Function of pref-1 as an inhibitor of adipocyte differentiation

International Journal of Obesity

Volumn 24, Issue , 2000, Pages S15-S19

  Sul, H S ^a   Smas, C ^a   Mei, B ^a   Zhou, L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adipocyte differentiation; Differential screening; Extracellular domain; Pref 1

Indexed keywords

DEXAMETHASONE; MEMBRANE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; TRANSCRIPTION FACTOR;

ADIPOCYTE; ALTERNATIVE RNA SPLICING; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL MEMBRANE; CONFERENCE PAPER; DOWN REGULATION; EXTRACELLULAR MATRIX; GENE ACTIVATION; GROWTH DISORDER; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ADIPOCYTES; ADIPOSE TISSUE; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; REPRESSOR PROTEINS;

EID: 0033694589     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801494     Document Type: Article

References (17)

1. Green H, Kehinde O. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 1976; 7: 105-113.
2. Gregoire F, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol Rev 1998; 78: 783-809.
3. Smith PJ, Wise LS, Rubin CS. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes. JBiol Chem 1988; 263: 9402-9408.
4. Spiegelman BS, Farmer SR. Decreases in tubulin and actin gene expression prior to morphological differentiation of 3T3 adipocytes. Cell 1982; 29: 53-60.
5. Smas CM, Sul HS. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993; 73: 725-734.
6. Smas CM, Sul HS. Molecular mechanisms of adipocyte differentiation and inhibitory action of pref-1. Crit Rev Eukar-yotic Gene Expression 1997; 7: 281-298.
7. Sul HS, Smas CM, Mei B, Zhou L. Regulation of fat synthesis and adipose differentiation. Prog Nucleic Acid Res Mol Biol 1997; 60: 317-345.
8. Carpenter G, Cohen S. Epidermal growth factor. J Biol Chem 1990; 265: 7709-7712.
9. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science 1999; 284: 770-776.
10. Smas CM, Green D, Sul HS. Structural characterization and alternate splicing of the gene encoding the preadipocyte EGF-like protein pref-1. Biochemistry 1994; 33: 9257-9265.
11. Smas CM, Chen L, Sul HS. Cleavage of membrane-associated pref-1 generates a soluble inhibitor of adipocyte differentiation. Mol Cell Biol 1997; 17: 977-988.
12. Smas CM, Kachinskas D, Liu C, Xie X, Dircks L, Sul HS. Transcriptional control of the pref-1 gene in 3T3-L1 adipocyte differentiation. Sequence requirement for differentiation-dependent suppression. J Biol Chem 1998; 273: 31751-31758.
13. Smas CM, Chen L, Zhou L, Latasa J-M, Sul HS. Transcriptional suppression of preadipocyte factor-1 by glucocorticoids promotes 3T3-L1 adipocyte differentiation. J Biol Chem 1999; 274: 12632-12641.
14. Hansen LH, Madsen B, Teisner B, Nielsen JH, Billestrup N. Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation. Mol Endocrinol 1998; 8: 1140-1149.
15. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bash-makov Y, Goldstein JL, Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expression nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Devl 1998; 12: 3182-3194.
16. Zhou YT, Wang ZW, Higa M, Newgard CB, Unger RH. Reversing adipocyte differentiation: implications for treatment of obesity. Proc Natl Acad Sci USA 1999; 96: 2391-2395.
17. Xing H, Northrop JP, Grove JR, Kilpatrick KE, Su JL, Ringold GM. TNFa-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARy without effects on pref-1 expression. Endocrinology 1997; 138: 2776-2783.