Introduction to immunostimulatory DNA sequences

Springer Seminars in Immunopathology

Volumn 22, Issue 1-2, 2000, Pages 1-9

  Van Uden, John ^a   Raz, Eyal ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BCG VACCINE; BETA INTERFERON; GAMMA INTERFERON; PALINDROMIC DNA;

ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; B LYMPHOCYTE ACTIVATION; DENDRITIC CELL; DNA DETERMINATION; DNA SEQUENCE; IMMUNE RESPONSE; IMMUNITY; IMMUNOSTIMULATION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL KILLER CELL; PLASMID; PRIORITY JOURNAL; REVIEW; TH1 CELL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN-PRESENTING CELLS; BASE SEQUENCE; CPG ISLANDS; DNA; DNA, BACTERIAL; FORECASTING; FREUND'S ADJUVANT; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; LYMPHOCYTE ACTIVATION; MICE; MODELS, IMMUNOLOGICAL; MYCOBACTERIUM BOVIS; TH1 CELLS;

EID: 0033741199     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002810050010     Document Type: Review

References (32)

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4. Functions for DNA methylation in vertebrates
5. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
6. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
7. Sensitization and antibody formation after injection of tubercule bacilli and paraffin oil
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11. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
12. CpG motifs in bacterial DNA trigger direct B-cell activation
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14. Activation of macrophages and B lymphocytes by an oligodeoxynucleotide derived from an acutely pathogenic simian immunodeficiency virus
15. Activation of human B cells by phosphorothioate oligodeoxynucleotides
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21. Hexamer palindromic oligonucleotides with 5'-CG-3' motif(s) induce production of interferon
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23. CpG motifs in porphyromonas gingivalis DNA stimulate interleukin-6 expression in human gingival fibroblasts
24. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium boris BCG induce interferons and activate natural killer cells
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27. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
28. Synthetic oligonucleotides with certain palindromes stimulate interferon production of human peripheral blood lymphocytes in vitro
29. Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length
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