Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation

Leukemia Research

Volumn 25, Issue 6, 2001, Pages 441-447

  Liu, Mingli ^a,b   Taketani, Takeshi ^a   Li, Rongsheng ^b   Takita, Junko ^a   Taki, Tomohiko ^a   Yang, Hong Wei ^a   Kawaguchi, Hiroyuki ^a   Ida, Kohmei ^a   Matsuo, Yoshinobu ^c   Hayashi, Yasuhide ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^c HAYASHIBARA BIOCHEMICAL LABORATORIES INC   (Japan)

Author keywords

Acute lymphoblastic leukemia; Methylation; p53 gene; p73 gene

Indexed keywords

BISULFITE; MESSENGER RNA; PROTEIN P53; PROTEIN P73; RESTRICTION ENDONUCLEASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B CELL LEUKEMIA; BURKITT LYMPHOMA; CONTROLLED STUDY; DNA METHYLATION; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; T CELL LEUKEMIA;

CPG ISLANDS; DNA METHYLATION; DNA-BINDING PROTEINS; EXONS; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, ACUTE; NUCLEAR PROTEINS; RNA, MESSENGER; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0035028445     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(00)00148-X     Document Type: Article

References (34)

1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
2. New p73 variants with altered C-terminal structures have varied transcriptional activities
3. Two new p73 splice variants, gamma and delta, with different transcriptional activity
4. Overexpression of the wild type p73 gene in breast cancer tissues and cell lines
5. DNA damage enables p73
6. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
7. Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines
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12. Activation of p73 silent allele in lung cancer
13. Alterations of p73 preferentially occur in gastric adenocarcinomas with foveolar epithelial phenotype
14. Overexpression of the wild type p73 gene in human bladder cancer
15. Elevated and biallelic expression of p73 is associated with progression of human bladder cancer
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