Biology of Hodgkin's lymphoma

Annals of Oncology

Volumn 13, Issue , 2002, Pages 11-18

  Kuppers R ^a   Schwering, I ^a   Brauninger A ^b   Rajewsky, K ^a   Hansmann, M L ^b  

^a UNIVERSITY OF COLOGNE   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Angioimmunoblastic lymphadenopathy; Cell fusion; Composite lymphoma; Hodgkin's lymphoma; Reed Sternberg cell; Somatic hypermutation

Indexed keywords

ANIMAL; B LYMPHOCYTE; CELL CLONE; GENE EXPRESSION; GENE REARRANGEMENT; GENETICS; HODGKIN DISEASE; HUMAN; PATHOLOGY; REED STERNBERG CELL; REVIEW; T LYMPHOCYTE; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL FUSION; CELL LINEAGE; CELL TRANSFORMATION; CELL TYPE; CONTROLLED STUDY; GENE MUTATION; GERMINAL CENTER; HISTOPATHOLOGY; LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; B-LYMPHOCYTES; CLONE CELLS; GENE EXPRESSION; GENE REARRANGEMENT; HODGKIN DISEASE; HUMANS; REED-STERNBERG CELLS; T-LYMPHOCYTES; ANIMAL; HUMAN; SUPPORT, NON-U.S. GOV'T;

B LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN;

EID: 0036258342     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/13.S1.11     Document Type: Article

References (64)

1. Pathology of lymphocyte predominance Hodgkin's disease
2. The Reed-Sternberg cell in classical Hodgkin's disease
3. Molecular biology of Hodgkin's lymphoma
4. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development
5. Clonal selection and learning in the antibody system
6. The origin of Hodgkin and Reed/Sternberg cells in Hodgkin's disease
7. Clonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's disease
8. Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal center-derived tumor B cells
9. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
10. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells
11. Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription
12. Clonality in nodular lymphocyte-predominant Hodgkin's disease
13. Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections
14. Molecular single-cell analysis of Hodgkin and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes
15. Germinal center founder cells display propensity for apoptosis before onset of somatic mutation
16. European Task Force on Lymphoma project on lymphocyte predominance Hodgkin's disease: Histologic and immunohistologic analysis of submitted cases reveals 2 types of Hodgkin's disease with a nodular growth pattern lymphocytes
17. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
18. Survival and clonal expansion of mutating 'forbidden' (immunoglobulin receptor-deficient) Epstein-Barr virus-infected B cells in angioimmunoblastic T cell lymphoma
19. Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: Potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease
20. The clonal relationship between nodular sclerosis Hodgkin's disease with a clonal Reed-Sternberg cell population and a subsequent B-cell small noncleaved cell lymphoma
21. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma
22. Common germinal-center B-cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin's disease and either follicular lymphoma or B-CLL
23. Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B cell
24. Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
25. Detection of clonal T-cell receptor γ-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin's disease
26. Origin of Reed-Sternberg cells in Hodgkin's disease
27. Hodgkin's disease: The Sternberg-Reed cell
28. The origins of Hodgkin's disease
29. Evidence that Hodgkin and Reed-Sternberg cells in Hodgkin disease do not represent cell fusions
30. MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: Results from single-cell polymerase chain reaction and molecular cytogenetic studies
31. TP53 gene mutations in Hodgkin lymphoma are infrequenct and not associated with absence of Epstein-Barr virus
32. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease
33. The origin of CD95 gene mutations in B cell lymphoma
34. Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction
35. Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells
36. Cultivated H-RS cells are resistant to CD95L-mediated apoptosis despite expression of wild-type CD95
37. The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
38. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
39. Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells
40. Characterization of NF-κB expression in Hodgkin's disease: Inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells
41. Mutations in the IκBα gene in Hodgkin's disease suggest a tumour suppressor role for IκBα
42. Overexpression of IκBα without inhibition of NF-κB activity and mutations in the IκBα gene in Reed-Sternberg cells
43. Clonal deleterious mutations in the IκBα gene in the malignant cells in Hodgkin's disease
44. Demonstration of light chain mRNA in Hodgkin's disease
45. Oct-2 and Bob-1 deficiency in Hodgkin and Reed-Sternberg cells
46. Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin's disease but not in lymphocyte predominant Hodgkin's disease correlates with immunoglobulin transcription
47. The transcription factor PU.1, necessary for B-cell development is expressed in lymphocyte predominance, but not classical Hodgkin's disease
48. Light-chain mRNA in lymphocyte-predominant and mixed-cellularity Hodgkin's disease
49. Somatic hypermutation in the heavy chain locus correlates with transcription
50. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation
51. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
52. Analysis of T-cell subpopulations in T-cell non-Hodgkin's lymphoma of angioimmunoblastic lymphadenopathy with dysproteinemia type by single target gene amplification of T cell receptor-β gene rearrangements
53. Recent results on the biology of Hodgkin and Reed-Sternberg cells. I. Biopsy material
54. Leu M1 and peanut agglutinin stain the neoplastic cells of Hodgkin's disease
55. Fascin, a sensitive new marker for Reed-Sternberg cells of Hodgkin's disease. Evidence for a dendritic or B cell derivation?
56. Hodgkin's cells express CD83, a dendritic cell lineage associated antigen
57. High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltration Hodgkin's lymphoma
58. Differentiation mechanisms and malignancy
59. Differentiation-linked leukemogenesis in lymphocytes
60. Deficient T cell fate specification in mice with an induced inactivation of Notch1
61. Notch1 expression in early lymphopoiesis influences B versus T lineage determination
62. Activated Notch 1 signaling promotes tumor cell proliferation and survival in Hodgkin's and anaplastic large cell lymphoma
63. Formation of multinucleated cells in a Hodgkin's-disease-derived cell line
64. Cell fusion is not involved in the generation of giant cells in the Hodgkin-Reed Sternberg cell line L1236