-
1
-
-
0031043106
-
Analysis of the synovial cellular infiltrate in early rheumatoid synovial tissue in relation to local disease activity
-
Tak, P. P., T. J. M. Smeets, M. R. Daha, P. M. Kluin, K. A. E. Meijers, R. Brand, A. E. Meinders, and F. C. Breedveld. 1997. Analysis of the synovial cellular infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum. 40:217.
-
(1997)
Arthritis Rheum.
, vol.40
, pp. 217
-
-
Tak, P.P.1
Smeets, T.J.M.2
Daha, M.R.3
Kluin, P.M.4
Meijers, K.A.E.5
Brand, R.6
Meinders, A.E.7
Breedveld, F.C.8
-
2
-
-
0001155701
-
Etiology and pathogenesis of rheumatoid arthritis
-
W.N. Kelly, E.D. Harris, S. Ruddy and C.B. Sledge, eds. W.B. Saunders Co., Philadelphia
-
Firestein, G. S. 1996. Etiology and pathogenesis of rheumatoid arthritis. In Textbook of rheumatology. 5th Ed. W.N. Kelly, E.D. Harris, S. Ruddy and C.B. Sledge, eds. W.B. Saunders Co., Philadelphia, p. 851.
-
(1996)
Textbook of Rheumatology. 5th Ed.
, pp. 851
-
-
Firestein, G.S.1
-
3
-
-
0025348745
-
How important are T cells in chronic rheumatoid synovitis
-
Firestein, G. S., and N. J. Zvaifler. 1990. How important are T cells in chronic rheumatoid synovitis. Arthritis Rheum. 33:768.
-
(1990)
Arthritis Rheum.
, vol.33
, pp. 768
-
-
Firestein, G.S.1
Zvaifler, N.J.2
-
4
-
-
0030615201
-
Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
-
Barnes, P. J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066.
-
(1997)
N. Engl. J. Med.
, vol.336
, pp. 1066
-
-
Barnes, P.J.1
Karin, M.2
-
5
-
-
0029563524
-
Nuclear factor-κB in rheumatoid synovium: Localization of p50 and p65
-
Handel, M. L., L. B. McMorrow, and E. M. Gravallese. 1995. Nuclear factor-κB in rheumatoid synovium: localization of p50 and p65. Arthritis Rheum. 38:1762.
-
(1995)
Arthritis Rheum.
, vol.38
, pp. 1762
-
-
Handel, M.L.1
McMorrow, L.B.2
Gravallese, E.M.3
-
6
-
-
15844384253
-
Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue
-
Marok, R., P. G. Winyard, A. Coumbe, M. L. Kus, K. Gaffney, S. Blades, P. I. Mapp, C. J. Morris, D. R. Blake, C. Kaltschmidt, and P. A. Baeuerle. 1996. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum. 39:583.
-
(1996)
Arthritis Rheum.
, vol.39
, pp. 583
-
-
Marok, R.1
Winyard, P.G.2
Coumbe, A.3
Kus, M.L.4
Gaffney, K.5
Blades, S.6
Mapp, P.I.7
Morris, C.J.8
Blake, D.R.9
Kaltschmidt, C.10
Baeuerle, P.A.11
-
7
-
-
0031886794
-
Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: Spontaneous activation of NF-κB and CBF1
-
Miyazawa, K., A. Mori, K. Yamamoto, and H. Okudaira. 1998. Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: Spontaneous activation of NF-κB and CBF1. Am. J. Pathol 152:793.
-
(1998)
Am. J. Pathol
, vol.152
, pp. 793
-
-
Miyazawa, K.1
Mori, A.2
Yamamoto, K.3
Okudaira, H.4
-
8
-
-
0029853213
-
SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo
-
Goldman, M. E., L. J. Ransone, D. W. Anderson, W. A. Gaarde, M. J. Suto, R. W. Sullivan, R. Shorthouse, M. Morikawa, and R. E. Morris. 1996. SP100030 is a novel T-cell-specific transcription factor inhibitor that possesses immunosuppressive activity in vivo. Transplant. Proc. 28:3106.
-
(1996)
Transplant. Proc.
, vol.28
, pp. 3106
-
-
Goldman, M.E.1
Ransone, L.J.2
Anderson, D.W.3
Gaarde, W.A.4
Suto, M.J.5
Sullivan, R.W.6
Shorthouse, R.7
Morikawa, M.8
Morris, R.E.9
-
9
-
-
0032510166
-
2-chloro-4-(trifluoromethyl)pyrimidine-5-N-(3′, 5′-bis(trifluoromethyl)phenyl)-carboxamide: A potent inhibitor of NF-κB-and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry
-
Sullivan, R. W., C. G. Bigam, P. E. Erdman, M. S. Palanki, D. W. Anderson, M. E. Goldman, L. J. Ransone, and M. J. Suto. 1998. 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3′, 5′-bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-κB-and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J. Med. Chem. 41:413.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 413
-
-
Sullivan, R.W.1
Bigam, C.G.2
Erdman, P.E.3
Palanki, M.S.4
Anderson, D.W.5
Goldman, M.E.6
Ransone, L.J.7
Suto, M.J.8
-
10
-
-
0032428729
-
AP-1 and nf-κb regulation in rheumatoid arthritis and mutine collagen-induced arthritis
-
Han, Z. N., D. L. Boyle, A. M. Manning, and G. S. Firestein. 1998. AP-1 and NF-κB regulation in rheumatoid arthritis and mutine collagen-induced arthritis. Autoimmunity. 28:197.
-
(1998)
Autoimmunity.
, vol.28
, pp. 197
-
-
Han, Z.N.1
Boyle, D.L.2
Manning, A.M.3
Firestein, G.S.4
-
11
-
-
0024380087
-
Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
-
Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17:6419.
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 6419
-
-
Schreiber, E.1
Matthias, P.2
Muller, M.M.3
Schaffner, W.4
-
12
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248
-
-
Bradford, M.M.1
-
13
-
-
0028143211
-
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor a (cA2) versus placebo in rheumatoid arthritis
-
Elliott, M. J., R. N. Maini, M. Feldmann, J. R. Kalden, C. Antoni, J. S. Smolen, B. Leeb, F. C. Breedveld, J. D. Macfarlane, H. Bijl, and J. N. Woody. 1994. Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor a (cA2) versus placebo in rheumatoid arthritis. Lancet 344: 1105.
-
(1994)
Lancet
, vol.344
, pp. 1105
-
-
Elliott, M.J.1
Maini, R.N.2
Feldmann, M.3
Kalden, J.R.4
Antoni, C.5
Smolen, J.S.6
Leeb, B.7
Breedveld, F.C.8
Macfarlane, J.D.9
Bijl, H.10
Woody, J.N.11
-
14
-
-
0013511183
-
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
-
Moreland, L. W., S. W. Baumgartner, M. H. Schiff, E. A. Tindall, R. M. Fleischmann, A. L. Weaver, R. E. Ettlinger, S. Cohen, W. J. Koopman, K. Mohler, M. B. Widmer, and C. M. Blosch. 1997. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N. Engl. J. Med. 337:141.
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 141
-
-
Moreland, L.W.1
Baumgartner, S.W.2
Schiff, M.H.3
Tindall, E.A.4
Fleischmann, R.M.5
Weaver, A.L.6
Ettlinger, R.E.7
Cohen, S.8
Koopman, W.J.9
Mohler, K.10
Widmer, M.B.11
Blosch, C.M.12
-
15
-
-
0033056503
-
IL-6 synthesis by rheumatoid synoviocytes is autonomously upregulated at the transcriptional level
-
Miyazawa, K., A. Mori, and H. Okudaira. 1999. IL-6 synthesis by rheumatoid synoviocytes is autonomously upregulated at the transcriptional level. J. Allergy Clin. Immunol. 103:S437.
-
(1999)
J. Allergy Clin. Immunol.
, vol.103
-
-
Miyazawa, K.1
Mori, A.2
Okudaira, H.3
-
16
-
-
0033545863
-
Defining therapeutic targets by using adenovirus: Blocking NF-κb inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators
-
Bondeson, J., B. Foxwell, F. Brennan, and M. Feldmann. 1999. Defining therapeutic targets by using adenovirus: blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators. Proc. Natl. Acad. Sci. USA 96:5668.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 5668
-
-
Bondeson, J.1
Foxwell, B.2
Brennan, F.3
Feldmann, M.4
-
17
-
-
0028295883
-
Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis
-
Firestein, G. S., D. L. Boyle, C. Yu, M. M. Paine, T. D. Whisenand, N. J. Zvaifler, and W. P. Arend. 1994. Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum. 37:644.
-
(1994)
Arthritis Rheum.
, vol.37
, pp. 644
-
-
Firestein, G.S.1
Boyle, D.L.2
Yu, C.3
Paine, M.M.4
Whisenand, T.D.5
Zvaifler, N.J.6
Arend, W.P.7
-
18
-
-
0028574382
-
Interleukin-1. Tumor necrosis factor and their specific inhibitors
-
Dayer, J. M., and D. Burger. 1994. Interleukin-1. tumor necrosis factor and their specific inhibitors. Eur. Cytokine Netw. 5:563.
-
(1994)
Eur. Cytokine Netw.
, vol.5
, pp. 563
-
-
Dayer, J.M.1
Burger, D.2
-
19
-
-
0033028896
-
Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-κB activation in synovial fibroblasts
-
Shin, H., I. Kitajima, T. Nakajima, Q. Shao, T. Tokioka, I. Takasaki, N. Hanyu, T. Kubo, and I. Maruyama. 1999. Thrombin receptor mediated signals induce expressions of interleukin 6 and granulocyte colony stimulating factor via NF-κB activation in synovial fibroblasts. Ann. Rheum. Dis. 58:55.
-
(1999)
Ann. Rheum. Dis.
, vol.58
, pp. 55
-
-
Shin, H.1
Kitajima, I.2
Nakajima, T.3
Shao, Q.4
Tokioka, T.5
Takasaki, I.6
Hanyu, N.7
Kubo, T.8
Maruyama, I.9
-
20
-
-
0033168701
-
NF-κB regulation by iκb kinase in primary fibroblast-like synoviocytes
-
Aupperle, K. R., B. L. Bennett, D. L. Boyle, P. P. Tak, A. M. Manning, and G. S. Firestein. 1999. NF-κB regulation by IκB kinase in primary fibroblast-like synoviocytes. J. Immunol. 163:427.
-
(1999)
J. Immunol.
, vol.163
, pp. 427
-
-
Aupperle, K.R.1
Bennett, B.L.2
Boyle, D.L.3
Tak, P.P.4
Manning, A.M.5
Firestein, G.S.6
-
21
-
-
0029842020
-
Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin
-
Sakurada, S., T. Kato, and T. Okamoto. 1996. Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin. Int. Immunol. 8:1483.
-
(1996)
Int. Immunol.
, vol.8
, pp. 1483
-
-
Sakurada, S.1
Kato, T.2
Okamoto, T.3
-
22
-
-
0031596140
-
Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblasts
-
Vincenti, M. P., C. I. Coon, and C. E. Brinckerhoff. 1998. Nuclear factor κB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1β-stimulated synovial fibroblasts. Arthritis Rheum. 41:1987.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1987
-
-
Vincenti, M.P.1
Coon, C.I.2
Brinckerhoff, C.E.3
-
23
-
-
0031689268
-
Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: Involvement of membrane-associated cytokines
-
Burger, D., R. Rezzonico, J. M. Li, C. Modoux, R. A. Pierce, H. G. Welgus, and J. M. Dayer. 1998. Imbalance between interstitial collagenase and tissue inhibitor of metalloproteinases 1 in synoviocytes and fibroblasts upon direct contact with stimulated T lymphocytes: involvement of membrane-associated cytokines. Arthritis Rheum. 41:1748.
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1748
-
-
Burger, D.1
Rezzonico, R.2
Li, J.M.3
Modoux, C.4
Pierce, R.A.5
Welgus, H.G.6
Dayer, J.M.7
-
24
-
-
0033178749
-
Essential role of T cell NF-κB activation in collagen-induced arthritis
-
Seetharaman, R., A. L. Mora, G. Nabozny, M. Boothby, and J. Chen. 1999. Essential role of T cell NF-κB activation in collagen-induced arthritis. J. Immunol. 163:1577.
-
(1999)
J. Immunol.
, vol.163
, pp. 1577
-
-
Seetharaman, R.1
Mora, A.L.2
Nabozny, G.3
Boothby, M.4
Chen, J.5
-
25
-
-
0031830389
-
Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue
-
Smeets, T. J. M., R. J. E. M. Dolhain, A. M. M. Miltenburg, R. de Kuiper, F. C. Breedveld, and P. P. Tak. 1998. Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue. Clin. Immunol. Immunopathol. 88:84.
-
(1998)
Clin. Immunol. Immunopathol.
, vol.88
, pp. 84
-
-
Smeets, T.J.M.1
Dolhain, R.J.E.M.2
Miltenburg, A.M.M.3
De Kuiper, R.4
Breedveld, F.C.5
Tak, P.P.6
-
26
-
-
0032032469
-
Sulfasalazine: A potent and specific inhibitor of nuclear factor κB
-
Wahl, C., S. Liptay, G. Adler, and R. M. Schmid. 1998. Sulfasalazine: a potent and specific inhibitor of nuclear factor κB. J. Clin. Invest. 101:1163.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1163
-
-
Wahl, C.1
Liptay, S.2
Adler, G.3
Schmid, R.M.4
-
27
-
-
0028167846
-
Inhibition of NF-κB by sodium salicylate and aspirin
-
Kopp, E., and S. Ghosh. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956.
-
(1994)
Science
, vol.265
, pp. 956
-
-
Kopp, E.1
Ghosh, S.2
-
28
-
-
0031862891
-
Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
-
Barnes, P. J. 1998. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin. Sci. 94:557.
-
(1998)
Clin. Sci.
, vol.94
, pp. 557
-
-
Barnes, P.J.1
-
29
-
-
0032505870
-
NF-κb activation provides the potential link between inflammation and hyperplasia in the arthritic joint
-
Miagkov, A. V., D. V. Kovalenko, C. E. Brown, J. R. Didsbury, J. P. Cogswell, S. A. Stimpson, A. S. Baldwin, and S. S. Makarov. 1998. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc. Natl. Acad. Sci. USA 95:13859.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 13859
-
-
Miagkov, A.V.1
Kovalenko, D.V.2
Brown, C.E.3
Didsbury, J.R.4
Cogswell, J.P.5
Stimpson, S.A.6
Baldwin, A.S.7
Makarov, S.S.8
|