Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

Immunity

Volumn 12, Issue 4, 2000, Pages 383-389

  Itano, Andrea ^a   Robey, Ellen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ALLELE; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL LABELING; CELL LINEAGE; CELL SELECTION; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOCHASTIC MODEL; THYMOCYTE; TRANSGENIC MOUSE;

EID: 0033716970     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80190-9     Document Type: Article

References (30)

1. Role of coreceptors in positive selection and lineage commitment
2. Functional commitment of helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity
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5. Thymic selection and cell division
6. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
7. Stochastic component to the development of class I MHC specific T cells
8. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells
9. Positive selection of thymocytes
10. Thymic selection: Two pathways to life and two to death
11. Regulation of T cell production in T cell receptor transgenic mice
12. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression
13. Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigen
14. Positive selection of thymocytes bearing alpha-beta T cell receptors
15. The differentiation of T lymphocytes. V. Evidence for intrathymic death of most thymocytes
16. Feedback regulation of T cell development in the thymus
17. Evidence for a single-niche model of positive selection
18. How many thymocytes audition for selection?
19. Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
20. Role of Bcl-2 in alpha beta T cell development in mice deficient in the common cytokine receptor gamma-chain: The requirement for Bcl-2 differs depending on the TCR/MHC affinity
21. Expansion of mature thymocyte subsets before emigration to the periphery
22. An activated form of Notch influences the choice between CD4 and CD8 T cell lineages
23. Constitutive CD8 expression allows inefficient maturation of CD4 + helper T cells in class II MHC mutant mice
24. The role of CD8 alpha' in the CD4 versus CD8 lineage choice
25. The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: Delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells
26. T-cell apoptosis detected in situ during positive and negative selection in the thymus
27. Turnover of naive- and memory-phenotype T cells
28. Thymic lineage commitment rather than selection causes genetic variations in size of CD4 and CD8 compartments
29. Homeostasis limits the development of mature CD8+ but not CD4+ thymocytes
30. Positive selection of lymphocytes