COX-1, COX-2 and articular joint disease: A role for chondroprotective agents

Biorheology

Volumn 39, Issue 1-2, 2002, Pages 171-179

  Colville Nash, Paul R ^a   Willoughby, Derek A ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CELECOXIB; CHONDROPROTECTIVE AGENT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIACETYLRHEIN; DICLOFENAC; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN; PROSTAGLANDIN E2; ROFECOXIB;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ARTHROPATHY; CARTILAGE DEGENERATION; CONFERENCE PAPER; CYTOKINE PRODUCTION; DRUG EFFICACY; EAR; ENZYME ACTIVITY; HUMAN; NONHUMAN; PROTEIN EXPRESSION; QUALITY OF LIFE; REMISSION; RHEUMATOID ARTHRITIS; TREATMENT OUTCOME;

ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, RHEUMATOID; CARTILAGE, ARTICULAR; CHRONIC DISEASE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; TREATMENT FAILURE;

EID: 0036283588     PISSN: 0006355X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (71)

1. Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis
2. Distribution of cyclooxygenase isoforms in murine chronic granulomatous inflammation. Implications for future anti-inflammatory therapy
3. Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration
4. NF-κB regulation by IκB kinase in primary fibroblast-like synoviocytes
5. NF-κB as a target for immunosuppressive and anti-inflammatory molecules
6. Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system
7. PGE2 inhibits production of Thl lymphokines but not of Th2 lymphokines
8. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta-12,14-prostaglandin J2
9. Defining therapeutic targets by using adenovirus: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
10. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB
11. A modified mouse air pouch model for evaluating the effects of compounds on granuloma-induced cartilage degradation
12. Effects of non-steroidal anti-inflammatory drugs on chondrocyte metabolism in vitro and in vivo
13. Non-steroidal anti-inflammatory drugs and articular cartilage
14. Pharmacological mediators of various immunological and non-immunological inflammatory reactions produced in the pleural cavity
15. Lymphocytes lacking IκB-α develop normally, but have selective defects in proliferation and function
16. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages
17. Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonist: Correlation with induction of heme oxygenase-1
18. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
19. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
20. The interactions of cytokines, NSAIDs and prostaglandins in cartilage destruction and repair
21. 15-Deoxy-Delta-12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
22. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions
23. Allergic lung responses are increased in prostaglandin H synthase-deficient mice
24. The effect of a T cell-specific NF-κB inhibitor or in vitro cytokine production and collagen-induced arthritis
25. Expression and selective inhibition of the constitutive and inducible forms of human cyclooxygenase
26. Inducible cyclooxygenase may have anti-inflammatory properties
27. The effects of cyclooxygenase 2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis induced monoarticular arthritis in the rat
28. Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation
29. Prostaglandin suppression of mitogen-stimulated lymphocytes in vitro. Changes with mitogen dose and preincubation
30. AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis
31. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase
32. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
33. Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells
34. Phosphorylation meets ubiquitination: The control of NF-κB activity
35. 2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats
36. The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
37. Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic
38. Diacetylrhein on a post-contusion model of experimental osteoarthritis in the rabbit
39. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxyge-nase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs
40. Role of prostaglandin on the regulation of macrophage proliferation and cytotoxic functions
41. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
42. Effects of diacerein on the quantity and phagocytic activity of thioglycollate-elicited mouse peritoneal macrophages
43. Rhein: An anthraquinone that modulates superoxide anion production from human neutrophils
44. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
45. Effects of diacerhein on granuloma induced cartilage breakdown in the mouse
46. Altered pain perception and inflammatory response in mice lacking prostacyclin receptor
47. Acetabular bone destruction related to non-steroidal anti-inflammatory drugs
48. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: Inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid
49. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)
50. The discovery of rofecoxib, [MK 966, Vioxx, 4-(4′-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor
51. Effect of non-steroidal anti-inflammatory drugs on the course of osteoarthritis
52. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2
53. The peroxisome prolierator-activated receptor gamma is a negative regulator of macrophage activation
54. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor
55. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
56. Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastro-intestinal ulcer models in rats
57. Rapid quantitation of joint destruction in irritant monoarticular arthritis induced by heat killed Mycobacterium tuberculosis
58. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
59. Prostaglandin endoperoxide H synthases-1 and -2
60. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
61. 2 inhibits multiple steps in the NF-κB signaling pathway
62. Cyclooxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy
63. Suppression of human lymphocyte migration by PGE2
64. The prostaglandins
65. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin like drugs
66. Towards a better aspirin
67. Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
68. Antigen stimulation of prostaglandin synthesis and control of immune responses
69. Eicosanoids and inflammation
70. COX-1, COX-2 and COX-3 and the future treatment of chronic inflammatory disease
71. Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT