The Dictyostelium CARMIL protein links capping protein and the Arp2/3 complex to type I myosins through their SH3 domains

Journal of Cell Biology

Volumn 153, Issue 7, 2001, Pages 1479-1497

  Jung, Goeh ^a   Remmert, Kirsten ^a   Wu, Xufeng ^a   Volosky, Joanne M ^a   Hammer III, John A ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Arp2 3 complex; Capping protein; Dictyostelium; Leucine rich repeats; Myosin I

Indexed keywords

ACTIN; ACTIN RELATED PROTEIN 2; ACTIN RELATED PROTEIN 3; CAPPING PROTEIN; F ACTIN; G ACTIN; HYBRID PROTEIN; LEUCINE; MYOSIN; MYOSIN IC; PROLINE; PROTEIN CARMIL; PROTEIN P116; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

ACTIN FILAMENT; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CHEMOTAXIS; COMPLEX FORMATION; CONTROLLED STUDY; DICTYOSTELIUM; DROSOPHILA; HUMAN; IMMUNOPRECIPITATION; MOLECULAR CLONING; MOUSE; MYOSIN IB; NONHUMAN; NUCLEOTIDE SEQUENCE; PINOCYTOSIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SRC HOMOLOGY DOMAIN;

ACTIN DEPOLYMERIZING FACTORS; ACTIN-RELATED PROTEIN 2; ACTIN-RELATED PROTEIN 3; ACTINS; ANIMALS; BINDING SITES; CAENORHABDITIS ELEGANS; CARRIER PROTEINS; CELL MEMBRANE STRUCTURES; CELL MOVEMENT; CHEMOTAXIS; CLONING, MOLECULAR; CYTOSKELETAL PROTEINS; DESTRIN; DICTYOSTELIUM; DROSOPHILA; ENDOCYTOSIS; HUMANS; MACROMOLECULAR SUBSTANCES; MICE; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; MYOSINS; PRECIPITIN TESTS; PROTEIN BINDING; PROTOZOAN PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; DICTYOSTELIUM;

EID: 0035954433     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.7.1479     Document Type: Article

References (77)

1. The Src homology domain 3 (SH3) of a yeast type I myosin, myo5p, binds to verprolin and is required for targeting to sites of actin polarization
2. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development
3. Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASp/Scar proteins
4. Signaling to actin: The Cdc42N-WASP-Arp2/3 connection
5. Myosin I
6. Control of actin assembly and disassembly at filament ends
7. Acanthamoeba castellanii capping protein: Properties, mechanism of action, immunological crossreactivity, and localization
8. The coronin family of actin-associated proteins
9. Isolation of a novel gene mutated in Wiskott-Aldrich Syndrome
10. Myosin I contributes to the generation of resting cortical tension
11. Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium
12. Activation of the Cdc42 effector N-WASp by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility
13. A role for myosin-I actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex
14. Experimental evidence for the contractile activities of Acanthamoeba myosin I-A and myosin I-B
15. Myosin I is located at the leading edge of locomoting Dictyostelium amoebae
16. Characterization of cytoplasmic actin isolated from Acanthamoeba castellanii by a new method
17. Fluid-phase uptake by macropinocytosis in Dictyostelium
18. Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins
19. Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization
20. Capping protein levels influence actin assembly and cell motility in Dictyostelium
21. Generation and characterization of Dictyostelium cells deficient in a myosin I heavy chain isoform
22. Dictyostelium discoideum contains a gene encoding a myosin I heavy chain
23. Sequence, expression pattern, intracellular localization, and targeted disruption of the Dictyostelium myosin-ID heavy chain isoform
24. Dictyostelium mutants lacking multiple classic myosin I isoforms reveal combinations of shared and distinct functions
25. Purification and assay of the Arp2/3 complex from Acanthamoeba castellanii
26. Kinetics of fluid phase pinocytosis in Dictyostelium discoideum amoebae
27. Proteins with leucine-rich repeats
28. Modular peptide recognition domains in eukaryotic signaling
29. Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization
30. Organization and ligand binding properties of the tail of Acanthamoeba myosin-IA
31. Fission yeast myosin-1, Myo1p, stimulates actin assembly by Arp2/3 complex and shares functions with WASp
32. Bee1, a yeast protein with homology to Wiskott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton
33. Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
34. The tail of two myosins
35. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex
36. Signaling to actin dynamics
37. Purification of a cortical complex containing 2 unconventional actins from Acanthamoeba by affinity-chromatography on profilin-agarose
38. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex
39. Increased expression of the Ras suppressor Rsu-1 enhances Erk-2 activation and inhibits Jun kinase activation
40. Unconventional myosins in cell movement, membrane traffic, and signal transduction
41. Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal organization
42. A complex of N-Wasp and WIP integrates signaling cascades that lead to actin polymerization
43. An actin-related protein from Dictyostelium discoideum is developmentally regulated and associated with mitochondria
44. The WASp homologue Las17p functions with the WIP homologue End5p/verprolin and is essential for endocytosis in yeast
45. A myosin I is involved in membrane recycling from early endosomes
46. Myosin I overexpression impairs cell migration
47. The myosin I SH3 domain and TEDS rule phosphorylation site are required for in vivo function
48. Overlapping functions of myosin-I isoforms?
49. Biochemical kinetic characterization of the Acanthamoeba myosin I ATPase
50. The Arp2/3 complex branches filament barbed ends: Functional antagonism with capping proteins
51. Molecular genetic analysis of myoC, a Dictyostelium myosin I
52. Length distribution of F-actin in Dictyostelium discoideum
53. WIP, a protein associated with Wiskott-Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells
54. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
55. Dictyostelium discoideum: Molecular approaches to cell biology
56. The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans signaling gene sem-5
57. Leucine-rich repeats and carboxyl terminus are required for interaction of yeast adenylate cyclase with ras proteins
58. Activation of the Arp2/3 complex-mediated actin polymerization by cortactin
59. The myosins in Dictyostelium
60. Actin-binding verprolin is a developmental protein required for the morphogenesis and function of the yeast actin cytoskeleton
61. The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast
62. The interfaces of actin and Acanthamoeba actobindin - Identification of a new actin-binding motif
63. The actin binding site of thymosin B4 mapped by mutational analysis
64. The developmental regulation of single cell motility in Dictyostelium discoideum
65. Role of tropomyosin, α-actinin, and actin binding protein 280 in stabilizing F-actin in basal and chemotactic factor activated neutrophils
66. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation
67. The world according to Arp: Regulation of actin nucleation by the Arp2/3 complex
68. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation
69. Activation of the yeast Arp2/3 complex by Beelp, a WASP-family protein
70. Functions of unconventional myosins
71. Identification of Acan 125 as a myosin-I-binding protein present with myosin-I on cellular organelles of Acanthamoeba
72. The myosin-I binding protein Acan125 binds the SH3 domain and belongs to the superfamily of leucine-rich repeat proteins
73. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
74. Vaccinia locomotion in host cells: Evidence for the universal involvement of actin-based motility sequences ABM-1 and ABM-2
75. Myosin-I moves actin filaments on a phospholipid substrate: Implications for membrane targeting
76. Acan 125 binding to the SH3 domain of Acanthamoeba myosin-IC