-
2
-
-
0029874138
-
The NF-κB and IκB proteins: New discoveries and insights
-
Baldwin, A. S. Jr. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 649-683
-
-
Baldwin A.S., Jr.1
-
3
-
-
0344222192
-
Sequential DNA damage-independent and -dependent activation of NF-κB by UV
-
Bender, K., M. Göttlicher, S. Whiteside, H. J. Rahmsdorf, and P. Herrlich. 1998. Sequential DNA damage-independent and -dependent activation of NF-κB by UV. EMBO J. 17:5170-5181.
-
(1998)
EMBO J.
, vol.17
, pp. 5170-5181
-
-
Bender, K.1
Göttlicher, M.2
Whiteside, S.3
Rahmsdorf, H.J.4
Herrlich, P.5
-
4
-
-
0033582285
-
Involvement of regulatory and catalytic suhunits of phosphoinositide 3-kinase in NF-κB activation
-
Beraud, C., W. J. Henzel, and P. A. Baeuerle. 1999. Involvement of regulatory and catalytic suhunits of phosphoinositide 3-kinase in NF-κB activation. Proc. Natl. Acad. Sci. USA 96:429-434.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 429-434
-
-
Beraud, C.1
Henzel, W.J.2
Baeuerle, P.A.3
-
5
-
-
0032537743
-
Lymphocyte signalling: A coordinating role for Vav?
-
Cantrell, D. 1998. Lymphocyte signalling: a coordinating role for Vav? Curr. Biol. 8:R535-R538.
-
(1998)
Curr. Biol.
, vol.8
-
-
Cantrell, D.1
-
6
-
-
0030004897
-
Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
-
Chen, Z. J., L. Parent, and T. Maniatis. 1996. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853-862.
-
(1996)
Cell
, vol.84
, pp. 853-862
-
-
Chen, Z.J.1
Parent, L.2
Maniatis, T.3
-
7
-
-
0032541670
-
IKAP is a scaffold protein of the IκB kinase complex
-
Cohen, L., W. J. Henzel, and P. A. Baeuerle. 1998. IKAP is a scaffold protein of the IκB kinase complex. Nature 395:292-296.
-
(1998)
Nature
, vol.395
, pp. 292-296
-
-
Cohen, L.1
Henzel, W.J.2
Baeuerle, P.A.3
-
8
-
-
0029055812
-
The small GTP-hinding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
-
Coso, O. A., M. Chiariello, J. C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-hinding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
-
(1995)
Cell
, vol.81
, pp. 1137-1146
-
-
Coso, O.A.1
Chiariello, M.2
Yu, J.C.3
Teramoto, H.4
Crespo, P.5
Xu, N.6
Miki, T.7
Gutkind, J.S.8
-
9
-
-
0032981244
-
The Rho family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium. ERK and NF-κB pathways
-
Costello, P. S., A. E. Walters, P. J. Mee, M. Turner, L. F. Reynolds, A. Prisco, N. Sarner, R. Zamoyska, and V. L. J. Tybulewicz. 1999. The Rho family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium. ERK and NF-κB pathways. Proc. Natl. Acad. Sci. USA 96:3035-3040.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3035-3040
-
-
Costello, P.S.1
Walters, A.E.2
Mee, P.J.3
Turner, M.4
Reynolds, L.F.5
Prisco, A.6
Sarner, N.7
Zamoyska, R.8
Tybulewicz, V.L.J.9
-
10
-
-
0031033292
-
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product
-
Crespo, P., K. E. Schuebel, A. A. Ostrom, J. S. Gutkind, and X. R. Bustelo. 1997. Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature 385:169-172.
-
(1997)
Nature
, vol.385
, pp. 169-172
-
-
Crespo, P.1
Schuebel, K.E.2
Ostrom, A.A.3
Gutkind, J.S.4
Bustelo, X.R.5
-
11
-
-
0031459881
-
Glucocorticoid-mediated repression of NF-κB dependent transcription involves direct interference with transactivation
-
De Bosscher, K., M. L. Schmitz, S. Plaisance, W. Vanden Berghe, W. Fiers, and G. Haegeman. 1997. Glucocorticoid-mediated repression of NF-κB dependent transcription involves direct interference with transactivation. Proc. Natl. Acad. Sci. USA 94:13504-13509.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 13504-13509
-
-
De Bosscher, K.1
Schmitz, M.L.2
Plaisance, S.3
Berghe, W.V.4
Fiers, W.5
Haegeman, G.6
-
12
-
-
0033537719
-
Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
-
Delhase, M., M. Hayakawa, Y. Chen, and M. Karin. 1999. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284:309-313.
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
13
-
-
0030610362
-
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
-
DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548-554.
-
(1997)
Nature
, vol.388
, pp. 548-554
-
-
DiDonato, J.A.1
Hayakawa, M.2
Rothwarf, D.M.3
Zandi, E.4
Karin, M.5
-
14
-
-
0027312371
-
Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains
-
Dorow, D. S., L. Devereux, E. Dietzsch, and T. DeKretser. 1993. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. Eur. J. Biochem. 213:701-710.
-
(1993)
Eur. J. Biochem.
, vol.213
, pp. 701-710
-
-
Dorow, D.S.1
Devereux, L.2
Dietzsch, E.3
DeKretser, T.4
-
15
-
-
0028847258
-
Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2
-
Dorow, D. S., L. Devereux, G. F. Tu, G. Price, J. K. Nicholl, G. R. Sutherland, and R. J. Simpson. 1995. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. Eur. J. Biochem. 234:492-500.
-
(1995)
Eur. J. Biochem.
, vol.234
, pp. 492-500
-
-
Dorow, D.S.1
Devereux, L.2
Tu, G.F.3
Price, G.4
Nicholl, J.K.5
Sutherland, G.R.6
Simpson, R.J.7
-
16
-
-
0028140164
-
PTK1, a novel protein kinase required for proliferation of human melanocytes
-
Ezoe, K., S. T. Lee, K. M. Strunk, and R. A. Spritz. 1994. PTK1, a novel protein kinase required for proliferation of human melanocytes. Oncogene 9:935-938.
-
(1994)
Oncogene
, vol.9
, pp. 935-938
-
-
Ezoe, K.1
Lee, S.T.2
Strunk, K.M.3
Spritz, R.A.4
-
17
-
-
0028340349
-
Identification and characterization of SPRK, a novel srchomology 3 domain-containing proline-rich kinase with serine/threonine kinase activity
-
Gallo, K. A., M. R. Mark, D. T. Scadden, Z. Wang, Q. Gu, and P. J. Godowski. 1994. Identification and characterization of SPRK, a novel srchomology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J. Biol. Chem. 269:15092-15100.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 15092-15100
-
-
Gallo, K.A.1
Mark, M.R.2
Scadden, D.T.3
Wang, Z.4
Gu, Q.5
Godowski, P.J.6
-
18
-
-
0032588186
-
NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
-
Guttridge, D. C., C. Albanese, J. Y. Reuther, R. G. Pestell, and A. S. Baldwin, Jr. 1999. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19:5785-5799.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
Albanese, C.2
Reuther, J.Y.3
Pestell, R.G.4
Baldwin A.S., Jr.5
-
19
-
-
15144353776
-
Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav
-
Han, J., K. Luby Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, and D. Broek. 1998 Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science 279:558-560.
-
(1998)
Science
, vol.279
, pp. 558-560
-
-
Han, J.1
Phelps, K.L.2
Das, B.3
Shu, X.4
Xia, Y.5
Mosteller, R.D.6
Krishna, U.M.7
Falck, J.R.8
White, M.A.9
Broek, D.10
-
20
-
-
0032566435
-
IkκB kinases serve as a target of CD28 signaling
-
Harhaj, E. W., and S. C. Sun. 1998. IKκB kinases serve as a target of CD28 signaling. J. Biol. Chem. 273:25185-25190.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25185-25190
-
-
Harhaj, E.W.1
Sun, S.C.2
-
21
-
-
0031915368
-
Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β
-
Hehner, S. P., M. Heinrich, P. M. Bork, M. Vogt, F. Ratter, V. Lehmann, K. Schulze-Osthoff, W. Dröge, and M. L. Schmitz. 1998. Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J. Biol. Chem. 273:1288-1298.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1288-1298
-
-
Hehner, S.P.1
Heinrich, M.2
Bork, P.M.3
Vogt, M.4
Ratter, F.5
Lehmann, V.6
Schulze-Osthoff, K.7
Dröge, W.8
Schmitz, M.L.9
-
23
-
-
0033537767
-
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
-
Hu, Y., V. Baud, M. Delhase, P. Zhang, T. Deerinck, M. Ellisman, R. Johnson, and M. Karin. 1999. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284: 316-320.
-
(1999)
Science
, vol.284
, pp. 316-320
-
-
Hu, Y.1
Baud, V.2
Delhase, M.3
Zhang, P.4
Deerinck, T.5
Ellisman, M.6
Johnson, R.7
Karin, M.8
-
24
-
-
0032217268
-
The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation
-
Huxford, T., D. B. Huang, S. Malek, and G. Ghosh. 1998. The crystal structure of the IκBα/NF-κB complex reveals mechanisms of NF-κB inactivation. Cell 95:759-770.
-
(1998)
Cell
, vol.95
, pp. 759-770
-
-
Huxford, T.1
Huang, D.B.2
Malek, S.3
Ghosh, G.4
-
25
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo, H., E. Nishida, K. Irie, P. Ten-Dijke, M. Saitoh, T. Moriguchi, M. Takagi, K. Matsumoto, K. Miyazono, and Y. Gotoh. 1997. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90-94.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
Ten-Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
26
-
-
23444453486
-
MLK-3: Identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain
-
Ing, Y. L., I. W. Leung, H. H. Heng, L. C. Tsui, and N. J. Lassam. 1994. MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain. Oncogene 9:1745-1750.
-
(1994)
Oncogene
, vol.9
, pp. 1745-1750
-
-
Ing, Y.L.1
Leung, I.W.2
Heng, H.H.3
Tsui, L.C.4
Lassam, N.J.5
-
27
-
-
0031909355
-
Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes
-
Jacinto, E., G. Werlen, and M. Karin. 1998. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 8: 31-41.
-
(1998)
Immunity
, vol.8
, pp. 31-41
-
-
Jacinto, E.1
Werlen, G.2
Karin, M.3
-
28
-
-
0029041568
-
Transcriptional regulation of the IL2 gene
-
Jain, J., C. Loh, and A. Rao. 1995. Transcriptional regulation of the IL2 gene. Curr. Opin. Immunol. 7:333-342.
-
(1995)
Curr. Opin. Immunol.
, vol.7
, pp. 333-342
-
-
Jain, J.1
Loh, C.2
Rao, A.3
-
29
-
-
0029556013
-
Costimulation requirement for AP-1 and NF-κB transcription factor activation in T cells
-
Jung, S., A. Yaron, I. Alkalay, A. Hatzubai, A. Avraham, and Y. Ben-Neriah. 1995. Costimulation requirement for AP-1 and NF-κB transcription factor activation in T cells. Ann. N. Y. Acad. Sci. 766:245-252.
-
(1995)
Ann. N. Y. Acad. Sci.
, vol.766
, pp. 245-252
-
-
Jung, S.1
Yaron, A.2
Alkalay, I.3
Hatzubai, A.4
Avraham, A.5
Ben-Neriah, Y.6
-
30
-
-
0033609170
-
Repression of NF-κB impairs Hela cell proliferation by functional interference with cell cycle checkpoint regulators
-
Kaltschmidt, B., C. Kaltschmidt, S. P. Hehner, W. Dröge, and M. L. Schmitz. 1999. Repression of NF-κB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators. Oncogene 18: 3213-3225.
-
(1999)
Oncogene
, vol.18
, pp. 3213-3225
-
-
Kaltschmidt, B.1
Kaltschmidt, C.2
Hehner, S.P.3
Dröge, W.4
Schmitz, M.L.5
-
32
-
-
0032483017
-
JNK or IKK. AP-1 or NF-κB, which are the targets for MEK kinase 1 action?
-
Karin, M., and M. Delhase. 1998. JNK or IKK. AP-1 or NF-κB, which are the targets for MEK kinase 1 action? Proc. Natl. Acad. Sci. USA 95:9067-9069.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9067-9069
-
-
Karin, M.1
Delhase, M.2
-
33
-
-
0028917384
-
Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain
-
Katoh, M., M. Hirai, T. Sugimura, and M. Terada. 1995. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. Oncogene 10:1447-1451.
-
(1995)
Oncogene
, vol.10
, pp. 1447-1451
-
-
Katoh, M.1
Hirai, M.2
Sugimura, T.3
Terada, M.4
-
34
-
-
0033559545
-
The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: Proof of cross-talk with the IκB kinase cascade
-
Kempiak, S. J., T. S. Hiura, and A. E. Nel. 1999. The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the IκB kinase cascade. J. Immunol. 162:3176-3187.
-
(1999)
J. Immunol.
, vol.162
, pp. 3176-3187
-
-
Kempiak, S.J.1
Hiura, T.S.2
Nel, A.E.3
-
35
-
-
0029150389
-
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
-
Köntgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965-1977.
-
(1995)
Genes Dev.
, vol.9
, pp. 1965-1977
-
-
Köntgen, F.1
Grumont, R.J.2
Strasser, A.3
Metcalf, D.4
Li, R.5
Tarlinton, D.6
Gerondakis, S.7
-
36
-
-
0032484215
-
Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3
-
Leung, I. W., and N. Lassam. 1998. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. J. Biol. Chem. 273:32408-32415.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32408-32415
-
-
Leung, I.W.1
Lassam, N.2
-
37
-
-
0031285250
-
Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway
-
Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88: 213-222.
-
(1997)
Cell
, vol.88
, pp. 213-222
-
-
Lee, F.S.1
Hagler, J.2
Chen, Z.J.3
Maniatis, T.4
-
38
-
-
0032482752
-
MEKK1 activates both IκB kinase α and IκB kinase β
-
Lee, F. S., R. T. Peters, L. C. Dang, and T. Maniatis. 1998. MEKK1 activates both IκB kinase α and IκB kinase β. Proc. Natl. Acad. Sci. USA 95:9319-9324.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 9319-9324
-
-
Lee, F.S.1
Peters, R.T.2
Dang, L.C.3
Maniatis, T.4
-
39
-
-
0032573165
-
Ionizing radiation and short wavelength UV activate NF-κH through two distinct mechanisms
-
Li, N., and M. Karin. 1998. Ionizing radiation and short wavelength UV activate NF-κH through two distinct mechanisms. Proc. Natl. Acad. Sci. USA 95:13012-13017.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13012-13017
-
-
Li, N.1
Karin, M.2
-
40
-
-
0033537739
-
Severe liver degeneration in mice lacking the IκB kinase 2 gene
-
Li, Q., D. Van Antwerp, F. Mercurio, K. F. Lee, and I. M. Verma. 1999a. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284: 321-325.
-
(1999)
Science
, vol.284
, pp. 321-325
-
-
Li, Q.1
Van Antwerp, D.2
Mercurio, F.3
Lee, K.F.4
Verma, I.M.5
-
41
-
-
0033563227
-
IKK1-deficient mice exhibit abnormal development of skin and skeleton
-
Li, Q., Q. Lu, J. Y. Hwang, D. Buscher, K. F. Lee, J. C. Izpisua-Belmonte, and I. M. Verma. 1999b. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 13:1322-1328.
-
(1999)
Genes Dev.
, vol.13
, pp. 1322-1328
-
-
Li, Q.1
Lu, Q.2
Hwang, J.Y.3
Buscher, D.4
Lee, K.F.5
Izpisua-Belmonte, J.C.6
Verma, I.M.7
-
42
-
-
0028943245
-
Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
-
Lin, A., A. Minden, H. Martinetto, F. X. Claret, C. Lange-Carter, F. Mercurio, G. L. Johnson, and M. Karin. 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290.
-
(1995)
Science
, vol.268
, pp. 286-290
-
-
Lin, A.1
Minden, A.2
Martinetto, H.3
Claret, F.X.4
Lange-Carter, C.5
Mercurio, F.6
Johnson, G.L.7
Karin, M.8
-
43
-
-
0033082990
-
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases
-
Lin, X., E. T. Cunningham Jr, Y. Mu, R. Geleziunas, and W. C. Greene. 1999. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity 10:271-280.
-
(1999)
Immunity
, vol.10
, pp. 271-280
-
-
Lin, X.1
Cunningham E.T., Jr.2
Mu, Y.3
Geleziunas, R.4
Greene, W.C.5
-
44
-
-
0032583947
-
NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
-
Ling, L., Z. Cao, and D. V. Goeddel. 1998. NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176. Proc. Natl. Acad. Sci. USA 95:3792-3797.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3792-3797
-
-
Ling, L.1
Cao, Z.2
Goeddel, D.V.3
-
45
-
-
0031017618
-
MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1
-
Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540-544.
-
(1997)
Nature
, vol.385
, pp. 540-544
-
-
Malinin, N.L.1
Boldin, M.P.2
Kovalenko, A.V.3
Wallach, D.4
-
46
-
-
0030613646
-
Catalysis by a multiprotein IκB kinase complex
-
Maniatis, T. 1997. Catalysis by a multiprotein IκB kinase complex. Science 278:818-819.
-
(1997)
Science
, vol.278
, pp. 818-819
-
-
Maniatis, T.1
-
47
-
-
0033106149
-
A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless and Hedgehog signaling pathways
-
Maniatis, T. 1999. A ubiquitin ligase complex essential for the NF-κB, Wnt/Wingless and Hedgehog signaling pathways. Genes Dev. 13:505-510.
-
(1999)
Genes Dev.
, vol.13
, pp. 505-510
-
-
Maniatis, T.1
-
48
-
-
0033537731
-
IκB kinases: Kinsmen with different crafts
-
May, M. J., and S. Ghosh. 1999. IκB kinases: kinsmen with different crafts. Science 284:271-273.
-
(1999)
Science
, vol.284
, pp. 271-273
-
-
May, M.J.1
Ghosh, S.2
-
49
-
-
0031204429
-
Involvement of Rel, Fos and Jun proteins in binding activity to the IL2 promoter CD28 response element/ AP-1 sequence in human T cells
-
McGuire, K. L., and M. Iacobelli. 1997. Involvement of Rel, Fos and Jun proteins in binding activity to the IL2 promoter CD28 response element/ AP-1 sequence in human T cells. J. Immunol. 159:1319-1327.
-
(1997)
J. Immunol.
, vol.159
, pp. 1319-1327
-
-
McGuire, K.L.1
Iacobelli, M.2
-
50
-
-
0030685825
-
IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
-
Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, and A. Rao. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860-866.
-
(1997)
Science
, vol.278
, pp. 860-866
-
-
Mercurio, F.1
Zhu, H.2
Murray, B.W.3
Shevchenko, A.4
Bennett, B.L.5
Li, J.6
Young, D.B.7
Barbosa, M.8
Mann, M.9
Manning, A.10
Rao, A.11
-
51
-
-
0032589935
-
IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
-
Mercurio, F., B. W. Murray, A. Shevchenko, B. L. Bennett, D. B. Young, J. W. Li, G. Pascual, A. Motiwala, H. Zhu, M. Mann, and A. M. Manning. 1999. IκB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell. Biol. 19:1526-1538.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1526-1538
-
-
Mercurio, F.1
Murray, B.W.2
Shevchenko, A.3
Bennett, B.L.4
Young, D.B.5
Li, J.W.6
Pascual, G.7
Motiwala, A.8
Zhu, H.9
Mann, M.10
Manning, A.M.11
-
52
-
-
0029054455
-
Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc and lck cooperate in hematopoietic cell proliferation
-
Miyazaki, T., Z. J. Liu, A. Kawahara, Y. Minami, K. Yamada, Y. Tsujimoto, E. L. Barsoumian, R. M. Permutter, and T. Taniguchi. 1995. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc and lck cooperate in hematopoietic cell proliferation. Cell 81:223-231.
-
(1995)
Cell
, vol.81
, pp. 223-231
-
-
Miyazaki, T.1
Liu, Z.J.2
Kawahara, A.3
Minami, Y.4
Yamada, K.5
Tsujimoto, Y.6
Barsoumian, E.L.7
Permutter, R.M.8
Taniguchi, T.9
-
53
-
-
0033605654
-
Activation of serum response factor by RhoA is mediated by the nuclear factor-κB and C/EBP transcription factors
-
Montaner, S., R. Perona, L. Saniger, and J. C. Lacal. 1999. Activation of serum response factor by RhoA is mediated by the nuclear factor-κB and C/EBP transcription factors. J. Biol. Chem. 274:8506-8515.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8506-8515
-
-
Montaner, S.1
Perona, R.2
Saniger, L.3
Lacal, J.C.4
-
54
-
-
0032583949
-
Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
-
Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537-3542.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3537-3542
-
-
Nakano, H.1
Shindo, M.2
Sakon, S.3
Nishinaka, S.4
Mihara, M.5
Yagita, H.6
Okumura, K.7
-
55
-
-
0031597368
-
Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase
-
Nemoto, S., J. A. DiDonato, and A. Lin. 1998. Coordinate regulation of IκB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-κB-inducing kinase. Mol. Cell. Biol. 18:7336-7343.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7336-7343
-
-
Nemoto, S.1
DiDonato, J.A.2
Lin, A.3
-
56
-
-
0033580466
-
The kinase TAK1 can activate the NIK-iκB as well as the MAP kinase cascade in the IL-1 signalling pathway
-
Ninomiya-Tsuji, J., K. Kishimoto, A. Hiyama, J. Inoue, Z. Cao, and K. Matsumoto. 1999. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398:252-256.
-
(1999)
Nature
, vol.398
, pp. 252-256
-
-
Ninomiya-Tsuji, J.1
Kishimoto, K.2
Hiyama, A.3
Inoue, J.4
Cao, Z.5
Matsumoto, K.6
-
57
-
-
0032902776
-
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation
-
Penninger, J. M., K. D. Fischer, T. Sasaki, I. Kozieradzki, J. Le, K. Tedford, K. Bachmaier, P. S. Ohashi, and M. F. Bachmann. 1999. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. Eur. J. Immunol. 29: 1709-1718.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 1709-1718
-
-
Penninger, J.M.1
Fischer, K.D.2
Sasaki, T.3
Kozieradzki, I.4
Le, J.5
Tedford, K.6
Bachmaier, K.7
Ohashi, P.S.8
Bachmann, M.F.9
-
58
-
-
0031034469
-
Activation of the nuclear factor-κB by Rho, CDc42, and Rac-1 proteins
-
Perona, R., S. Montaner, L. Saniger, I. Sanchez-Perez, R. Bravo, and J. C. Lacal. 1997. Activation of the nuclear factor-κB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11:463-475.
-
(1997)
Genes Dev.
, vol.11
, pp. 463-475
-
-
Perona, R.1
Montaner, S.2
Saniger, L.3
Sanchez-Perez, I.4
Bravo, R.5
Lacal, J.C.6
-
59
-
-
0029760613
-
The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1
-
Rana, A., K. Gallo, P. Godowski, S. Hirai, S. Ohno, L. Zon, J. M. Kyriakis, and J. Avruch. 1996. The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem. 271:19025-19028.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19025-19028
-
-
Rana, A.1
Gallo, K.2
Godowski, P.3
Hirai, S.4
Ohno, S.5
Zon, L.6
Kyriakis, J.M.7
Avruch, J.8
-
60
-
-
0031586174
-
Identification and characterization of an IκB kinase
-
Regnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373-383.
-
(1997)
Cell
, vol.90
, pp. 373-383
-
-
Regnier, C.H.1
Song, H.Y.2
Gao, X.3
Goeddel, D.V.4
Cao, Z.5
Rothe, M.6
-
61
-
-
0032541657
-
IKK-γ is an essential regulatory subunit of the IκB kinase complex
-
Rothwarf, D. M., E. Zandi, G. Natoli, and M. Karin. 1998. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 395:297-300.
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
Karin, M.4
-
62
-
-
0031001510
-
CD28 mediates transcriptional upregulation of the interleukin-2 (IL2) promoter through a composite element containing the CD28RE and NF-IL2B AP-1 sites
-
Shapiro, V. S., K. E. Truitt, J. B. Imboden, and A. Weiss. 1997. CD28 mediates transcriptional upregulation of the interleukin-2 (IL2) promoter through a composite element containing the CD28RE and NF-IL2B AP-1 sites. Mol. Cell. Biol. 17:4051-4058.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 4051-4058
-
-
Shapiro, V.S.1
Truitt, K.E.2
Imboden, J.B.3
Weiss, A.4
-
63
-
-
0028291525
-
JNK is involved in signal integration during costimulation of T lymphocytes
-
Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriah. 1994. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77:727-736.
-
(1994)
Cell
, vol.77
, pp. 727-736
-
-
Su, B.1
Jacinto, E.2
Hibi, M.3
Kallunki, T.4
Karin, M.5
Ben-Neriah, Y.6
-
64
-
-
0033119952
-
Embryonic lethality, liver degeneration and impaired NF-κB activation in IKK-β-deficient mice
-
Tanaka, M., M. E. Fuentes, K. Yamaguchi, M. H. Durnin, S. A. Dalrymple, K. L. Hardy, and D. V. Goeddel. 1999. Embryonic lethality, liver degeneration and impaired NF-κB activation in IKK-β-deficient mice. Immunity 10: 421-429.
-
(1999)
Immunity
, vol.10
, pp. 421-429
-
-
Tanaka, M.1
Fuentes, M.E.2
Yamaguchi, K.3
Durnin, M.H.4
Dalrymple, S.A.5
Hardy, K.L.6
Goeddel, D.V.7
-
65
-
-
0029913510
-
Signaling from the small GTP-binding proteins Rac and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family
-
Teramoto, H., O. A. Coso, H. Miyata, T. Igishi, T. Miki, and J. S. Gutkind. 1996. Signaling from the small GTP-binding proteins Rac and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. J. Biol. Chem. 271:27225-27228.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 27225-27228
-
-
Teramoto, H.1
Coso, O.A.2
Miyata, H.3
Igishi, T.4
Miki, T.5
Gutkind, J.S.6
-
66
-
-
0030462564
-
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
-
Tibbles, L. A., Y. L. Ing, F. Kiefer, J. Chan, N. Iscove, J. R. Woodgett, and N. J. Lassam. 1996. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J. 15:7026-7035.
-
(1996)
EMBO J.
, vol.15
, pp. 7026-7035
-
-
Tibbles, L.A.1
Ing, Y.L.2
Kiefer, F.3
Chan, J.4
Iscove, N.5
Woodgett, J.R.6
Lassam, N.J.7
-
68
-
-
0032508714
-
A mammalian scaffold complex that selectively mediates MAP kinase activation
-
Whitmarsh, A. J., J. Cavanagh, C. Tournier, J. Yasuda, and R. J. Davis. 1998. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281:1671-1674.
-
(1998)
Science
, vol.281
, pp. 1671-1674
-
-
Whitmarsh, A.J.1
Cavanagh, J.2
Tournier, C.3
Yasuda, J.4
Davis, R.J.5
-
69
-
-
0030611595
-
IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK
-
Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and NIK. Science 278:866-869.
-
(1997)
Science
, vol.278
, pp. 866-869
-
-
Woronicz, J.D.1
Gao, X.2
Cao, Z.3
Rothe, M.4
Goeddel, D.V.5
-
70
-
-
0032568792
-
Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation
-
Yamaoka, S., G. Courtois, C. Bessia, S. T. Whiteside, R. Weil, F. Agou, H. E. Kirk, R. J. Kay, and A. Israel. 1998. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93:1231-1240.
-
(1998)
Cell
, vol.93
, pp. 1231-1240
-
-
Yamaoka, S.1
Courtois, G.2
Bessia, C.3
Whiteside, S.T.4
Weil, R.5
Agou, F.6
Kirk, H.E.7
Kay, R.J.8
Israel, A.9
-
71
-
-
17944401842
-
Identification of the receptor component of the IκBα-ubiquitin ligase
-
Yaron, A., A. Hatzubai, M. Davis, I. Lavon, S. Amit, A. M. Manning, J. S. Andersen, M. Mann, F. Mercurio, and Y. Ben-Neriah. 1998. Identification of the receptor component of the IκBα-ubiquitin ligase. Nature 396:590-594.
-
(1998)
Nature
, vol.396
, pp. 590-594
-
-
Yaron, A.1
Hatzubai, A.2
Davis, M.3
Lavon, I.4
Amit, S.5
Manning, A.M.6
Andersen, J.S.7
Mann, M.8
Mercurio, F.9
Ben-Neriah, Y.10
-
72
-
-
0032483967
-
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
-
Yujiri, T., S. Sather, G. R. Fanger, and G. L. Johnson. 1998. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282:1911-1914.
-
(1998)
Science
, vol.282
, pp. 1911-1914
-
-
Yujiri, T.1
Sather, S.2
Fanger, G.R.3
Johnson, G.L.4
-
73
-
-
0030613551
-
The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
-
Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91: 243-252.
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
74
-
-
0033605575
-
Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through iκb kinase-α and IκB kinase-β
-
Zhao, Q., and F. S. Lee. 1999. Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-κB through IκB kinase-α and IκB kinase-β. J. Biol. Chem. 274:8355-8358.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8355-8358
-
-
Zhao, Q.1
Lee, F.S.2
|