3′-3′-linked oligonucleotides: Synthesis and stability studies

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 7, 1996, Pages 827-832

  Chaix, Carole ^a   Iyer, Radhakrishnan P ^a   Agrawal, Sudhir ^a  

^a HYBRIDON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGONUCLEOTIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN;

EID: 0029981506     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00115-1     Document Type: Article

References (13)

1. Uhlmann, E.; Peyman, A. Chem. Rev. 1990, 90, 544.
2. Zamecnik, P. C.; Stephenson, M. L. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 280.
3. Agrawal, S.; Iyer, R. P. Curr. Op. Biotech. 1995, 6, 12 and references therein.
4. Walder, R. Y.; Walder, J. A. Proc. Natl. Acad. Sci. USA 1988, 85, 5011.
5. Agrawal, S.; Lisziewicz, J. J. Biotech. Healthcare 1994, 1, 167.
6. Temsamani, J.; Tang, J.-Y.; Padmapriya, A.; Kubert, M.; Agrawal, S. Antisense Res. Dev. 1993, 3, 277and references therein.
7. Ramalho Ortigao, J. F.; Rosch, H.; Selter, H.; Frohlich, A.; Lorenz, A.; Montenach, M.; Seliger, H. Antisense Res. Dev. 1992, 2, 129.
8. Koga, M.; Moore, M. F.; Beaucage, S. L. J. Org. Chem. 1991, 56, 3757.
9. (a) Beaucage, S. L. In Protocols for Oligonucleotides and Analogs; Agrawal, S., Ed.; Humana Press: Totowa, NJ, 1993; Vol. 20, pp 33-61;
10. (b) CPG-linked nucleosides, nucleoside phosphoramidite monomers and other DNA synthesis reagents were obtained from commercial sources and used as such.
11. Pompon, A.; Lefebvre, I.; Imbach, J. -L. Biochem. Pharmacol. 1992, 43, 1769.
12. For a comparative stability study involving PO and PS oligonucleotides, see: Sands, H.; Gorey-Feret, L. J.; Cocuzza, A. J.; Hobbs, F. W.; Chidester, D.; Trainor, G. L. Mol. Pharmacol. 1994, 45, 932.
13. Agrawal, S.; Temsamani, J.; Galbraith, W.; Tang, J.Y. Clin. Pkarmacokinet. 1995, 28, 7 and references therein.