Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat

Cancer Letters

Volumn 115, Issue 1, 1997, Pages 31-38

  Pogribny, Igor P ^a   Miller, Barbara J ^a   James, S Jill ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Cytosine methylation; Hepatocarcinogenesis; Methyl deficiency; p53 gene; Tumor progression

Indexed keywords

CELL DNA; CYTOSINE; FOLIC ACID; MESSENGER RNA; METHYL GROUP; METHYLTRANSFERASE; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; DNA STRAND; ENZYME ACTIVITY; EXON; FOLIC ACID DEFICIENCY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; NUTRITIONAL DEFICIENCY; PRECANCER; PRIORITY JOURNAL; RAT; TUMOR GROWTH;

ANIMALS; CYTOSINE; DNA METHYLATION; DNA MODIFICATION METHYLASES; FOLIC ACID DEFICIENCY; GENES, P53; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; RNA, MESSENGER;

ANIMALIA; MAMMALIA;

EID: 0031149098     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)04708-3     Document Type: Article

References (34)

1. [1] Arnaud, M., Dante, R. and Niveleau, A. (1985) DNA methyltransferases in normal and avian sarcoma virus-transformed rat cells. Quantitation of 5-methyldeoxycytosine in DNA and enzyme kinetics study, Biochim. Biophys. Acta, 826, 108-112.
2. [2] Balaghi, M. and Wagner, C. (1993) DNA methylation in folate deficiency: use of CpG methylase, Biochem. Biophys. Res. Commun., 193, 1184-1190.
3. [3] Baylin, S.B., Herman, J.G., Wales, M.M., Vertino, P., Wu, J., Kuerbitz, S. and Issa, J.-P. (1995) Hypermethylation of CpG islands and inactivation of tumor suppressor genes, Proc. Am. Assoc. Cancer Res., 36, 691-692.
4. [4] Bestor, T.H. (1992) Activation of mammalian DNA methyltransferase by cleavage of a zinc binding regulatory domain, EMBO J., 7, 2611-2617.
5. [5] Bestor, T.H., Laudano, A., Mattaliano, R. and Ingram, V. (1988) Cloning and sequencing of a cDNA encoding DNA methyltransferase in mouse cells. The carboxyl terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases, J. Mol. Biol., 203, 971-983.
6. [6] Bestor, T.H. and Tycko, B. (1996) Creation of genomic methylation patterns, Nature, 12, 363-367.
7. [7] Christman, J.K., Sheikhnejad, G., Dizik, M., Abileah, S. and Wainfan, E. (1993) Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency, Carcinogenesis, 14, 551-557.
8. [8] Clark, S.J., Harrison, J. and Frommer, M. (1995) CpNpG methylation in mammalian cells, Nature Genet., 10, 20-27.
9. [9] Clark, S.J., Harrison, J., Paul, C.L. and Frommer, M. (1994) High sensitivity mapping of methylated cytosines, Nucleic Acids Res., 22, 2990-2997.
10. [10] Gama-Sosa, M.A., Slagel, V.A., Trewyn, R.W., Oxenhandler, R., Kuo, K.C., Gehhhrke, C.W. and Ehrlich, M. (1983) The 5-methylcytosine content of DNA from human tumors, Nucleic Acids Res., 11, 6883-6894.
11. [11] Goelz, S.E., Vogelstein, B., Hamilaton, S.R. and Feinberg, A.P. (1985) Hypomethylation of DNA from benign and malignant neoplasms, Science, 228, 187-190.
12. [12] Gottlieb, T.M. and Oren, M. (1996) p53 in growth control and neoplasia, Biochim. Biophys. Acta Rev. Cancer, 1287, 77-102.
13. [13] Hohn, T., Corsten, S., Rieke, S., Müller, M. and Rothnie, H. (1996) Methylation of coding region alone inhibits gene expression in plant protoplasts, Proc. Natl. Acad. Sci. USA, 93, 8334-8339.
14. [14] Issa, J.P., Vertino, P.M., Wu, J., Sazawal, S., Celano, P., Nelkin, B., Hamilton, S.R. and Baylin, S.B. (1993) Increased cytosine DNA-methyltransferase activity during colon cancer progression, J. Natl. Cancer Inst., 85, 1235-1240.
15. [15] Kastan, M.B. (1996) Signalling to p53: where does it all start?, BioEssays, 18, 617-619.
16. [16] Keshet, I., Lieman-Hurwitz, J. and Cedar, H. (1986) DNA methylation affects for formation of active chromatin, Cell, 44, 535-543.
17. [17] Klimasauskas, S., Kumar, S., Roberts, R.J. and Cheng, X. (1994) Hhal methyltransferase flips its target base out of the DNA helix, Cell, 76, 357-369.
18. [18] Komura, J., Okada, T. and Ono, T. (1995) Repression of transient expression by DNA methylation in transcribed regions of reporter genes introduced into cultured human cells, Biochim. Biophys. Acta, 1260, 73-78.
19. [19] Laird, P.W. and Jaenisch, R. (1994) DNA methylation and cancer, Hum. Mol. Genet., 3, 1487-1495.
20. [20] Levine, A.J. and Zambetti, G.P. (1993) A comparison of the biological activities of wild-type and mutant p53, FASEB J., 7, 855-865.
21. [21] Magewu, A.N. and Jones, P.A. (1994) Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer, Mol. Cell. Biol., 14, 4225-4232.
22. [22] Martienssen, R.A. and Richards, E.J. (1995) DNA methylation in eukaryotes, Curr. Opin. Genet. Dev., 5, 234-242.
23. [23] Meehan, R., Lewis, J., Cross, S., Nan, X., Jeppesen, P. and Bird, A. (1992) Transcriptional repression by methylation of CpG, J. Cell Sci., 103 (Suppl. 16), 9-14.
24. [24] Paul, C.L. and Clark, S.J. (1996) Cytosine methylation: quantitation by automated genomic sequencing and GENESCAN(TM) analysis, BioTechniques, 21, 126-133.
25. [25] Pogribny, I.P., Basnakian, A.G., Miller, B.J., Lopatina, N.G., Poirier, L.A. and James, S.J. (1995) Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats, Cancer Res., 55, 1894-1901.
26. [26] Pogribny, I.P., Poirier, L.A. and James, S.J. (1995) Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl-deficient rats, Carcinogenesis, 16, 2863-2867.
27. [27] Shen, J., Rideout, W.M. and Jones, P.A. (1992) High frequency mutagenesis by a DNA methyltransferase, Cell, 71, 1073-1080.
28. [28] Smith, M.L., Yeleswarapu, L., Scalamogna, P., Locker, J. and Lombardi, B. (1993) p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male F344 rats, Carcinogenesis, 14, 503-510.
29. [29] Soussi, T., de Fromentel, C.C. and May, P. (1990) Structural aspects of the p53 gene protein in relation to gene evolution, Oncogene, 5, 945-952.
30. [30] Szyf, M. (1996) The DNA methylation machinery as a target for anticancer therapy, Pharmacol. Ther., 70, 1-37.
31. [31] Tornaletti, S. and Pfeifer, G.P. (1995) Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers, Oncogene, 10, 1493-1499.
32. [32] Tucker, K.L., Beard, C., Dausman, J., Jackson-Grusby, L., Laird, P.W., Lei, H. and Jaenisch, R. (1996) Germ-line passage is required for establishment of methylation and expression patterns of imprinted genes but not nonimprinted genes, Genes Dev., 10, 1008-1020.
33. [33] Wu, J.J., Herman, J.G., Wilson, G., Lee, R.Y., Yen, R.W.C., Mabry, M., De Bustros, A., Nelkin, B.D. and Baylin, S.B. (1996) Expression of prokaryotic Hhal DNA methyltransferase is transforming and lethal to NIH 3T3 cells, Cancer Res., 56, 616-622.
34. [34] Xu, G., Flynn, J., Glickman, J.F. and Reich, N. (1995) Purification and stabilization of mouse DNA methyltransferase, Biochem. Biophys. Res Commun., 207, 544-551.