A conserved domain of Schizosaccharomyces pombe dfp1+ is uniquely required for chromosome stability following alkylation damage during S phase

Molecular and Cellular Biology

Volumn 22, Issue 13, 2002, Pages 4477-4490

  Fung, Amy D ^a   Ou, Jiongwen ^a   Bueler, Stephanie ^a   Brown, Grant W ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MESYLIC ACID METHYL ESTER; PROTEIN DFP1; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CELL CYCLE S PHASE; DNA DAMAGE; DNA REPLICATION; GENETIC STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SCHIZOSACCHAROMYCES POMBE; SEQUENCE ANALYSIS; ULTRAVIOLET RADIATION;

ALKYLATION; AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL CYCLE PROTEINS; CELL NUCLEUS; CHROMOSOMES, FUNGAL; CONSERVED SEQUENCE; DNA DAMAGE; DNA REPLICATION; FUNGAL PROTEINS; METHYL METHANESULFONATE; MITOSIS; MUTATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; S PHASE; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

FUNGI; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

EID: 0036277242     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.13.4477-4490.2002     Document Type: Article

References (65)

1. Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast
2. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45p during S phase
3. A quantitative assay to measure chromosome stability in Schizosaccharomyces pombe
4. The Cdc7 protein kinase is required for origin firing during S phase
5. Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases
6. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase
7. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast
8. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated
9. Cell cycle regulation of DNA replication initiator factor Dbf4p
10. Cdc7 is required throughout the yeast S phase to activate replication origins
11. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin on budding yeast
12. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
13. Initiation of DNA replication in eukaryotic cells
14. Cell cycle checkpoints: Preventing an identity crisis
15. Fission yeast genes involved in coupling mitosis to completion of DNA replication
16. Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1
17. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase
18. Checkpoints: Controls that ensure the order of cell cycle events
19. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
20. nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control
21. The Cdc7/Dbf4 protein kinase: Target of the S phase checkpoint?
22. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
23. Efficient targeted integration at leu1-32 and ura4-294 in Schizosaccharomyces pombe
24. Regulation of chromosome replication
25. Functions of fission yeast orp2 in DNA replication and checkpoint control
26. Characterization of the yeast Cdc7/Dbf4 complex purified from insect cells: Its protein kinase activity is regulated by Rad53p
27. 1/S transition in mammalian cells
28. Uninterrupted MCM2-7 function required for DNA replication fork progression
29. The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle
30. Emerging mechanisms of eukaryotic DNA replication initiation
31. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
32. Initiating DNA synthesis: From recruiting to activating the MCM complex
33. Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes
34. S-phase specific activation of Cds1 kinase defines a subpathway of the checkpoint response in S. pombe
35. The DNA replication checkpoint response stabilizes stalled replication forks
36. Dbf4 motifs: Conserved motifs in activation subunits for Cdc7 kinases essential for S-phase
37. +, a Schizosacchromyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication
38. CDC7 kinase complex as a molecular switch for DNA replication
39. Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe
40. Molecular genetic analysis of fission yeast Schizosaccharomyces pombe
41. Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance
42. Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
43. The Cdt1 protein is required to license DNA for replication in fission yeast
44. Hierarchy of S-phase-promoting factors: Yeast Dbf4-Cdc7 kinase requires prior S-phase cyclin-dependent kinase activation
45. The G2-phase DNA-damage checkpoint
46. Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase
47. Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability
48. + gene encodes the large subunit of replication protein A
49. A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage
50. When checkpoints fail
51. Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast
52. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
53. Cdc7p-Dbf4p becomes famous in the cell cycle
54. Schizosaccharomyces pombe Hsk1p is a potential Cds1p target required for genome integrity
55. rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
56. A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage
57. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast
58. Loading of an Mcm protein onto DNA replication origins is regulated by Cdc6p and CDKs
59. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
60. Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts
61. Rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint
62. DNA damage checkpoints update: Getting molecular
63. Cdc7p-Dbf4p binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway
64. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase
65. Formation of a preinitiation complex by S-phase cyclin CDK-dependent loading of Cdc45p onto chromatin