Loss of the BCL-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis

Cancer Biology and Therapy

Volumn 1, Issue 2, 2002, Pages 136-144

  Decker, Roy H ^a   Wang, Shujie ^a   Dai, Yun ^a   Dent, Paul ^a   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2; Cytochrome c; Flavopiridol; Leukemia; Phosphorylation loop

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CYTARABINE; CYTOCHROME C; ENZYME INHIBITOR; FLAVONOID; FLAVOPIRIDOL; PIPERIDINE DERIVATIVE; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL STRAIN U937; CHEMISTRY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECT; HUMAN; METABOLISM; MITOCHONDRION; MYELOID LEUKEMIA; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SECRETION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CYTARABINE; CYTOCHROME C GROUP; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; LEUKEMIA, MYELOID; MITOCHONDRIA; PHOSPHORYLATION; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-BCL-2; U937 CELLS;

EID: 0036490982     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.58     Document Type: Article

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