Altered expression of cyclin D1 and cyclin-dependent kinase 4 in azoxymethane-induced mouse colon tumorigenesis

Carcinogenesis

Volumn 19, Issue 11, 1998, Pages 2001-2006

  Wang, Qian Shu ^a   Papanikolaou, Alexandros ^a   Sabourin, Carol L K ^b   Rosenberg, Daniel W ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; CYCLIN D1; CYCLIN DEPENDENT KINASE;

ADENOMA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTESTINE CRYPT; MALE; MOUSE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031751847     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.11.2001     Document Type: Article

References (61)

1. Shike, M., Winawar, S.J., Greenwald, P.H., Bloch, A. and Hill, M.J. (1990) Primary prevention of colorectal cancer: WHO collaborating center for prevention of colorectal cancer. Bull. WHO, 68, 377-385.
2. American Cancer Society (1996) Cancer Facts and Figures. American Cancer Society, New York, pp. 6-9.
3. Druckrey, E. (1972) Organ-specific carcinogenesis in the digestive tract. In Nakahara, W., Takayama, S., Sugimura, T. and Odashima, S. (eds) Topics in Chemical Carcinogenesis. University Park Press, Baltimore, MD, pp. 73-101.
4. Shamsuddin, A.K.M. and Trump, B.F. (1981) Colon epithelium. II. In vivo studies of colon carcinogenesis: light microscopic, histochemical and ultrastructural studies of histogenesis of azoxymethane-induced colon carcinomas in Fischer 344 rats. J. Natl Cancer Inst., 66, 389-401.
5. Papanikolaou, A., Wang, Q.-S., Delker, D.A. and Rosenberg, D.W. (1998) Azoxymethane-induced tumors and aberrant crypt foci in mice of different tumor susceptibility. Cancer Lett., in press.
6. Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
7. Vivona, A.A., Shpitz, B., Medline, A., Bruce, W.R., Hay, K., Ward, M.A., Stern, H.S. and Gallinger, S. (1993) K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis. Carcinogenesis, 14, 1777-1781.
8. Okamoto, M., Ohtsu, H., Kominami, R. and Yonekawa, H. (1995) Mutational and LOH analyses of p53 alleles in colon tumors induced by 1,2-dimethylhydrazine in F1 hybrid mice. Carcinogenesis, 16, 2659-2666.
9. Singh, J., Kelloff, G.F. and Reddy, B.S. (1997) Modulation of alterations in p53 tumor suppressor gene and its association with activation of ras protooncogenes during chemoprevention of colon cancer. J. Oncol., 10, 449-456.
10. Maltzman, T., Whittington, J., Driggers, L., Stephens, J. and Ahnen, D. (1997) AOM-induced mouse colon tumors do not express full-length APC protein. Carcinogenesis, 18, 2435-2439.
11. Sherr, C.J. (1994) G1 phase progression: cyclin on cue. Cell, 79, 551-555.
12. Cordon-Cardo, C. (1995) Mutation of cell cycle regulators: biological and clinical implications for human neoplasia. Am. J. Pathol., 147, 545-560.
13. Sherr, C.J. (1996) Cancer cell cycles. Science, 274, 1672-1677.
14. Hartwell, L.H. and Kastan, M.B. (1994) Cell cycle control and cancer. Science, 266, 1821-1828.
15. Bartkova, J., Lukas, J., Muller, H., Strauss, M., Gusterson, B. and Bartek, J. (1995) Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res., 55, 949-956.
16. Arber, N., Hibshoosh, H., Moss, S.F., Sutter, T., Zhang, Y., Begg, M., Wang, S., Weinstein, I.B. and Holt, P.R. (1996) Increased expression of cyclin D1 is an early event in multistage colorectal carcinogenesis. Gastroenterology, 110, 669-674.
17. de Boer, C.J., Loyson, S., Kluin, P.M., Kluin-Nelemans, H.C., Schuuring, E. and van Krieken, J.H. (1993) Multiple breakpoints within the BCL-1 locus in B-cell lymphoma: rearrangements of the cyclin D1 gene. Cancer Res., 53, 4148-4152.
18. Gillett, C., Fantl, V., Smith, R., Fisher, C., Bartek, J., Dickson, C., Barnes, D. and Peters, G. (1994) Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res., 54, 1812-1817.
19. Zhang, Y.-J., Jiang, W., Chen, C.J., Lee, C.S., Kahn, S.M., Santella, R.M. and Weinstein, I.B. (1993) Amplification and overexpression of cyclin D1 in human hepatocellular carcinoma. Biochem. Biophys. Res. Commun., 196, 1010-1016.
20. Jiang, W., Kahn, S.M., Tomita, N., Zhang, Y.J., Lu, S.H. and Weinstein, J.B. (1992) Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res., 52, 2980-2983.
21. Bartkova, J., Lukas, J., Strauss, M. and Bartek, J. (1994) The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinoma. Int. J. Cancer, 58, 568-573.
22. Masciullo, V., Scambia, G., Marone, M., Giannitelli, C., Ferrandina, G., Bellacosa, A., Benedetti-Panici, P. and Mancuso, S. (1997) Altered expression of cyclin D1 and CDK4 genes in ovarian carcinomas. Int. J. Cancer, 74, 390-395.
23. Arber, N., Doki, Y., Han, E.K.-H. et al. (1997) Antisense to cyclin D1 inhibits the growth and tumorigenicity of human colon cancer cells. Cancer Res., 57, 1569-1574.
24. INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res., 55, 4833-1836.
25. Khatib, Z.A., Matsushime, H., Valentine, M., Shapiro, D.N., Sherr, C.J. and Look, A.T. (1993) Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res., 53, 5535-5541.
26. Zhang, T., Nanney, L.B., Luongo, C., Lamps, L., Heppner, K.J., DuBois, R.N. and Beauchamp, R.D. (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenoma polyposis patients. Cancer Res., 57, 169-175.
27. Wang, Q.-S., Sabourin, C.L.K., Wang, H. and Stoner, G.D. (1996) Overexpression of cyclin D1 and cyclin E in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis. Carcinogenesis, 17, 1583-1588.
28. Wang, Q.-S., Sabourin, C.L.K., Bijur, G.N., Robertson, F.M. and Stoner, G.D. (1996) Alterations in transforming growth factor-α and epidermal growth factor receptor during rat esophageal tumorigenesis. Mol. Carcinogen., 15, 144-153
29. Zhang, T., Nanney, L.B., Peeler, M.O., Williams, C.S., Lamps, L., Heppner, K.J., DuBois, R.N. and Beauchamp, R.D. (1997) Decreased transforming growth factor type II receptor expression in intestinal adenomas from Min/ + Mice is associated with increased cyclin D1 and cyclin-dependent kinase 4 expression. Cancer Res., 57, 1638-1643.
30. Matsushime, H., Roussel, M.F., Ashmun, R.A. and Sherr, C.J. (1991) Colony-stimulating factor 1 regulates novel cyclins during G1 phase of the cell cycle. Cell, 65, 701-713.
31. Matsushime, H., Ewen, M.E., Strom, D.K., Kato, J.Y., Hanks, S.K., Roussel, M.F. and Sherr, C.J. (1992) Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. Cell, 71, 323-334.
32. Konecki, D.S., Brennand, J., Fuscoe, J.C., Caskey, C.T. and Chinault, A.C. (1982) Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants. Nucleic Acid Res., 10, 6763-6775.
33. Sardelli, S. (1993) Amplification: A Forum for PCR Users, vol. 9. Perkin-Elmer Cetus, Norwalk, CT, pp. 3-5.
34. Fiala, E.S. (1977) Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer, 40, 2436-2445.
35. Druckrey, E. (1970) Production of colonic carcinomas by 1,2-dialkylhydrazines and azoxyalkanes. In Burdette, W.J. (ed.) Carcinoma of the Colon and Antecedent Epithelium. Thomas, Springfield, EL, pp. 267-279.
36. Decaens, C., Bara, J., Rosa, B., Daher, N. and Burtin, P. (1983) Early oncofetal antigenic modifications during rat colonic carcinogenesis. Cancer Res., 43, 355-362.
37. Bairow, B.J., O'Riordan, M.A., Stellato, T.A., Calkins, B.M. and Pretlow, T.P. (1990) Enzyme-altered foci in colons of carcinogen-treated rats. Cancer Res., 50, 1911-1916.
38. Maskens, A.P. and Dujardin-Loits, R.M. (1981) Experimental adenomas and carcinomas of the large intestine behave as distinct entities: most carcinomas arise de novo in flat mucosa. Cancer, 47, 81-89.
39. Mueller, A., Odze, R., Jenkins, T.D., Shahsesfaei, A., Nakagawa, H., Inomoto, T. and Rustgi, A.K. (1997) A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor, and p53 abnormalities. Cancer Res., 57, 5542-5549.
40. Naitoh, H., Shibata, J., Kawaguchi, A., Kodama, M. and Hattori, T. (1995) Overexpression and localization of cyclin D1 mRNA and antigen in esophageal cancer. Am. J. Pathol., 146, 1161-1169.
41. Jares, P., Fernandez, P.L., Campo, E., Nadal, A., Bosch, F., Aiza, G., Nayach, I., Traserra, J. and Cardesa, A. (1994) PRAD-1/Cyclin D1 gene amplification correlates with messenger RNA overexpression and tumor progression in human laryngeal carcinomas. Cancer Res., 54, 4813-4817.
42. Leach, F.S., Elledge, S.J., Sherr, C.J., Willson, J.K.V., Markowitz, S., Kinzler, K.W. and Vogelstein, B. (1993) Amplification of cyclin genes in colorectal carcinomas. Cancer Res., 53, 1986-1989.
43. Filmus, J., Robles, A.I., Shi, W., Wong, M.J., Colombo, L.L. and Conti, C.J. (1994) Induction of cyclin D1 overexpression by activated ras. Oncogene, 9, 3627-3633.
44. Arber, N., Sutter, T., Miyake, M., Kahn, S.M., Venkatraj, V.S., Sobrino, A., Warburton, D., Holt, P.R. and Weinstein, I.B. (1996) Increased expression of cyclin D1 and the RB tumor suppressor gene in c-K-ras transformed rat enterocytes. Oncogene, 12, 1903-1908.
45. Winston, J.T., Coats, S.R., Wang, Y.-Z. and Pledger, W.J. (1996) Regulation of the cell cycle machinery by oncogenic ras. Oncogene, 12, 127-134.
46. kip1. Mol. Cell. Biol., 17, 3850-3857.
47. Pretlow, T.P., Brasitus, T.A., Fulton, N.C., Cheyer, C. and Kaplan, E.L. (1993) K-ras mutations in putative preneoplastic lesions in human colon. J. Natl Cancer Inst., 85, 2004-2007.
48. Minamoto, T., Yamashita, N., Ochiai, A., Mai, M., Sugimura, T., Ronai, Z. and Esumi, H. (1995) Mutant K-ras in apparently normal mucosa of colorectal cancer patients: its potential as a biomarker of colorectal tumorigenesis. Cancer, 75, 1520-1526.
49. Bos, J.L., Fearon, E.R., Hamilton, S.R., Verlann-de Vries, M., van Boom, J.H., van der Eb, A.J. and Volgelstein, B. (1987) Prevalence of ras gene mutations in human colorectal cancer. Nature, 327, 293-297.
50. Stopera, S.A., Murphy, L.C. and Bird, R.P. (1992) Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer. Carcinogenesis, 13, 2081-2085.
51. Zaidi, N.H., Pretlow, T.P., O'Riordan, M.A., Dumenco, L.L., Allay, E. and Gerson, S.L. (1995) Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon. Carcinogenesis, 16, 451-456.
52. Jacoby, R.F., Llor, X., Teng, B.B., Davidson, N.O. and Brasitus, T.A. (1991) Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonie mucosa. J. Clin. Invest., 87, 624-630.
53. Singh, J., Kulkarni, N., Kelloff, G. and Reddy, B.S. (1994) Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis. Carcinogenesis, 15, 1317-1323.
54. Prall, O.W., Sarcevic, B., Musgrove, E.A., Watts, C.K.W. and Sutherland, R.L. (1997) Estrogen-induced activation of Cdk4 and Cdk2 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J. Biol. Chem., 272, 10882-10894.
55. Ko, T.C., Sheng, H.M., Reisman, D., Thompson, E.A. and Beauchamp, R.D. (1995) Transforming growth factor-β 1 inhibits cyclin D1 expression in intestinal epithelial cell. Oncogene, 10, 177-184.
56. Ewen, M.E., Sluss, H.K., Whitehouse, L.L. and Livingston, D.M. (1993) TGF-β inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell, 74, 1009-1020.
57. Alexandrow, M.G. and Moses, H.L. (1995) Transforming growth factor-β and cell cycle regulation. Cancer Res., 55, 1452-1457.
58. Thorup, I. (1997) Histomorphological and immunohistochemical characterization of colonic aberrant crypt foci in rats: relationship to growth factor expression. Carcinogenesis, 18, 465-472.
59. Gryfe, R., Swallow, C., Bapat, B., Redston, M., Gallinger, S. and Couture, J. (1997) Molecular biology of colorectal cancer. Curr. Probl. Cancer, 21, 233-300.
60. Tsushima, H., Kawata, S., Tamura, S. et al. (1996) High levels of transforming growth factor β1 in patients with colorectal cancer: association with disease progression. Gastroenterology, 110, 375-382.
61. Markowitz, S., Wang, J., Myeroff, L. et al. (1995) Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science, 268, 1336-1338.