Science, medicine, and the future. Non-insulin dependent diabetes mellitus: The gathering storm

British Medical Journal

Volumn 314, Issue 7085, 1997, Pages 955-959

  O'Rahilly, Stephen ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Department of Metabolic Medicine ^*  (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; INSULIN;

DIAGNOSIS; DIET; GENETIC PREDISPOSITION; HIGH RISK POPULATION; HUMAN; INSULIN RELEASE; LOW BIRTH WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SHORT SURVEY; TEAMWORK;

B-LYMPHOCYTES; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; OBESITY; PREVALENCE; WORLD HEALTH;

EID: 0030966013     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (17)

1. McKeigue PM, Marmot MG, Syndercombe-Court YD, Cottier DE, Rahman S, Riemersma RA, et al. Diabetes, hyperinsulinaemia and coronary risk factors in Bangladeshis in East London. Br Heart J 1988;60:390-6.
2. Hodge AM, Dowse GK, Zimmet PZ, Collins VR. Prevalence and secular trends in obesity in Pacific and Indian Ocean island populations. Obes Res 1995;3 (suppl 2):77-87S.
3. Krook A, O'Rahilly S, Mutani insulin receptors in syndromes of insulin resistance. Baillières Clin Endocrinol Metab 1996;10:97-122.
4. Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MD, et al. Close linkage of glucokinase locus on chromosome 7p to early onset non-insulin-dependent diabetes mellitus. Nature 1992;356:162-4.
5. Stoffel M, Froguel P, Takeda J, Zouali H, Vionnet N, Nishi S, et al. Human glucokinase gene: isolation, characterisation and identification of two missense mutations linked to early onset non-insulin-dependent (type 2) diabetes mellitus. Proc Natl Acad Sci USA 1992;89:7698-702.
6. Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M, et al. Mutations in the hepatocyte nuclear factor-1 alpha gene in maturity onset diabetes of the young (MODY3). Nature 1996;384:455-8.
7. Yamagata K, Furuta H, Oda N, kaisaki PJ, Menzel S, Cox NJ. et al. Mutations in the hepatocyte nuclear factor-4 alpha gene in maturity onset diabetes of the young (MODY1). Nature 1996;384:458-60.
8. Maasseti JA, Kadowaki T. Maternally inherited diabetes and deafness: a new diabetes subtype. Diabetologia 1996;39:375-82.
9. Barker DJP, Hales CN, Fall CHD, Osmond C, Phipps K, Clark PMS. Type 2 (non-insulin dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 1993;36:62-7.
10. Hales CN, Barker DJP. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992;35:595-601.
11. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32.
12. Tontonoz P, Hu F, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARgamma2, a lipid-activated transcription factor. Cell 1994;79:1147-56.
13. Nolan JJ, Ludvik B, Beerdsen P, Joyce M, Olefsky J. Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N Engl J Med 1994;331:1188-93.
14. Cooper GJS, Willis AC, Clark A, Turner RC, Sim RB, Reid KBM. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 1987;84:8628-32.
15. Westermark P, Wernstedt C, Wilander E, Hayden DW, O'Brien TD, Johnson KH. Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 1987;84:3881-5.
16. Turner RC. United Kingdom prospective diabetes study. III. Prevalence of hypertension and hypotensive therapy in patients with newly diagnosed diabetes. A multi-center study. Hypertension 1985;7:8-13.
17. Davies M, Day J. Screening for diabetes. BMJ 1994;308:1160-1.