The antioxidant activity of regularly consumed fruit and vegetables reflects their phenolic and vitamin C composition

Free Radical Research

Volumn 36, Issue 2, 2002, Pages 217-233

  Proteggente, Anna R ^a   Pannala, Ananth Sekher ^a   Paganga, George ^a   Van Buren, Leo ^b   Wagner, Eveline ^a   Wiseman, Sheila ^b   Van De Put, Frans ^b   Dacombe, Clive ^c   Rice Evans, Catherine A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNILEVER RESEARCH VLAARDINGEN   (Netherlands)

^c UNILEVER RESEARCH   (United Kingdom)

Author keywords

Anthocyanin; Antioxidant activity; Flavanol; Flavonoid analysis; HPLC analysis; Hydroxycinnamate; TEAC; Vitamin C

Indexed keywords

ANTHOCYANIN; ASCORBIC ACID; FERRIC ION; FLAVANONE; FLAVONOL; METHANOL; OXYGEN RADICAL; PARA COUMARIC ACID; PHENOL; PLANT EXTRACT; POLYPHENOL; TROLOX C; WATER;

ANTIOXIDANT ACTIVITY; APPLE; ARTICLE; BANANA; BROCCOLI; CABBAGE; CAULIFLOWER; CONTROLLED STUDY; COOKING; CORRELATION FUNCTION; FLUORESCENCE ANALYSIS; FOOD ANALYSIS; FOOD COMPOSITION; FOOD INTAKE; FRUIT; GRAPE; GRAPEFRUIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEEK; LETTUCE; NONHUMAN; ONION; ORANGE (FRUIT); PEA; PEACH; PEAR; RASPBERRY; REDUCTION; SPINACH; STRAWBERRY; TOMATO; UNITED KINGDOM; VEGETABLE;

ANTHOCYANINS; ANTIOXIDANTS; ASCORBIC ACID; CHROMANS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARIC ACIDS; FLAVONOIDS; FRUIT; OXIDATION-REDUCTION; PHENOLS; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, ULTRAVIOLET; VEGETABLES;

ALLIUM CEPA; ALLIUM PORRUM; BRASSICA OLERACEA VAR. BOTRYTIS; BRASSICA OLERACEA VAR. CAPITATA; CITRUS X PARADISI; FRAGARIA X ANANASSA; LACTUCA; LYCOPERSICON ESCULENTUM; MALUS X DOMESTICA; PHYSALIS GRISEA; PHYSALIS PUBESCENS INTEGRIFOLIA; PISUM SATIVUM; PRUNUS DOMESTICA; PRUNUS PERSICA; PYRUS COMMUNIS; RUBUS GLAUCUS; RUBUS ILLECEBROSUS; SPINACIA OLERACEA; VITIS SP.;

EID: 0036486864     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760290006484     Document Type: Article

References (67)

1. Macheix, J.-J., Fleuriet, A. and Billot, J. (1990) Fruit Phenolics (CRC Press, Boca Raton, FL).
2. Hertog, M.G.L., Hollman, P.C.H. and Katan, M.B. (1992) "Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands", J. Agric. Food Chem. 40, 2379-2383.
3. Clifford, M.N. (1999) "Chlorogenic acids and other cinnates-nature, occurrence and dietary burden", J. Sci. Food Agric. 79, 362-372.
4. Tomás-Barbéran, F.A. and Clifford, M.N. (2000) "Flavanones, chalcones and dihydrochalcones-nature, occurrence and dietary burden", J. Sci. Food Agric. 80, 1073-1080.
5. Clifford, M.N. (2000) "Anthocyanins-nature, occurrence and dietary burden", J. Sci. Food Agric. 80, 1063-1072.
6. Hollman, P.C.H. and Arts, I.C.W. (2000) "Flavonols, flavones and flavanols-nature, occurrence and dietary burden", J. Sci. Food Agric. 80, 1081-1093.
7. Harborne, J.B. and Mabry, T.J. (1982) The Flavonoids: Advances in Research (Chapman & Hall, London).
8. Gey, K.F., Puska, P., Jordan, P. and Moser, U.K. (1991) "Inverse correlation between plasma Vitamin E and mortality from ischemic-heart-disease in crosscultural epidemiology", Am. J. Clin. Nutr. 53, S326-S334.
9. Ziegler, R.G. (1991) "Vegetables, fruits and carotenoids and the risk of cancer", Am. J. Clin. Nutr. 53, 251S-259S.
10. Gaziano, J.M., Manson, J.E., Buring, J.E. and Hennekens, C.H. (1992) "Dietary antioxidants and cardiovascular disease", Ann. New York Acad. Sci. 669, 249-259.
11. Gaziano, J.M. and Hennikens, C.H. (1996) "Update on dietary antioxidants and cancer", Pathol. Biol. 44, 42-45.
12. Gandini, S., Merzenich, H., Robertson, C. and Boyle, P. (2000) "Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients", Eur. J. Cancer 36, 636-646.
13. Joseph, J.A., Shukitt-Hale, B., Desinova, N.A., Prior, R.L., Cao, G., Martin, A., Taglialatela, G. and Bickford, P.C. (1998) "Long-term dietary strawberry, spinach, or Vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioural deficits", J. Neurosci. 18, 8047-8055.
14. Cao, Y. and Cao, R. (1999) "Angiogenesis inhibited by drinking tea", Nature 398, 381.
15. Fuhrman, B., Lavy, A. and Aviram, M. (1995) "Consumption of red wine with meals reduces the susceptibility of human plasma and LDL to lipid peroxidation", Am. J. Clin. Nutr. 61, 549-554.
16. Gaziano, J.M. (1996) "Antioxidants in cardiovascular disease: randomized trials", Nutrition 12, 583-588.
17. Hertog, M.G., Kromhout, D., Aravinis, C., Blackburn, H., Buzina, R., Fidanza, E, Giampaoli, S., Jansen, A., Menotti, A., Nedeljkovic, S., Pekkarinen, M., Simic, B.S., Toshima, H., Feskens, E.J.M., Hollman, P.C.H. and Katan, M.B. (1995) "Flavonoid intake and long-term risk of coronary-heart-disease and cancer in the seven countries study", Arch. Intern. Med. 155, 381-386.
18. Middleton, Jr., E., Kandaswami, C. and Theoharides, T.C. (2000) "The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer", Pharmacol. Rev. 52, 673-751.
19. Rice-Evans, C.A., Miller, N.J. and Paganga, G. (1996) "Structure-antioxidant activity relationships of flavonoids and phenolic acids", Free Radic. Biol. Med. 20, 933-956.
20. Visioli, E, Bellomo, G. and Galli, C. (1998) "Free radical-scavenging properties of olive oil polyphenols", Biochem. Biophys. Res. Commun. 247, 60-64.
21. Jovanovic, S.V, Steenken, S., Simic, M.C. and Hara, Y. (1998) "Antioxidant properties of flavonoids: reduction potentials and electron transfer reactions of flavonoids radicals", In: Rice-Evans, C.A. and Packer, L., eds, Flavonoids in Health and Disease (Marcel Dekker, New York), pp 137-161.
22. Paganga, G., Miller, N. and Rice-Evans, C. (1999) "The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute?", Free Radic. Res. 30, 153-162.
23. Cao, G., Sofic, E. and Prior, R.L. (1996) "Antioxidant capacity of tea and common vegetables", J. Agric. Food Chem. 44, 3426-3431.
24. Wang, H., Cao, G. and Prior, R.L. (1996) "Total antioxidant capacity of fruits", J. Agric. Food Chem. 44, 701-705.
25. Halliwell, B. and Gutteridge, J.M.C. (1999) Free Radicals in Biology and Medicine (Oxford University Press, New York).
26. Hollman, P.C.H. and Katan, M.B. (1997) "Absorption, metabolism and health effects of dietary flavonoids in man", Biomed. Pharmacother. 51, 305-310.
27. Nielsen, S.E., Kall, M., Justesen, U., Schou, A. and Dragsted, L.O. (1997) "Human absorption and excretion of flavonoids after broccoli consumption", Cancer Lett. 114, 173-174.
28. Olthof, M.R., Hollman, P.C.H. and Katan, M.B. (2001) "Chlorogenic acid and caffeic acid are absorbed in humans", J. Nutr. 131, 66-71.
29. Hollman, P.C.H., Gaag, M.V.D., Mengelers, M.J.B., van Trijp, J.M.P., de Vries, J.H.M. and Katan, M.B. (1996) "Absorption and disposition kinetics of the dietary antioxidant quercetin in man", Free Radic. Biol. Med. 21, 703-707.
30. Murkovic, M., Toplak, H., Adam, U. and Pfannhauser, W. (2000) "Analysis of anthocyanins in plasma for determination of their bioavailability", J. Food Compos. Anal. 13, 291-296.
31. Scalbert, A. and Williamson, G. (2000) "Dietary intake and bioavailability of polyphenols", J. Nutr. 130, 2073S-2085S.
32. Rechner, A.R., Spencer, J.P.E., Kuhnle, G., Hahn, U. and Rice-Evans, C.A. (2001) "Novel biomarkers of the metabolism of caffeic acid derivatives in vivo", Free Radic. Biol. Med. 30, 1213-1222.
33. Oldreive, C., Zhao, K.C., Paganga, G., Halliwell, B. and Rice-Evans, C. (1998) "Inhibition of nitrous acid-dependent tyrosine nitration and DNA base deamination by flavonoids and other phenolic compounds", Chem. Res. Toxicol. 11, 1574-1579.
34. Speek, A.J., Schrijer, J. and Schreurs, W.H.P. (1984) "Fluorimetric determination of total Vitamin C in whole blood by high-performance liquid-chromatography with pre-column derivatization", J. Chromatogr. 305, 53-60.
35. Singleton, V.L. and Rossi, J.A. (1965) "Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents", Am. J. Enol. Vitic. 16, 144-158.
36. Re, R., Pellegrini, N,, Proteggente, A.R., Pannala, A.S. and Rice-Evans, C.A. (1999) "Antioxidant activity applying an improved ABTS radical cation decolorization assay", Free Radic. Biol. Med. 26, 1231-1237.
37. Benzie, L.F.F. and Strain, J.J. (1999) "Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration", Meth. Enzymol. 299, 15-27.
38. Cao, G., Verdon, C.P., Wu, A.H.B., Wang, H. and Prior, R.L. (1995) "Automated-assay of oxygen radical absorbance capacity with the COBAS FARA-II", Clin. Chem. 41, 1738-1744.
39. Hakkinen, S.H. and Torronen, A.R. (2000) "Content of flavonols and selected phenolic acid in strawberries and Vaccinium species: influence of cultivar, cultivation site and technique", Food Res. Int. 33, 517-524.
40. Merken, H.M. and Beecher, G.R. (2000) "Measurement of food flavonoids by high-performance liquid chromatography: a review", J. Agric. Food Chem. 48, 577-599.
41. Satué-Gracia, M.T., Heinonen, M. and Frankel, E.N. (1997) "Anthocyanins as antioxidants on human low-density lipoprotein and lecithin-liposome systems", J. Agric. Food Chem. 45, 3362-3367.
42. Ghiselli, A., Nardini, M., Baldi, A. and Scaccini, C. (1998) "Antioxidant activity of different phenolic fractions separated from an Italian red wine", J. Agric. Food Chem. 46, 361-367.
43. Bronner, W.E. and Beecher, G.R. (1995) "Extraction and measurement of prominent flavonoids in orange and grape-fruit concentrates", J. Chromatogr. A 705, 247-256.
44. Justesen, U., Knuthsen, P. and Leth, T. (1998) "Quantitative analysis of flavonols, flavones and flavanones in fruits, vegetables and beverages by high-performance liquid chromatography with photo-diode array and mass spectrometric detection", J. Chromatogr. A 799, 101-110.
45. Moon, J.-H., Nakata, R., Oshima, S., Inakuma, T. and Terao, J. (2000) "Accumulation of quercetin conjugates in blood plasma after short-term ingestion of onion by women", Am. J. Physiol-Regulat., Integr. Comp. Physiol. 279, R461-R467.
46. Price, K.R., Casuscelli, F., Colquhoun, I.J. and Rhodes, M.J.C. (1997) "Hydroxycinnamic acid esters from broccoli florets", Phytochemistry 45, 1683-1687.
47. Ferreres, F., Castañer, M. and Tomás-Barberán, F.A. (1997) "Acylated flavonol glycosides from spinach leaves (Spinacia oleracea)", Phytochemistry 45, 1701-1705.
48. Nielsen, J.K., Nørbaek, R. and Olsen, C.E. (1998) "Kaempferol tetraglucosides from cabbage leaves", Phytochemistry 49, 2171-2176.
49. Nielsen, J.K., Olsen, C.E. and Petersen, M.K. (1993) "Acylated flavonol glycosides from cabbage leaves", Phytochemistry 34, 539-544.
50. Plumb, G.W., Price, K.R., Rhodes, M.J.C. and Williamson, G. (1997) "Antioxidant properties of the major polyphenolic compounds in broccoli", Free Radic. Res. 27, 429-435.
51. Stewart, A.J., Bozonnet, S., Mullen, W., Jenkins, G.I., Lean, M.E.J. and Crozier, A. (2000) "Occurrence of flavonols in tomatoes and tomato-based products", J. Agric. Food Chem. 48, 2663-2669.
52. Heinonen, I.M., Meyer, A.S. and Frankel, E.N. (1998) "Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation", J. Agric. Food Chem. 46, 4107-4112.
53. Kalt, W., Forney, C.F., Martin, A. and Prior, R.L. (1999) "Antioxidant capacity, Vitamin C, phenolics and anthocyanins after fresh storage of small fruits", J. Agric. Food Chem. 47, 4638-4644.
54. Wang, S.Y and Lin, H.-S. (2000) "Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage", J. Agric. Food Chem. 48, 140-146.
55. Vinson, J.A., Hao, Y., Su, X. and Zubik, L. (1998) "Phenol antioxidant quantity and quality in foods: vegetables", J. Agric. Food Chem. 46, 3630-3634.
56. Sanoner, P., Guyot, S., Marnet, N., Molle, D. and Drilleau, J.-E (1999) "Polyphenol profiles of French cider apple varieties (Malus domestica sp.)", J. Agric. Food Chem. 47, 4847-4853.
57. Chang, S., Tan, C., Frankel, E.N. and Barrett, D. (2000) "Low-density lipoprotein antioxidant activity of phenolic compounds and polyphenol oxidase activity in selected cling-stone peach cultivars", J. Agric. Food Chem. 48, 147-151.
58. Gardner, PT., White, T.A.C., McPhail, D.B. and Duthie, G.G. (2000) "The relative contributions of Vitamin C, carotenoids and phenolics to the antioxidant potential of fruit juices", Food Chem. 68, 471-474.
59. Prior, R.L., Cap, G., Martin, A., Sofic, E., McEwen, J., O'Brien, C., Lischner, N., Ehlenfeldt, M., Kalt, W, Krewer, G. and Mainland, C.M. (1998) "Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species", J. Agric. Food Chem. 46, 2686-2693.
60. Kahkonen, M.P., Hopia, A.I., Vuorela, H.J., Rauha, J.-P, Pihlaja, K., Kujala, T.S. and Heinonen, M. (1999) "Antioxidant activity of plants extracts containing phenolic compounds", J. Agric. Food Chem. 47, 3954-3962.
61. Pekkarinen, S.S., Stockmann, H., Schwarz, K., Heinonen, I.M. and Hopia, A.I. (1999) "Antioxidant activity and partitioning of phenolic acids in bulk and emulsified methyl linoleate", J. Agric. Food Chem. 47, 3036-3043.
62. Gerritsen, M.E., Carley, W.W., Ranges, G.E., Shen, C.P., Phan, S.A., Ligon, G.F. and Perry, C.A. (1995) "Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression", Am. J. Pathol. 147, 278-292.
63. Panes, J., Gerritsen, M.E., Anderson, D.C., Miyasaka, M. and Granger, D.M. (1996) "Apigenin inhibits tumor necrosis factor-induced intercellular adhesion molecule-1 upregulation in vivo", Microcirculation 3, 279-286.
64. Soriani, M., Rice-Evans, C.A. and Tyrrell, R.M. (1998) "Modulation of the UVA activation of haem oxygenase, collagenase and cyclooxygenase gene expression by epigallocatechin in human skin cells", FEBS Lett. 439, 253-257.
65. Schroeter, H., Williams, R.J., Matin, R., Iversen, L. and Rice-Evans, C.A. (2000) "Phenolic antioxidants attenuate neuronal call death following uptake of oxidized low density lipoprotein", Free Radic. Biol. Med. 29, 1222-1233.
66. Spencer, J.P.E., Schroeter, H., Kuhnle, G., Srai, S.K.S., Tyrrell, R.M., Hahn, U. and Rice-Evans, C. (2001) "Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress-induced cell death involving caspace-3 activation", Biochem. J. 354, 493-500.
67. Schroeter, H., Spencer, J.P.E., Rice-Evans, C. and Williams, R.J. (2001) "Flavonoids protect neurones from oxidised low-density lipoprotein-induced apoptosis involving JNK, c-jun and caspase-3", Biochem. J., 358, 547-557.