The lamellipodium: Where motility begins

Trends in Cell Biology

Volumn 12, Issue 3, 2002, Pages 112-120

  Small, J Victor ^a   Stradal, Theresia ^b   Vignal, Emmanuel ^a   Rottner, Klemens ^b  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; MYOSIN; PROTEIN; RHO FACTOR;

ACTIN FILAMENT; ACTIN POLYMERIZATION; BRANCHING MORPHOGENESIS; CELL ADHESION; CELL CYCLE; CELL MATURATION; CELL MEMBRANE; CELL MOTILITY; CELL ULTRASTRUCTURE; CYTOARCHITECTURE; CYTOSKELETON; FILOPODIUM; LAMELLIPODIUM; MOLECULAR DYNAMICS; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CELL MOVEMENT; MACROMOLECULAR SUBSTANCES; MOLECULAR MOTOR PROTEINS; PROTEINS; PSEUDOPODIA; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

HARNESS;

EID: 0036498546     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02237-1     Document Type: Review

References (99)

1. The crawling movement of metazoan cells
2. On the mechanisms of cortical actin flow and its role in cytoskeletal organization of fibroblasts
3. Subcellular distribution of rhodamine-actin microinjected into living fibroblastic cells
4. Assembling an actin cytoskeleton for cell attachment and movement
5. Mechanism of actin-based motility
6. Surfing pathogens and the lessons learned for actin polymerization
7. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly
8. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
9. The actin cytoskeleton
10. VASP dynamics during lamellipodia protrusion
11. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
12. A WASp-VASP complex regulates actin polymerization at the plasma membrane
13. Negative regulation of fibroblast motility by Ena/VASP proteins
14. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac
15. Scar/WAVE is localised at the tips of protruding lamellipodia in living cells
16. N-WASP, WAVE and Mena play different roles in the organization of actin cytoskeleton in lamellipodia
17. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
18. The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia
19. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes
20. Regulating cellular actin assembly
21. Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed
22. Exchange of actin subunits at the leading edge of living fibroblasts: Possible role of treadmilling
23. Rho GTPases and the actin cytoskeleton
24. Rho family proteins: Coordinating cell responses
25. Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
26. Activation of Rac and Cdc42 by integrins mediates cell spreading
27. Rho GTPases and signaling networks
28. Signaling from Ras to Rac and beyond: Not just a matter of GEFs
29. Differential localization of Rho GTPases in live cells: Regulation by hypervariable regions and RhoGDI binding
30. Localized Rac activation dynamics visualized in living cells
31. Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras
32. Leukocytes navigate by compass: Roles of PI3Kγ and its lipid products
33. GEF at work: Vav in protruding filopodia
34. Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells
35. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
36. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
37. Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin
38. Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
39. p21-activated protein kinase: A crucial component of morphological signaling?
40. Pak to the future
41. The Arp2/3 complex branches filament barbed ends: Functional antagonism with capping proteins
42. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins
43. Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia
44. Actin machinery: Pushing the envelope
45. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation
46. New tricks for an old dog?
47. Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles
48. Activation of the Arp2/3 complex by the actin filament binding protein Abp1p
49. Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation
50. Drebrin particles: Components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia
51. Actin-binding protein requirement for cortical stability and efficient locomotion
52. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells
53. Filamins as integrators of cell mechanics and signalling
54. Structural and functional aspects of filamins
55. The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin
56. Ultrastructural localization of alpha-actinin and filamin in cultured cells with the immunogold staining (IGS) method
57. Actinin-4 is preferentially involved in circular ruffling and macropinocytosis in mouse macrophages: Analysis by fluorescence ratio imaging
58. The role of the cortical cytoskeleton: F-actin crosslinking proteins protect against osmotic stress, ensure cell size, cell shape and motility, and contribute to phagocytosis and development
59. The coronin family of actin-associated proteins
60. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells
61. Architectural dynamics and gene replacement of coronin suggest its role in cytokinesis
62. Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach
63. Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction
64. Parallel actin bundles and their multiple actin-bundling proteins
65. Phosphorylation of human fascin inhibits its actin binding and bundling activities
66. Cell-matrix adhesions differentially regulate fascin phosphorylation
67. Regulation of actin filament cross-linking and bundle shape in Drosophila bristles
68. Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones
69. Fimbrin, a new microfilament-associated protein present in microvilli and other cell surface structures
70. Lamellipodia architecture: Actin filament turnover and the lateral flow of actin filaments during motility
71. Mechanism of lateral movement of filopodia and radial actin bundles across neuronal growth cones
72. Regulated tyrosine phosphorylation at the tips of growth cone filopodia
73. Putting a new twist on actin: ADF/cofilins modulate actin dynamics
74. Hyperosmotic stress-induced reorganization of actin bundles in Dictyostelium cells over-expressing cofilin
75. Live dynamics of Dictyostelium cofilin suggests a role in remodeling actin latticework into bundles
76. Actin filament organization in the fish keratocyte lamellipodium
77. Visualization and molecular analysis of actin assembly in living cells
78. Comparisons of CapG and gelsolin-null macrophages: Demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing
79. Myosin I is located at the leading edges of locomoting Dictyostelium amoebae
80. The localization of myosin VI at the Golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation
81. A role for myosin VII in dynamic cell adhesion
82. Myosin-X, a novel myosin with pleckstrin homology domains, associates with regions of dynamic actin
83. The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization
84. A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex
85. An intact SH3 domain is required for myosin I-induced actin polymerization
86. The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains
87. Myosin-V: Head to tail
88. Function of myosin-V in filopodial extension of neuronal growth cones
89. Myosin VI is an actin-based motor that moves backwards
90. Myosin drives retrograde F-actin flow in neuronal growth cones
91. Getting to the point with myosin VI
92. Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts
93. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho
94. Secrets of actin-based motility revealed by a bacterial pathogen
95. Cell motility driven by actin polymerization
96. Visualising the actin cytoskeleton
97. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
98. Intact alpha-actinin molecules are needed for both the assembly of actin into the tails and the locomotion of Listeria monocytogenes inside infected cells
99. Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles