Hodgkin and Reed-Sternberg cells represent an expansion of a single clone originating from a germinal center B-cell with functional immunoglobulin gene rearrangements but defective immunoglobulin transcription

Blood

Volumn 95, Issue 4, 2000, Pages 1443-1450

  Marafioti, Theresa ^b   Hummel, Michael ^b   Foss, Hans Dieter ^b   Laumen, Helmut ^b   Korbjuhn, Petra ^b   Anagnostopoulos, Ioannis ^b   Lammert, Hetty ^b   Demel, Gudrun ^b   Theil, Jan ^b   Wirth, Thomas ^b   Stein, Harald ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; FEMALE; GENE CONTROL; GENE REARRANGEMENT; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; MALE; PRIORITY JOURNAL; REED STERNBERG CELL; TRANSCRIPTION REGULATION;

EID: 17044443197     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.4.1443.004k55_1443_1450     Document Type: Article

References (40)

1. Lukes RJ, Butler JJ. The pathology and nomenclature of Hodgkin's disease. Cancer Res. 1966; 26:1063.
2. Harris NL, Jaffe ES, Stein H, et al. A revised European-American classification ol lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood. 1994;84:1361.
3. Marafioti T, Hummel M, Anagnostopoulos I, et al. Origin of nodular lymphocyte-predominant Hodgkin's disease from a clonal expansion of highly mutated germinal-centre B cells. N Engl J Med. 1997;337:453.
4. Braeuninger A, Küppers R, Strickler J, Wacker HH, Rajewsky K, Hansmann ML, Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin disease represent clonal populations of germinal centre-derived tumor cells. Proc Natl Acad Sci USA. 1997;94:9337.
5. Ohno T, Stribley JA, Wu G, Hinrichs SH, Weisenburger DD, Chan WC. Clonality in nodular lymphocyte-predominant Hodgkin's disease. N Engl J Med. 1997;337:459.
6. Stein H, Mason DY, Gerdes J, et al. The expression of the Hodgkin's disease-associated antigen Ki-1 in reactive and neoplastic lymphoid tissue. Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985;66:848.
7. Yatabe Y, Oka K, Asia J, Mori N. Poor correlation between clonal immunoglobulin gene rearrangement and immunoglobulin gene transcription in Hodgkin's disease. Am J Pathol. 1996;149:1351.
8. Manzanal A, Sauton A, Oliva H, Bellas C. Evaluation ol clonal immunoglobulin gene rearrangements in Hodgkin's disease using the polymerase chain reaction (PCR). Histopathology. 1995;27: 21.
9. Orazi A, Jiang B, Lee C, et al. Correlation between presence of clonal rearrangements of immunoglobulin heavy chain genes and B-cell antigen expression in Hodgkin's disease. Am J Clin Pathol. 1995;104:413.
10. Al Saati T, Galoin S, Gravel S, et al. IgH and TcR-gamma gene rearrangement identified in Hodgkin's disease by PCR demonstrate lack of correlation between genotype, phenotype and Epstein-Barr virus status. J Pathol. 1997;181:387.
11. Tamaru J, Hummel M, Zemlin M, Kalvelage B, Stein H. Hodgkin's disease with B-cell phenotype often shows a VDJ rearrangement and somatic mutations in the VH genes. Blood. 1994;84:708.
12. Roth J, Daus H. Trümper L, Gause A, Salamon-Looijen M, Pfreundschuh M. Detection of immunoglobulin heavy-chain gene rearrangement at the single-cell level in malignant lymphoma: no rearrangement is found in Hodgkin and Reed-Sternberg cells. Int J Cancer. 1994;57:799.
13. Küppers R, Rajewsky K, Zhao M, et al. Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA. 1994;91:10,962.
14. Kanzler H, Küppers R, Hansmann ML, Rajewsky K. Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal centre B cells. J Exp Med. 1996;184:1.
15. Hummel M, Ziemann K, Lammert H, Pileri S, Sabattini E, Stein H. Hodgkin's disease with monoclonal and polyclonal populations of Reed-Sternberg cells. N Engl J Med. 1995;333:901.
16. Delabie J, Tierens A, Gavriil T, Wu G, Weisenburger DD, Chan WC. Phenotype, genotype and clonality of Reed-Sternberg cells in nodular sclerosis Hodgkin's disease: results of a single-cell study. Br J Haematol. 1996;94:198.
17. Deng F, Lu G, Li G, Yang G. Hodgkin's disease: immunoglobulin heavy and light chain gene rearrangements revealed in single Hodgkin/Reed-Sternberg cells. J Clin Pathol: Mol Pathol. 1999; 52:37.
18. Cordell JL, Falini B, Erber WN, et al. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem. 1984;32: 219.
19. Cook GP, Tomlinson IM. The human immunoglobulin VH repertoire, Immunol Today. 1995;16: 237.
20. Tamaru J, Hummel M, Marafioti T, et al. Burkitt's lymphomas express VH genes with a moderate number of antigen-selected somatic mutations. Am J Pathol. 1995;147:1398.
21. Klein U, Goossens T, Fischer M, et al. Somatic hypermutation in normal and transformed human B cells. Immunol Rev. 1998;162:261.
22. Foss HD, Herbst H, Oelmann E, et al. Lymphotoxin, tumour necrosis factor and interleukin-6 gene transcripts are present in Hodgkin and Reed-Sternberg cells of most Hodgkin's disease cases. Br J Haematol. 1993;84:627.
23. Annweiler A, Müller-Immerglück M, Wirth T. Oct2 transactivation from a remote enhancer position requires a B-cell-restricted activity. Mol Cell Biol. 1992;12:3107.
24. Pelletier MR, Hatada EN, Scholz G, Scheidereit C. Efficient transcription of an immunoglobulin kappa promoter requires specific sequence elements overlapping with and downstream of the transcriptional start site. Nucleic Acids Res. 1997; 25:3995.
25. Rajewski K. Clonal selection and learning in the antibody system. Nature. 1996;381:751.
26. Hell K, Pringle JH, Hansmann ML, et al. Demonstration of light chain mRNA in Hodgkin's disease. J Pathol. 1993;171:137.
27. Lauritzen AF, Pluzek KJ, Kristensen LE, Nielsen HW. Detection of immunoglobulin light chain mRNA in nodular sclerosing Hodgkin's disease by in situ hybridization with biotinylated oligonucleotide probes compared with immunohistochemical staining with poly- and monoclonal antibodies. Histopathology. 1992;21:353.
28. Jox A, Zander T, Küppers R, et al. Somatic mutations within the untranslated regions of rearranged Ig genes in a case of classical Hodgkin's disease as a potential cause for the absence of immunoglobulin in the lymphoma cells. Blood. 1999;93:3964.
29. Reich L, Sharir H, Ber R, Wirth T, Bergman Y, Laskov R. Coordinate suppression of myeloma-specific genes and expression of fibroblast-specific genes in myeloma X fibroblast somatic cell hybrids. Somat Cell Mol Genet. 1996;22:1.
30. Junker S, Lamm M, Nielsen V, Matthias P. Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner. J Cell Sci. 1997;110:2579.
31. Foss H-D, Reusch R, Demel G, et al. Frequent expression of the B-cell specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin. Blood. 1999;94:3108.
32. Bargou RC, Leng C, Krappmann D, et al. High-level nuclear NF-κB and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells. Blood. 1996;87:4340.
33. Stein H, Hansmann ML, Lennert K, Brandtzaeg P, Gatter KC, Mason DY. Reed-Stemberg and Hodgkin cells in lymphocyte-predominant Hodgkin's disease of nodular subtype contain J chain. Am J Clin Pathol. 1986:86:292.
34. Pinkus GS, Said JW. Hodgkin's disease, lymphocyte predominance type, nodular -f urther evidence for a B cell derivation: L&H variants of Reed-Sternberg cells express L26, a pan B cell marker. Am J Pathol. 1988;133:211.
35. Korkolopoulou P, Cordell J, Jones M, et al. The expression of the B cell marker mb-1 (CD79a) in Hodgkin's disease. Histopathology. 1994;24:511.
36. Stoler MH, Nichols GE, Symbula M, Weiss LM. Lymphocyte predominance Hodgkin's disease: evidence for a kappa light chain-restricted monotypic B-cell neoplasm. Am J Pathol. 1995;146: 812.
37. Hell K, Hansmann ML, Pringle JH. Combination of Hodgkin's disease and diffuse large cell lymphoma: an in situ hybridisation study for immunoglobulin light chain messenger RNA. Histopathology. 1995;27:491.
38. Schmid C, Sargent C, lsaacson PG. L and H cells of nodular lymphocyte predominant Hodgkin's disease show immunoglobulin light-chain restriction. Am J Pathol. 1991;39:1281.
39. Marafioti T, Hummel M, Anagnostopoulos I, Foss H-D, Huhn D, Stein H. Classical Hodgkin's disease and follicular lymphoma originating from the same germinal center B-cell. J Clin Oncol. 1999; 17:3804.
40. Grosschedl R, Baltimore D. Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements Cell. 1985;41:88.