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Volumn 12, Issue 5, 2002, Pages 347-357

DNA methylation changes in leukaemia

Author keywords

Cancer; DNA methyltransferase; Epigenetic; Leukaemia; Methylation

Indexed keywords

5 METHYLCYTOSINE; ACTIN; CALCITONIN; DNA METHYLTRANSFERASE; ESTROGEN RECEPTOR; PROTEIN P15; RETINOBLASTOMA PROTEIN; S ADENOSYLMETHIONINE; T LYMPHOCYTE RECEPTOR BETA CHAIN; UVOMORULIN;

EID: 0036387011     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1044-579X(02)00055-X     Document Type: Article
Times cited : (60)

References (83)
  • 2
    • 0025716314 scopus 로고
    • DNA methylation and epigenetic inheritance
    • Holliday R (1990) DNA methylation and epigenetic inheritance. Philos Trans R Soc Lond B Biol Sci 326:329-338
    • (1990) Philos Trans R Soc Lond B Biol Sci , vol.326 , pp. 329-338
    • Holliday, R.1
  • 4
    • 0032103212 scopus 로고    scopus 로고
    • Altered patterns of DNA methylation on chromosomes from leukemia cell lines: Identification of 5-methylcytosines by indirect immunodetection
    • Bensaada M, Kiefer H, Tachdjian G, Lapierre LM, Cacheux V, Niveleau A, Metezeau P (1998) Altered patterns of DNA methylation on chromosomes from leukemia cell lines: identification of 5-methylcytosines by indirect immunodetection. Cancer Genet Cytogenet 103:101-109
    • (1998) Cancer Genet Cytogenet , vol.103 , pp. 101-109
    • Bensaada, M.1    Kiefer, H.2    Tachdjian, G.3    Lapierre, L.M.4    Cacheux, V.5    Niveleau, A.6    Metezeau, P.7
  • 5
    • 0026317881 scopus 로고
    • High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer
    • El-Deiry WS, Nelkin BD, Celano P, Yen RW, Falco JP, Hamilton SR, Baylin SB (1991) High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer. Proc Natl Acad Sci USA 88: 3470-3474
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3470-3474
    • El-Deiry, W.S.1    Nelkin, B.D.2    Celano, P.3    Yen, R.W.4    Falco, J.P.5    Hamilton, S.R.6    Baylin, S.B.7
  • 6
    • 0030009868 scopus 로고    scopus 로고
    • Mechanisms for the involvement of DNA methylation in colon carcinogenesis
    • Schmutte C, Yang AS, Nguyen TT, Beart RW, Jones PA (1996) Mechanisms for the involvement of DNA methylation in colon carcinogenesis. Cancer Res 56:2375-2381
    • (1996) Cancer Res , vol.56 , pp. 2375-2381
    • Schmutte, C.1    Yang, A.S.2    Nguyen, T.T.3    Beart, R.W.4    Jones, P.A.5
  • 7
    • 0029812553 scopus 로고    scopus 로고
    • Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation
    • Lee PJ, Washer LL, Law DJ, Boland CR, Horon IL, Feinberg AP (1996) Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation. Proc Natl Acad Sci USA 93:10366-10370
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10366-10370
    • Lee, P.J.1    Washer, L.L.2    Law, D.J.3    Boland, C.R.4    Horon, I.L.5    Feinberg, A.P.6
  • 9
    • 0030006213 scopus 로고    scopus 로고
    • Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
    • Belinsky SA, Nikula KJ, Baylin SB, Issa JP (1996) Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci USA 93:4045-4050
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4045-4050
    • Belinsky, S.A.1    Nikula, K.J.2    Baylin, S.B.3    Issa, J.P.4
  • 10
    • 0031907905 scopus 로고    scopus 로고
    • Increased DNA methyltransferase expression in leukemia
    • Melki JR, Warnecke P, Vincent PC, Clark SJ (1998) Increased DNA methyltransferase expression in leukemia. Leukemia 12:311-316
    • (1998) Leukemia , vol.12 , pp. 311-316
    • Melki, J.R.1    Warnecke, P.2    Vincent, P.C.3    Clark, S.J.4
  • 11
    • 0035283201 scopus 로고    scopus 로고
    • Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    • Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, Niho Y, Sasaki H (2001) Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 97:1172-1179
    • (2001) Blood , vol.97 , pp. 1172-1179
    • Mizuno, S.1    Chijiwa, T.2    Okamura, T.3    Akashi, K.4    Fukumaki, Y.5    Niho, Y.6    Sasaki, H.7
  • 13
    • 0010648051 scopus 로고
    • Proliferative activity of blast cells in leukemia and myelofibrosis. Morphological differences between proliferating and non-proliferating blast cells
    • Killmann SA (1965) Proliferative activity of blast cells in leukemia and myelofibrosis. Morphological differences between proliferating and non-proliferating blast cells. Acta Med Scand 178:263-280
    • (1965) Acta Med Scand , vol.178 , pp. 263-280
    • Killmann, S.A.1
  • 14
    • 0027504621 scopus 로고
    • Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH-3T3 cells
    • Wu JJ, Issa JP, Herman JG, Bassett DE, Nelkin BD, Baylin SB (1993) Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH-3T3 cells. Proc Natl Acad Sci USA 90:8891-8895
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8891-8895
    • Wu, J.J.1    Issa, J.P.2    Herman, J.G.3    Bassett, D.E.4    Nelkin, B.D.5    Baylin, S.B.6
  • 16
    • 0029868994 scopus 로고    scopus 로고
    • Overproduction of DNA cytosine methyltransferases causes methylation and C→T mutations at non-canonical sites
    • Bandaru B, Gopal J, Bhagwat AS (1996) Overproduction of DNA cytosine methyltransferases causes methylation and C→T mutations at non-canonical sites. J Biol Chem 271:7851-7859
    • (1996) J Biol Chem , vol.271 , pp. 7851-7859
    • Bandaru, B.1    Gopal, J.2    Bhagwat, A.S.3
  • 17
    • 0025145277 scopus 로고
    • 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
    • Rideout III WM, Coetzee GA, Olumi AF, Jones PA (1990) 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 249:1288-1290
    • (1990) Science , vol.249 , pp. 1288-1290
    • Rideout W.M. III1    Coetzee, G.A.2    Olumi, A.F.3    Jones, P.A.4
  • 19
    • 17144460958 scopus 로고
    • Hypomethylation of DNA: A nongenotoxic mechanism involved in tumor promotion
    • Counts JL, Goodman JI (1995) Hypomethylation of DNA: a nongenotoxic mechanism involved in tumor promotion. Toxicol Lett 82/83:663-672
    • (1995) Toxicol Lett , vol.82-83 , pp. 663-672
    • Counts, J.L.1    Goodman, J.I.2
  • 20
    • 0029824194 scopus 로고    scopus 로고
    • Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma
    • Cravo M, Pinto R, Fidalgo P, Chaves P, Gloria L, Nobreleitao C, Mira FC (1996) Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma. Gut 39:434-438
    • (1996) Gut , vol.39 , pp. 434-438
    • Cravo, M.1    Pinto, R.2    Fidalgo, P.3    Chaves, P.4    Gloria, L.5    Nobreleitao, C.6    Mira, F.C.7
  • 22
    • 0027256637 scopus 로고
    • Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency
    • Christman JK, Sheikhnejad G, Dizik M, Abileah S, Wainfan E (1993) Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. Carcinogenesis 14:551-557
    • (1993) Carcinogenesis , vol.14 , pp. 551-557
    • Christman, J.K.1    Sheikhnejad, G.2    Dizik, M.3    Abileah, S.4    Wainfan, E.5
  • 23
    • 0028925741 scopus 로고
    • Breaks in genomic DNA and within the p53gene are associated with hypomethylation in livers of folate/methyl-deficient rats
    • Pogribny IP, Basnakian AG, Miller BJ, Lopatina NG, Poirier LA, James SJ (1995) Breaks in genomic DNA and within the p53gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res 55:1894-1901
    • (1995) Cancer Res , vol.55 , pp. 1894-1901
    • Pogribny, I.P.1    Basnakian, A.G.2    Miller, B.J.3    Lopatina, N.G.4    Poirier, L.A.5    James, S.J.6
  • 24
    • 0031149098 scopus 로고    scopus 로고
    • Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat
    • Pogribny IP, Miller BJ, James SJ (1997) Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat. Cancer Lett 115:31-38
    • (1997) Cancer Lett , vol.115 , pp. 31-38
    • Pogribny, I.P.1    Miller, B.J.2    James, S.J.3
  • 25
    • 17144441661 scopus 로고
    • A microassay for measuring cytosine DNA methyltransferase activity during tumor progression
    • Belinsky SA, Nikula KJ, Baylin SB, Issa JP (1995) A microassay for measuring cytosine DNA methyltransferase activity during tumor progression. Toxicol Lett 82/83:335-340
    • (1995) Toxicol Lett , vol.82-83 , pp. 335-340
    • Belinsky, S.A.1    Nikula, K.J.2    Baylin, S.B.3    Issa, J.P.4
  • 29
    • 0031662164 scopus 로고    scopus 로고
    • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
    • Walsh CP, Chaillet JR, Bestor TH (1998) Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet 20:116-117
    • (1998) Nat Genet , vol.20 , pp. 116-117
    • Walsh, C.P.1    Chaillet, J.R.2    Bestor, T.H.3
  • 30
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B (1983) Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301:89-92
    • (1983) Nature , vol.301 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 31
    • 0032468051 scopus 로고    scopus 로고
    • Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
    • Nakamura N, Takenaga K (1998) Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines. Clin Exp Metastasis 16:471-479
    • (1998) Clin Exp Metastasis , vol.16 , pp. 471-479
    • Nakamura, N.1    Takenaga, K.2
  • 32
    • 0032403478 scopus 로고    scopus 로고
    • Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias
    • Nakayama M, Wada M, Harada T, Nagayama J, Kusaba H, Ohshima K, Kozuru M, Komatsu H, Ueda R, Kuwano M (1998) Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias. Blood 92:4296-4307
    • (1998) Blood , vol.92 , pp. 4296-4307
    • Nakayama, M.1    Wada, M.2    Harada, T.3    Nagayama, J.4    Kusaba, H.5    Ohshima, K.6    Kozuru, M.7    Komatsu, H.8    Ueda, R.9    Kuwano, M.10
  • 33
    • 0030983076 scopus 로고    scopus 로고
    • DNA methylation and genetic instability in colorectal cancer cells
    • Lengauer C, Kinzler KW, Vogelstein B (1997) DNA methylation and genetic instability in colorectal cancer cells. Proc Natl Acad Sci USA 94:2545-2550
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2545-2550
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 34
    • 0025159811 scopus 로고
    • Presence of cell lineage-specific hypomethylated sites in the major breakpoint cluster region
    • Litz CE, Goldfarb AN, Strickler JG, Brunning RD (1990) Presence of cell lineage-specific hypomethylated sites in the major breakpoint cluster region. Cancer Res 50:4984-4990
    • (1990) Cancer Res , vol.50 , pp. 4984-4990
    • Litz, C.E.1    Goldfarb, A.N.2    Strickler, J.G.3    Brunning, R.D.4
  • 35
  • 36
    • 0026443770 scopus 로고
    • T-cell receptor beta chain gene rearrangement in acute myeloid leukemia always occurs at the allele that contains the undermethylated J beta 1 region
    • Ohyashiki JH, Ohyashiki K, Kawakubo K, Tauchi T, Nakazawa S, Kimura N, Toyama K (1992) T-cell receptor beta chain gene rearrangement in acute myeloid leukemia always occurs at the allele that contains the undermethylated J beta 1 region. Cancer Res 52:6598-6602
    • (1992) Cancer Res , vol.52 , pp. 6598-6602
    • Ohyashiki, J.H.1    Ohyashiki, K.2    Kawakubo, K.3    Tauchi, T.4    Nakazawa, S.5    Kimura, N.6    Toyama, K.7
  • 40
    • 0028898746 scopus 로고
    • Transcriptional silencing of human alu sequences and inhibition of protein binding in the box b regulatory elements by 5′-CG-3′ methylation
    • Kochanek S, Renz D, Doerfler W (1995) Transcriptional silencing of human alu sequences and inhibition of protein binding in the box b regulatory elements by 5′-CG-3′ methylation. FEBS Lett 360:115-120
    • (1995) FEBS Lett , vol.360 , pp. 115-120
    • Kochanek, S.1    Renz, D.2    Doerfler, W.3
  • 42
    • 0027304429 scopus 로고
    • Nucleosome interactions with a human alu element - Transcriptional repression and effects of template methylation
    • Englander EW, Wolffe AP, Howard BH (1993) Nucleosome interactions with a human alu element - transcriptional repression and effects of template methylation. J Biol Chem 268:19565-19573
    • (1993) J Biol Chem , vol.268 , pp. 19565-19573
    • Englander, E.W.1    Wolffe, A.P.2    Howard, B.H.3
  • 44
    • 0033179375 scopus 로고    scopus 로고
    • Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia
    • Melki JR, Vincent PC, Clark SJ (1999) Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res 59:3730-3740
    • (1999) Cancer Res , vol.59 , pp. 3730-3740
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 48
    • 0033545329 scopus 로고    scopus 로고
    • Detailed methylation analysis of the glutathione S-transferase Pi (GSTP1) gene in prostate cancer
    • Millar DS, Ow KK, Paul CL, Russell PJ, Molloy PL, Clark SJ (1999) Detailed methylation analysis of the glutathione S-transferase Pi (GSTP1) gene in prostate cancer. Oncogene 18:1313-1324
    • (1999) Oncogene , vol.18 , pp. 1313-1324
    • Millar, D.S.1    Ow, K.K.2    Paul, C.L.3    Russell, P.J.4    Molloy, P.L.5    Clark, S.J.6
  • 50
    • 0031025368 scopus 로고    scopus 로고
    • Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies
    • Herman JG, Civin CI, Issa JP, Collector MI, Sharkis SJ, Baylin SB (1997) Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res 57:837-841
    • (1997) Cancer Res , vol.57 , pp. 837-841
    • Herman, J.G.1    Civin, C.I.2    Issa, J.P.3    Collector, M.I.4    Sharkis, S.J.5    Baylin, S.B.6
  • 52
    • 0025900902 scopus 로고
    • Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation
    • Malinen T, Palotie A, Pakkala S, Peltonen L, Ruutu T, Jansson SE (1991) Acceleration of chronic myeloid leukemia correlates with calcitonin gene hypermethylation. Blood 77:2435-2440
    • (1991) Blood , vol.77 , pp. 2435-2440
    • Malinen, T.1    Palotie, A.2    Pakkala, S.3    Peltonen, L.4    Ruutu, T.5    Jansson, S.E.6
  • 56
    • 0033215453 scopus 로고    scopus 로고
    • p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing
    • Cameron EE, Baylin SB, Herman JG (1999) p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing. Blood 94:2445-2451
    • (1999) Blood , vol.94 , pp. 2445-2451
    • Cameron, E.E.1    Baylin, S.B.2    Herman, J.G.3
  • 57
    • 85047695221 scopus 로고    scopus 로고
    • Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells
    • in press
    • Song JZ, Stirzaker C, Harrison J, Melki JR, Clark SJ (2002) Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells. Oncogene (in press)
    • (2002) Oncogene
    • Song, J.Z.1    Stirzaker, C.2    Harrison, J.3    Melki, J.R.4    Clark, S.J.5
  • 59
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X, Ng HH, Johnson CA, Laherty CD, Turner BM, Eisenman RN, Bird A (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393:386-389
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 60
    • 0032574859 scopus 로고    scopus 로고
    • Gene silencing. Methylation meets acetylation
    • Bestor TH (1998) Gene silencing. Methylation meets acetylation. Nature 393:311-312
    • (1998) Nature , vol.393 , pp. 311-312
    • Bestor, T.H.1
  • 61
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB (1999) Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 21:103-107
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 62
    • 0034105545 scopus 로고    scopus 로고
    • DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: Clinical results and possible mechanisms of action
    • Lubbert M (2000) DNA methylation inhibitors in the treatment of leukemias, myelodysplastic syndromes and hemoglobinopathies: clinical results and possible mechanisms of action. Curr Top Microbiol Immunol 249:135-164
    • (2000) Curr Top Microbiol Immunol , vol.249 , pp. 135-164
    • Lubbert, M.1
  • 64
    • 0027239823 scopus 로고
    • Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
    • Hanada M, Delia D, Aiello A, Stadtmauer E, Reed JC (1993) Bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia. Blood 82:1820-1828
    • (1993) Blood , vol.82 , pp. 1820-1828
    • Hanada, M.1    Delia, D.2    Aiello, A.3    Stadtmauer, E.4    Reed, J.C.5
  • 65
    • 0024339596 scopus 로고
    • Analysis of ras gene mutations and methylation state in human leukemias
    • Browett PJ, Norton JD (1989) Analysis of ras gene mutations and methylation state in human leukemias. Oncogene 4:1029-1036
    • (1989) Oncogene , vol.4 , pp. 1029-1036
    • Browett, P.J.1    Norton, J.D.2
  • 66
    • 0025895882 scopus 로고
    • Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation
    • Lubbert M, Miller CW, Koeffler HP (1991) Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation. Blood 78:345-356
    • (1991) Blood , vol.78 , pp. 345-356
    • Lubbert, M.1    Miller, C.W.2    Koeffler, H.P.3
  • 67
    • 0026800684 scopus 로고
    • A switch toward demethylation is associated with the expression of myeloperoxidase in acute myeloblastic and promyelocytic leukemias
    • Lubbert M, Oster W, Ludwig WD, Ganser A, Mertelsmann R, Herrmann F (1992) A switch toward demethylation is associated with the expression of myeloperoxidase in acute myeloblastic and promyelocytic leukemias. Blood 80:2066-2073
    • (1992) Blood , vol.80 , pp. 2066-2073
    • Lubbert, M.1    Oster, W.2    Ludwig, W.D.3    Ganser, A.4    Mertelsmann, R.5    Herrmann, F.6
  • 68
    • 0033758181 scopus 로고    scopus 로고
    • Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia
    • Watt PM, Kumar R, Kees UR (2000) Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia. Genes Chromosomes Cancer 29:371-377
    • (2000) Genes Chromosomes Cancer , vol.29 , pp. 371-377
    • Watt, P.M.1    Kumar, R.2    Kees, U.R.3
  • 71
    • 0025874367 scopus 로고
    • Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia
    • Nelkin BD, Przepiorka D, Burke PJ, Thomas ED, Baylin SB (1991) Abnormal methylation of the calcitonin gene marks progression of chronic myelogenous leukemia. Blood 77:2431-2434
    • (1991) Blood , vol.77 , pp. 2431-2434
    • Nelkin, B.D.1    Przepiorka, D.2    Burke, P.J.3    Thomas, E.D.4    Baylin, S.B.5
  • 72
    • 0027302339 scopus 로고
    • Development of molecular genetic methods for monitoring myeloid malignancies
    • Palotie A, Syvanen AC (1993) Development of molecular genetic methods for monitoring myeloid malignancies. Scand J Clin Lab Invest Suppl
    • (1993) Scand J Clin Lab Invest Suppl
    • Palotie, A.1    Syvanen, A.C.2
  • 75
    • 0033046553 scopus 로고    scopus 로고
    • Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia
    • Melki JR, Vincent PC, Clark SJ (1999) Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia. Leukemia 13:877-883
    • (1999) Leukemia , vol.13 , pp. 877-883
    • Melki, J.R.1    Vincent, P.C.2    Clark, S.J.3
  • 76
    • 0030046322 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B
    • Herman JG, Jen J, Merlo A, Baylin SB (1996) Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B. Cancer Res 56:722-727
    • (1996) Cancer Res , vol.56 , pp. 722-727
    • Herman, J.G.1    Jen, J.2    Merlo, A.3    Baylin, S.B.4
  • 78
    • 0033188280 scopus 로고    scopus 로고
    • Homozygous deletion and methylation of p16 and p15 gene in acute leukemia
    • Chen W, Zhang W, Zhu J (1999) Homozygous deletion and methylation of p16 and p15 gene in acute leukemia. Zhonghua Xue Ye Xue Za Zhi 20:474-476
    • (1999) Zhonghua Xue Ye Xue Za Zhi , vol.20 , pp. 474-476
    • Chen, W.1    Zhang, W.2    Zhu, J.3
  • 82
    • 0033215506 scopus 로고    scopus 로고
    • Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells
    • Dottori M, Down M, Huttmann A, Fitzpatrick DR, Boyd AW (1999) Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells. Blood 94:2477-2486
    • (1999) Blood , vol.94 , pp. 2477-2486
    • Dottori, M.1    Down, M.2    Huttmann, A.3    Fitzpatrick, D.R.4    Boyd, A.W.5
  • 83
    • 0034662782 scopus 로고    scopus 로고
    • Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2
    • Tatarelli C, Linnenbach A, Mimori K, Croce CM (2000) Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2. Genomics 68:1-12
    • (2000) Genomics , vol.68 , pp. 1-12
    • Tatarelli, C.1    Linnenbach, A.2    Mimori, K.3    Croce, C.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.