Abnormal immune function of hemopoietic cells from alymphoplasia (aly) mice, a natural strain with mutant NF-κB-inducing kinase

Journal of Immunology

Volumn 165, Issue 2, 2000, Pages 804-812

  Yamada, Takuji ^a   Mitani, Tasuku ^b   Yorita, Kazuko ^b   Uchida, Daisuke ^b   Matsushima, Akemi ^b   Iwamasa, Kikue ^a   Fujita, Shigeru ^a   Matsumoto, Mitsuru ^b  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOTOXIN; M PROTEIN; PHOSPHOTRANSFERASE; RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; BONE MARROW CELL; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE MUTATION; HEMATOPOIETIC CELL; IMMUNE DEFICIENCY; LYMPHATIC SYSTEM DISEASE; LYMPHOID ORGAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPLEEN FUNCTION; T LYMPHOCYTE ACTIVATION;

EID: 0034662002     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.2.804     Document Type: Article

References (39)

1. Fu, Y.-X., and D. D. Chaplin. 1999. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17:399.
2. Miyawaki, S., Y. Nakamura, H. Suzuka, M. Koba, R. Yasumizu, S. Ikehara, and Y. Shibata. 1994. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice. Eur. J. Immunol. 24:429.
3. Shinkura, R., F. Malsuda, T. Sakiyama, T. Tsubata, H. Hiai, M. Paumen, S. Miyawaki, and T. Honjo. 1996. Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. Int. Immunol. 8:1067.
4. Shinkura, R., K. Kitada, F. Matsuda, K. Tashiro, K. Ikuta, M. Suzuki, K. Kogishi, T. Serikawa, and T. Honjo. 1999. Alymphoplasia is caused by a point mutation in the mouse gene encoding NF-κb-inducing kinase. Nat. Genet. 22:74.
5. Malinin, N. L., M. P. Boldin, A. V. Kovalenko, and D. Wallach. 1997. MAP3K-related kinase involved in NF-κB induction by TNF, CD95 and IL-1. Nature 385:540.
6. DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548.
7. Régnier, C. H., H. Y. Song, X. Gao, D. V. Goeddel, Z. Cao, and M. Rothe. 1997. Identification and characterization of an IκB kinase. Cell 90:373.
8. Zandi, E., D. M. Rothwarf, M. Delhase, M. Hayakawa, and M. Karin. 1997. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell 91:243.
9. Woronicz, J. D., X. Gao, Z. Cao, M. Rothe, and D. V. Goeddel. 1997. IκB kinase-β: NF-κB activation and complex formation with IκB kinase-α and N1K. Science 278:866.
10. Mercurio, F., H. Zhu, B. W. Murray, A. Shevchenko, B. L. Bennett, J. Li, D. B. Young, M. Barbosa, M. Mann, A. Manning, et al. 1997. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science 278:860.
11. Nakano, H., M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura. 1998. Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc. Natl. Acad. Sci. USA 95:3537.
12. Matsumoto, M., K. Iwamasa, P. D. Rennert, T. Yamada, R. Suzuki, A. Matsushima, M. Okabe, S. Fujita, and M. Yokoyama. 1999. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-α-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J. Immunol. 163:1584.
13. Fütterer, A., K. Mink, A. Luz, M. H. Kosco-Vilbois, and K. Pfeffer. 1998. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9:59.
14. Ware, C. F., T. L. VanArsdale, P. D. Crowe, and J. L. Browning. 1995. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198:175.
15. -1-) mutant mice. J. Exp. Med. 185:2157.
16. Matsumoto, M., S. Mariathasan, M. H. Nahm, F. Baranyay, J. J. Peschon, and D. D. Chaplin. 1996. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science 271:1289.
17. Fu, Y.-X., H. Molina, M. Matsumoto, G. Huang, J. Min, and D. D. Chaplin. 1997. Lymphotoxin-α (LTα) supports development of splenic follicular structure that is required for IgG responses. J. Exp. Med. 185:2111.
18. Matsumoto, M., Y.-X. Fu, H. Molina, G. Huang, J. Kim, D. A. Thomas, M. H. Nahm, and D. D. Chaplin. 1997. Distinct roles of lymphotoxin-α and the type I TNF receptor in the establishment of follicular dendritic cells from non-bone marrow-derived cells. J. Exp. Med. 186:1997.
19. Akbar, S. M. F., M. Onji, K. Inaba, K.-I. Yamamura, and Y. Ohta. 1993. Low responsiveness of hepatitis B virus-transgenic mice in antibody response to T-cell-dependent antigen: defect in antigen-presenting activity of dendritic cells. Immunology 78:468.
20. Kraal, G. 1992. Cells in the marginal zone of the spleen. Int. Rev. Cytol. 132:31.
21. Koike, R., T. Nishimura, R. Yasumizu, H. Tanaka, Y. Hataba, T. Watanabe, S. Miyawaki, and M. Miyasaka. 1996. The splenic marginal zone is absent in alymphoplastic aly mutant mice. Eur. J. Immunol. 26:669.
22. Lin, X., E. T. Cunningham, Jr., Y. Mu, R. Geleziunas, and W. C. Greene. 1999. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-κB acting through the NF-κB-inducing kinase and IκB kinases. Immunity 10:271.
23. Rosenberg, A. S., and A. Singer. 1992. Cellular basis of skin allograft rejection: an in vivo model of immune-mediated tissue destruction. Annu. Rev. Immunol. 10:333.
24. Bull, P., T. Hunter, and I. M. Verma. 1989. Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts. Mol. Cell. Biol. 9:5239.
25. Hannink, M., and H. M. Temin. 1990. Structure and autoregulation of the c-rel promoter. Oncogene 5:1843.
26. Ryseck, R.-P., P. Bull, M. Takamiya, V. Bours, U. Siebenlist, P. Dobrzanski, and R. Bravo. 1992. RelB, a new Rel family transcription activator that can interact with p50-NF-κB. Mol. Cell. Biol. 12:674.
27. Finco, T. S., and A. S. Baldwin. 1995. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3:263.
28. Carroll, M. C. 1998. The role of complement and complement receptors in induction and regulation of immunity. Annu. Rev. Immunol. 16:545.
29. Molina, H., V. M. Holers, B. Li, Y. Fung, S. Mariathasan, J. Goellner, J. Strauss-Schoenberger, R. W. Karr, and D. D. Chaplin. 1996. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc. Natl. Acad. Sci. USA 93:3357.
30. Oliver, A. M., F. Martin, G. L. Gartland, R. H. Carter, and J. F. Kearney. 1997. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27:2366.
31. Köntgen, F., R. J. Grumont, A. Strasser, D. Metcalf, R. Li, D. Tarlinton, and S. Gerondakis. 1995. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1965.
32. Kang, S. M., B. Beverly, A. C. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardo. 1992. Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 257:1134.
33. Harhaj, E. W., and S.-C. Sun. 1998. IκB kinases serve as a target of CD28 signaling. J. Biol. Chem. 273:25185.
34. Kempiak, S. J., T. S. Hiura, and A. E. Nel. 1999. The Jun kinase cascade is responsible for activating the CD28 response element of the IL-2 promoter: proof of cross-talk with the IκB kinase cascade. J. Immunol. 162:3176.
35. Stancovski, I., and D. Baltimore. 1997. NF-κB activation: the IκB kinase revealed? Cell 91:299.
36. Franzoso, G., L. Carlson, L. Poljak, E. W. Shores, S. Epstein, A. Leonardi, A. Grinberg, T. Tran, T. Scharton-Kersten, M. Anver, et al. 1998. Mice deficient in nuclear factor (NF)-κB/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J. Exp. Med. 187:147.
37. Caamaño, J. H., C. A. Rizzo, S. K. Durham, D. S. Barton, C. Raventós-Suárez, C. M. Snapper, and R. Bravo. 1998. Nuclear factor (NF)-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses. J. Exp. Med. 187:185.
38. Steiger, J., P. W. Nickerson, W. Steurer, M. Moscovitch-Lopatin, and T. B. Strom. 1995. IL-2 knockout recipient mice reject islet cell allografts. J. Immunol. 155:489.
39. Waldmann, H. 1999. Transplantation tolerance: where do we stand? Nat. Med. 5:1245.