Effects of double-strand break repair proteins on vertebrate telomere structure

Nucleic Acids Research

Volumn 30, Issue 13, 2002, Pages 2862-2870

  Wei, Chao ^a   Skopp, Rose ^b   Takata, Minoru ^c   Takeda, Shunichi ^d   Price, Carolyn M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c KAWASAKI MEDICAL SCHOOL   (Japan)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEOPROTEIN; DOUBLE STRANDED DNA; KU ANTIGEN; PROTEIN KINASE C; RAD51 PROTEIN;

ANIMAL CELL; CELL LINE; CHICKEN; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; GENE DELETION; GENE DISRUPTION; GENE FUSION; GENE MUTATION; GENETIC SCREENING; HOMOLOGOUS RECOMBINATION; KNOCKOUT GENE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; REVIEW; SPECIES DIFFERENCE; STRUCTURE ANALYSIS; TELOMERE; VERTEBRATE; YEAST;

ANIMALIA; GALLUS GALLUS; VERTEBRATA;

EID: 0036639851     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkf396     Document Type: Review

References (48)

1. DNA double strand break repair in mammalian cells
2. DNA double-strand breaks: Signaling, repair and the cancer connection
3. DNA ends: Maintenance of chromosome termini versus repair of double strand breaks
4. Telomere length regulation
5. Mammalian telomeres end in a large duplex loop
6. Pot1, the putative telomere end-binding protein in fission yeast and humans
7. The telomerase reverse transcriptase: Components and regulation
8. Telomere maintenance by recombination in human cells
9. Recombination in telomere-length maintenance
10. Telomeric chromatin: Replicating and wrapping up chromosome ends
11. Use of gene knockouts in cultured cells to study apoptosis
12. Homologous DNA recombination in vertebrate cells
13. DNA-PKcs is critical for telomere capping
14. Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang
15. The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
16. Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells
17. Identification of a Saccharomyces cerevisiae Ku80 homologue: Roles in DNA double-strand break rejoining and in telomeric maintenance
18. Yeast Ku as a regulator of chromosomal DNA end structure
19. The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities
20. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres
21. Telomere maintenance is dependent on activities required for end repair of double-strand breaks
22. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere
23. The many interfaces of Mre11
24. DNA double-strand break repair from head to tail
25. Telomerase expression in chickens: Constitutive activity in somatic tissues and down-regulation in culture
26. Cloning and characterization of the chicken gene encoding the telomeric protein TRF2
27. How many proteins does it take to make a telomere?
28. Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death
29. Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52
30. The controlling role of ATM in homologous recombinational repair of DNA damage
31. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
32. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
33. Genetic analysis of the DNA-dependent protein kinase reveals an inhibitory role of Ku in late S-G2 phase DNA double-strand break repair
34. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
35. Telomere end-replication problem and cell aging
36. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
37. Telomere length dynamics in telomerase-positive immortal human cell populations
38. TRF2 protects human telomeres from end-to-end fusions
39. Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27
40. Evidence for a new step in telomere maintenance
41. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
42. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
43. The role of the Mre11-Rad50-Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres
44. Differential suppression of DNA repair deficiencies of yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase)
45. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process
46. Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
47. Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs
48. Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line