A. & Gallop, M. A. (1994) J. Med. Chem. 37, 1385-1401.
3. Terrett, N. K., Gardner, M., Gordon, D. W., Kobylecki, R. J. & Steele, J. (1995) Tetrahedron 51, 8135-8173.
4. Thompson, L. A. & Ellman, J. A. (1996) Chem. Rev. (Washington, D.C.) 96, 555-600.
5. Furka, A., Sebestyen, F., Asgedom, M. & Dibo, G. (1991) Int. J. Pept. Protein Res. 37, 487-493.
6. Houghten, R. A., Pinilla, C., Blondelle, S. E., Appel, J. R., Cooley, C. T. & Cuervo, J. H. (1991) Nature (London) 354, 84-86.
7. Freier, S. M, Konings, D. A. M., Wyatt, J. R. & Ecker, D. J. (1995) J. Med. Chem. 38, 344-352.
8. Konings, D. A. M., Wyatt, J. R., Ecker, D. J. & Freier, S. M. (1996) J. Med. Chem. 39, 2710-2719.
9. Freier, S. M, Konings, D. A. M., Wyatt, J. R. & Ecker, D. J. (1996) Bioorg. Med. Chem. 4, 717-725.
10. Lam, K. S., Hruby, V. J., Lebl, M., Knapp, R. J., Kazmierski, W. M., Hersh, E. M. & Salmon, S. E. (1993) Bioorg. Med. Chem. Lett. 3, 419-424.
11. Brenner, S. & Lerner, R. A. (1992) Proc. Natl. Acad. Sci. USA 89, 5181-5183.
12. Needels, M. N., Jones, D. G., Tate, E. H., Heinkcl, G. L., Kochersperger, L. M., Dower, W. J., Barrett, R. W. & Gallop, M. A. (1993) Proc. Natl. Acad. Sci. USA 90, 10700-10704.
13. Kerr, J. M., Banville, S. C. & Zuckermann, R. N. (1993) J. Am. Chem. Soc. 115, 2529-2531.
14. Nikolaiev, V., Stierandova, A., Krchnak, V., Seligmann, B., Lam, K. S., Salmon, S. E. & Lebl, M. (1993) Pept. Res. 6, 161-170.
15. Ohlmeyer, M. H. J., Swanson, R. N., Dillard, L. W., Reader, J. C., Asouline, G., Kobayashi, R., Wigler, M. & Still, W. C. (1993) Proc. Natl. Acad. Sci. USA 90, 10922-10926.
16. Nestler, H. P., Bartlett, P. A. & Still, W. C. (1994) J. Org. Chem. 59, 4723-4724.
17. Ni, Z. J., Maclean, D., Holmes, C. P., Ruhland, B., Murphy, M. M., Jacobs, J. W., Gordon, E. M. & Gallop, M. A. (1996) J. Med. Chem. 39, 1601-1608.
18. Geysen, H. M., Wagner, C. D., Bodnar, W. M., Markworth, C. J., Parke, G. J., Schoenen, F. J., Wagner, D. S. & Kinder, D. S. (1996) Chem. Biol. 3, 679-688.
19. Edwards, P. N., Main, B. G. & Shute, R. E. (1996) U.K. Patent Appl. GB 2,297,551 A.
20. Moran, E. J., Sarshar, S., Cargill, J. F., Shahbaz, M. M., Lio, A., Mjalli, A. M. M. & Armstrong, R. W. (1995) J. Am. Chem. Soc. 117, 10787-10788.
21. Nicolaou, K. C., Xiao, X.-Y., Parandoosh, Z., Senyei, A. & Nova, M. P. (1995) Angew. Chem. Int. Ed. Engl. 34, 2289-2291.
22. Murphy, M. M., Schullek, J. R., Gordon, E. M. & Gallop, M. A. (1995) J. Am. Chem. Soc. 117, 7029-7030.
23. Shapiro, G. & Buechler, D. (1994) Tetrahedron Lett. 35, 5421-5424.
24. Cheung, H. S. & Cushman, D. W. (1973) Biochim. Biophys. Acta 293, 451-463.
25. Loffet, A. & Zhang, H. X. (1993) Int. J. Pept. Protein Res. 42, 346-351.
26. Petrillo, E. W. & Ondetti, M. A. (1982) Med. Res. Rev. 2, 1-41.
27. Bull, H. G., Thornberry, N. A., Cordes, M. H. J., Patchett, A. A. & Cordes, E. H. (1985) J. Biol. Chem. 260, 2952-2962.
28. Salmon, S. E., Lam, K. S., Lebl, M., Kandola, A., Khattri, P. S., Wade, S., Patek, M., Kocis, P., Krchnak, V., Thorpe, D. & Felder, S. (1993) Proc. Natl. Acad. Sci. USA 90, 11708-11712.
29. Appell, K. C., Chung, T. D. Y., Ohlmeyer, M. J. H., Sigal. N. H., Baldwin, J. J. & Chelsky, D. (1996) J. Biomol. Screening 1, 27-31.
30. Holmes, C. P. & Jones, D. G. (1995) J. Org. Chem. 60, 2318-2319.