H-phosphonate derivatives as novel peptide deformylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 18, 1998, Pages 2479-2482

  Hu, Yun Jin ^a   Rajagopalan, P T Ravi ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROANILINE; ANTIINFECTIVE AGENT; ARYLFORMAMIDASE; CARBOXYPEPTIDASE A; CYTOSOL AMINOPEPTIDASE; FORMYLPEPTIDE; HYDROLYASE INHIBITOR; METALLOPROTEINASE INHIBITOR; PHOSPHONIC ACID DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME MECHANISM; NONHUMAN; PROKARYOTE; PROTEIN PROCESSING;

AMIDOHYDROLASES; AMINOPEPTIDASES; ANTI-INFECTIVE AGENTS; ENZYME INHIBITORS; FERROUS COMPOUNDS; KINETICS; MODELS, CHEMICAL; PHOSPHONIC ACIDS; ZINC;

EID: 0032558522     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00443-0     Document Type: Article

References (20)

1. 1. Kozak, M. Microbiol. Rev. 1983, 47, 1.
2. 2. Adams, J. M. J. Mol. Biol. 1968, 33, 571.
3. 3. Livingston, D. M.; Leder, P. Biochemistry 1969, 8, 435.
4. 4. Takeda, M.; Webster, R. E. Proc. Natl. Acad. Sci. U.S.A. 1968, 60, 1487.
5. 5. Mazel, D.; Pochet, S.; Marliere, P. EMBO J. 1994, 13, 914.
6. 6. Rajagopalan, P. T. R.; Yu, X. C.; Pei, D. J. Am. Chem. Soc. 1997, 119, 12418.
7. 7. Chan, M. K.; Gong, W.; Rajagopalan, P. T. R.; Hao, B.; Tsai, C. M.; Pei, D. Biochemistry 1997, 36, 13904.
8. 8. Meinnel, T.; Blanquet, S.; Dardel, F. J. Mol. Biol. 1996, 262, 375.
9. 9. Becker, A.; Schlichting, I.; Kabsch, W.; Schultz, S.; Wagner, A. F. V. J. Biol. Chem. 1998, 273, 11413.
10. 10. Giannousis, P. P.; Bartlett, P. A. J. Med. Chem. 1987, 30, 1603.
11. 11. Jacobsen, N. E.; Bartlett, P. A. J. Am. Chem. Soc. 1981, 103, 654.
12. 12. Rajagopalan, P. T. R.; Datta, A.; Pei, D. Biochemistry 1997, 36, 13910.
13. 12
14. 14. Wei, Y.; Pei, D. Anal. Biochem. 1997, 250, 29.
15. 15. Kock P.; Nakatani, Y.; Luu, B.; Ourisson, G. Bull. Soc. Chim. Fr. 1983, 11, 189.
16. 16. Li, W.; Ewing, W. R.; Harris, B. D.; Joulie, M. M. J. Am. Chem. Soc. 1990, 112, 7659.
17. 17. Brian, C.; Peter, G.; Mark, D. Nucleic Acids Res. 1986, 14, 5399.
18. 18. Zhang, X.; Abad, J.-L.; Huang, Q.; Zheng, F.; Gaffney, B.; Jones, R. Tetrahedron Lett. 1997, 38, 7135.
19. +): m/z 531.
20. 20. Assay was performed with 10 mM formyl-Met-Ala-Ser (ref 12) as substrate.