The discovery of rofecoxib, [MK 966, VIOXX®, 4-(4'- methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 13, 1999, Pages 1773-1778

  Prasit, P ^a   Wang, Z ^a   Brideau, C ^a   Chan, C C ^a   Charleson, S ^a   Cromlish, W ^a   Ethier, D ^a   Evans, J F ^a   Ford Hutchinon, A W ^a   Gauthier, J Y ^a   Gordon, R ^a   Guay, J ^a   Gresser, M ^a   Kargman, S ^a   Kennedy, B ^a   Leblanc, Y ^a   Leger S ^a   Mancini, J ^a   O'Neill, G P ^a   Ouellet, M ^a   Percival, M D ^a   Perrier, H ^a   Riendeau, D ^a   Rodger, I ^a   Tagari, P ^a   Therien M ^a   Vickers, P ^a   Wong, E ^a   Xu, L J ^a   Young, R N ^a   Zamboni, R ^a   Boyce, S ^b   Rupniak, N ^b   Forrest, M ^b   Visco, D ^b   Patrick, D ^b   more..

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; INDOMETACIN; MELOXICAM; ROFECOXIB; TILMACOXIB; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC SUSCEPTIBILITY; NONHUMAN; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHO CELLS; CRICETINAE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; HUMANS; INDOMETHACIN; INHIBITORY CONCENTRATION 50; ISOENZYMES; LACTONES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SULFONES;

EID: 0033526928     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00288-7     Document Type: Article

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