Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-center B cells

New England Journal of Medicine

Volumn 337, Issue 7, 1997, Pages 453-458

  Marafioti, Theresa ^a,b   Hummel, Michael ^a,b   Anagnostopoulos, Ioannis ^a,b   Foss, Hans Dieter ^a,b   Falini, Brunangelo ^c   Delsol, Georges ^d   Isaacson, Peter G ^e   Pileri, Stefano ^f   Stein, Harald ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Consult Ref Ctr Lymph Node P ^*  (Germany)

^c UNIVERSITY OF PERUGIA   (Italy)

^d CHU PURPAN   (France)

^e ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^f UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; DISEASE ASSOCIATION; GENE EXPRESSION; GENE MUTATION; GENE REARRANGEMENT; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA ANALYSIS;

EID: 0030791751     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199708143370703     Document Type: Article

References (34)

1. Lukes RJ, Craver LF, Hall TC, Rappaport H, Ruben P. Report of the Nomenclature Committee. Cancer Res 1966;26:1311.
2. Jackson H Jr, Parker F Jr. Hodgkin's disease. I. General considerations. N Engl J Med 1944;230:1-8.
3. Lukes RJ, Butler JJ. The pathology and nomenclature of Hodgkin's disease. Cancer Res 1966;26:1063-83.
4. Regula DP Jr, Hoppe RT, Weiss LM. Nodular and diffuse types of lymphocyte predominance Hodgkin's disease. N Engl J Med 1988;318:214-9.
5. Colby TV, Hoppe RT, Warnke RA. Hodgkin's disease: a clinicopathologic study of 659 cases. Cancer 1982;49:1848-58.
6. Stein H, Hansmann ML, Lennert K, Brandtzaeg P, Gatter KC, Mason DY. Reed-Sternberg and Hodgkin cells in lymphocyte-predominant Hodgkin's disease of nodular subtype contain J chain. Am J Clin Pathol 1986; 86:292-7.
7. Pinkus GS, Said JW. Hodgkin's disease, lymphocyte predominance type, nodular - further evidence for a B cell derivation: L & H variants of Reed Sternberg cells express L26, a pan B cell marker. Am J Pathol 1988; 133:211-7.
8. Korkolopoulou P, Cordell J, Jones M, et al. The expression of the B-cell marker mb-1 (CD79a) in Hodgkin's disease. Histopathology 1994;24:511-5.
9. Angel CA, Pringle JH, Naylor J, West KP, Lauder I. Analysis of antigen receptor genes in Hodgkin's disease. J Clin Pathol 1993;46:337-40.
10. Angel CA, Pringle JH, Primrose L, Lauder I. Detection of immunoglobulin heavy chain gene rearrangements in Hodgkin's disease using PCR. J Clin Pathol 1993;46:940-2.
11. Pan LX, Diss TC, Peng HZ, Norton AJ, Isaacson PG. Nodular lymphocyte predominance Hodgkin's disease: a monoclonal or polyclonal B-cell disorder? Blood 1996;87:2428-34.
12. Delabie J, Tierens A, Wu G, Weisenburger DD, Chan WC. Lymphocyte predominance Hodgkin's disease: lineage and clonality determination using a single-cell assay. Blood 1994;84:3291-8.
13. Wickert RS, Weisenburger DD, Tierens A, Greiner TC, Chan WC. Clonal relationship between lymphocytic predominance Hodgkin's disease and concurrent or subsequent large-cell lymphoma of B lineage. Blood 1995;86:2312-20.
14. Greiner TC, Gascoyne RD, Anderson ME, et al. Nodular lymphocyte-predominant Hodgkin's disease associated with large-cell lymphoma: analysis of Ig gene rearrangements by V-J polymerase chain reaction. Blood 1996;88:657-66.
15. Tamaru J, Hummel M, Zemlin M, Kalvelage B, Stein H. Hodgkin's disease with a B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes. Blood 1994;84:708-15.
16. Kuppers R, Rajewsky K, Zhao M, et al. Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci U S A 1994;91:10962-6.
17. Stoler MH, Nichols GE, Symbula M, Weiss LM. Lymphocyte predominance Hodgkin's disease: evidence for a kappa light chain-restricted monotypic B-cell neoplasm. Am J Pathol 1995;146:812-8.
18. Hell K, Hansmann ML, Pringle JH, Lauder I, Fischer R. Combination of Hodgkin's disease and diffuse large cell lymphoma: an in situ hybridization study for immunoglobulin light chain messenger RNA. Histopathology 1995;27:491-9.
19. Schmid C, Sargent C, Isaacson PG. L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction. Am J Pathol 1991;139:1281-9.
20. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 1994;84:1361-92.
21. Kanzler H, Küppers R, Hansmann ML, Rajewsky K. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 1996;184:1495-505.
22. Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini K, Stein H. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N Engl J Med 1995;333:901-6.
23. Marks JD, Tristem M, Karpas A, Winter G. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur J Immunol 1991;21:985-91.
24. Ramasamy I, Brisco M, Morley A. Improved PCR method for detecting monoclonal immunoglobulin heavy chain rearrangement in B cell neoplasms. J Clin Pathol 1992;45:770-5.
25. H genes with no or very little somatic mutations like the physiologic cells of the follicle mantle. Blood 1994;84: 403-7.
26. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire. Immunol Today 1995;16:237-42.
27. Foss HD, Herbst H, Oelmann E, et al. Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases. Br J Haematol 1993;84: 627-35.
28. Roth J, Daus H, Trumper L, Gause A, Salamon-Looijen M, Pfreundschuh M. Detection of immunoglobulin heavy-chain gene rearrangement at the single-cell level in malignant lymphomas: no rearrangement is found in Hodgkin and Reed Sternberg cells. Int J Cancer 1994;57:799-804.
29. Pascual V, Liu YJ, Magalski A, de Bouteiller O, Banchereau J, Capra JD. Analysis of somatic mutation in five B cell subsets of human tonsil. J Exp Med 1994;180:329-39.
30. Rajewsky K. Clonal selection and learning in the antibody system. Nature 1996;381:751-8.
31. Hansmann ML, Fellbaum C, Hui PK, Moubayed P. Progressive transformation of germinal centers with and without association to Hodgkin's disease. Am J Clin Pathol 1990;93:219-26.
32. Sundeen JT, Cossman J, Jaffe ES. Lymphocyte predominant Hodgkin's disease nodular subtype with coexistent "large cell lymphoma": histological progression or composite malignancy? Am J Surg Pathol 1988;12:599-606.
33. Ree HJ, Neiman RS, Martin AW, Dallenbach F, Stein H. Paraffin section markers for Reed-Sternberg cells: a comparative study of peanut agglutinin, Leu-M1, LN-2, and Ber-H2. Cancer 1989;63:2030-6.
34. Falini B, Bigerna B, Pasqualucci L, et al. Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin's disease. Blood 1996;87:465-71.