Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast

Molecular Biology of the Cell

Volumn 12, Issue 5, 2001, Pages 1257-1274

  Takeda, T ^a   Ogino, K ^a   Tatebayashi, K ^a   Ikeda, H ^a   Arai, K I ^a   Masai, H ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CDC 7 RELATED KINASE; CHECKPOINT KINASE RAD3; COHESIN; FUNGAL PROTEIN; HSK1 KINASE; MINICHROMOSOME MAINTENANCE PROTEIN 2; PROTEIN HSK1 89; RAD21 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CHROMATID; CHROMOSOME STRUCTURE; CONTROLLED STUDY; DNA REPLICATION; ENZYME ACTIVATION; GENE DELETION; GENE FUNCTION; GENE MUTATION; LETHALITY; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; TEMPERATURE DEPENDENCE; YEAST;

SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE;

EID: 0034765174     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.5.1257     Document Type: Article

References (75)

1. Components and dynamics of DNA replication complexes in S. cerevisiae: Redistribution of MCM proteins and Cdc45 during S phase
2. Nucleotide-dependent recognition of chromosomal origins of DNA replication by a multiprotein complex
3. Mutational effect of fission yeast Polα on cell cycle events
4. Replication checkpoint enforced by kinase Cds1 and Chk1
5. The Cdc7 protein kinase is required for origin firing during S phase
6. Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases
7. Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast
8. Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase
9. The yeast gene, DBF4, essential for entry into S phase is cell cycle regulated
10. Cell cycle regulation of DNA replication initiator factor Dbf4
11. The role of MCM/P1 proteins in the licensing of DNA replication
12. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
13. Two steps in the assembly of complexes at yeast replication origins in vivo
14. Cdc7 is required throughout the yeast S phase to activate replication origins
15. Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
16. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
17. DNA polymerase alpha, a component of the replication initiation complex, is essential for the checkpoint coupling S phase to mitosis in fission yeast
18. Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels
19. The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of 5 phase
20. A direct link between sister chromatids cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
21. Shizosaccharomyces pombe
22. Genetic control of the cell cycle in yeast II. Genes controlling DNA replication and its initiation
23. Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae
24. Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex
25. cdt1 is an essential target of the Cdc10/Sct1 transcription factor: Requirement for DNA replication and inhibition of mitosis
26. Molecular genetic studies of the Cdc7 protein kinase and induced mutagenesis in yeast
27. A tusion protein library: An improved method for rapid screening and characterization of DNA binding or interacting proteins
28. A DNA helicase activity is associated with an MCM4, -6 and -7 protein complex
29. Biochemical function of mouse minichromosome maintenance 2 protein
30. Inhibition of mcm4,6,7 helicase activity by phosphorylation with cyclin A/Cdk2
31. Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein
32. cdc18 by CDK phosphorylation
33. Identification and characterization of a human protein kinase related to budding yeast Cdc7p
34. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
35. First the CDKs, now DDKs
36. The role of MCM proteins in the control of genome duplication
37. + gene product couples S phase to start and mitosis
38. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition
39. A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5
40. Licensing of DNA replication by a multiprotein complex of MCM/P1 proteins in Xenopus eggs
41. A nowd growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells
42. Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis
43. S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
44. Negative regulation of Cdc18 DNA replication protein by Cdc2
45. Fission yeast cdc21, a member of MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle
46. Human Cdc7-related kinase complex: In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a critical threonine residue of Cdc7 by Cdks
47. 1+, a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae CDC7, is required for chromosomal replication
48. Cdc7 kinase complex as a molecular switch for DNA replication
49. Thiamine-repressible expression vectors pREP and pRIP for fission yeast
50. Cohesin: Chromosomal proteins that prevent premature separation of sister chromatids
51. Molecular genetic analysis of the fission yeast Schizosaccharomyces pombe
52. Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle
53. Viewpoints: Putting the cell cycle in order
54. Putting it all together: Building a prereplicative complex
55. cdc18 plays a major role controlling the initiation of DNA replication in fission yeast
56. High-frequency transformation method and library transducing vectors for cloning mammalian cDNAs by transcomplementation of Shizosaccharomyces pombe
57. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
58. Fission yeast cut5 links nuclear chromatin and M phase regulator in the replication checkpoint control
59. +
60. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: In vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7
61. Cdc7 protein kinase for DNA metabolism comes of age
62. Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex
63. Ctf7p is essential for sister chromatids cohesion and links mitotic chromosome structure to the DNA replication machinery
64. Shizosaccharomyces pombe Hsk1p is a potential Cds1p target required for genome integrity
65. Cell cycle control of DNA replication
66. +, encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S phase initiation as well as in S phase checkpoint control and recovery from DNA damages
67. Loading of an Mcm protein onto DNA-replication origins is regulated by Cdc6p and Cdks
68. Fission yeast Esol is required for establishing sister chromatid cohesion during S phase
69. ts mutant that is aberrant in chromosome segregation, microtuble function, DNA repair and sensitive to hydroxyurea: Possible involvement of Rad21 in ubiquitin-mediated proteolysis
70. BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication
71. Characterizaton of fission yeast cohesin: Essential proteolysis of tad21 phosphorylated in the S phase
72. Yeast cohesin complex requires a conserved protein, Eco1 (Ctf7), to establish cohesion between sister chromatids during DNA replication
73. The Mcm2-3-5 proteins: Are they replication licensing factors?
74. Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase
75. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1