Characterization of the human TESTIN gene localized in the FRA7G region at 7q31.2

Genomics

Volumn 68, Issue 1, 2000, Pages 1-12

  Tatarelli, Caterina ^a   Linnenbach, Alban ^a   Mimori, Koshi ^a   Croce, Carlo M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTESTOSTERONE;

ARTICLE; CANCER; CANCER RISK; CARCINOGENESIS; CHROMOSOME 7Q; CHROMOSOME ABERRATION; GENE LOCATION; GENE LOCUS; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0034662782     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6272     Document Type: Article

References (59)

1. Chromosome 7q allelic losses in pancreatic carcinoma
2. Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse
3. Genetic alteration mapping on chromosome 7 in primary breast cancer
4. Integrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B
5. FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease
6. Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis
7. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
8. LIM domains: Multiple roles as adapters and functional modifiers in protein interactions
9. Loss of heterozygosity at 7q31 in breast cancer: Results from an International Collaborative Study Group. The Breast Cancer Somatic Genetics Consortium
10. Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1
11. Loss of heterozygosity at the familial RCC t(3;8) locus in most clear cell renal carcinomas
12. Identification of a 1300 kilobase deletion unit on chromosome 7q31.3 in invasive epithelial ovarian carcinomas
13. Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31.1), a known fragile site (FRA7G) that is frequently deleted in human cancers
14. Inactivation of p16 in human mammary epithelial cells by CpG island methylation
15. Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11
16. Instability at chromosomal fragile sites
17. Bcl-2 gene hypomethylation and high-level expression in B-all chronic lymphocytic leukemia
18. Hypermethylation of tumor suppressor genes in cancer
19. Fish mapping of YAC clones at human chromosomal band 7q31.2: Identification of YACs spanning FRA7G within the common region of LOH in breast and prostate cancer
20. FRA7G extends over a broad region: Coincidence of human endogenous retroviral sequences (HERV-H) and small polydispersed circular DNAs (spcDNA) and fragile sites
21. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer
22. The role of the FHIT/FRA3B locus in cancer
23. Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary turnouts and tumour-derived cell lines
24. Sequence of the FRA3B common fragile region: Implications for the mechanism of FHIT deletion
25. A molecular cytogenetic analysis of 7q31 in prostate cancer
26. Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression
27. Hypermethylation of the DAP-kinase CpG island is a common alteration in B-cell malignancies
28. Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation
29. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3
30. Frequent loss of heterozygosity in the region of the D7S523 locus in advanced ovarian cancer
31. Allelotyping of acute myelogenous leukemia: Loss of heterozygosity at 7q31.1 (D7S486) and q33-q34 (D7S498, D7S505)
32. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs
33. Loss of heterozygosity at 7q31 is a frequent and early event in prostate cancer
34. Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: Implications for the mechanism of fragile site induction
35. Molecular anatomy of chromosome 7q deletions in myeloid neoplasms: Evidence for multiple critical loci
36. Detailed deletion mapping with a refined physical map of 7q31 localizes a putative tumor suppressor gene for breast cancer in the region of MET
37. Loss of heterozygosity of chromosome 9p21 and 7q31 is correlated with high incidence of recurrent tumor in head and neck squamous cell carcinoma
38. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
39. Cancer-specific chromosome alterations in the constitutive fragile region FRA3B
40. Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site
41. Commonly deleted region on the long arm of chromosome 7 in differentiated adenocarcinoma of the stomach
42. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
43. Characteristics of Epstein-Barr virus transformed B cell lines from patients with Alzheimer's disease and age-matched controls
44. LIM domain proteins in leukaemia and development
45. The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control
46. Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors
47. Loss of heterozygosity on the long arm of human chromosome 7 in sporadic renal cell carcinomas
48. DNA methylation
49. Replacement of Fhit in cancer cells suppresses tumorigenicity
50. The most common fragile site in man is 3p14
51. Common fragile sites and cancer
52. The FHIT gene 3p14.2 is abnormal in lung cancer
53. Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas
54. Loss of heterozygosity of the long arm of chromosome 7 in follicular and anaplastic thyroid cancer, but not in papillary thyroid cancer
55. p53 Activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3
56. Constitutive fragile sites and cancer
57. Frequent loss of heterozygosity in human primary squamous cell and colon carcinomas at 7q31.1: Evidence for a broad range tumor suppressor gene
58. Differential loss of heterozygosity at 7q31.2 in follicular and papillary thyroid tumors