Clonal deleterious mutations in the iκbα gene in the malignant cells in Hodgkin's lymphoma

Journal of Experimental Medicine

Volumn 191, Issue 2, 2000, Pages 395-401

  Jungnickel, Berit ^a   Staratschek Jox, Andrea ^a   Bräuninger, Andreas ^b   Spieker, Tilmann ^b   Wolf, Jürgen ^a   Diehl, Volker ^a   Hansmann, Martin Leo ^b   Rajewsky, Klaus ^a   Küppers, Ralf ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Hodgkin's lymphoma; I B ; Nuclear factor B; Reed Sternberg cell; Tumor suppressor gene

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CARCINOGENESIS; CELL ACTIVATION; DEGRADATION; EPSTEIN BARR VIRUS; GENE MUTATION; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATORY CELL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; REED STERNBERG CELL; TUMOR SUPPRESSOR GENE;

ADULT; CHILD; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; HODGKIN DISEASE; HUMANS; I-KAPPA B PROTEINS; MALE; TUMOR CELLS, CULTURED;

EID: 0034677104     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.2.395     Document Type: Article

References (30)

1. Cossman, J., C. Messineo, and A. Bagg. 1998. Reed-Sternberg cell: survival in a hostile sea. Lab. Invest. 78:229-235.
2. Küppers, R., K. Rajewsky, M. Zhao, G. Simons, R. Laumann, R. Fischer, and M.L. Hansmann. 1994. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal imnumoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc. Natl. Acad. Sci. USA. 91:10962-10966.
3. Kanzler, H., R. Küppers, ML. Hansmann, and K. Rajewsky. 1996. Hodgkin and Reed-Sternberg cells in Hodgkin's disease-represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184:1495-1505.
4. Rajewsky, K. 1996. Clonal selection and learning in the antibody system. Nature. 381:751-758.
5. Montesinos-Rongen, M., A. Roers, R. Küppers, K. Rajewsky, and M.L. Hansmann. 1999. Mutation of the p53 gene is not a typical feature of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Blood. 94:1755-1760.
6. Gravel, S., G. Delsol, and T. Al Saati. 1998. Single-cell analysis of the t(14,18)(q31,q21) chromosomal translocation in Hodgkin's disease demonstrates the absence of this translocation in neoplastic Hodgkin and Reed-Sternberg cells. Blood. 91:2866-2874.
7. Armbinder, R.F., and L.M. Weiss. 1999. Association of Epstein-Barr virus with Hodgkin's disease. In Hodgkin's Disease. P.M. Mauch, J.O. Armitage, V. Diehl, R.T. Hoppe, and L.M. Weiss, editors. Lippincott Williams and Wilkins, Philadelphia. 79-98.
8. Bargou, R.C., C. Leng, D. Krappmann, F. Emmerich, M.Y. Mapara, K. Bommert, H.D. Royer, C. Scheidereit, and B. Dörken. 1996. High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood. 87:4340-4347.
9. Bargou, R.C., F. Emmerich, D. Krappmann, K. Bommert, M.Y. Mapara, W. Arnold, H.D. Royer, E. Grinstein, A. Greiner, C. Scheidereit, and U. Dörken. 1997. Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J. Clin. Invest. 100:2961-2969.
10. Baldwin, A.S. 1996. The NF-κB and 1κB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-681.
11. Wulczyn, F.G., D. Krappmann, and C. Scheidereit. 1996. The NF-kappa B/Rel and I kappa B gene families: mediators of immune response and inflammation. J. Mol. Med. 74: 749-769.
12. Luque, I., and C. Gelinas. 1997. Rel/NF-kappa B and I kappa B factors in oncogenesis. Semin. Cancer Biol. 8:103-111.
13. Wood, K.M., M. Roff, and R.T. Hay. 1998. Defective Ikappa-Balpha in Hodgkin cell lines with constitutively active NF-kappaB. Oncogene. 16:2131-2139.
14. Cabannes, E., G. Khan, F. Aillet, R.F. Jarrett, and R.T. Hay. 1999. Mutations in the Iκβα gene in Hodgkin's disease suggest a tumour suppressor role for Iκβα. Oncogene. 18:3063-3070.
15. Drexler, H.G. 1993. Recent results on the biology of Hodgkin and Reed-Sternberg cells. II. Continuous cell lines. Leuk. Lymphoma. 9:1-25.
16. Küppers, R., M. Zhao, K. Rajewsky, and M.L. Hansmann. 1993. Detection of clonal B cell populations in paraffin-embedded tissues by polymerase chain reaction. Am. J. Pathol. 143:230-239.
17. Kanzler, H., M.L. Hansmann, U. Kapp, J. Wolf, V. Diehl, K. Rajewsky, and R. Küppers. 1996. Molecular single cell analysis demonstrates the derivation of a peripheral blood-derived cell line (L1236) from the Hodgkin/Reed-Sternberg cells of a Hodgkin's lymphoma patient. Blood. 87:3429-3436.
18. Ito, C.Y., N. Adey, V.I., Bautch, and A.S.J. Baldwin. 1995. Structure and evolution of the human IKBA gene. Genomics. 29:490-495.
19. Weber-Matthiesen, K., J. Deerberg, M. Poetsch, W. Grote, and B. Schlegelberger. 1995. Numerical chromosome aberrations are present within the CD30+ Hodgkin and Reed-Sternberg cells in 100% of analyzed cases of Hodgkin's disease. Blood. 86:1464-1468.
20. Falzetti, D., B. Crescenzi, C. Matteuci, B. Falini, M.F. Martelli, H. Van Den Berghe, and C. Mecucci. 1999. Genomic instability and recurrent breakpoints are main cytogenetic findings in Hodgkin's disease. Haematologica. 84:298-305.
21. Barrios, L., M.R. Caballin, R. Miro, C. Fuster, G. Berrozpe, A. Subias, X. Batlle, and J. Egozcue. 1988. Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability. Hum. Genet. 78:320-324.
22. Shen, H.M., A. Peters, B. Baron, X. Zhu, and U. Storb. 1998. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science. 280:1750-1752.
23. Pasqualucci, L., A. Migliazza, N. Fracchiolla, C. William, A. Neri, L. Baldini, R.S.K. Chaganti, U. Klein, R. Küppers, K. Rajewsky, and R. Dalla-Favera. 1998. BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. USA. 95:11816-11821.
24. Huxford, T., D.B. Huang, S. Malek, and G. Ghosh. 1998. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell. 95:759-770.
25. Jacobs, M.D., and S.C. Harrison. 1998. Structure of an IkappaBalpha/NF-kappaB complex. Cell. 95:749-758.
26. Ernst, M.K., L.L. Dunn, and N.R. Rice. 1995. The PEST-like sequence of I kappa B alpha is responsible for inhibition of DNA binding but not for cytoplasmic retention of c-Rel or Re1A homodimers. Mol. Cell Biol. 15:872-882.
27. Beg, A.A., W.C. Sha, R.T. Bronson, and D. Baltimore. 1995. Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev. 9:2736-2746.
28. Krappmann, D., F. Emmerich, U. Kordes, E. Scharschmidt, B. Dörken, and C. Scheidereit. 1999. Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells. Oncogene. 18:943-953.
29. Beauparlant, P., I. Kwan, R. Bitar, P. Chou, A.E. Koromilas, N. Sonenberg, and J. Hiscott. 1994. Disruption of kappa B alpha regulation by antisense RNA expression leads to malignant transformation. Oncogene. 9:3189-3197.
30. Haskill, S., A.A. Beg, S.M. Tompkins, J.S. Morris, A.D. Yurochko, A. Sampson-Johannes, K. Mondal, P. Ralph, and A.S.J. Baldwin. 1991. Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. Cell. 65:1281-1289.