Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.

International journal of oncology

Volumn 21, Issue 1, 2002, Pages 73-80

  Wang, Hui ^a   Hang, Jie ^a   Shi, Zhenqi ^a   Li, Mao ^a   Yu, Dong ^a   Kandimalla, Ekambar R ^a   Agrawal, Sudhir ^a   Zhang, Ruiwen ^a  

^a University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; CAMPTOTHECIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE; GENE EXPRESSION MODULATOR 231; IRINOTECAN; OLIGONUCLEOTIDE;

ANIMAL; ARTICLE; BODY WEIGHT; BREAST TUMOR; CANCER TRANSPLANTATION; COLON TUMOR; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; EXPERIMENTAL NEOPLASM; FEMALE; GENETICS; HUMAN; LUNG TUMOR; MALE; METABOLISM; MOUSE; NUDE MOUSE; PROSTATE TUMOR; SURVIVAL RATE; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BODY WEIGHT; BREAST NEOPLASMS; CAMPTOTHECIN; COLONIC NEOPLASMS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PROSTATIC NEOPLASMS; SURVIVAL RATE; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

EID: 0036653149     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (0)